公开(公告)号：US10975402B2

公开(公告)日：2021-04-13

申请号：US16548545

申请日：2019-08-22

Applicant: GENOMATICA, INC.

Inventor： Jason J. Lutes ,  Stephen B. Del Cardayre

IPC: C12N1/20 ,  C12P13/02 ,  C12N9/18 ,  C12N9/10 ,  C12N15/70 ,  C12N9/16

Abstract: The disclosure relates to a recombinant microorganism engineered to express an enzyme which catalyzes the conversion of a primary amine and an acyl thioester to a fatty amide. The disclosure further encompasses a method of producing a fatty amide by culturing the recombinant microorganism in the presence of a carbon source.

公开(公告)号：US20210040514A1

公开(公告)日：2021-02-11

申请号：US16736405

申请日：2020-01-07

Applicant: Genomatica, Inc.

Inventor： Andreas W. Schirmer ,  Mathew A. Rude ,  Shane A. BRUBAKER

IPC: C12P7/64 ,  C12N9/02 ,  C10L1/02 ,  C12N9/88 ,  C12P7/04 ,  C12P7/24 ,  C12P5/02

Abstract: Compositions and methods for producing aldehydes, alkanes, and alkenes are described herein. The aldehydes, alkanes, and alkenes can be used in biofuels.

公开(公告)号：US10894953B2

公开(公告)日：2021-01-19

申请号：US15873977

申请日：2018-01-18

Applicant: Genomatica, Inc.

Inventor： Andrew M. Shumaker ,  Bernardo M. da Costa ,  Kevin Holden ,  Louis G. Hom ,  Tarah S. Baron ,  Noah Helman

IPC: C12N9/18 ,  C12N9/10 ,  C12P7/64

Abstract: The disclosure relates to enzyme variants with improved ester synthase properties for the production of fatty acid esters. Further contemplated are recombinant host cells that express such variants, cell cultures comprising the recombinant host cells and fatty acid ester compositions produced by such recombinant host cells.

公开(公告)号：US20210009983A1

公开(公告)日：2021-01-14

申请号：US16802133

申请日：2020-02-26

Applicant: Genomatica, Inc.

Inventor： Derek L. GREENFIELD ,  Donald E. TRIMBUR ,  Andreas W. SCHIRMER ,  Cindy CHANG ,  Behnaz BEHROUZIAN ,  Jessica WINGER

IPC: C12N9/00 ,  C07K14/245 ,  C12P7/64

Abstract: The disclosure relates to acetyl-CoA carboxylase (ACC) variants and host cells expressing them for the production of malonyl-CoA derived compounds including fatty acid derivatives. Further contemplated are methods of producing increased amounts of malonyl-CoA derived compounds and related cell cultures.

公开(公告)号：US20210002195A1

公开(公告)日：2021-01-07

申请号：US16799743

申请日：2020-02-24

Applicant: Genomatica, Inc.

Inventor： SVB Janardhan Garikipati ,  Michael Japs ,  Ishmael M. Sonico

IPC: C07C29/80 ,  C12P7/18 ,  C08G18/32 ,  C08G65/34 ,  B01D3/00 ,  B01D3/14 ,  C07C31/20

Abstract: A process of purifying 1,4-butanediol (1,4-BDO) from a fermentation broth including separating solid materials, salts and water, and subjecting the resulting material to a two, three or four column distillation system, that can include a wiped film evaporator to produce a purified 1,4-butanediol.

公开(公告)号：US10676763B2

公开(公告)日：2020-06-09

申请号：US15326844

申请日：2015-07-17

Applicant: REG Life Sciences, LLC

Inventor： Andreas W. Schirmer ,  Noah Helman ,  Haibo Wang ,  Zhihao Hu ,  Vikranth Arlagadda ,  Alma Itzel Ramos-Solis ,  Elizabeth Clarke

IPC: C12P7/18 ,  C12N9/16 ,  C12N9/00 ,  C12N15/52 ,  C12N9/18 ,  C12N9/02 ,  C12N9/04 ,  C12N15/63

Abstract: The disclosure relates to fatty diols and recombinant microorganisms for producing them. More particularly, the disclosure relates to recombinant microorganisms engineered to produce fatty diols via fermentation. Further encompassed is a process that uses the microorganisms to produce fatty diols from a simple carbon source.

公开(公告)号：US10669561B2

公开(公告)日：2020-06-02

申请号：US15323360

申请日：2015-07-02

Applicant: Genomatica, Inc.

Inventor： Stephanie J. Culler ,  Mark J. Burk ,  Robin E. Osterhout ,  Priti Pharkya

IPC: C12N15/00 ,  C12N1/20 ,  C12N9/00 ,  C12N9/02 ,  C12N9/88 ,  C12N9/90 ,  C07H21/04 ,  C12P7/04 ,  C12N15/52 ,  C12P5/02 ,  C12P7/40 ,  C12N9/04

Abstract: The invention provides a non-naturally occurring microbial organism having a butadiene, crotyl alcohol, 2,4-pentadienoate, 3-buten-2-ol, or 3-buten-1-ol, pathway. The microbial organism contains at least one exogenous nucleic acid encoding an enzyme in a pathway. The invention additionally provides a method for producing butadiene, crotyl alcohol, 2,4-pentadienoate, 3-buten-2-ol, or 3-buten-1-ol. The method can include culturing a butadiene, crotyl alcohol, 2,4-pentadienoate, 3-buten-2-ol, or 3-buten-1-ol-producing microbial organism, where the microbial organism expresses at least one exogenous nucleic acid encoding a pathway enzyme in a sufficient amount, and under conditions and for a sufficient period of time to produce butadiene, crotyl alcohol, 2,4-pentadienoate, 3-buten-2-ol, or 3-buten-1-ol.

公开(公告)号：US10450404B2

公开(公告)日：2019-10-22

申请号：US14560830

申请日：2014-12-04

Applicant: MITSUBISHI CHEMICAL CORPORATION ,  GENOMATICA, INC.

Inventor： Masaru Utsunomiya ,  Yusuke Izawa ,  Norikazu Konishi ,  Kota Tanaka ,  Shinichiro Matsuzono ,  Takayuki Suzuki ,  Michael Japs ,  Mark Burk ,  Warren Clark

IPC: C08G18/42 ,  C08G63/16 ,  C08G63/183 ,  C08G18/66 ,  C12P7/18

Abstract: At the time of producing a polyester by using a dicarboxylic acid component and a biomass-resource-derived diol as raw materials, a polyester is efficiently produced with good color tone, as the raw material diol derived from biomass resources, a diol in which the content of a cyclic carbonyl compound having a carbon atom number of 5 or 6 is from 0.01 to 12 ppm by mass, is used, and by controlling the content of a cyclic carbonyl compound having a carbon atom number of 5 or 6 in the raw material diol to fall in a prescribed range, the color tone of the polyester is improved.

公开(公告)号：US10415042B2

公开(公告)日：2019-09-17

申请号：US15184940

申请日：2016-06-16

Applicant: Genomatica, Inc.

Inventor： Anthony P. Burgard ,  Priti Pharkya ,  Robin E. Osterhout

IPC: C12N1/21 ,  C12N15/52 ,  C12N9/04 ,  C12N9/02 ,  C12N9/10 ,  C12N9/80 ,  C12N9/88 ,  C12P13/00 ,  C12P7/44 ,  C12P13/02 ,  C12P17/10 ,  C12P7/46 ,  C12P7/62

Abstract: The invention provides a non-naturally occurring microbial organism having an adipate, 6-aminocaproic acid or caprolactam pathway. The microbial organism contains at least one exogenous nucleic acid encoding an enzyme in the respective adipate, 6-aminocaproic acid or caprolactam pathway. The invention additionally provides a method for producing adipate, 6-aminocaproic acid or caprolactam. The method can include culturing an adipate, 6-aminocaproic acid or caprolactam producing microbial organism, where the microbial organism expresses at least one exogenous nucleic acid encoding an adipate, 6-aminocaproic acid or caprolactam pathway enzyme in a sufficient amount to produce the respective product, under conditions and for a sufficient period of time to produce adipate, 6-aminocaproic acid or caprolactam.

公开(公告)号：US10385344B2

公开(公告)日：2019-08-20

申请号：US15016896

申请日：2016-02-05

Applicant: Genomatica, Inc.

Inventor： Robin E. Osterhout

IPC: C12P9/00 ,  C12N15/52 ,  C12N9/04 ,  C12N9/88 ,  C12P7/40 ,  C12P7/44 ,  C12P7/62 ,  C12N9/10 ,  C12P7/24

Abstract: The invention provides non-naturally occurring microbial organisms having a (2-hydroxy-3-methyl-4-oxobutoxy)phosphonate pathway, p-toluate pathway, and/or terephthalate pathway. The invention additionally provides methods of using such organisms to produce (2-hydroxy-3-methyl-4-oxobutoxy)phosphonate pathway, p-toluate pathway or terephthalate pathway.