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    Microorganisms and methods for improving product yields on methanol using acetyl-CoA synthesis
    101.
    发明授权
    Microorganisms and methods for improving product yields on methanol using acetyl-CoA synthesis 有权

    公开(公告)号：US10808262B2

    公开(公告)日：2020-10-20

    申请号：US15039221

    申请日：2014-11-25

    Applicant: GENOMATICA, INC.

    Inventor： Robin E. Osterhout ,  Anthony P. Burgard ,  Priti Pharkya ,  Stefan Andrae

    IPC: C12N1/16 ,  C12N1/20 ,  C12P7/02 ,  C12P5/02 ,  C12P7/18 ,  C12N1/14 ,  C12P7/42 ,  C12P7/40 ,  C12N15/70 ,  C12N15/81 ,  C12P7/04 ,  C12P7/44 ,  C12P13/00 ,  C12P17/10

    Abstract: The invention provides non-naturally occurring microbial organisms containing enzymatic pathways and/or metabolic modifications for enhancing carbon flux through acetyl-CoA. In some embodiments, the microbial organisms having such pathways also include pathways for generating reducing equivalents, formaldehyde fixation and/or formate assimilation. The enhanced carbon flux through acetyl-CoA, in combination with pathways for generating reducing equivalents, formaldehyde fixation and/or formate assimilation can, in some embodiments, be used for production of a bioderived compound. Accordingly, in some embodiments, the microbial organisms of the invention can include a pathway capable of producing a bioderived compound of the invention. The invention still further provides a bioderived compound produced by a microbial organism of the invention, culture medium having the bioderived compound of the invention, compositions having the bioderived compound of the invention, a biobased product comprising the bioderived compound of the invention, and a process for producing a bioderived compound of the invention.

    ALDEHYDE DEHYDROGENASE VARIANTS AND METHODS OF USE
    105.
    发明申请
    ALDEHYDE DEHYDROGENASE VARIANTS AND METHODS OF USE 审中-公开

    公开(公告)号：US20200040312A1

    公开(公告)日：2020-02-06

    申请号：US16499531

    申请日：2018-03-29

    Applicant: Genomatica, Inc.

    Inventor： Kevin Hoff ,  Cara Ann Tracewell ,  Kui Chan ,  Amit Shah ,  Joseph Warner ,  Michael Noble

    IPC: C12N9/02

    Abstract: The invention provides polypeptides and encoding nucleic acids of aldehyde dehydrogenase variants. The invention also provides cells expressing aldehyde dehydrogenase variants. The invention further provides methods for producing 3-hydroxybutyraldehyde (3-HBal) and/or 1,3-butanediol (1,3-BDO), or an ester or amide thereof, comprising culturing cells expressing an aldehyde dehydrogenase variant or using lysates of such cells. The invention additional provides methods for producing 4-hydroxybutyraldehyde (4-HBal) and/or 1,4-butanediol (1,4-BDO), or an ester or amide thereof, comprising culturing cells expressing an aldehyde dehydrogenase variant or using lysates of such cells.

    Microorganisms and methods for the production of aniline
    110.
    发明授权
    Microorganisms and methods for the production of aniline 有权

    公开(公告)号：US10167477B2

    公开(公告)日：2019-01-01

    申请号：US15914308

    申请日：2018-03-07

    Applicant: Genomatica, Inc.

    Inventor： Priti Pharkya

    IPC: C12P13/00 ,  C12N15/52 ,  C12N15/70 ,  C12N9/88 ,  C12N9/10

    Abstract: A non-naturally occurring microbial organism having an aniline pathway includes at least one exogenous nucleic acid encoding an aniline pathway enzyme expressed in a sufficient amount to produce aniline. The aniline pathway includes (1) an aminodeoxychorismate synthase, an aminodeoxychorismate lyase, and a 4-aminobenzoate carboxylyase or (2) an anthranilate synthase and an anthranilate decarboxylase. A method for producing aniline, includes culturing these non-naturally occurring microbial organisms under conditions and for a sufficient period of time to produce aniline.

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