公开(公告)号：US11221295B2

公开(公告)日：2022-01-11

申请号：US15748508

申请日：2016-08-02

Applicant: UNIVERSITY OF DURHAM

Inventor： David Carty ,  Eckart Wrede ,  Nils Hendrik Nahler

IPC: G01N21/64 ,  G01J3/44 ,  G01N33/497 ,  A61B5/08 ,  G01N21/31 ,  A61B5/097 ,  A61B5/00 ,  G01N33/00

Abstract: Apparatuses and methods are provided for quantifying an analyte in a gas or liquid phase. A light source with an emission spectrum overlapping an absorption of the analyte, and a pair of reflective mirrors located on an optical axis to form an optical cavity can be included. An off-axis photon detector can be configured as a fluorescence detector and located off the cavity axis and arranged to provide a first signal in response to fluorescence within the cavity. An axial photon detector can be located axially, and external, to the cavity and arranged to provide a second signal. The portion of the apparatus including the light source, the cavity, and the axial photon detector can be configured with a cavity-enhanced absorption spectrometer, and the portion of the apparatus including the off-axis photon detector can be configured with a cavity-enhanced laser-induced fluorescence (CELIF) spectrophotometer.

公开(公告)号：US11191449B2

公开(公告)日：2021-12-07

申请号：US14473888

申请日：2014-08-29

Applicant: Capnia, Inc.

Inventor： Anthony D. Wondka ,  Anish Bhatnagar ,  Pedro E. De La Serna

IPC: A61B5/083 ,  A61B5/08 ,  A61B5/097 ,  G01N33/497

Abstract: A breath parameter measuring device is described which takes into account breathing patterns which historically have been incompatible with accurate measurements. In particular, during fast breathing patterns, the sensor performing the measurement may not be able to respond quickly enough to provide the true reading. The disclosure may be useful for example in the case of neonatal breath carbon dioxide measurements.

公开(公告)号：US20210341460A1

公开(公告)日：2021-11-04

申请号：US16866271

申请日：2020-05-04

Applicant: Omachron Intellectual Property Inc.

Inventor： Wayne Ernest Conrad

IPC: G01N33/497 ,  G01N15/14

Abstract: A COVID-19 test method, a test apparatus and a system to control entry to an event uses particle count and spectrographic data. The present embodiments of the invention provide testing apparatuses, systems and methods. These embodiments may provide for an apparatus, system and method for non-invasive respiratory testing. Also, the embodiments may provide for a system and method for determining test sufficiency for a non-invasive respiratory testing apparatus. Also, the embodiments may provide for a system and method for permitting access to a venue for a subject.

公开(公告)号：US20210338102A1

公开(公告)日：2021-11-04

申请号：US17238052

申请日：2021-04-22

Applicant: HyperSpectral APD, LLC

Inventor： David M. Palacios ,  Harry Hopper

IPC: A61B5/08 ,  A61B10/00 ,  G01N21/359 ,  G01N1/42 ,  G01N33/497 ,  G01N21/3504 ,  G01J3/45 ,  A61B5/00 ,  G01N21/25 ,  G01J3/18

Abstract: A method comprising at least one light source configured to generate a light of at least one wavelength and project the light over an optical path, a sample device, the device containing a sample obtained from exhalation of a person, a vortex mask configured to receive the light after the light passes through at least a portion of the sample device, the vortex mask including a series of concentric circles etched in a substrate, the vortex mask configured to provide destructive interference of coherent light received from the at least one light source, a detector configured to detect and measure wavelength intensities from the light in the optical path, the wavelength intensities being impacted by the light passing through the sample, the detector receiving the light that remained after passing through the vortex mask, and a processor configured to provide measurement results based on the wavelength intensities.

公开(公告)号：US11156378B2

公开(公告)日：2021-10-26

申请号：US16749900

申请日：2020-01-22

Applicant: Johnson Controls Technology Company

Inventor： Ryan J. Bykowski ,  Scott Ambelang ,  Daniel R. Gottschalk ,  Eric Mackey

IPC: A61B5/145 ,  F24F11/52 ,  G01N33/00 ,  G01N33/497 ,  F24F11/64 ,  F24F11/30 ,  F24F110/65 ,  F24F120/12 ,  F24F110/66

Abstract: A sensor unit includes an air quality sensor configured to generate air quality data that includes a value for volatile organic compounds. The sensor unit is configured to determine a first health metric indicative of a condition within a space in which the sensor unit is located based on the value in a first mode of operation, to determine a second health metric indicative of a person's health based on the value in a second mode of operation, and to generate a notification indicating at least one of the first health metric or the second health metric.

公开(公告)号：US20210318290A1

公开(公告)日：2021-10-14

申请号：US17238082

申请日：2021-04-22

Applicant: University of Louisville Research Foundation, Inc.

Inventor： Xiaoan Fu ,  Michael Nantz ,  Michael Bousamra ,  Victor van Berkel

IPC: G01N33/497 ,  H01J49/00 ,  H01J49/38 ,  G01N30/72 ,  G01N33/543 ,  G01N33/574 ,  G01N33/64 ,  A61B5/08

Abstract: Provided is a non-invasive method of detecting or screening for a cancer in a subject specimen originating in a tissue outside of the lung. The method includes detecting elevated levels of one or more carbonyl-containing volatile organic compounds (VOCs) that are biomarkers for the cancer in exhaled breath from the subject specimen. The method may further include obtaining exhaled breath from the subject specimen; forming adducts of the carbonyl-containing VOCs with a reactive chemical compound; quantifying the adducts of the carbonyl-containing VOCs to establish a subject value for each of the adducts; and comparing each subject value to a threshold healthy specimen value for each of the adducts of the carbonyl-containing VOCs. One or more subject values at quantities greater than threshold healthy specimen values are also useful for screening for the cancer in the subject specimen.

公开(公告)号：US20210318208A1

公开(公告)日：2021-10-14

申请号：US16844180

申请日：2020-04-09

Applicant: Hygieia Sciences LLC

Inventor： Charlene Warres Bayer ,  William Hiller

IPC: G01N1/22 ,  G01N33/497 ,  G01N30/72 ,  H01J49/26 ,  G01N30/86 ,  H01J49/00

Abstract: Analysis of a breath sample is a noninvasive point-of-care tool with ever increasing screening and clinical applicability. Herein we describe a method to analyze the content of low-level, trace volatile organic compounds from alveolar breath captured as a breath sample from a patient suspected of having a disease related to coronavirus infection. The breath sample is then analyzed using a gas phase analysis methodology, such as gas chromatography-mass spectroscopy (“GCMS”), to generate an analysis result, such as a GCMS spectrum. A computer system is then used to develop a fingerprint pattern from the analysis result. The fingerprint pattern is then used to determine a patient status for the patient. The fingerprint pattern is typically a grouping of 75 to 450 compounds of known concentration which are indicative of a particular disease related to coronavirus.

公开(公告)号：US11119080B2

公开(公告)日：2021-09-14

申请号：US15538111

申请日：2015-12-23

Applicant: Biometry Inc.

Inventor： Thomas T. Morgan ,  David L. Carnahan ,  Bryan Nolan

IPC: G01N30/95 ,  G01N27/12 ,  G01N30/92 ,  G01N33/497

Abstract: A mini point of care gas chromatographic test strip and method to measure analytes is disclosed. A system for determining the concentration of at least one analyte in a fluid sample having a plurality of analytes includes a base substrate, a first electrode pair disposed over the base substrate, and a first sensing chemistry responsive to at least one analyte in the sample. The first sensing chemistry is in electrical communication with the first electrode pair, and a first chromatographic layer is disposed over the at least one sensing chemistry. At least one analyte of the plurality of analytes moves through the first chromatographic layer at a different rate relative to the movement of other analytes of the plurality of analytes.

公开(公告)号：US20210278357A1

公开(公告)日：2021-09-09

申请号：US17327825

申请日：2021-05-24

Applicant: FUJITSU LIMITED

Inventor： Satoru Momose ,  Michio USHIGOME ,  Kazuaki Karasawa ,  Osamu Tsuboi

IPC: G01N27/12 ,  G01N33/84 ,  G01N33/497

Abstract: A gas sensor device includes a first electrode, a second electrode, and a polythiophene film which is formed between the first and second electrodes to be electrically coupled to the first and second electrodes, and to which cuprous bromide is adsorbed.

公开(公告)号：US20210267478A1

公开(公告)日：2021-09-02

申请号：US16805142

申请日：2020-02-28

Applicant: Picomole Inc.

Inventor： Christopher Quentin Purves

IPC: A61B5/087 ,  A61B5/093 ,  G01N33/497 ,  G01N33/00 ,  G01N33/50

Abstract: An apparatus and method for collecting a breath sample are provided. The apparatus has a breath input interface configured to receive exhaled breath, a container connected to the breath input interface for receiving at least some of the exhaled breath, the container having a cavity with a volume that is controllable, and at least one controller configured to control the volume of the cavity to increase at a volume increase rate that is at most equal to a flow rate of the exhaled breath received by the breath input interface.