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公开(公告)号：US20140255299A1
公开(公告)日：2014-09-11
申请号：US14240801
申请日：2012-08-24
CPC分类号： A61K38/10 , A01N43/38 , A61K9/513 , A61K9/5153 , A61K38/16 , A61K38/1761 , A61K45/06 , C07K7/08
摘要： In an aspect, the invention relates to compositions and methods for permeabilizing membranes of cells. In an aspect, the invention relates to compositions and methods for killing cells. In an aspect, the invention relates to compositions and methods of permeabilizing the membranes of cancer cells or microbial cells.
摘要翻译： 一方面，本发明涉及用于使细胞膜渗透的组合物和方法。 一方面，本发明涉及杀死细胞的组合物和方法。 一方面，本发明涉及透化癌细胞或微生物细胞的膜的组合物和方法。
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公开(公告)号：US08802076B2
公开(公告)日：2014-08-12
申请号：US13252516
申请日：2011-10-04
申请人： Soman Abraham , Kam Leong , Herman Staats , Ashley St. John
发明人： Soman Abraham , Kam Leong , Herman Staats , Ashley St. John
CPC分类号： A61K39/39 , A61K9/5123 , A61K9/513 , A61K38/191 , A61K38/20 , A61K38/2006 , A61K38/2013 , A61K38/2066 , A61K38/208 , A61K38/21 , A61K39/0008 , A61K39/085 , A61K39/12 , A61K39/145 , A61K2039/5252 , A61K2039/55505 , A61K2039/55527 , A61K2039/55555 , B82Y5/00 , C12N2760/16134 , Y10S977/773 , Y10S977/906
摘要： Provided are nanoparticles comprising heparin, chitosan, and at least one immunomodulatory agent, e.g. a cytokine. The cytokine can be selected from the group consisting of TNF, IL-12, IL-2, IL-23, IL-1α, IL-10, IL-18, and combinations thereof. Further provided are methods of making a nanoparticle comprising mixing a first composition comprising heparin with a second composition comprising chitosan in the presence of at least one cytokine to form a third composition. Further provided are methods of modulating an immune response comprising co-administering to a subject an antigen or vaccine with nanoparticles comprising heparin, chitosan, and at least one cytokine.
摘要翻译： 提供了包含肝素，壳聚糖和至少一种免疫调节剂的纳米颗粒，例如。 一种细胞因子。 细胞因子可以选自TNF，IL-12，IL-2，IL-23，IL-1α，IL-10，IL-18及其组合。 还提供了制备纳米颗粒的方法，其包括在至少一种细胞因子的存在下将包含肝素的第一组合物与包含壳聚糖的第二组合物混合以形成第三组合物。 还提供了调节免疫应答的方法，其包括用包含肝素，壳聚糖和至少一种细胞因子的纳米颗粒向受试者共同施用抗原或疫苗。
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公开(公告)号：US20120269888A1
公开(公告)日：2012-10-25
申请号：US13503068
申请日：2010-10-20
申请人： Jan Matthijs Jetten , Jacobus Eversdijk , Kjeld Jacobus Cornelis van Bommel , Johannes Wilhelmus Timmermans , Aafke Tessa ten Cate , Theodoor Maximiliaan Slaghek
发明人： Jan Matthijs Jetten , Jacobus Eversdijk , Kjeld Jacobus Cornelis van Bommel , Johannes Wilhelmus Timmermans , Aafke Tessa ten Cate , Theodoor Maximiliaan Slaghek
IPC分类号： A23D9/007 , A61K9/48 , A61K47/44 , A61K47/36 , A61K47/42 , A61K47/38 , A61K38/02 , A61K31/20 , A61K31/197 , A61K33/00 , A61P3/02 , A61P1/14 , B05D7/00 , B05D3/00 , A23J7/00 , A23D9/00 , A23D9/013 , A23L1/00 , A61K9/10 , B82Y5/00
CPC分类号： A61K47/38 , A23P10/35 , A61K9/167 , A61K9/1676 , A61K9/1682 , A61K9/5036 , A61K9/5042 , A61K9/5052 , A61K9/5073 , A61K9/5078 , A61K9/5089 , A61K9/5115 , A61K9/5123 , A61K9/513 , A61K9/5192 , A61K9/7007 , A61K47/36 , A61K47/42 , B01J13/02
摘要： The invention is directed to a barrier composition, to a vehicle comprising said barrier composition, to a layer comprising said barrier composition, to a foodstuff comprising said vehicle or layer, to a pharmaceutical or nutraceutical composition comprising said vehicle or layer, to a method for protecting one or more active ingredients, and to the use of said barrier composition.The barrier composition of the invention comprises: a hydrophobic organic phase; and 0.1-75 vol. %, based on the total volume of the barrier composition, of biodegradable solid plate-like particles.
摘要翻译： 本发明涉及一种阻挡组合物，包含所述阻挡组合物的载体，包含所述阻挡组合物的层，包含所述载体或层的食品，包含所述载体或层的药物或营养组合物， 保护一种或多种活性成分，以及使用所述阻挡组合物。 本发明的阻隔组合物包括：疏水性有机相; 和0.1-75体积 ％，基于阻隔组合物的总体积，可生物降解的固体板状颗粒。
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公开(公告)号：US20120178139A1
公开(公告)日：2012-07-12
申请号：US13397202
申请日：2012-02-15
CPC分类号： A61K47/6811 , A61K9/1075 , A61K9/513 , A61K38/00 , A61K39/0008 , A61K39/001 , A61K47/64 , A61K47/6803 , A61K47/6815 , A61K47/6843 , A61K47/6849 , A61K2039/6031 , A61K2039/605 , A61K2039/6056 , C07K7/08 , C07K14/62 , C07K14/70539 , C07K16/18 , C07K16/28 , C07K2317/56 , C07K2317/622 , C07K2317/92 , C07K2319/00 , C07K2319/21 , C07K2319/22 , C07K2319/23 , C07K2319/30 , C07K2319/33 , C07K2319/41 , C07K2319/43 , C07K2319/74 , C12N9/82 , C12N9/96 , C12Y305/01001
摘要： Peptides that specifically bind erythrocytes are described. These are provided as peptidic ligands having sequences that specifically bind, or as antibodies or fragments thereof that provide specific binding, to erythrocytes. The peptides may be prepared as molecular fusions with therapeutic agents, tolerizing antigens, or targeting peptides. Immunotolerance may be created by use of the fusions and choice of an antigen on a substance for which tolerance is desired.
摘要翻译： 描述了特异性结合红细胞的肽。 这些作为肽配体提供，其具有与红细胞特异性结合的序列，或作为提供特异性结合的抗体或其片段。 肽可以制备成具有治疗剂，耐受抗原或靶向肽的分子融合物。 可以通过使用融合物和在需要耐受性的物质上选择抗原来产生免疫耐受性。
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公开(公告)号：US20120135047A1
公开(公告)日：2012-05-31
申请号：US13266122
申请日：2010-04-23
申请人： Aaron Dodd , Felix Meiser , Marck Norret , Adrian Russell , H William Bosch
发明人： Aaron Dodd , Felix Meiser , Marck Norret , Adrian Russell , H William Bosch
IPC分类号： A61K31/196 , C07C229/42 , A61K9/14 , B82Y40/00 , B82Y5/00
CPC分类号： A61K31/196 , A61K9/0053 , A61K9/0087 , A61K9/14 , A61K9/141 , A61K9/143 , A61K9/145 , A61K9/146 , A61K9/16 , A61K9/1682 , A61K9/4808 , A61K9/4825 , A61K9/4858 , A61K9/5115 , A61K9/5123 , A61K9/513 , A61K9/5138 , A61K9/5192 , A61K47/12 , A61K47/20 , Y02A50/465 , Y10T428/2982
摘要： The present invention relates to methods for producing particles of diclofenac using dry milling processes as well as compositions comprising diclofenac, medicaments produced using diclofenac in particulate form and/or compositions, and to methods of treatment of an animal, including man, using a therapeutically effective amount of diclofenac administered by way of said medicaments.
摘要翻译： 本发明涉及使用干磨法生产双氯芬酸颗粒的方法以及包含双氯芬酸的组合物，使用颗粒形式的双氯芬酸和/或组合物制备的药物，以及使用治疗有效的方法治疗动物，包括人的方法 通过所述药物施用的双氯芬酸的量。
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公开(公告)号：US20120107268A1
公开(公告)日：2012-05-03
申请号：US13252516
申请日：2011-10-04
申请人： Soman Abraham , Kam Leong , Herman Staats , Ashley St. John
发明人： Soman Abraham , Kam Leong , Herman Staats , Ashley St. John
IPC分类号： A61K38/20 , A61K38/21 , A61K39/00 , A61K39/02 , A61P31/12 , A61P37/04 , A61K38/19 , A61K39/12 , B82Y5/00
CPC分类号： A61K39/39 , A61K9/5123 , A61K9/513 , A61K38/191 , A61K38/20 , A61K38/2006 , A61K38/2013 , A61K38/2066 , A61K38/208 , A61K38/21 , A61K39/0008 , A61K39/085 , A61K39/12 , A61K39/145 , A61K2039/5252 , A61K2039/55505 , A61K2039/55527 , A61K2039/55555 , B82Y5/00 , C12N2760/16134 , Y10S977/773 , Y10S977/906
摘要： Provided are nanoparticles comprising heparin, chitosan, and at least one immunomodulatory agent, e.g. a cytokine. The cytokine can be selected from the group consisting of TNF, IL-12, IL-2, IL-23, IL-1α, IL-10, IL-18, and combinations thereof. Further provided are methods of making a nanoparticle comprising mixing a first composition comprising heparin with a second composition comprising chitosan in the presence of at least one cytokine to form a third composition. Further provided are methods of modulating an immune response comprising co-administering to a subject an antigen or vaccine with nanoparticles comprising heparin, chitosan, and at least one cytokine.
摘要翻译： 提供了包含肝素，壳聚糖和至少一种免疫调节剂的纳米颗粒，例如。 一种细胞因子。 细胞因子可以选自TNF，IL-12，IL-2，IL-23，IL-1α，IL-10，IL-18及其组合。 还提供了制备纳米颗粒的方法，其包括在至少一种细胞因子的存在下将包含肝素的第一组合物与包含壳聚糖的第二组合物混合以形成第三组合物。 还提供了调节免疫应答的方法，其包括用包含肝素，壳聚糖和至少一种细胞因子的纳米颗粒向受试者共同施用抗原或疫苗。
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公开(公告)号：US20120037265A1
公开(公告)日：2012-02-16
申请号：US13208789
申请日：2011-08-12
CPC分类号： C07D417/12 , A61K9/143 , A61K9/145 , A61K9/146 , A61K9/5115 , A61K9/5123 , A61K9/513 , A61K31/5415 , B63B22/026 , B63B27/34 , B63B2035/442 , B63B2035/448 , B65H75/38 , B65H75/4402 , B65H75/4415 , B65H75/4486 , B65H2701/33 , B67D9/00 , Y10T428/2982
摘要： A system for offloading a fluid from an offshore structure comprises an annular conduit support structure disposed about the offshore structure. The support structure is fixably coupled to the offshore structure. In addition, the system comprises an annular reel disposed about the offshore structure and rotatably coupled to the support structure. The reel includes a conduit fairlead configured to move relative to the support structure. Further, the system comprises a flexible conduit having a fluid inlet end and a fluid outlet end. The flexible conduit includes a first portion wrapped around the conduit support structure and a second portion extending from the conduit support structure through the fairlead.
摘要翻译： 用于从海上结构卸载流体的系统包括围绕海上结构设置的环形导管支撑结构。 支撑结构与海上结构固定连接。 另外，该系统包括围绕海上结构设置并可旋转地联接到支撑结构的环形卷轴。 卷轴包括构造成相对于支撑结构移动的导管道。 此外，该系统包括具有流体入口端和流体出口端的柔性导管。 柔性导管包括围绕导管支撑结构缠绕的第一部分和从导管支撑结构延伸穿过导线管的第二部分。
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98.发明公开公开(公告)号：US20240301431A1
公开(公告)日：2024-09-12
申请号：US18020145
申请日：2021-10-05
发明人： Won Jong KIM , Jin Seong KIM , Hyeong Mok PARK
IPC分类号： C12N15/115 , A61K9/51 , A61K47/69 , A61P27/02
CPC分类号： C12N15/115 , A61K9/513 , A61K47/6923 , A61K47/6929 , A61P27/02 , C12N2310/16
摘要： The present disclosure relates to a polymer-coated gold nanoparticle-aptamer nanoconstruct having reactive oxygen species sensitivity and capable of treating inflammatory diseases through reactive oxygen species scavenge and TNF-α capture.
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公开(公告)号：US12065664B2
公开(公告)日：2024-08-20
申请号：US17128736
申请日：2020-12-21
IPC分类号： A61K39/395 , A61K9/00 , A61K9/51 , A61K31/105 , A61K31/7105 , A61K31/713 , A61K47/68 , A61K47/69 , A61K48/00 , A61P35/02 , C07K16/28 , C12N15/88
CPC分类号： C12N15/88 , A61K9/0019 , A61K9/513 , A61K31/105 , A61K31/7105 , A61K31/713 , A61K39/395 , A61K47/6849 , A61K47/6911 , A61K48/0066 , A61P35/02 , C07K16/2812 , C07K16/2896
摘要： Disclosed are targeted lipid based particles for delivery of nucleic acid molecules (such as siRNA) to leukocytes (such as T-Cells and B-cells). Further disclosed are uses of the targeted lipid based particles for treating Leukocytes-associated diseases, such as, cancer.
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公开(公告)号：US12006500B2
公开(公告)日：2024-06-11
申请号：US17157920
申请日：2021-01-25
申请人： Sirnaomics, Inc.
发明人： Danny Tang , Xueping Chen , Patrick Y. Lu , Vera Simonenko , David Evans , John Xu , Deling Wang , Alan Lu
IPC分类号： C12N15/113 , A61K9/51 , A61K31/713 , A61K47/28 , A61K47/69 , A61P31/14
CPC分类号： C12N15/113 , A61K9/513 , A61K31/713 , A61K47/28 , A61K47/6931 , A61P31/14
摘要： Compositions and methods for development of potent siRNA therapeutics for prevention and treatment of Corona Virus (2019-nCoV; COVID-19) infections are provided. The compositions include a pharmaceutical composition comprising siRNA cocktails that target critical viral genes and pharmaceutically acceptable polymeric nanoparticle carriers and liposomal nanoparticle carriers. Administration methods for prevention and treatment are provided, including airway instillation, subcutaneous injections and nebulizer aerosolization.
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