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324 条记录 (耗时 0.04 秒)

    Controlled release bioactive agent delivery device
    102.
    发明授权
    Controlled release bioactive agent delivery device 失效
    控制释放生物活性剂输送装置

    公开(公告)号：US07824704B2

    公开(公告)日：2010-11-02

    申请号：US11203981

    申请日：2005-08-15

    申请人： Aron B. Anderson ,  Laurie R. Lawin ,  Byron C. Shen ,  Eugene de Juan ,  Signe E. Varner ,  Ralph A. Chappa

    发明人： Aron B. Anderson ,  Laurie R. Lawin ,  Byron C. Shen ,  Eugene de Juan ,  Signe E. Varner ,  Ralph A. Chappa

    IPC分类号： A61F2/00

    CPC分类号： A61K31/58 ,  A61F2310/00353 ,  A61K9/0051

    摘要： The invention provides retrievable devices for sustained delivery of bioactive agent to a site within a patient, the devices including a body member having a direction of extension, a longitudinal axis along the direction of extension, and a proximal end and a distal end, wherein at least a portion of the body member deviates from the direction of extension; a cap at the proximal end of the body member; and a polymeric coated composition in contact with a surface of the body member, the polymeric coated composition including a first polymer, a second polymer, and a bioactive agent.

    摘要翻译： 本发明提供了用于将生物活性剂持续递送到患者内的部位的可回收装置，所述装置包括具有延伸方向的本体构件，沿着延伸方向的纵向轴线，以及近端和远端，其中， 身体构件的至少一部分偏离延伸方向; 在主体构件的近端处的帽; 以及与本体构件的表面接触的聚合物涂覆的组合物，所述聚合物涂覆的组合物包含第一聚合物，第二聚合物和生物活性剂。

    Methods, devices, and coatings for controlled active agent release
    103.
    发明授权
    Methods, devices, and coatings for controlled active agent release 有权
    用于控制活性剂释放的方法，装置和涂层

    公开(公告)号：US07709049B2

    公开(公告)日：2010-05-04

    申请号：US11223811

    申请日：2005-09-09

    申请人： Ralph A. Chappa

    发明人： Ralph A. Chappa

    IPC分类号： A61L33/00 ,  A41D19/00 ,  B05D7/00 ,  A61F2/00

    CPC分类号： A61L27/54 ,  A61L27/34 ,  A61L31/10 ,  A61L31/16 ,  A61L2300/602

    摘要： The present invention relates to methods, devices, and coatings, wherein active agent release is determined by deposition rate of a coating or material. In an embodiment, the invention includes a method for coating a medical device, including identifying active agent elution rates for a coating composition applied to substrates at a plurality of coating deposition rates, selecting one of the coating deposition rates, and applying the coating composition to the medical device at the selected deposition rate. In an embodiment, the invention includes a combination including a medical device and a composition for coating the surface of a medical device with an active agent in a manner that permits the coated surface to release the active agent over time when implanted in vivo.

    摘要翻译： 本发明涉及方法，装置和涂层，其中通过涂层或材料的沉积速率确定活性剂释放。 在一个实施方案中，本发明包括用于涂覆医疗装置的方法，包括鉴定以多种涂布沉积速率施加到基材上的涂料组合物的活性剂洗脱速率，选择一种涂布沉积速率，以及将涂料组合物施用于 医疗器械以选定的沉积速率。 在一个实施方案中，本发明包括一种组合，其包括医疗装置和用于用活性剂涂覆医疗装置的表面的组合物，使得当植入体内时涂覆的表面随时间推移释放活性剂。

    Hydrophilic polymeric coatings for medical articles
    104.
    发明授权
    Hydrophilic polymeric coatings for medical articles 有权
    用于医疗用品的亲水性聚合物涂层

    公开(公告)号：US07691476B2

    公开(公告)日：2010-04-06

    申请号：US11445806

    申请日：2006-06-02

    申请人： Michael J. Finley

    发明人： Michael J. Finley

    IPC分类号： B32B9/04

    CPC分类号： A61L29/085 ,  A61L29/14 ,  A61L2400/10 ,  C09D5/00 ,  Y10T428/31504 ,  Y10T428/31551

    摘要： The invention provides a durable, lubricious coating for a medical article that can be prepared from a first polymer that is synthetic, soluble in a polar liquid, and having first reactive groups, and a second polymer that is synthetic, hydrophilic, and that includes second reactive groups. The first reactive groups and a portion of the second reactive groups react to bond the first polymer to the second polymer. A portion of the second reactive groups remains unbonded which, upon neutralization, provide lubricious properties to the coating. In some aspects the coating is formed using a crosslinking agent having latent reactive groups. The coatings provide particularly long dry out times and are very useful for catheterization processes. In addition, the coatings can be subject to sterilization with ethylene oxide and retain very good durable and lubricious properties.

    摘要翻译： 本发明提供了一种用于医疗制品的耐久，润滑的涂层，其可以由合成的，可溶于极性液体的第一聚合物制备并具有第一反应性基团的第一聚合物，以及合成，亲水的第二聚合物，并且包括第二聚合物 反应性基团。 第一反应性基团和一部分第二反应性基团使第一聚合物与第二聚合物结合。 第二反应性基团的一部分保持未结合，其在中和时向涂层提供润滑性质。 在一些方面，使用具有潜在反应性基团的交联剂形成涂层。 涂层提供特别长的干燥时间，并且对于导尿过程非常有用。 此外，涂层可以与环氧乙烷进行灭菌，并保持非常好的持久和润滑性能。

    Bioactive agent release coating
    107.
    发明授权
    Bioactive agent release coating 有权
    生物活性剂释放涂层

    公开(公告)号：US07442402B2

    公开(公告)日：2008-10-28

    申请号：US11281845

    申请日：2005-11-17

    申请人： Stephen J. Chudzik ,  Aron B. Anderson ,  Ralph A. Chappa ,  Timothy M. Kloke

    发明人： Stephen J. Chudzik ,  Aron B. Anderson ,  Ralph A. Chappa ,  Timothy M. Kloke

    IPC分类号： B05D3/00 ,  A61K9/14 ,  A61F13/00 ,  A61F2/00

    CPC分类号： A61L31/16 ,  A61L29/085 ,  A61L29/16 ,  A61L31/10 ,  A61L2300/602 ,  A61L2300/606 ,  C08L33/06

    摘要： A coating composition for use in coating implantable medical devices to improve their ability to release bioactive agents in vivo. The coating composition is particularly adapted for use with devices that undergo significant flexion and/or expansion in the course of their delivery and/or use, such as stents and catheters. The composition includes the bioactive agent in combination with a mixture of a first polymer component such as poly(butyl methacrylate) and a second polymer component such as poly(ethylene-co-vinyl acetate).

    摘要翻译： 用于涂覆可植入医疗装置以提高其在体内释放生物活性剂的能力的涂料组合物。 涂料组合物特别适用于在其输送和/或使用过程（例如支架和导管）中经历显着弯曲和/或膨胀的装置。 组合物包括与第一聚合物组分如聚（甲基丙烯酸丁酯）和第二聚合物组分如聚（乙烯 - 共 - 乙酸乙烯酯）的混合物的组合的生物活性剂。

    Reagent and method for providing coatings on surfaces
    109.
    发明授权
    Reagent and method for providing coatings on surfaces 有权
    用于在表面上提供涂层的试剂和方法

    公开(公告)号：US07348055B2

    公开(公告)日：2008-03-25

    申请号：US10028518

    申请日：2001-12-21

    申请人： Ralph A. Chappa ,  Sean M. Stucke ,  Richard A. Amos ,  Terrence P. Everson ,  Stephen J. Chudzik ,  Dale G. Swan ,  Peter H. Duquette

    发明人： Ralph A. Chappa ,  Sean M. Stucke ,  Richard A. Amos ,  Terrence P. Everson ,  Stephen J. Chudzik ,  Dale G. Swan ,  Peter H. Duquette

    IPC分类号： B32B27/00

    CPC分类号： B82Y30/00 ,  A61L27/34 ,  C09D4/00 ,  Y10S522/904 ,  Y10T428/249991 ,  Y10T428/249992 ,  C08F220/56 ,  C08F220/54

    摘要： A grafting reagent and related method of using the reagent to form a polymeric layer on a support surface, and particularly a porous support surface, in a manner that provides and/or preserves desired properties (such as porosity) of the surface. The reagent and method can be used to provide a thin, conformable, uniform, uncrosslinked coating having desired properties onto the surface of a preformed, and particularly a porous, polymeric substrate. The method includes the steps of a) providing a porous support surface, b) providing a nonpolymeric grafting reagent comprising a photoinitator group, c) providing one or more polymerizable monomers adapted to be contacted with the surface, in the presence of the grafting reagent, and to be polymerized upon activation of the photoinitiator; and d) applying the grafting reagent and monomer(s) to the surface in a manner, and under conditions, suitable to coat the surface with the grafting reagent and to cause the polymerization of monomers to the surface upon activation of the grafting reagent.

    摘要翻译： 以提供和/或保留表面的所需性质（例如孔隙率）的方式使用试剂在支撑表面上，特别是多孔载体表面上形成聚合物层的接枝试剂和相关方法。 试剂和方法可用于提供具有所需性质的薄的，一致的，均匀的未交联的涂层，其具有预先形成的，特别是多孔的聚合物基材的表面。 该方法包括以下步骤：a）提供多孔载体表面，b）提供包含光引发剂基团的非聚合物接枝剂，c）在接枝剂存在下，提供适于与表面接触的一种或多种可聚合单体， 并在激活光引发剂时聚合; 和d）以接枝试剂的方式和条件下将接枝试剂和单体施用于表面，并且在接枝试剂活化时使单体聚合成表面。

    Low friction particulate coatings
    110.
    发明申请
    Low friction particulate coatings 审中-公开
    低摩擦颗粒涂层

    公开(公告)号：US20080057298A1

    公开(公告)日：2008-03-06

    申请号：US11512022

    申请日：2006-08-29

    申请人： Michael J. Finley

    发明人： Michael J. Finley

    IPC分类号： B32B5/16 ,  B32B15/04 ,  A61L33/00 ,  B05D1/12 ,  G11B5/64

    CPC分类号： A61L29/085 ,  A61L31/10 ,  Y10T428/254 ,  Y10T428/265 ,  Y10T428/31504 ,  Y10T428/31678 ,  C08L27/18

    摘要： The invention provides a low-friction halogenated nano- or microparticulate coating and method for forming the coating on articles, such as implantable medical articles. The halogenated nano- or microparticles, desirably fabricated from PTFE, are present on the surface of the coating and covalently coupled to a coupling component, which facilitates formation of the coating. The coatings are biocompatible and can be formed on a selected portion of a medical device in a straightforward process. In some aspects the nano- or microparticulate coatings are formed on a system for the insertion of a medical device, wherein the system includes a catheter.

    摘要翻译： 本发明提供了低摩擦卤化纳米或微粒涂层和用于在诸如可植入医疗制品的物品上形成涂层的方法。 期望由PTFE制成的卤化纳米颗粒或微粒存在于涂层的表面上并且共价偶联到偶联组分上，这有利于涂层的形成。 涂层是生物相容的并且可以在简单的过程中形成在医疗装置的选定部分上。 在一些方面，纳米或微粒涂层形成在用于插入医疗装置的系统上，其中该系统包括导管。