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公开(公告)号：US20060084116A1
公开(公告)日：2006-04-20
申请号：US11226928
申请日：2005-09-13
Applicant: Umesh Muchhal
Inventor： Umesh Muchhal
IPC: G01N33/53
CPC classification number: G01N33/6845 , G01N33/54306 , G01N33/566 , G01N33/56977 , G01N2333/70539 , G01N2500/04
Abstract: Methods, apparatuses, and compounds for screening or detecting binding of candidate peptides to an MHC construct is provided. A first component including at least one candidate peptides and a second component including at least one MHC construct are contacted. One of the components is immobilized on a solid support. The presence, absence, or quantity of binding of the peptide and said MHC construct is then determined.
Abstract translation: 提供了用于筛选或检测候选肽与MHC构建体的结合的方法，装置和化合物。 接触包含至少一种候选肽的第一组分和包含至少一种MHC构建体的第二组分。 其中一个组分固定在固体支持物上。 然后确定肽和所述MHC构建体的结合的存在，不存在或数量。
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公开(公告)号：US20060030525A1
公开(公告)日：2006-02-09
申请号：US11189438
申请日：2005-07-25
Applicant: Shannon Marshall , Gregory Moore
Inventor： Shannon Marshall , Gregory Moore
IPC: A61K38/17 , A61K31/56 , C07K14/775
CPC classification number: C07K14/775 , A61K38/00
Abstract: The present invention relates to novel apolipoprotein A-I proteins with altered immunogenicity.
Abstract translation: 本发明涉及具有改变的免疫原性的新型载脂蛋白A-1蛋白。
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公开(公告)号：US20050221443A1
公开(公告)日：2005-10-06
申请号：US11008091
申请日：2004-12-08
Applicant: John Desjarlais , Araz Eivazi , Duc-Hanh Nguyen , Jonathan Zalevsky
Inventor： John Desjarlais , Araz Eivazi , Duc-Hanh Nguyen , Jonathan Zalevsky
IPC: C07H21/04 , C07K14/525 , C07K14/715 , C12N15/09 , C12P21/02
CPC classification number: C07K14/7151
Abstract: The invention relates to novel proteins with TNFSF agonist activity and nucleic acids encoding these proteins. The invention further relates to the use of the novel proteins in the treatment of TNFSF-related disorders.
Abstract translation: 本发明涉及具有TNFSF激动剂活性的新蛋白质和编码这些蛋白质的核酸。 本发明还涉及新型蛋白质在治疗TNFSF相关疾病中的用途。
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公开(公告)号：US20050180948A1
公开(公告)日：2005-08-18
申请号：US10963994
申请日：2004-10-12
Applicant: John Desjarlais , Anton Filikov , Paul Steed , Jonathan Zalevsky , David Szymkowski
Inventor： John Desjarlais , Anton Filikov , Paul Steed , Jonathan Zalevsky , David Szymkowski
IPC: A61K38/00 , C07K14/525 , C07K14/705 , A61K38/19
CPC classification number: C07K14/525 , A61K38/191 , C07K14/70575
Abstract: The invention relates to novel proteins with TNF-alpha antagonist activity and nucleic acids encoding these proteins. The invention further relates to the use of the novel proteins in the treatment of TNF-alpha related disorders.
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公开(公告)号：US20250011440A1
公开(公告)日：2025-01-09
申请号：US18885442
申请日：2024-09-13
Applicant: Xencor, Inc.
Inventor： Aaron Keith Chamberlain , Bassil Dahiyat , John Desjarlais , Sher Bahadur Karki , Gregory Lazar
Abstract: The present application relates to optimized IgG immunoglobulin variants, engineering methods for their generation, and their application, particularly for therapeutic purposes.
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Patent Agency Ranking
公开(公告)号：US20240239879A1
公开(公告)日：2024-07-18
申请号：US18440895
申请日：2024-02-13
Applicant: Xencor, Inc.
Inventor： Aaron Keith Chamberlain , Bassil Dahiyat , John R. Desjarlais , Sher Bahadur Karki , Gregory Alan Lazar
IPC: C07K16/18 , A61K39/00 , C07K14/715 , C07K16/08 , C07K16/22 , C07K16/24 , C07K16/28 , C07K16/32 , C07K16/42
CPC classification number: C07K16/18 , C07K14/7151 , C07K16/082 , C07K16/22 , C07K16/241 , C07K16/2863 , C07K16/2866 , C07K16/2893 , C07K16/2896 , C07K16/32 , C07K16/4291 , A61K2039/505 , C07K2317/24 , C07K2317/52 , C07K2317/524 , C07K2317/526 , C07K2317/90 , C07K2319/30 , Y02A50/30
Abstract: The present application relates to a variant Fc region comprising at least one modification relative to a wild-type human Fc region, where the modification selected from the group consisting of 434S, 252Y/428L, 252Y/434S, and 428L/434S, and the numbering is according to the EU index.
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公开(公告)号：US11932685B2
公开(公告)日：2024-03-19
申请号：US17079299
申请日：2020-10-23
Applicant: Xencor, Inc.
Inventor： Aaron Keith Chamberlain , Bassil Dahiyat , John R. Desjarlais , Sher Bahadur Karki , Gregory Alan Lazar
IPC: C07K16/00 , A61K39/395 , C07H21/04 , C07K14/715 , C07K16/08 , C07K16/18 , C07K16/22 , C07K16/24 , C07K16/28 , C07K16/32 , C07K16/42 , C12N1/20 , C12N5/00 , C12N5/16 , C12N15/00 , A61K39/00
CPC classification number: C07K16/18 , C07K14/7151 , C07K16/082 , C07K16/22 , C07K16/241 , C07K16/2863 , C07K16/2866 , C07K16/2893 , C07K16/2896 , C07K16/32 , C07K16/4291 , A61K2039/505 , C07K2317/24 , C07K2317/52 , C07K2317/524 , C07K2317/526 , C07K2317/90 , C07K2319/30 , Y02A50/30
Abstract: The present application relates to a variant Fc region comprising at least one modification relative to a wild-type human Fc region, where the modification selected from the group consisting of 434S, 252Y/428L, 252Y/434S, and 428L/434S, and the numbering is according to the EU index.
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公开(公告)号：US11932675B2
公开(公告)日：2024-03-19
申请号：US17067508
申请日：2020-10-09
Applicant: Genentech, Inc. , Xencor, Inc.
Inventor： John Desjarlais , Matthew Bernett , Michael Hedvat , Rajat Varma , Suzanne Schubbert , Christine Bonzon , Rumana Rashid , Juan Diaz , Patrick Holder , Christine Huang
CPC classification number: C07K14/5443 , A61P35/00 , C07K16/2818 , A61K38/00 , C07K2319/30
Abstract: The present invention relates to fusion proteins comprising variant IL-15 proteins, fusion proteins comprising variant anti-PD-1 antigen binding domains, and fusion proteins comprising variant IL-15 proteins and variant anti-PD-1 antigen binding domains. The present invention also relates to nucleic acid molecules, expression vectors, host cells and methods for making such fusion proteins and the use of such fusion proteins in the treatment of cancer.
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99.发明公开公开(公告)号：US20240026002A1
公开(公告)日：2024-01-25
申请号：US18452395
申请日：2023-08-18
Applicant: Xencor, Inc.
Inventor： Matthew J. Bernett , Gregory Moore , John Desjarlais , Michael Hedvat , Christine Bonzon
CPC classification number: C07K16/2818 , A61P35/00 , A61P37/06 , C07K16/2803 , C07K16/2827 , C07K2317/55 , C07K2317/622 , C07K2317/64 , C07K2317/76 , C07K2317/52 , C07K2317/33 , C07K2317/31 , A61K2039/507
Abstract: The present invention is directed to bispecific, heterodimeric immunomodulatory antibodies.
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公开(公告)号：US11851466B2
公开(公告)日：2023-12-26
申请号：US17062458
申请日：2020-10-02
Applicant: Xencor, Inc.
Inventor： Matthew Bernett , John R. Desjarlais , Rajat Varma , Ke Liu , Rumana Rashid , Nargess Hassanzadeh-Kiabi , Michael Hedvat
CPC classification number: C07K14/5434 , A61P35/00 , C07K16/2818 , C07K16/2827 , A61K2039/505 , C07K2317/622 , C07K2319/30
Abstract: The present invention relates to targeted IL-12 heterodimeric Fc fusion proteins, where the fusion proteins bind to human PD-1 or human PD-L1.
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