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公开(公告)号：US20120125840A1
公开(公告)日：2012-05-24
申请号：US13360669
申请日：2012-01-28
Applicant: Charles Satish Smith
Inventor： Charles Satish Smith
IPC: C02F9/00
CPC classification number: C02F3/006 , C02F1/683 , C02F3/28 , C02F3/282 , C02F3/34 , C02F3/343 , C02F11/04 , C02F11/185 , C02F2101/20 , C02F2103/20 , C02F2103/26 , C02F2209/02 , C02F2209/03 , C02F2209/04 , C02F2209/06 , C02F2209/40 , C02F2303/10 , C12M27/20 , C12M41/00 , C12M41/26 , C12M41/34 , C12M41/40 , C12M41/44 , C12M41/48 , Y02E50/343 , Y02W10/30
Abstract: Systems and methods for performing anaerobic digestion of biomaterials using a clarifier, a batch reactor, and/or a digester are disclosed. The clarifier performs pretreatment processing of biomaterial to improve anaerobic digestion. The batch reactor and/or the digester are coupled to the clarifier and are configured to digest the processed biomaterial. A control system for an anaerobic digestion process includes a flow control system, a temperature control system, and a totalization system. The flow control system controls the flow of biomaterial and the delivery of chemical agents to the biomaterial based on conductivity, temperature, pressure, and/or composition of the biomaterial. The temperature control system includes a heat source and heat exchangers that control the temperature of the biomaterial. The totalization system senses the volume of biomaterial in at least one stage of an anaerobic digestion process and a controller controls the flow control system based upon the sensed volume of biomaterial.
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92.发明申请Methods and Systems of Growing and Harvesting Cells in a Hollow Fiber Bioreactor System with Control Conditions 有权在具有控制条件的中空纤维生物反应器系统中生长和收获细胞的方法和系统公开(公告)号：US20120088224A1
公开(公告)日：2012-04-12
申请号：US13269512
申请日：2011-10-07
Applicant: Thomas G. DILORENZO , Edward Allan STANTON, IV , Glen Delbert ANTWILER , Michael E. KINZIE , Brian J. Nankervis , Monique Givens , Casey V. Medina , Jon A. Dodd
Inventor： Thomas G. DILORENZO , Edward Allan STANTON, IV , Glen Delbert ANTWILER , Michael E. KINZIE , Brian J. Nankervis , Monique Givens , Casey V. Medina , Jon A. Dodd
CPC classification number: C12M41/44 , C12M23/42 , C12M23/44 , C12M25/10 , C12M25/12 , C12M29/16 , C12M29/20 , C12M41/48 , G06F8/38
Abstract: Embodiments described herein generally relate to methods and systems for using an air removal chamber as a control for a process in a cell expansion system. The air removal chamber may be mounted on a fluid conveyance assembly for use with the system. Fluid is pumped into a fluid containment chamber of the air removal chamber, in which the level of fluid in the fluid containment chamber may be monitored through the use of one or more sensors. The sensors are capable of detecting air, a lack of fluid, fluid, and/or a gas/fluid interface, e.g., an air/fluid interface, at measuring positions within the air removal chamber. Protocols for use with the system may include one or more stop conditions. In an embodiment, the stopping of a process is automated based on the detection of air, a lack of fluid, and/or a gas/fluid interface in the air removal chamber.
Abstract translation: 本文描述的实施例一般涉及使用空气除去室作为电池膨胀系统中的工艺的控制的方法和系统。 排气室可以安装在流体输送组件上以与系统一起使用。 流体被泵送到空气移除室的流体容纳室中，其中流体容纳室中的流体水平可以通过使用一个或多个传感器来监测。 传感器能够在空气去除室内的测量位置处检测空气，缺乏流体，流体和/或气体/流体界面，例如空气/流体界面。 用于该系统的协议可以包括一个或多个停止条件。 在一个实施例中，基于在空气移除室中检测空气，缺乏流体和/或气体/流体界面，自动停止过程。
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93.发明申请Configurable Methods and Systems of Growing and Harvesting Cells in a Hollow Fiber Bioreactor System 有权中空纤维生物反应器系统中生长和收获细胞的可配置方法和系统公开(公告)号：US20120086657A1
公开(公告)日：2012-04-12
申请号：US13269323
申请日：2011-10-07
Applicant: Edward Allan STANTON, IV , Glen Delbert ANTWILER , Patrick J. HOWLEY , Michael E. KINZIE , Jon A. DODD , Casey V. MEDINA
Inventor： Edward Allan STANTON, IV , Glen Delbert ANTWILER , Patrick J. HOWLEY , Michael E. KINZIE , Jon A. DODD , Casey V. MEDINA
CPC classification number: C12M41/44 , C12M23/42 , C12M23/44 , C12M25/10 , C12M25/12 , C12M29/16 , C12M29/20 , C12M41/48 , G06F8/38
Abstract: Embodiments described herein generally relate to methods and systems for configuring settings of a cell expansion system including a bioreactor. Through a user interface, a user may configure display settings, system settings, and settings associated with protocols for loading, growing and/or harvesting cells. In configuring settings for protocols and associated processes, a diagram view or window of the cell expansion system is displayed in embodiments. The diagram view displays the process settings as graphical user interface elements. Settings available for configuration are enabled for selection in the diagram view. The diagram view allows the user to visualize the settings available for task configuration and to configure enabled settings. Configured settings are stored and capable of retrieval for subsequent execution or modification of the applicable protocol.
Abstract translation: 本文描述的实施例通常涉及用于配置包括生物反应器的细胞扩增系统的设置的方法和系统。 通过用户界面，用户可以配置显示设置，系统设置和与用于加载，增长和/或收集单元的协议相关联的设置。 在配置协议和关联进程的设置时，在实施例中显示单元扩展系统的图表视图或窗口。 图表视图将进程设置显示为图形用户界面元素。 可用于配置的设置在图表视图中启用选择。 图表视图允许用户可视化可用于任务配置的设置，并配置启用的设置。 存储配置的设置并能够检索以便后续执行或修改适用的协议。
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公开(公告)号：US20110159590A1
公开(公告)日：2011-06-30
申请号：US13008048
申请日：2011-01-18
Applicant: Yoseph SHAALTIEL
Inventor： Yoseph SHAALTIEL
Abstract: A device, system and method for axenically culturing and harvesting cells and/or tissues, including bioreactors and fermentors. The device is preferably disposable but nevertheless may be used continuously for a plurality of consecutive culturing/harvesting cycles prior to disposal of same. This invention also relates to batteries of such devices which may be used for large-scale production of cells and tissues. According to preferred embodiments of the present invention, the present invention is adapted for use with plant cell culture.
Abstract translation: 一种用于轴培养和收获包括生物反应器和发酵罐的细胞和/或组织的装置，系统和方法。 该装置优选是一次性的，但是在处理之前可以连续使用多个连续的培养/收获循环。 本发明还涉及可用于大规模生产细胞和组织的这种装置的电池。 根据本发明的优选实施方案，本发明适用于植物细胞培养。
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公开(公告)号：US20100267142A1
公开(公告)日：2010-10-21
申请号：US12761810
申请日：2010-04-16
Applicant: Gary Wang , King-Ming Chang , Lewis Ho
Inventor： Gary Wang , King-Ming Chang , Lewis Ho
Abstract: A scalable packed-bed cell culture device includes a matrix vessel, a mixing vessel, a communicating means, a driving means and a controlling means. The matrix vessel includes porous matrixes packed therein. The mixing vessel includes a mixing means configured for mixing a culture medium. The communicating means is connected between the matrix vessel and the mixing vessel. The driving means is configured for driving the culture medium to flow between the matrix vessel and the mixing vessel. The controlling means configured for controlling the culture medium to submerge the porous matrixes at high level, and to emerge the porous matrixes at low level. An inoculation method and a culture method for scalable packed-bed cell culture device is also herein provided for eliminating the limitation of aeration or oxygenation during culture, alleviating the gradient effect, eliminating the channeling effect in conventional packed-bed bioreactors.
Abstract translation: 可膨胀的填充床细胞培养装置包括矩阵容器，混合容器，连通装置，驱动装置和控制装置。 基质容器包括填充在其中的多孔基体。 混合容器包括配置用于混合培养基的混合装置。 连通装置连接在矩阵容器和混合容器之间。 驱动装置被构造成用于驱动培养基在矩阵容器和混合容器之间流动。 所述控制装置被配置为控制所述培养基以高水平淹没所述多孔基质，并且以低水平出现所述多孔基质。 本文还提供了一种用于可膨胀的填充床细胞培养装置的接种方法和培养方法，用于消除培养期间通气或氧合的限制，减轻梯度效应，消除常规填充床生物反应器中的通道效应。
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Patent Agency Ranking
公开(公告)号：US20100255582A1
公开(公告)日：2010-10-07
申请号：US12418371
申请日：2009-04-03
Applicant: Blaise D. Porter , Kent S. Vilendrer
Inventor： Blaise D. Porter , Kent S. Vilendrer
CPC classification number: C12N5/0068 , C12M23/26 , C12M23/46 , C12M41/40 , C12M41/44
Abstract: An apparatus and method is described for seeding and culturing cells on a sample. The apparatus includes a chamber in which the volume of the chamber may be adjusted without compromising the seal or sterility of the chamber. The apparatus enables the seeding of cells in a reduced volume and culturing of cells in an increased volume. Further, the apparatus enables application of forces, strains and torques to a sample during seeding, culturing or transportation of the sample.
Abstract translation: 描述了用于在样品上接种和培养细胞的装置和方法。 该装置包括腔室，其中可以调节腔室的体积而不损害腔室的密封或无菌性。 该装置能够以减小的体积接种细胞并以增加的体积培养细胞。 此外，该装置能够在接种，培养或运送样品期间向样品施加力，应变和扭矩。
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公开(公告)号：US20100136673A1
公开(公告)日：2010-06-03
申请号：US12690977
申请日：2010-01-21
Applicant: Yoseph SHAALTIEL
Inventor： Yoseph SHAALTIEL
IPC: C12M3/00
Abstract: A device, system and method for axenically culturing and harvesting cells and/or tissues, including bioreactors and fermentors. The device is preferably disposable but nevertheless may be used continuously for a plurality of consecutive culturing/harvesting cycles prior to disposal of same. This invention also relates to batteries of such devices which may be used for large-scale production of cells and tissues. According to preferred embodiments of the present invention, the present invention is adapted for use with plant cell culture.
Abstract translation: 一种用于轴培养和收获包括生物反应器和发酵罐的细胞和/或组织的装置，系统和方法。 该装置优选是一次性的，但是在处理之前可以连续使用多个连续的培养/收获循环。 本发明还涉及可用于大规模生产细胞和组织的这种装置的电池。 根据本发明的优选实施方案，本发明适用于植物细胞培养。
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98.发明申请CELL CULTURE METHOD, CELL CULTURE SYSTEM AND CULTURE MEDIUM ADJUSTEMENT APPARATUS 有权细胞培养方法，细胞培养系统和培养中等调节剂公开(公告)号：US20100062530A1
公开(公告)日：2010-03-11
申请号：US12450480
申请日：2008-04-24
Applicant: Satoshi Tanaka , Yoichi Ishizaki , Ryo Suenaga , Yoriko Tokita , Masahito Kogure
Inventor： Satoshi Tanaka , Yoichi Ishizaki , Ryo Suenaga , Yoriko Tokita , Masahito Kogure
CPC classification number: C12M41/32 , C12M23/14 , C12M23/26 , C12M27/02 , C12M29/26 , C12M33/18 , C12M41/26 , C12M41/44
Abstract: In a cell culture in a sealed cell culture container, gradual deterioration of culture environment is prevented. A cell culture method in which cell culture is conducted by adding a fresh culture medium to a culture container in which cells and a culture medium are enclosed, which includes the steps ofadjusting the pH of said culture medium to be added to be higher than the pH which is optimum for culture of the cells, and/or adjusting the partial pressure of dissolved carbon dioxide of the culture medium to be added to be lower than the pressure which is optimum for culture of the cells, and/or adjusting the partial pressure of dissolved oxygen of the culture medium to be added to be higher than the pressure which is optimum for culture of the cells; and mixing the adjusted culture medium and the culture medium in said culture container to adjust at least any of the pH, the partial pressure of dissolved carbon dioxide and the partial pressure of dissolved oxygen to be optimum for culture of said cells, thereby to culture the cells in the culture container.
Abstract translation: 在密闭的细胞培养容器中的细胞培养物中，防止了培养环境的逐渐恶化。 一种细胞培养方法，其中通过向封闭细胞和培养基的培养容器中加入新鲜培养基进行细胞培养，其包括将待加入的培养基的pH调节至高于 调节细胞培养最适宜的pH值，和/或将待添加的培养基溶解二氧化碳的分压调整至低于细胞培养最佳的压力，和/或调节分压 的待添加培养基的溶解氧高于培养细胞的最佳压力; 并将调节后的培养基和培养液混合，调节pH，溶解二氧化碳的分压和溶解氧的分压中的至少任意一种，使其培养成最适于培养所述细胞， 细胞在培养容器中。
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99.发明申请Process For Cell Culturing By Continuous Perfusion And Alternating Tangential Flow 有权通过连续灌注和交替切向流动细胞培养的方法公开(公告)号：US20080131934A1
公开(公告)日：2008-06-05
申请号：US10591118
申请日：2005-03-04
Applicant: John Crowley , Maike Wubben , Jose Manuel Coco Martin
Inventor： John Crowley , Maike Wubben , Jose Manuel Coco Martin
CPC classification number: C12N5/0621 , C07K16/00 , C07K2317/14 , C12M25/10 , C12M29/10 , C12M41/44 , C12N5/00 , C12N5/0602 , C12N2521/00 , C12P19/34 , C12P21/00
Abstract: The invention relates to a process for the culturing of cells by continuous perfusion culturing of a cell culture comprising cell culture medium and cells, wherein cell culture medium is added to the cell culture, the cell culture is circulated over a filter module comprising hollow fibers resulting in an outflow of liquid having a lower cell density than the cell culture and the flow within the filter module is an alternating tangential flow. Preferably, culture medium is added at a particular perfusion rate and/or biomass is removed form the culture at least once. The method is especially suitable for the culturing of aggregating cells. The invention also relates to such a process wherein a biological substance, preferably an antibody, is produced by the cells, which biological substance may be further purified in downstream processing.
Abstract translation: 本发明涉及通过连续灌注培养包含细胞培养基和细胞的细胞培养细胞的方法，其中向细胞培养物中加入细胞培养基，将细胞培养物循环在包含中空纤维的过滤组件上，得到 在具有比细胞培养物更低的细胞密度的液体的流出中，并且过滤器模块内的流动是交替的切向流。 优选地，以特定的灌注速率加入培养基，和/或从培养物中除去生物质至少一次。 该方法特别适用于培养聚集细胞。 本发明还涉及这样的方法，其中生物物质，优选抗体由细胞产生，该生物物质可以在下游加工中进一步纯化。
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公开(公告)号：US20080109100A1
公开(公告)日：2008-05-08
申请号：US11927899
申请日：2007-10-30
Applicant: Maina Macharia , Michael Tay
Inventor： Maina Macharia , Michael Tay
IPC: G06F19/00
CPC classification number: C12M41/48 , C10L1/02 , C12M41/12 , C12M41/44 , C12M41/46 , C12M45/09 , G05B13/04 , G05B13/048
Abstract: System and method for managing batch fermentation in biofuel production. An optimizer executes a nonlinear multivariate predictive model of a batch fermentation process in accordance with an end of batch objective specifying a target end of batch biofuel concentration to determine an optimal batch trajectory over a temporal control horizon specifying a biofuel and/or sugar concentration trajectory over the batch fermentation process. A nonlinear control model for the batch fermentation process that includes the temporal control horizon driven by biofuel concentration during the batch fermentation process is executed per the determined optimal batch trajectory using received process information as input, thereby generating model output including target values for manipulated variables for the batch fermentation process, including batch fermentation temperature. The batch fermentation process is controlled per the target values to produce biofuel in accordance with the determined optimal batch trajectory, to substantially optimize the end of batch biofuel yield.
Abstract translation: 在生物燃料生产中管理分批发酵的系统和方法。 优化器根据批量目标的结束执行分批发酵过程的非线性多变量预测模型，指定批生物燃料浓度的目标结束，以确定在指定生物燃料和/或糖浓度轨迹的时间控制范围上的最佳批次轨迹 分批发酵过程。 使用接收到的过程信息作为输入，根据确定的最佳批次轨迹执行包括在分批发酵过程中由生物燃料浓度驱动的时间控制水平的分批发酵过程的非线性控制模型，从而生成模型输出，包括用于操纵变量的目标值 分批发酵工艺，包括分批发酵温度。 按照目标值控制分批发酵过程，以根据确定的最佳批次轨迹生产生物燃料，以基本上优化批量生物燃料产量的结束。
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