公开(公告)号：US4710584A

公开(公告)日：1987-12-01

申请号：US680559

申请日：1984-12-11

Applicant: Gerard Lang ,  Serge Forestier ,  Alain LaGrange

Inventor： Gerard Lang ,  Serge Forestier ,  Alain LaGrange

IPC: A61K8/00 ,  A61K8/33 ,  A61K8/35 ,  A61K8/36 ,  A61K8/41 ,  A61K8/92 ,  A61K8/97 ,  A61Q1/00 ,  A61Q1/04 ,  A61Q3/02 ,  A61Q5/02 ,  A61Q5/10 ,  A61Q17/04 ,  C07C45/29 ,  C07C45/63 ,  C07C45/64 ,  C07C49/697 ,  C07C49/747 ,  C07C49/753 ,  C07C49/757 ,  C07C49/798 ,  C07C59/86 ,  C07C69/738 ,  C07C235/78 ,  A61K7/42

CPC classification number: C07C49/798 ,  C07C45/292 ,  C07C45/63 ,  C07C45/64 ,  C07C49/697 ,  C07C49/747 ,  C07C49/753 ,  C07C49/757

Abstract: New derivatives of 3-benzylidene camphor, process for preparing them and their use as protective agents against UV rays and as medicaments.Derivatives of 3-benzylidene camphor of formula: ##STR1## in which R denotes a hydrogen atom, a methyl or ethyl radical,R' denotes a hydrogen atom, a methyl or ethyl radical,R and R' being unable simultaneously to denote a hydrogen atom,R.sub.1 denotes a --COOR.sub.2, --CONHR.sub.2, --COO.sup.- M.sup.+, --CHO, --CH(OR.sub.4).sub.2 or --CH.sub.2 OR.sub.4 group,R.sub.2 being an alkyl, alkenyl, cycloalkyl or aralkyl radical containing at most 20 carbon atoms, optionally substituted by hydroxy, alkoxy, amine or quaternary ammonium groups,M denoting a hydrogen atom, an alkali metal or a N.sup.+ (R.sub.3).sub.4 group, R.sub.3 being a hydrogen atom or a C.sub.1 to C.sub.4 alkyl or hydroxyalkyl radical,R.sub.4 denoting H, alkyl, cycloalkyl or aralkyl containing at most 20 carbon atoms.Application in cosmetics for protection against UV rays.Therapeutic application for the treatment of dermatological and rheumatic complaints; anti-tumour activity.

Abstract translation: 3-亚苄基樟脑的新衍生物，其制备方法及其作为紫外线和药物的保护剂的用途。 其中R表示氢原子，甲基或乙基，R'表示氢原子，甲基或乙基，R和R'不能同时表示氢原子的3-亚苄基樟脑衍生物 原子，R 1表示-COOR 2，-CONHR 2，-COO-M +，-CHO，-CH（OR 4）2或-CH 2 OR 4基团，R 2是含有至多20个碳原子的烷基，烯基，环烷基或芳烷基， 羟基，烷氧基，胺或季铵基团，M表示氢原子，碱金属或N +（R3）4基团，R3表示氢原子或C1至C4烷基或羟烷基，R4代表H，烷基， 含有至多20个碳原子的环烷基或芳烷基。 化妆品中应用于防紫外线。 治疗皮肤病和风湿性疾病的治疗应用; 抗肿瘤活性。

公开(公告)号：US4656029A

公开(公告)日：1987-04-07

申请号：US721424

申请日：1985-04-09

Applicant: Jean F. Grollier ,  Gerard Lang ,  Serge Forestier ,  Georges Rosenbaum

Inventor： Jean F. Grollier ,  Gerard Lang ,  Serge Forestier ,  Georges Rosenbaum

IPC: A61K20060101 ,  A61K8/60 ,  A61Q17/04 ,  A61K7/06 ,  A61K7/135 ,  A61K7/42 ,  A61K7/44

CPC classification number: A61Q17/04 ,  A61K8/602 ,  Y10S424/01

Abstract: The present invention relates to a cosmetic composition containing, as an agent for protecting against light, pure aloesin or an aloe extract containing at least 40% of aloesin and less than 5% of barbaloin, in a quantity of 0.5 to 20% by weight, in a cosmetically acceptable medium.Such a cosmetic composition can consist of a protective composition, a sunscreen composition or a cosmetic composition stabilized against light and can be applied on skin or to hair.

Abstract translation: 本发明涉及以0.5〜20重量％的量含有至少40％芦荟碱和小于5％巴布醇的纯芦荟提取物作为防光防霉剂的纯化芦荟提取物， 在化妆品可接受的介质中。 这种化妆品组合物可以由保护性组合物，防晒组合物或抗光稳定的化妆品组合物组成，并且可以施用于皮肤或头发上。

公开(公告)号：US4588839A

公开(公告)日：1986-05-13

申请号：US511646

申请日：1983-07-07

Applicant: Gerard Lang ,  Alain Malaval ,  Gerard Malle

Inventor： Gerard Lang ,  Alain Malaval ,  Gerard Malle

IPC: A61K8/35 ,  A61K20060101 ,  A61K8/00 ,  A61K8/33 ,  A61K8/46 ,  A61K31/18 ,  A61Q13/00 ,  A61Q17/04 ,  C07C20060101 ,  C07C49/437 ,  C07C49/453 ,  C07C49/743 ,  C07C67/00 ,  C07C301/00 ,  C07C309/25 ,  C07C311/00 ,  C07C311/02 ,  C07C311/13 ,  C07C311/15 ,  C07C311/16 ,  C07C311/17 ,  C07C311/27 ,  C07D303/08 ,  C07D317/46 ,  C07D317/54 ,  C07D319/16 ,  C07D319/18 ,  C08K5/42 ,  C08K5/43 ,  C09K15/28 ,  C11B9/00 ,  C07C143/78 ,  A61K7/42

CPC classification number: A61Q17/04 ,  A61K8/466

Abstract: Compounds having the formula: ##STR1## in which X.sub.1 =H or Y; X.sub.2 is hydrogen, halogen, C.sub.1 -C.sub.4 alkyl or alkoxy, Y or Z; X.sub.3 is H, halogen, C.sub.1 -C.sub.4 alkyl or alkoxy, Y or Z; or X.sub.2 and X.sub.3 together form an alkylidenedioxy containing 1 or 2 C; Y is ##STR2## in which R.sub.1 is H or C.sub.1 -C.sub.4 alkyl or hydroxyalkyl and R.sub.2 is H, alkyl or alkenyl, cycloalkyl, aryl or aralkyl, it being impossible for R.sub.1 and R.sub.2 to be hydrogen simultaneously; and Z denotes ##STR3## in which R.sub.3 is H, --CN or --COR.sub.5 and R.sub.4 is --COR.sub.6, R.sub.5 and R.sub.6 being C.sub.1 -C.sub.20 alkoxy or alkylamino, with the proviso that one of the symbols X.sub.1, X.sub.2 and X.sub.3 is different from the other two and that if X.sub.1 =H, X.sub.2 and X.sub.3 are different from one another and cannot have the meanings Z.sub.2 and Z.sub.3, one of the two necessarily being Y or Z.sub.1 ; if X.sub.1 has the meaning Y, X.sub.2 and X.sub.3 are different from Y and cannot simultaneously have the meaning Z.sub.1, Z.sub.2 or Z.sub.3 are disclosed for use as UV filters.

Abstract translation: 具有下式的化合物：其中X1 = H或Y; X 2是氢，卤素，C 1 -C 4烷基或烷氧基，Y或Z; X 3为H，卤素，C 1 -C 4烷基或烷氧基，Y或Z; 或X2和X3一起形成含有1或2个C的亚烷基二氧基; Y是，其中R1是H或C1-C4烷基或羟烷基，R2是H，烷基或烯基，环烷基，芳基或芳烷基，R1和R2不可能同时是氢; 并且Z表示其中R 3为H，-CN或-COR 5且R 4为-COR 6，R 5和R 6为C 1 -C 20烷氧基或烷基氨基，其条件是符号X1，X2 X3与另外两个不同，如果X1 = H，则X2和X3彼此不同，不能含义Z2和Z3，其中一个必须为Y或Z1; 如果X1具有意义Y，则X2和X3与Y不同，不能同时具有含义Z1，Z2或Z3用作UV滤光片。

公开(公告)号：US4539320A

公开(公告)日：1985-09-03

申请号：US484604

申请日：1983-04-13

Applicant: Gerard Lang ,  Jean Maignan ,  Jean-Luc Leveque ,  Laurent Rasseneur

Inventor： Gerard Lang ,  Jean Maignan ,  Jean-Luc Leveque ,  Laurent Rasseneur

IPC: C11D3/48 ,  A61K8/00 ,  A61K8/33 ,  A61K8/34 ,  A61K8/36 ,  A61K8/365 ,  A61K8/40 ,  A61K8/44 ,  A61K8/49 ,  A61K9/10 ,  A61K31/54 ,  A61Q1/00 ,  A61Q17/04 ,  A61Q19/00 ,  C07D279/12 ,  C09K3/20 ,  C11D1/00 ,  C11D9/30 ,  C11D9/32

CPC classification number: C07D279/12 ,  A61K8/49 ,  A61Q19/00 ,  A61Q1/00 ,  A61Q1/14 ,  A61Q19/004 ,  A61Q19/007

Abstract: A composition for topical application to the skin comprises, in an appropriate cosmetic vehicle, as an active agent, a compound of the formula ##STR1## wherein, R.sub.1 and R.sub.2 represent hydrogen or lower alkyl; R.sub.3 represents hydrogen, alkyl containing 1-4 carbon atoms, mono- or polyhydroxyalkyl having 2-16 carbon atoms, carbamylalkyl, carboxyalkyl or alkoxycarbonylalkyl; R.sub.4 represents hydrogen or --COOR.sub.5 represents hydrogen, alkyl having 1-18 carbon atoms optionally interrupted by one or more hetero atoms, or mono- or polyhydroxyalkyl having 2-18 carbon atoms; and n is 0 or 1.This composition improves the elasticity and suppleness of the skin.

Abstract translation: 用于局部施用于皮肤的组合物在合适的化妆品载体中包含作为活性剂，式IMA的化合物，其中R 1和R 2表示氢或低级烷基; R3表示氢，含有1-4个碳原子的烷基，具有2-16个碳原子的单羟基烷基或多羟基烷基，氨基甲酰基烷基，羧基烷基或烷氧基羰基烷基; R4表示氢或-COOR5表示氢，任选被一个或多个杂原子间隔的具有1-18个碳原子的烷基，或具有2-18个碳原子的单羟基或多羟基烷基; 并且n为0或1.该组合物改善了皮肤的弹性和柔软性。

公开(公告)号：US4465688A

公开(公告)日：1984-08-14

申请号：US393647

申请日：1982-06-29

Applicant: Braham Shroot ,  Jean Maignan ,  Gerard Lang

Inventor： Braham Shroot ,  Jean Maignan ,  Gerard Lang

IPC: A61K31/16 ,  A61K8/35 ,  A61K8/37 ,  A61K8/42 ,  A61K8/44 ,  A61K8/49 ,  A61K31/11 ,  A61K31/12 ,  A61K31/165 ,  A61K31/19 ,  A61K31/215 ,  A61K31/40 ,  A61K31/4015 ,  A61K31/44 ,  A61K31/495 ,  A61K31/535 ,  A61K31/5375 ,  A61P17/00 ,  A61Q19/00 ,  C07C45/00 ,  C07C49/747 ,  C07C51/00 ,  C07C59/86 ,  C07C62/38 ,  C07C67/00 ,  C07C69/738 ,  C07C231/00 ,  C07C233/00 ,  C07C233/12 ,  C07C235/32 ,  C07C235/78 ,  C07C253/00 ,  C07C255/40 ,  C07D207/04 ,  C07D207/40 ,  C07D209/56 ,  C07D211/06 ,  C07D241/04 ,  C07D265/30 ,  C07D295/16 ,  C07D295/185 ,  C07D207/404

CPC classification number: A61K8/35 ,  A61K8/37 ,  A61K8/42 ,  A61K8/44 ,  A61K8/49 ,  A61K8/4913 ,  A61Q19/00 ,  C07C59/86 ,  C07D207/40 ,  C07D295/185

Abstract: The invention concerns adducts of 1,8-dihydroxy-9-anthrone, of formula: ##STR1## in which: R.sub.1 and R.sub.2, taken together, form one of the following divalent residues: ##STR2## R.sub.3, R.sub.4, R'.sub.4, R.sub.5 and R'.sub.5 representing H, an alkyl group having 1-8 C with the exception of R.sub.5 =R'.sub.5 =CH.sub.3, a monohydroxyalkyl group with 2-8 C, possibly interrupted by one or more oxygens, a cycloalkyl group having 4-6 C, a phenyl group, or a benzyl group.Utilization of the compounds (I) in human or veterinary medicine, in particular in the treatment of psoriasis and or warts, and in cosmetics.

Abstract translation: 本发明涉及1,8-二羟基-9-蒽酮的加合物，其具有下式：其中：R 1和R 2一起形成以下二价残基之一：（i）

公开(公告)号：US4464301A

公开(公告)日：1984-08-07

申请号：US346893

申请日：1982-02-08

Applicant: Braham Shroot ,  Jean Maignan ,  Gerard Lang

Inventor： Braham Shroot ,  Jean Maignan ,  Gerard Lang

IPC: C07C69/738 ,  A61K31/19 ,  A61K31/215 ,  A61K31/34 ,  A61K31/341 ,  A61P31/04 ,  C07C59/90 ,  C07D307/58 ,  C07C50/18 ,  A61K31/12

CPC classification number: C07C59/90

Abstract: 1,8-Dihydroxy-9-anthrone derivatives, substituted in the 10-position by an unsaturated radical, are described which have utility as ingredients in human and veterinary pharmaceutical and cosmetic preparations and which are compounds of the structural formula ##STR1## wherein R.sub.1 represents a hydrogen atom or a --CO.sub.2 R'.sub.2 radical,R.sub.2 and R'.sub.2 identical or different, represent a hydrogen atom, a linear or branched chain alkyl radical having 1 to 6 carbon atoms, a cycloalkyl radical having 4 to 6 carbon atoms or a benzyl radical,or R.sub.1 and R.sub.2 taken together form a radical --CO--, and n is 0 or 1,with the proviso that when n is 0 and R.sub.1 is --CO.sub.2 R'.sub.2,R.sub.2 and R'.sub.2 do not simultaneously represent the radical CH.sub.3, and the isomers of the compounds of formula (I) and mixtures thereof.

Abstract translation: 在10位被不饱和基团取代的1,8-二羟基-9-蒽酮衍生物被描述为具有作为人类和兽医用药物和化妆品制剂中的成分的作用，并且是结构式为“IMAGE”（I ）其中R1表示氢原子或-CO2R'2基团，R2和R'2相同或不同，表示氢原子，具有1至6个碳原子的直链或支链烷基，环烷基具有4至6个 碳原子或苄基，或者R 1和R 2一起形成基团-CO-，n为0或1，条件是当n为0且R 1为-CO 2 R'2时，R 2和R'2为 同时代表基团CH 3，和式（I）化合物的异构体及其混合物。

公开(公告)号：US4425321A

公开(公告)日：1984-01-10

申请号：US929193

申请日：1978-07-28

Applicant: Bernard Jacquet ,  Gerard Lang ,  Alain Malaval

Inventor： Bernard Jacquet ,  Gerard Lang ,  Alain Malaval

IPC: A61K8/19 ,  A61K8/27 ,  A61L15/46 ,  A61Q15/00 ,  C07C51/09 ,  C07C51/41 ,  C07C61/22 ,  A61K7/32 ,  A61K7/36

CPC classification number: C07C61/22 ,  A61K8/19 ,  A61K8/27 ,  A61Q15/00 ,  C07C403/20 ,  C07C51/09 ,  C07C51/412 ,  C07C2101/16 ,  Y10S424/05

Abstract: Deodorant compositions containing at least one zinc or magnesium salt of a polyacid of the general formula: ##STR1## in which X is--CH.dbd.CH--or--CHOH--CHOH--, Y is H, a saturated or unsaturated aliphatic radical of 1 to 10 carbon atoms, which is unsubstituted or substituted by one or more hydroxyls, a saturated or unsaturated alicyclic radical of up to 30 carbon atoms, which is unsubstituted or substituted by one or more hydroxyls and/or a carboxylic acid group, or Y denotes a carboxylic acid radical when p=O, Z denotes a saturated or unsaturated hydrocarbon radical of up to 6 carbon atoms, n is an integer less than 10, p is O or an integer less than or equal to n, and R is H or a lower alkyl group, and of a positional isomer of such a polyacid, exhibit the advantage that they prevent the development of odors without thereby destroying the biological equilibrium of the skin. The compositions may be in the form of creams, lotions, solids, such as roll-on blocks, sticks or compacted powders, aerosols and the like.

Abstract translation: 含有通式如下的多酸的至少一种锌盐或镁盐的除臭剂组合物：其中X是-CH = CH-或-CHOH-CHOH-，Y是H，饱和或不饱和脂族基团 未被取代或被一个或多个羟基取代的至多30个碳原子的饱和或不饱和脂环基团，其未被取代或被一个或多个羟基和/或羧酸基取代，或 当p = O时，Y表示羧酸基团，Z表示最多6个碳原子的饱和或不饱和烃基，n为小于10的整数，p为O或小于或等于n的整数，R为 H或低级烷基，以及这种多酸的位置异构体，具有防止气味发生而不破坏皮肤生物平衡的优点。 组合物可以是乳膏，洗剂，固体，例如滚涂块，棒或压实粉末，气雾剂等的形式。

公开(公告)号：US4293542A

公开(公告)日：1981-10-06

申请号：US793316

申请日：1977-05-03

Applicant: Gerard Lang ,  Serge Forestier

Inventor： Gerard Lang ,  Serge Forestier

IPC: A61K8/49 ,  A61K31/44 ,  A61Q17/04 ,  A61K7/00 ,  A61K7/021 ,  A61K7/44

CPC classification number: A61Q17/04 ,  A61K8/4926

Abstract: A cosmetic composition for imparting to human skin after exposure to sunlight a coloration resembling a natural tan comprising a cosmetic vehicle suitable for topical application to the skin and an effective amount of at least one compound of the formula ##STR1## wherein R.sub.1 represents hydrogen or amino; R.sub.2 represents hydrogen, lower alkyl or amino; R.sub.3 represents hydrogen, lower alkyl or amino; R.sub.4 represents hydrogen, lower alkyl or chlorine; and R.sub.5 represents hydrogen, lower alkyl or hydroxy, or amino when R.sub.1 is amino, with the proviso that R.sub.1, R.sub.2 and R.sub.3 are not simultaneously amino; and at least one of R.sub.1, R.sub.2 R.sub.3 means amino or an acid addition salt thereof.

Abstract translation: 一种化妆品组合物，其用于在阳光下暴露于人体皮肤，其着色为天然棕褐色，其包含适合局部施用于皮肤的化妆品载体和有效量的至少一种下式化合物，其中R 1表示氢或氨基 ; R2代表氢，低级烷基或氨基; R3代表氢，低级烷基或氨基; R4代表氢，低级烷基或氯; 并且当R 1为氨基时，R 5表示氢，低级烷基或羟基或氨基，条件是R 1，R 2和R 3不同时为氨基; R1，R2 + L，R3中的至少一个表示氨基或其酸加成盐。

公开(公告)号：US20070261178A1

公开(公告)日：2007-11-15

申请号：US11539459

申请日：2006-10-06

Applicant: Christine Rondeau ,  Gerard Lang ,  Jean Cotteret

Inventor： Christine Rondeau ,  Gerard Lang ,  Jean Cotteret

IPC: A61Q5/10

CPC classification number: A61Q5/065 ,  A61K8/49 ,  A61K8/4926 ,  A61K8/494 ,  A61K8/4946 ,  A61K8/4953 ,  A61K8/894 ,  A61K8/898 ,  A61Q5/10

Abstract: The invention relates to a composition for dyeing keratinous fibres, in particular human keratinous fibres such as hair, comprising, in an appropriate dyeing medium, at least one cationic direct dye of a given formula, and which is characterized in that it contains, in addition, at least one silicone chosen from the aminated silicones, the polyoxyalkylenated silicones, the silicone gums and resins. The invention also relates to the dyeing methods and devices using it.

Abstract translation: 本发明涉及一种用于染色角质纤维，特别是人角质纤维如毛发的组合物，其在适当的染色介质中包含至少一种给定式的阳离子直接染料，其特征在于，其还包含另外 ，选自胺化硅氧烷，聚氧化烯化硅氧烷，硅氧烷树胶和树脂中的至少一种硅氧烷。 本发明还涉及使用它的染色方法和装置。

公开(公告)号：US20060070191A1

公开(公告)日：2006-04-06

申请号：US11121156

申请日：2005-05-04

Applicant: Gerard Lang ,  Jean Cotteret

Inventor： Gerard Lang ,  Jean Cotteret

IPC: A61K8/49 ,  A61K8/41

CPC classification number: A61K8/4946 ,  A61K8/49 ,  A61K8/4926 ,  A61K8/494 ,  A61K8/4953 ,  A61Q5/065

Abstract: The invention relates to a composition for dyeing keratinous fibres, in particular human keratinous fibres such as hair, comprising, in an appropriate dyeing medium, at least one cationic direct dye of a given formula, and which is characterized in that it contains, in addition, at least one nonionic surfactant chosen from the group consisting of alkyl polyglucosides, sugar or alkyl sugar fatty acid esters, fatty sugar amides and mixtures thereof. The invention also relates to the dyeing methods and devices using it.

Abstract translation: 本发明涉及一种用于染色角质纤维，特别是人角质纤维如毛发的组合物，其在适当的染色介质中包含至少一种给定式的阳离子直接染料，其特征在于，其还包含另外 ，至少一种选自烷基聚葡糖苷，糖或烷基糖脂肪酸酯，脂肪糖酰胺及其混合物的非离子表面活性剂。 本发明还涉及使用它的染色方法和装置。