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公开(公告)号：US20230272006A1
公开(公告)日：2023-08-31
申请号：US18143282
申请日：2023-05-04
申请人： Adel NEFZI
发明人： Adel NEFZI
摘要： The subject invention provides compounds, peptidomimetics, and methods of synthesis thereof. The subject invention provides the synthesis and use of guanidino acids and/or poly guanidino acids not only as vehicles for drug delivery but as toolbox for drug discovery. The peptidomimetic of the subject invention comprises oligo(guanidino acid)s or poly(guanidino acid)s with guanidines as peptide bond surrogates. The incorporation of the guanidine as amide bond surrogates offers significant differences in polarity, hydrogen bonding capability, and acid-base character.
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公开(公告)号：US20230272004A1
公开(公告)日：2023-08-31
申请号：US17418746
申请日：2019-12-27
申请人： POLUS INC.
发明人： Jinhwan KIM , Hyoung An CHOI , Sang Yeon LEE
CPC分类号： C07K7/06 , C07K7/08 , C07K14/62 , C07K2319/35 , C07K2319/21
摘要： The present invention relates to a ramp tag for insulin overexpression represented by an amino acid sequence of RGSX1GGX2R (wherein, X1 means any amino acids in the number of 0-8, and X2 means S or T) and a method for manufacturing insulin, in which the ramp tag is applied, and when the ramp tag according to the present invention is used, in the process of manufacturing recombinant proteins, without changing the ORF sequence, such as the codon optimization method, translation efficiency of insulin is increased, thereby providing the effect of remarkably increasing the expression amount of insulin.
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公开(公告)号：US11739121B2
公开(公告)日：2023-08-29
申请号：US17058519
申请日：2019-06-07
摘要： The methods and compositions of the disclosure provide for novel therapeutic compounds to treat obesity and aspects related thereto. Embodiments of the disclosure relate to oligonucleotide therapeutic (ONT) agents targeting miR-22 miRNA for the treatment of human obesity and related cardiometabolic disorders. Accordingly, aspects of the disclosure relate to modified nucleic acids, including locked nucleic acids, ethylene-bridged nucleotides, peptide nucleic acids, phosphorodiamidate morpholino oligonucleotides, and or a 5′(E)-vinyl-phosphonate modification.
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94.发明公开公开(公告)号：US20230265158A1
公开(公告)日：2023-08-24
申请号：US18054566
申请日：2022-11-11
发明人： Andrea MAHR , Toni WEINSCHENK , Oliver SCHOOR , Jens FRITSCHE , Harpreet SINGH , Lea STEVERMANN
IPC分类号： C07K14/74 , C12N9/64 , G01N33/566 , C12N5/0783 , C07K14/47 , G01N33/569 , C12Q1/6886 , A61K45/06 , A61K39/00 , A01N37/46 , A61K38/17 , C07K16/28 , A61K38/06 , C07K14/00 , C07K16/30 , A61K38/08 , C07K16/18 , G01N33/50 , C07K7/02 , C07K7/06 , C07K14/725 , A61K38/00
CPC分类号： C07K14/70539 , A01N37/46 , A61K38/06 , A61K38/08 , A61K38/1774 , A61K39/0005 , A61K39/0011 , A61K45/06 , C07K7/02 , C07K7/06 , C07K14/001 , C07K14/47 , C07K14/4702 , C07K14/4748 , C07K14/7051 , C07K16/18 , C07K16/30 , C07K16/2833 , C12N5/0636 , C12N5/0638 , C12N9/6491 , C12Q1/6886 , G01N33/505 , G01N33/566 , G01N33/5088 , G01N33/56972 , G01N33/56977 , A61K38/00 , A61K2039/54 , A61K2039/57 , A61K2039/572 , A61K2039/585 , A61K2039/5158 , C07K2317/24 , C07K2317/31 , C07K2317/34 , C07K2319/00 , C07K2319/40 , C12N2501/998 , C12N2502/11 , C12Q2600/106 , C12Q2600/158 , C12Y304/24 , G01N2333/47 , G01N2333/7051 , G01N2333/70503 , G01N2333/70539 , G01N2500/10
摘要： A method of treating a patient who has hepatocellular carcinoma (HCC), colorectal carcinoma (CRC), glioblastoma (GB), gastric cancer (GC), esophageal cancer, NSCLC, pancreatic cancer (PC), renal cell carcinoma (RCC), benign prostate hyperplasia (BPH), prostate cancer (PCA), ovarian cancer (OC), melanoma, breast cancer (BRCA), CLL, Merkel cell carcinoma (MCC), SCLC, Non-Hodgkin lymphoma (NHL), AML, gallbladder cancer and cholangiocarcinoma (GBC, CCC), urinary bladder cancer (UBC), and uterine cancer (UEC) includes administering to said patient a composition containing a population of activated T cells that selectively recognize cells in the patient that aberrantly express a peptide. A pharmaceutical composition contains activated T cells that selectively recognize cells in a patient that aberrantly express a peptide, and a pharmaceutically acceptable carrier, in which the T cells bind to the peptide in a complex with an MHC class I molecule, and the composition is for treating the patient who has HCC, CRC, GB, GC, esophageal cancer, NSCLC, PC, RCC, BPH, PCA, OC, melanoma, BRCA, CLL, MCC, SCLC, NHL, AML, GBC, CCC, UBC, and/or UEC. A method of treating a patient who has HCC, CRC, GB, GC, esophageal cancer, NSCLC, PC, RCC, BPH, PCA, OC, melanoma, BRCA, CLL, MCC, SCLC, NHL, AML, GBC, CCC, UBC, and/or UEC includes administering to said patient a composition comprising a peptide in the form of a pharmaceutically acceptable salt, thereby inducing a T-cell response to the HCC, CRC, GB, GC, esophageal cancer, NSCLC, PC, RCC, BPH, PCA, OC, melanoma, BRCA, CLL, MCC, SCLC, NHL, AML, GBC, CCC, UBC, and/or UEC.
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公开(公告)号：US20230257421A1
公开(公告)日：2023-08-17
申请号：US18103694
申请日：2023-01-31
CPC分类号： C07K7/06 , A61P35/02 , C07K5/1016 , A61K38/00
摘要： The present invention relates to series of peptidomimetic compounds selectively targeting CBX8 of polycomb chromobox protein homolog proteins. Pharmaceutical compositions of those compounds and methods of using them in the treatment of diseases involved CBX8 pharmacology, including various cancers and leukemia, by administering therapeutically effective amounts of such compound alone or together with other therapeutics, are within the scope of this disclosure.
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96.发明授权公开(公告)号：US11719705B2
公开(公告)日：2023-08-08
申请号：US16010347
申请日：2018-06-15
发明人： Heather Agnew , Bert Tsunyin Lai , Suresh Mark Pitram , Blake Farrow , James R. Heath , David Bunck , Jingxin Liang , Arundhati Nag , Samir Das
CPC分类号： G01N33/6869 , C07K7/06 , C07K14/54
摘要： The present application provides stable peptide-based IL-17F and IL-17A capture agents and methods of use as detection agents. The application further provides methods of manufacturing IL-17F capture agents.
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公开(公告)号：US11718844B2
公开(公告)日：2023-08-08
申请号：US15699543
申请日：2017-09-08
申请人： BioAtla, Inc.
发明人： Jay M. Short , Hwai Wen Chang , Gerhard Frey
IPC分类号： C12N15/10 , C07K14/315 , C12N9/68 , C12N9/72 , G01N33/68 , C07K7/06 , C07K14/47 , C07K14/575 , C12N9/16 , G01N33/543 , G01N33/573 , A61K38/00
CPC分类号： C12N15/102 , C07K7/06 , C07K14/3153 , C07K14/47 , C07K14/575 , C07K14/57545 , C07K14/57563 , C12N9/16 , C12N9/6435 , C12N9/6459 , C12N9/6462 , C12N15/1058 , C12Y304/21007 , C12Y304/21069 , C12Y304/21073 , G01N33/54306 , G01N33/573 , G01N33/6845 , G01N33/6854 , A61K38/00 , C12Y302/01035 , C12Y304/23015 , C12Y304/24029 , Y02A50/30
摘要： This disclosure relates to a method of generating conditionally active biologic proteins from wild type proteins, in particular therapeutic proteins, which are reversibly or irreversibly inactivated at the wild type normal physiological conditions. For example, evolved proteins are virtually inactive at body temperature, but are active at lower temperatures.
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公开(公告)号：US20230242582A1
公开(公告)日：2023-08-03
申请号：US17918930
申请日：2021-04-12
发明人： Jae-Hoon YU , Soon-sil HYUN , Jane CHO , Dong-Woo KIM
CPC分类号： C07K7/06 , A61K47/42 , A61K9/5169
摘要： The present disclosure relates to a novel amphipathic, alpha-helical cell-penetrating peptide and uses thereof. The cell-penetrating peptide of the present disclosure has a nanoparticle self-association characteristic and penetrates into eukaryotic cells at a nanomolar concentration, which allows the peptide to be advantageously used for delivery, into cells, of a drug or the like that is difficult to penetrate into the cells.
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99.发明公开公开(公告)号：US20230241110A1
公开(公告)日：2023-08-03
申请号：US18164418
申请日：2023-02-03
发明人： Heiko SCHUSTER , Franziska HOFFGAARD , Jens FRITSCHE , Oliver SCHOOR , Toni WEINSCHENK , Daniel Johannes KOWALEWSKI , Chih-Chiang TSOU
IPC分类号： A61K35/17 , A61P35/00 , A61K39/39 , C07K16/28 , C07K7/06 , C07K14/54 , A61P35/02 , A61K39/00 , A61K45/06 , C12N5/0783 , A61K39/12 , C07K16/24 , A61K39/395 , A61K38/08 , C07K14/47
CPC分类号： A61K35/17 , A61P35/00 , A61K39/39 , C07K16/2818 , C07K7/06 , C07K14/5434 , A61P35/02 , A61K39/001102 , A61K45/06 , C12N5/0636 , A61K39/001114 , A61K39/001118 , A61K39/12 , C07K16/244 , A61K39/39558 , C07K16/2821 , A61K38/08 , C07K14/4748 , A61K2039/5156 , A61K45/05
摘要： The present invention relates to peptides, proteins, nucleic acids and cells for use in immunotherapeutic methods. In particular, the present invention relates to the immunotherapy of cancer. The present invention furthermore relates to tumor-associated T-cell peptide epitopes, alone or in combination with other tumor-associated peptides that can for example serve as active pharmaceutical ingredients of vaccine compositions that stimulate anti-tumor immune responses, or to stimulate T cells ex vivo and transfer into patients. Peptides bound to molecules of the major histocompatibility complex (MHC), or peptides as such, can also be targets of antibodies, soluble T-cell receptors, and other binding molecules.
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100.发明公开公开(公告)号：US20230241106A1
公开(公告)日：2023-08-03
申请号：US18047234
申请日：2022-10-17
IPC分类号： A61K35/17 , C07K14/47 , A61K39/00 , C07K7/06 , C07K7/08 , C07K14/725 , C07K16/30 , C12N15/115 , C12P21/02 , C12Q1/6881 , C12Q1/6886 , G01N33/574
CPC分类号： A61K35/17 , A61K39/0011 , C07K7/06 , C07K7/08 , C07K14/4727 , C07K14/4748 , C07K14/7051 , C07K16/30 , C12N15/115 , C12P21/02 , C12Q1/6881 , C12Q1/6886 , G01N33/57484 , A61K2039/5158 , C12N2310/16 , C12Q2600/136 , C12Q2600/156 , C12Q2600/158 , G01N2333/70539 , G01N2500/04
摘要： The present invention relates to peptides, proteins, nucleic acids and cells for use in immunotherapeutic methods. In particular, the present invention relates to the immunotherapy of cancer. The present invention furthermore relates to tumor-associated T-cell peptide epitopes, alone or in combination with other tumor-associated peptides that can for example serve as active pharmaceutical ingredients of vaccine compositions that stimulate anti-tumor immune responses, or to stimulate T cells ex vivo and transfer into patients. Peptides bound to molecules of the major histocompatibility complex (MHC), or peptides as such, can also be targets of antibodies, soluble T-cell receptors, and other binding molecules.
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