公开(公告)号：US3803324A

公开(公告)日：1974-04-09

申请号：US21519072

申请日：1972-01-03

申请人： BOEHRINGER MANNHEIM GMBH

发明人： WINTER W ,  THIEL M ,  STOCH K ,  RITTER K ,  SCHAUMANN W ,  DIETMANN K

IPC分类号： C07C281/16 ,  A61K27/00

CPC分类号： C07C281/16

摘要： AMINO-GUANIDINE DERIVATIVES CONSTITUTING BLOOD PRESSURE REGULATING AGENTS AND BEING CHARACTERIZED BY THEIR ABILITY TO DECREASE BLOOD PRESSURE HAVING THE FORMULA:


WHEREIN R1 AND R2 ARE EACH HYDROGEN OR LOWER ALKYL, AND WHEN JOINED TOGETHER FORM ALKYLENE CONTAINING 2 TO 3 CARBON ATOMS, AND X IS PHENYL SUBSTITUTED BY AT LEAST ONE HALOGEN ATOM, AND THE SALTS THEREOF WITH PHARMACEUTICALLY ACCEPTABLE ACIDS.
X-NH-NH-C(=N-R1)-NH-R2

公开(公告)号：US3794562A

公开(公告)日：1974-02-26

申请号：US3794562D

申请日：1972-11-13

申请人： BOEHRINGER MANNHEIM GMBH

发明人： BERGMEYER H ,  NAHER G ,  WEIMANN G ,  THUM W

IPC分类号： A61K31/70 ,  C07K1/30 ,  C07K14/37 ,  C07K14/41 ,  C07K14/76 ,  C12N9/00 ,  C12N9/04 ,  C12N9/12 ,  C12N9/60 ,  H01J23/24 ,  H01J25/00 ,  H01J25/02 ,  C07G7/02

CPC分类号： C12N9/0006 ,  A61K31/70 ,  C12N9/00 ,  C12N9/12 ,  C12N9/60 ,  H01J23/24 ,  H01J25/00 ,  H01J25/02 ,  Y10S435/814

摘要： DISSOLVED PROTEINS ARE ENRICHED BY USE OF POLYETHYLENEIMINE, IN ENRICHMENT PROCESSES SUCH AS PRECIPITATION, PURIFICATION AND FRACTIONATION OF PROTEINS.

公开(公告)号：US3791931A

公开(公告)日：1974-02-12

申请号：US3791931D

申请日：1971-11-30

申请人： BOEHRINGER MANNHEIM GMBH

发明人： BERGMEYER H ,  MOLLERING H ,  WEIMANN G ,  NAHER G ,  GRUBER W ,  THUM W ,  WAHLEFELD A

IPC分类号： C12Q1/26 ,  C12Q1/32 ,  G01N31/14

CPC分类号： C12Q1/32 ,  C12Q1/26 ,  Y10S435/842

摘要： Lactate dehydrogenase is quickly and reliably determined by means of a color test by contacting the test composition with the reagent comprising serum albumin, pig''s heart diaphorase and nicotinamide-adenine-dinucleotide, wherein the diaphorase is preferably obtained from the protein fraction of pig''s heart insoluble in 1.6 to 2.8M ammonium sulphate by treatment with 0.1 to 0.3 percent weight/volume polyethyleneimine, heating at 70* to 80* C., adsorption on a weakly acidic cation exchanger and subsequent elution.

摘要翻译： 通过使测试组合物与包含血清白蛋白，猪心脏肌苷酸和烟酰胺 - 腺嘌呤二核苷酸的试剂接触，通过颜色测试快速可靠地测定乳酸脱氢酶，其中，心肌黄酶优选地从不溶于猪心脏的蛋白质级分中获得 1.6至2.8M硫酸铵，用0.1至0.3％重量/体积的聚乙烯亚胺处理，加热至70℃至80℃，在弱酸性阳离子交换剂上吸附并随后洗脱。

公开(公告)号：US3787391A

公开(公告)日：1974-01-22

申请号：US3787391D

申请日：1971-11-22

申请人： BOEHRINGER MANNHEIM GMBH

发明人： FAULAND E ,  JUHRAN W ,  JAHN W ,  KAMPE W ,  STORK H

IPC分类号： C07D239/70 ,  A61K31/522 ,  C07C243/38 ,  C07H19/16 ,  C07H19/167 ,  C07D51/54

CPC分类号： C07H19/16 ,  C07C243/38 ,  Y02P20/55

摘要： NEW ADENOSINE COMPOUNDS OF THE FORMULA:

2-R1,6-((R2,(R3-NH-NH-CO-)PHENYL)-X-A-NH-),9-(3,4-DI(HO-),

5-(HO-CH2-)-TETRAHYDROFURAN-2-YL)-9H-PURINE

WHERE R1 IS HYDROGRN OR HALOGEN; R2 IS HYDROGEN, HALOGEN, HYDROXYL, ALKYL OR ALKOXY; R3 IS HYDROGEN OR -CO-R4, WHEREIN R4 IS ARYL WHICH IS OPTIONALLY SUBSTITUTED ONE OR MORE TIMES BY HALOGEN AND/OR LKYL, ALKOXY AND/OR HYDROXYALKYLENEOXY; A IS A STRAIGHTCHAINED OR BRANCHED ALKYLENE RADICAL CONTAINING UP TO 3 CARBON ATOMS AND X IS A VALENCY BOND OR OXYGEN: AND THE PHYSIOLOGICALLY COMPATIBLE SALTS THEREOF, EXHIBIT REMARKABLE EFFECTIVENES IN IMPROVING THE BLOOD CIRCULATION OF MAMMALS AND ALSO BRING ABOUT A DEPRESSION OF SERUM LIPIDS.

公开(公告)号：US3778350A

公开(公告)日：1973-12-11

申请号：US3778350D

申请日：1970-08-05

申请人： BOEHRINGER MANNHEIM GMBH

发明人： BERGMEYER H ,  SCHMIDT F ,  STORK H ,  BERNT E ,  GRUBER W

IPC分类号： G01N33/66 ,  C12Q1/54 ,  G01N31/14

CPC分类号： C12Q1/54

摘要： GLUCOSE IS DETERMINED ENZYMATICALLY WITH A STABLE DIAGNOSTIC AGENT MIXTURE COMPRISING HEXOLKINASE, GLUCOSE-6PHOSPHATE DEHYDROGENASE, ATP, MAGNESIUM SULFATE, NADP. AND A BUFFER CONTAINING AN AZIDE.

公开(公告)号：US3759793A

公开(公告)日：1973-09-18

申请号：US3759793D

申请日：1970-12-21

申请人： BOEHRINGER MANNHEIM GMBH

发明人： STORK HARALD ,  SCHMIDT FELIX HELMUT

IPC分类号： G01N33/92 ,  C12Q1/34 ,  C12Q1/44 ,  C12Q1/61 ,  G01N33/48 ,  C12K1/04

CPC分类号： C12Q1/44 ,  C12Q1/61 ,  G01N2333/904 ,  G01N2333/9121 ,  G01N2333/918 ,  Y10S435/939

摘要： LIPOPROTEINS AND/OR PROTEIN FREE NEUTRAL FATS PRESENT IN BODY FLUIDS, I.E., TRI-, DI- AND MONOGLYCERIDES, ARE DETERMINED COMPLETELY ENZYMATICALLY BY USING THE LIPASE OBTAINED FROM RHIZOPUS ARRHIZUS TO SPLIT THE GLYCERIDE TO BE DETERMINED, AND THEN IN KNOWN FASHION CONVERTING THE RESULTING GLYCERIDE TO PYRUVATE, AND CONVERTING THE PYRUVATE TO LACTIC ACID WITH NADH, THE PHOTOMETRICALLY DETERMINED AMOUNT OF NADH USED UP BEING A MEASURE OF THE INITIAL GLYCERIDE CONTENT.

公开(公告)号：US3754862A

公开(公告)日：1973-08-28

申请号：US3754862D

申请日：1972-02-29

申请人： BOEHRINGER MANNHEIM GMBH

发明人： WAHLEFELD A ,  BERNT E ,  GRUBER W ,  BERGMEYER H

IPC分类号： G01N33/72 ,  G01N33/16

CPC分类号： G01N33/728 ,  Y10S436/903 ,  Y10T436/146666

摘要： Total bilirubin is determined with a stable, accurate, widerange reagent composition comprising: A. AT LEAST ONE OF THE GROUP OF CHLOROPHENYL DIAZONIUM CHLORIDES CONSISTING OF 2,4-DICHLORO-, 2,5-DICHLORO- OR 2-CHLORO-4-NITROPHENYL-DIAZONIUM CHLORIDE AND, B. AN ALKYL-PHENOL POLYETHYLENE OXIDE; TO PRODUCE A COLOR WHICH IS THEN TAKEN AS A MEASURE OF BILIRUBIN CONTENT.

公开(公告)号：US3753974A

公开(公告)日：1973-08-21

申请号：US3753974D

申请日：1970-12-01

申请人： BOEHRINGER MANNHEIM GMBH

发明人： KAISER F ,  VOIGTLANDER W ,  SCHAUMANN W ,  STACH K

IPC分类号： C07J19/00 ,  A61K20060101 ,  A61K31/585 ,  C07C20060101 ,  C07C43/02 ,  C07C173/00

CPC分类号： C07J19/005

摘要： NERIIFOLIN ETHERS, OPTIONALLY ACYLATED, OF THE FORMULA

17-(2-(O=)-2,5-DIHYDROFUR-4-YL),3-((3-(R1-O-),4-(CH3-O-),

5-(R2-O-),6-CH3-TETRAHYDROPYRAN-2-YL)-O-),14-HO-ANDROSTANE

WHEREIN ONE OF THE SUBSTITUENTS R1 AND R2 IS A LOWER ALKYL OR ALKOXYALKYL RADICAL AND THE OTHER IS A HYDROGEN ATOM OR A LOWER ACYL RADICAL. THESE NERIIFOLIN DERIVATIVES ARE HIGHLY EFFECTIVE THERAPEUTIC AGENTS AND ARE SUITABLE FOR ORAL ADMINISTRATION IN THE TREATMENT OF CARDIAC INSUFFICIENCY.

公开(公告)号：US3716537A

公开(公告)日：1973-02-13

申请号：US3716537D

申请日：1970-06-01

申请人： BOEHRINGER MANNHEIM GMBH

发明人： HEERDT R ,  HUBNER M ,  SCHMIDT F ,  WEYER R

IPC分类号： A61K31/505 ,  B42F5/00 ,  C07D239/69 ,  C07D409/12 ,  C07D51/42

CPC分类号： C07D239/69 ,  C07D409/12 ,  Y10S514/866

摘要： Certain novel sulfonylaminopyrimidines having the general formula

WHEREIN A is a lower alkylene radical, B is a lower alkyl radical, X is a straight or branched-chain lower alkylene radical, R1 is a straight or branched-chain alkyl, cycloalkyl, cycloalkyl-alkyl, aryl, e.g., phenyl or naphthyl, aralkyl, e.g., benzyl or naphthyl-ethyl, alkoxy, cycloalkoxy, alkoxyalkyl, alkoxyalkoxy or alkylmercapto radical and R2 is a hydrogen atom or a lower alkyl radical and wherein R1 and R2 can, together, also form an alkylene ring of three to five methylene radicals, as well as the physiologically compatible salts thereof, have strong blood sugar reducing activity.

摘要翻译： 某些具有通式为WHEREIN A的新型磺酰氨基嘧啶具有低级亚烷基，B为低级烷基，X为直链或支链低级亚烷基，R1为直链或支链烷基，环烷基，环烷基 - 烷基， 芳基，例如苯基或萘基，芳烷基，例如苄基或萘基 - 乙基，烷氧基，环烷氧基，烷氧基烷基，烷氧基烷氧基或烷基巯基，R2是氢原子或低级烷基，其中R1和R2可一起形成 三至五个亚甲基的亚烷基环及其生理上相容的盐具有强烈的血糖降低活性。

公开(公告)号：US3711564A

公开(公告)日：1973-01-16

申请号：US3711564D

申请日：1969-10-13

申请人： BOEHRINGER MANNHEIM GMBH

发明人： HUBNER M ,  HEERDT R ,  SCHMIDT F ,  STACH K ,  AUMULLER W

IPC分类号： C07D239/69 ,  C07D51/42

CPC分类号： C07D239/69 ,  C07C2603/18

摘要： Novel sulfonylaminopyrimidines, particularly 4-( Beta fluorenyl-(9)-acylamido-alkylene)-N-(pyrimidinyl-(2))-benzenesulfonamide compounds and the corresponding indan-5-sulfonamide compounds, exhibit outstanding antidiabetic activity.

摘要翻译： 新的磺酰氨基嘧啶，特别是4- [芴基 - （9） - 酰氨基 - 亚烷基] -N- [嘧啶基 - （2）] - 苯 - 磺酰胺化合物和相应的茚满-5-磺酰胺化合物，表现出优异的抗糖尿病活性。