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    METHOD AND APPARATUS FOR DETERMINING A VERTICAL POSITION OF A HORIZONTALLY EXTENDING INTERFACE BETWEEN A FIRST COMPONENT AND A SECOND COMPONENT
    103.
    发明申请
    METHOD AND APPARATUS FOR DETERMINING A VERTICAL POSITION OF A HORIZONTALLY EXTENDING INTERFACE BETWEEN A FIRST COMPONENT AND A SECOND COMPONENT 有权

    公开(公告)号：US20210172725A1

    公开(公告)日：2021-06-10

    申请号：US17110451

    申请日：2020-12-03

    Applicant: Roche Diagnostics Operations, Inc.

    Inventor： Michael Rein

    IPC: G01B11/02 ,  G01N33/49 ,  G01N15/05 ,  G01N35/00

    Abstract: A method for determining a vertical position of a horizontally extending interface between first and second components is presented. The first and second components are contained in a laboratory sample container in layers vertically separated from each other. The method comprises generating first data, generating second data in the form of picture data of the laboratory sample container containing the first and second components, determining a first probability distribution function in response to the first data, determining a second probability distribution function in response to the second data, and determining the vertical position of the horizontally extending interface depending on the first and second probability distribution functions. The first data depend on the vertical position of the horizontally extending interface. The first and second probability distribution functions assign a probability of the presence of the horizontally extending interface to a vertical position.

    HYBRIDIZING ALL-LNA OLIGONUCLEOTIDES
    104.
    发明申请
    HYBRIDIZING ALL-LNA OLIGONUCLEOTIDES 有权

    公开(公告)号：US20210155976A1

    公开(公告)日：2021-05-27

    申请号：US17126439

    申请日：2020-12-18

    Applicant: Roche Diagnostics Operations, Inc.

    Inventor： Frank Bergmann ,  Dieter Heindl ,  Michael Schraeml ,  Johannes Stoeckel

    IPC: C12Q1/6816

    Abstract: The present report relates to hybridizing single-stranded (ss-) oligonucleotides which entirely consist of locked nucleic acid (LNA) monomers. The present document shows hybridization experiments with pairs of entirely complementary ss-oligonucleotides which fail to form a duplex within a given time interval. The present report provides methods to identify such incompatible oligonucleotide pairs. In another aspect, the present report provides pairs of complementary ss-oligonucleotides which are capable of rapid duplex formation. The present report also provides methods to identify and select compatible oligonucleotide pairs. In yet another aspect the present report provides use of compatible oligonucleotide pairs as binding partners in binding assays, e.g. immunoassays.

    Method of operating a laboratory sample distribution system, laboratory sample distribution system, and laboratory automation system
    107.
    发明授权
    Method of operating a laboratory sample distribution system, laboratory sample distribution system, and laboratory automation system 有权

    公开(公告)号：US10989725B2

    公开(公告)日：2021-04-27

    申请号：US15988637

    申请日：2018-05-24

    Applicant: Roche Diagnostics Operations, Inc.

    Inventor： Shubin Ren

    IPC: G01N35/04 ,  G01N35/00 ,  B65G54/02

    Abstract: A method of operating a laboratory sample distribution system is presented. The system comprises sample container carriers comprising a magnetically active device and configured to carry a sample container, interconnected transport plane modules configured to support carriers, and electro-magnetic actuators arranged in rows and columns below each transport plane module and configured to move a carrier on top of the transport plane modules by applying a magnetic force to the carrier. The method comprises assigning transport plane modules to a route category. At least two traffic lanes are formed on the route categorized transport plane module. The carriers are moved within each traffic lane in a transport direction. The transport directions are opposite to each other. The method also comprises assigning another transport plane module to a waypoint category. A change from one transport direction to the opposite transport direction is possible on the waypoint categorized transport plane module.

    Method of operating a laboratory sample distribution system, laboratory sample distribution system and laboratory automation system
    108.
    发明授权
    Method of operating a laboratory sample distribution system, laboratory sample distribution system and laboratory automation system 有权

    公开(公告)号：US10962557B2

    公开(公告)日：2021-03-30

    申请号：US16021219

    申请日：2018-06-28

    Applicant: Roche Diagnostics Operations, Inc.

    Inventor： Falk Hoehnel

    IPC: G01N35/00 ,  G01N35/04 ,  B65G54/02

    Abstract: A method of operating a laboratory sample distribution system is presented. The system comprises container carriers, a gateway having a network interface, and transport modules. Each module comprises a transport surface and are adjacent in a row-direction and column-direction to form a transport surface. The module comprises a driver arranged below the transport surface to move container carriers on the transport surface and left, right, upper and lower network interfaces. The left and right network interfaces connect modules in rows and the upper and lower network interfaces connect modules in columns. The network interface of the gateway is connected to a network interface of a first module. The method comprises sending an explore command from the gateway to the first module, propagating an initialization command from the first module to the remaining modules, storing addresses within the modules, and using the addresses by the gateway to address the modules.

    Identification, authentication, and authorization method in a laboratory system
    109.
    发明授权
    Identification, authentication, and authorization method in a laboratory system 有权

    公开(公告)号：US10944760B2

    公开(公告)日：2021-03-09

    申请号：US16580068

    申请日：2019-09-24

    Applicant: Roche Diagnostics Operations, Inc.

    Inventor： Lothar Gramelspacher ,  Andrzej Knafel ,  Anton Steimle

    IPC: H04L29/06 ,  H04L9/32 ,  G06F21/33 ,  G06F21/34 ,  G16H10/40

    Abstract: An identification, authentication and authorization method in a laboratory system is presented. The system comprises at least one laboratory device. The method comprises receiving identification data identifying a user; receiving identity confirmation data to authenticate the user; and generating authentication data upon successful authentication of the user. The authentication data is configured to enable authentication of the user based on only the identification data during a validity time period without repeated receipt of the identity confirmation data. The method further comprises receiving the identification data by an identification unit; validating the authentication data corresponding to the identification data comprising the step of verifying non-expiry of the validity time period; and granting authorization to the user for the laboratory device upon successful validation of the authentication data.

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