公开(公告)号：US11524266B1

公开(公告)日：2022-12-13

申请号：US16778557

申请日：2020-01-31

Applicant: Combat Capabilities Development Command, Chemical Biological Center

Inventor： Gregory W Peterson ,  Joseph L Lenhart ,  Randy A Mrozek

IPC: B01D69/14 ,  A62D3/33 ,  A62D3/37 ,  A62D3/35 ,  B01D69/02 ,  A62D3/38 ,  B01D71/24 ,  A62D101/26 ,  A62D101/02 ,  C01B3/00 ,  C01B39/00

Abstract: A composite material is provided comprising a porous polymeric matrix having metal-organic framework (MOF) domains dispersed within the porous polymeric matrix, each of said MOF domains in fluid communication with the external environment through the pores in the porous polymeric matrix. A process of using the composite material to chemically modify or detoxify a chemical warfare agent or a toxic industrial chemical is also provided. The chemical warfare agent or the toxic industrial chemical is brought into contact with a MOF domain within the porous polymeric matrix so that the MOFs adsorb and chemically modify the chemical warfare agent or the toxic industrial chemical. A process for producing such a composite material is also disclosed.

公开(公告)号：US11433371B2

公开(公告)日：2022-09-06

申请号：US16361940

申请日：2019-03-22

Applicant: The Government of the United States of America, as represented by the Secretary of the Navy

Inventor： Jeffrey G. Lundin ,  Christopher L. McGann ,  Spencer L. Giles ,  Grant Daniels ,  Robert B. Balow ,  Jorge L. Miranda-Zayas ,  James H. Wynne

IPC: B01J20/26 ,  B01J20/06 ,  B01J20/28 ,  B01J20/30 ,  A62D3/38 ,  A62D101/26 ,  A62D101/02

Abstract: Materials for decontamination of compounds having a phosphorous-sulfur bond or a phosphorous-oxygen bond. A porous polymer, such as poly(dicyclopentadiene), contains particles of zirconium hydroxide. The polymer optionally has hydroperoxide groups.

公开(公告)号：US11331527B2

公开(公告)日：2022-05-17

申请号：US15775403

申请日：2015-11-12

Applicant: Helsingin yliopisto

Inventor： Ullastiina Hakala ,  Risto Hakala

IPC: A62D3/34 ,  A62D3/32 ,  A62D3/35 ,  A62D3/38 ,  A62D101/02 ,  A62D101/04

Abstract: There are disclosed processes for destructing a toxic chemical including the steps of mixing the toxic chemical with a liquid phase formed by an aqueous mixture of water and an ionic liquid or molten salt which is miscible with water, the ionic liquid or molten salt comprising a tertiary amine group or quaternary ammonium group; and contacting the toxic chemical in the liquid phase with the ionic liquid or molten salt so as to decompose the toxic chemical.

公开(公告)号：US10688330B2

公开(公告)日：2020-06-23

申请号：US15535050

申请日：2015-12-10

Applicant: Yeda Research and Development Co. Ltd. ,  University of Washington

Inventor： Dan S. Tawfik ,  Haim Leader ,  Yaacov Ashani ,  Izhack Cherny ,  Moshe Goldsmith ,  Per Jr. Greisen ,  Sagar D. Khare ,  Gustav Oberdorfer ,  David Baker ,  Sarel Fleishman ,  Adi Goldenzweig ,  Nidhi Aggarwal

IPC: C12N9/16 ,  A61P25/00 ,  A62D3/02 ,  A62D101/02 ,  A62D101/26

Abstract: A genetically modified polypeptide is disclosed which comprises an amino acid sequence of phosphotriesterase (PTE) having at least twice the catalytic efficiency for a V-type nerve agent as a polypeptide which consists of the sequence as set forth in SEQ ID NO: 1, when assayed under identical conditions.

公开(公告)号：US10512810B1

公开(公告)日：2019-12-24

申请号：US16511561

申请日：2019-07-15

Applicant: Battelle Memorial Institute

Inventor： Erik W. Edwards ,  Steven Risser ,  Jeffrey Boyce

IPC: A62D3/30 ,  B65D81/32 ,  A62D101/02 ,  A62D101/26

Abstract: A method of employing an assembly containing a shelf-stable formulation for decontaminating skin exposed to nerve agents in a package forming a first chamber and a second chamber separated by a barrier with water located in the first chamber and a dry sponge and diacetylmonoxime or derivatives thereof, located in the second chamber, wherein the diacetylmonoxime is distributed within the sponge, the method comprising opening the barrier between the first and second chambers, shaking the package to move the water into sponge until the sponge is wet, tearing open the package, removing the sponge and wiping the sponge on skin. Preferably polyethylene glycol is distributed in the sponge and wiping the sponge on the skin leaves a mixture of diacetylmonoxime and polyethylene glycol on the skin.

公开(公告)号：US10413769B2

公开(公告)日：2019-09-17

申请号：US14795608

申请日：2015-07-09

Applicant: C. Steven McDaniel

Inventor： C. Steven McDaniel

IPC: A62D5/00 ,  A62D3/02 ,  C09D5/00 ,  C12N9/16 ,  C12N11/08 ,  C09D5/34 ,  C09J11/02 ,  C12N11/16 ,  C09D7/63 ,  A62D101/02 ,  A62D101/26

Abstract: Disclosed herein are novel coatings and paints comprising a biomolecule composition, wherein the biomolecule composition comprises a phosphoric triester hydrolase. Also disclosed herein are methods of detoxification of a surface contaminated with an organophosphorus compound by contacting the surface with such a coating or paint. Also disclosed herein are novel coating and paint components derived from microorganisms.

公开(公告)号：US10384090B2

公开(公告)日：2019-08-20

申请号：US15878573

申请日：2018-01-24

Applicant: Government of the United States of America as Represented by the Secretary of the Air Force

Inventor： Jeffery Ray Owens ,  Wallace Bruce Salter ,  Katherine Moss Simpson

IPC: A62D3/36 ,  D06M13/272 ,  D06M13/335 ,  D06M13/352 ,  D06M13/355 ,  D06M16/00 ,  A62D101/02 ,  A62D101/22 ,  A62D101/26 ,  A62D101/28

Abstract: A method of using select Schiff base compounds for chemical agent detoxification. The method including applying a compound to the contaminated substrate. The compound includes an imine having at least one Schiff base nitrogen and an alkyl substituent or an aryl substituent having an electron acceptor. The at least one Schiff base nitrogen is spaced away from the electron acceptor by a distance ranging from about 200 pm to about 1000 pm. The substrate and the compound are dried. The at least one Schiff base nitrogen of the compound promotes a nucleophilic attack on an electrophilic site of the toxic chemical agent.

公开(公告)号：US10273163B2

公开(公告)日：2019-04-30

申请号：US15434008

申请日：2017-02-15

Applicant: Aqua Resources Corporation

Inventor： Orville Lee Maddan

IPC: C01G41/02 ,  C01G37/02 ,  C01G33/00 ,  C01G35/00 ,  C09C1/34 ,  C09C1/00 ,  C09K21/02 ,  D21H17/67 ,  D21H21/10 ,  C08K3/22 ,  D01F6/92 ,  A62D3/38 ,  C25B1/46 ,  C25B9/08 ,  C01F17/00 ,  A62D3/36 ,  B82Y30/00 ,  B82Y40/00 ,  C01B13/36 ,  C01F5/08 ,  C01F5/14 ,  C01F5/22 ,  C01F7/02 ,  C01F7/14 ,  C01F11/02 ,  C01F11/04 ,  C01G1/02 ,  C01G3/00 ,  C01G3/02 ,  C01G5/00 ,  C01G9/00 ,  C01G9/02 ,  C01G23/00 ,  C01G25/00 ,  C01G31/00 ,  C01G31/02 ,  C01G45/00 ,  C01G45/02 ,  C01G49/00 ,  C01G49/02 ,  C01G51/04 ,  C01G53/00 ,  C01G53/04 ,  C25B1/00 ,  C25B1/20 ,  H01B7/295 ,  A62D101/02 ,  G02F1/00

Abstract: Nanoplatelet forms of metal hydroxide and metal oxide are provided, as well as methods for preparing same. The nanoplatelets are suitable for use as fire retardants and as agents for chemical or biological decontamination.

公开(公告)号：US10189864B2

公开(公告)日：2019-01-29

申请号：US15048921

申请日：2016-02-19

Applicant: Lawrence Livermore National Security, LLC

Inventor： Carlos Valdez ,  Edmond Y. Lau ,  Brian P. Mayer

IPC: C07F1/08 ,  C07D401/14 ,  C07F3/06 ,  C07F15/02 ,  C07F15/04 ,  C07F15/06 ,  A62D3/38 ,  A62D101/26 ,  A62D101/02 ,  A62D101/04 ,  A62D101/45

Abstract: A catalyst includes a bis(2-pyridylmethyl)amine-based ligand. A method of forming a catalyst, may include: reacting bis(2-pyridylmethyl)amine-based compound with a terminal azide and/or a terminal alkyne in the presence of Cu(I) to form a bis(2-pyridylmethyl)amine-based ligand. A method of using such catalysts may include neutralizing toxicity of at least one organophosphorus-based compound by reacting the organophosphorus-based compound with a bis(2-pyridylmethyl)amine-based ligand-metal complex.

公开(公告)号：US10143874B1

公开(公告)日：2018-12-04

申请号：US15711411

申请日：2017-09-21

Applicant: U.S. Army Edgewood Chemical Biological Center

Inventor： Sue Y Bae ,  Mark A. Guelta ,  Steven P Harvey

IPC: C12N9/48 ,  A62D3/02 ,  C12N15/03 ,  A62D101/02 ,  A62D101/04

Abstract: Disclosed herein are non-wild-type organophosphorus acid anhydrolases having three site mutations, methods of production, and methods of use to effectively degrade toxic chemicals such as((RS)-Propan-2-yl methylphosphonofluoridate)(Sarin) and other organophosphorus compounds. Also provided are organophosphorus acid anhydrolase mutants capable of degrading Sarin with distinct selective stereospecificity preferences differing from the wild-type organophosphorus acid anhydrolase