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    Microorganisms and methods for improving product yields on methanol using acetyl-CoA synthesis
    4.
    发明授权
    Microorganisms and methods for improving product yields on methanol using acetyl-CoA synthesis 有权

    公开(公告)号：US10808262B2

    公开(公告)日：2020-10-20

    申请号：US15039221

    申请日：2014-11-25

    Applicant: GENOMATICA, INC.

    Inventor： Robin E. Osterhout ,  Anthony P. Burgard ,  Priti Pharkya ,  Stefan Andrae

    IPC: C12N1/16 ,  C12N1/20 ,  C12P7/02 ,  C12P5/02 ,  C12P7/18 ,  C12N1/14 ,  C12P7/42 ,  C12P7/40 ,  C12N15/70 ,  C12N15/81 ,  C12P7/04 ,  C12P7/44 ,  C12P13/00 ,  C12P17/10

    Abstract: The invention provides non-naturally occurring microbial organisms containing enzymatic pathways and/or metabolic modifications for enhancing carbon flux through acetyl-CoA. In some embodiments, the microbial organisms having such pathways also include pathways for generating reducing equivalents, formaldehyde fixation and/or formate assimilation. The enhanced carbon flux through acetyl-CoA, in combination with pathways for generating reducing equivalents, formaldehyde fixation and/or formate assimilation can, in some embodiments, be used for production of a bioderived compound. Accordingly, in some embodiments, the microbial organisms of the invention can include a pathway capable of producing a bioderived compound of the invention. The invention still further provides a bioderived compound produced by a microbial organism of the invention, culture medium having the bioderived compound of the invention, compositions having the bioderived compound of the invention, a biobased product comprising the bioderived compound of the invention, and a process for producing a bioderived compound of the invention.

    MICROORGANISMS AND METHODS FOR IMPROVING PRODUCT YIELDS ON METHANOL USING ACETYL-COA SYNTHESIS
    9.
    发明申请
    MICROORGANISMS AND METHODS FOR IMPROVING PRODUCT YIELDS ON METHANOL USING ACETYL-COA SYNTHESIS 有权

    公开(公告)号：US20210332393A1

    公开(公告)日：2021-10-28

    申请号：US17064404

    申请日：2020-10-06

    Applicant: Genomatica, Inc.

    Inventor： Robin E. Osterhout ,  Anthony P. Burgard ,  Priti Pharkya ,  Stefan Andrae

    IPC: C12P5/02 ,  C12P7/18 ,  C12N1/14 ,  C12N1/20 ,  C12P7/42 ,  C12P7/02 ,  C12P7/40 ,  C12N15/70 ,  C12N15/81 ,  C12P7/04 ,  C12P7/44 ,  C12P13/00 ,  C12P17/10

    Abstract: The invention provides non-naturally occurring microbial organisms containing enzymatic pathways and/or metabolic modifications for enhancing carbon flux through acetyl-CoA. In some embodiments, the microbial organisms of the invention having such pathways also include pathways for generating reducing equivalents, formaldehyde fixation and/or formate assimilation. The enhanced carbon flux through acetyl-CoA, in combination with pathways for generating reducing equivalents, formaldehyde fixation and/or formate assimilation can, in some embodiments, be used for production of a bioderived compound. Accordingly, in some embodiments, the microbial organisms of the invention can include a pathway capable of producing a bioderived compound of the invention. The invention still further provides a bioderived compound produced by a microbial organism of the invention, culture medium having the bioderived compound of the invention, compositions having the bioderived compound of the invention, a biobased product comprising the bioderived compound of the invention, and a process for producing a bioderived compound of the invention.

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