公开(公告)号：US20230322976A1

公开(公告)日：2023-10-12

申请号：US18017685

申请日：2021-07-30

Applicant: Toray Industries, Inc. ,  Biodynamic Research Foundation

Inventor： Tsubasa Okano ,  Satoshi Ujiie

IPC: G01N30/06 ,  C08F20/56

CPC classification number: C08F20/56 ,  G01N30/06 ,  G01N2030/027 ,  G01N2030/067

Abstract: A method enables evaluation of the purity of an active pharmaceutical ingredient contained in a complex, and a method of producing a complex in which the purity of the active pharmaceutical ingredient is not less than 95.0%. The purity evaluation method includes: a reaction step of reacting a complex with a nitrogen-containing nucleophile such as hydroxylamine in the presence of a protonic acid in a polar solvent; and an evaluation step of evaluating the purity of the reaction mixture obtained by the reaction step, by high-performance liquid chromatography. The method of producing a complex includes a reaction step of reacting an anthracycline drug with an N-(2-hydroxypropyl)methacrylamide polymer in the presence of a protonic acid in a polar solvent at not more than 10° C., to obtain the complex.

公开(公告)号：US20230287191A1

公开(公告)日：2023-09-14

申请号：US18020137

申请日：2021-09-03

Applicant: TORAY INDUSTRIES, INC.

Inventor： Hirokazu IIMORI ,  Masataka NAKAMURA

IPC: C08J7/04 ,  C08J7/056 ,  C08J7/12

CPC classification number: C08J7/0427 ,  C08J7/056 ,  C08J7/12 ,  C08J2383/04 ,  C08J2433/10 ,  C08J2433/26 ,  C08J2379/08

Abstract: The purpose of the present invention is to provide a coated silicone member manufacturing method which enables, even when a highly water-repellent silicone member having a water surface contact angle of more than 110° is processed at a low temperature, formation of, on the surface, a coating having a sufficiently low surface contact angle with respect to an aqueous solution containing a salt and a protein. The present invention provides a coated silicone member manufacturing method comprising: (A) a degradative reaction step for degrading the surface of a silicone member; (B) a contact step b for bringing a solution b containing a polycarbodiimide into contact with the surface-degraded silicone member; and (C) a contact step c for bringing a solution c containing a polymer C into contact with the surface-degraded silicone member. The polymer C has an alkyl amide group and hydroxyl group.

公开(公告)号：US11733250B2

公开(公告)日：2023-08-22

申请号：US17487089

申请日：2021-09-28

Applicant: Toray Industries, Inc. ,  NATIONAL CANCER CENTER

Inventor： Michimoto Kobayashi ,  Mitsuaki Sanada ,  Yoshiyuki Sasajima ,  Giman Jung ,  Tesshi Yamada ,  Kazufumi Honda

IPC: G01N33/68 ,  C07K16/18 ,  C07K14/775 ,  G01N33/574

CPC classification number: G01N33/6893 ,  C07K14/775 ,  C07K16/18 ,  G01N33/57438 ,  G01N2333/775 ,  G01N2800/06 ,  G01N2800/067

Abstract: The purpose of the present invention is to provide a simple and highly accurate method for detecting pancreatic exocrine dysfunction with minimal invasiveness to a subject. The method comprising in vitro measurement of two APOA2 protein variants, mutants thereof and/or fragments thereof in a body fluid sample derived from the subject and detection of the presence or absence of pancreatic exocrine dysfunction on the basis of the measured amounts, and a detection kit for pancreatic exocrine dysfunction including antibodies that can specifically bind to said proteins are provided.

公开(公告)号：US11710831B2

公开(公告)日：2023-07-25

申请号：US17276273

申请日：2019-09-26

Applicant: Toray Industries, Inc.

Inventor： Masamichi Utsunomiya ,  Fumitaka Watanabe

IPC: H01M4/86 ,  H01M8/0245 ,  H01M8/1018 ,  H01M8/10

CPC classification number: H01M4/861 ,  H01M4/8652 ,  H01M4/8657 ,  H01M8/0245 ,  H01M8/1018 ,  H01M2008/1095

Abstract: A fuel cell with high productivity, high power generation performance and high durability is described, along with a gas diffusion electrode base material having a microporous layer on one side of an electrically conductive porous base material, where the electrically conductive porous base material contains carbon fiber and resin carbide and has a density of 0.25 to 0.39 g/cm3 and a pore mode diameter in a range of 30 to 50 μm. The microporous layer contains a carbonaceous powder and a fluororesin and has a surface roughness of 2.0 to 6.0 μm, a porosity of 50 to 95%, and a pore mode diameter of 0.050 to 0.100 μm.

公开(公告)号：US20230212687A1

公开(公告)日：2023-07-06

申请号：US17988959

申请日：2022-11-17

Applicant: TORAY INDUSTRIES, INC. ,  NATIONAL CANCER CENTER

Inventor： Makiko YOSHIMOTO ,  Hiroko SUDO ,  Atsuko MIYANO ,  Satoko KOZONO ,  Takahiro OCHIYA ,  Hiroyuki FUJIMOTO ,  Fumihiko URABE ,  Juntaro MATSUZAKI

IPC: C12Q1/6886

CPC classification number: C12Q1/6886 ,  C12Q2600/158 ,  C12Q2600/178

Abstract: This invention provides a kit or device for detection of prostate cancer and a method for detecting prostate cancer. This invention provides a kit or device for detection of prostate cancer comprising a nucleic acid capable of specifically binding to an miRNA in a sample from a subject or a complementary strand thereof and a method for detecting prostate cancer comprising measuring the miRNA in vitro.

公开(公告)号：US11685813B2

公开(公告)日：2023-06-27

申请号：US17288959

申请日：2019-10-24

Applicant: Toray Industries, Inc.

Inventor： Itaru Asano ,  Tomohiko Nakamura ,  Yota Okuno ,  Nobuhiro Morioka

IPC: C08J3/14 ,  C08G69/08

CPC classification number: C08J3/14 ,  C08G69/08 ,  C08J2377/00

Abstract: A method produces polyamide fine particles by polymerizing a polyamide monomer (A) in the presence of a polymer (B) at a temperature equal to or higher than the crystallization temperature of a polyamide to be obtained, wherein the polyamide monomer (A) and the polymer (B) are homogeneously dissolved at the start of polymerization, and polyamide fine particles are precipitated after the polymerization. Polyamide fine particles have a number average particle size of 0.1 to 100 μm, a sphericity of 90 or more, a particle size distribution index of 3.0 or less, a linseed oil absorption of 100 mL/100 g or less, and a crystallization temperature of 150° C. or more.

公开(公告)号：US20230198097A1

公开(公告)日：2023-06-22

申请号：US17926328

申请日：2021-05-21

Applicant: Toray Industries, Inc.

Inventor： Nobuyasu Kai ,  Keiichi Kamon ,  Hiroko Tanaka ,  Akimitsu Tsukuda ,  Naoki Imazu

IPC: H01M50/451 ,  C08F20/18 ,  C08L33/08 ,  H01M50/426 ,  H01M50/42 ,  H01M50/431 ,  H01M50/446 ,  H01M50/489

CPC classification number: H01M50/451 ,  C08F20/18 ,  C08L33/08 ,  H01M50/42 ,  H01M50/426 ,  H01M50/431 ,  H01M50/446 ,  H01M50/489 ,  C08L2203/16 ,  C08L2203/20 ,  C08L2205/025

Abstract: A porous film includes a porous base and a porous layer containing particles A disposed at least on one side thereof, wherein the particles A contain a mixture including a polymer formed from a fluorine-containing (meth)acrylate monomer and a polymer formed from a (meth)acrylate monomer having a hydroxyl group or a copolymer including a fluorine-containing (meth)acrylate monomer and a (meth)acrylate monomer having a hydroxyl group, with the (meth)acrylate monomer having a hydroxyl group accounting for more than 2 mass% and 30 mass% or less of all components of the particles A, which account for 100 mass%.

公开(公告)号：US20230167252A1

公开(公告)日：2023-06-01

申请号：US17913294

申请日：2021-03-22

Applicant: Toray Industries, Inc.

Inventor： Tomoki Ashibe ,  Daichi Miyazaki ,  Mitsuhito Suwa

IPC: C08J5/18 ,  C08G73/10 ,  H10K59/12

CPC classification number: C08J5/18 ,  C08G73/106 ,  H10K59/1201 ,  C08J2379/08

Abstract: The present invention provides a resin film that is less likely to suffer peeling or creasing of a layer formed on the resin film in a high temperature process for producing a device and that can be used suitably to produce a product that requires transparency, where the resin film comprises a resin that has a repeating unit as represented by the chemical formula (1) and has a light transmittance of 68% or more at a wavelength of 400 nm, a glass transition temperature of 370° C. or more, and a weight loss starting temperature of 440° C. or more,




where in the chemical formula (1), A denotes a tetravalent tetracarboxylic acid residue containing 2 or more carbon atoms and B denotes a divalent diamine residue containing 2 or more carbon atoms.

公开(公告)号：US20230151171A1

公开(公告)日：2023-05-18

申请号：US17919802

申请日：2021-04-23

Applicant: Toray Industries, Inc.

Inventor： Hirotaka Kondo ,  Yoshiyuki Oka

IPC: C08J9/00 ,  C08J9/10 ,  B32B5/18

CPC classification number: C08J9/0061 ,  C08J9/103 ,  B32B5/18 ,  C08J2323/06 ,  C08J2323/12 ,  C08J2203/184 ,  B32B2266/025 ,  B32B2605/08 ,  B32B2307/732 ,  B32B2307/50

Abstract: A polyolefin resin foam sheet includes a resin mixture as a base resin, the resin mixture including 0% by mass or more and 30% by mass or less of polyethylene resin, 30% by mass or more and 80% by mass or less of polypropylene resin, and 20% by mass or more and 40% by mass or less of a polyolefin elastomer, the polyolefin resin foam sheet fulfilling a range of −35% or more and 0% or less for dimensional changes in machine and transverse directions under heating for 10 minutes at a temperature 20° C. higher than a maximum melting point that is a highest melting peak in a differential scanning calorimetry.

公开(公告)号：US20230149197A1

公开(公告)日：2023-05-18

申请号：US17912923

申请日：2021-02-01

Applicant: TORAY Industries, Inc.

Inventor： Yao CHEN ,  Satoshi YAMADA ,  Hidetoshi SUZUKI ,  Koji OHATA

IPC: A61F5/01

CPC classification number: A61F5/0113

Abstract: Provided is an orthotic device that achieves both a holding force and an orthotic force necessary for improvement of deformation and function of a lower limb and trackability to friction, fluctuation, compression and the like occurring during operation between an orthotic site and the orthotic device, is easy to wear, does not impair appearance during wearing, and in addition, maintains an appropriate holding force and orthotic force for a long period of time, and can be continuously used. A lower-limb orthotic device of the present invention includes: a fabric band A1 covering at least a part of an ankle portion including a malleolus and/or at least a part of a knee portion; a fabric band A2 covering a foot portion including a metatarsal bone; and at least one fabric band B, in which at least a part of the fabric band B covers the foot portion including a fifth metatarsal bone or a cuboid bone, the fabric band B is disposed to be positioned from the foot portion including the fifth metatarsal bone or the cuboid bone to the ankle portion and/or the knee portion, one end of the fabric band B in a longitudinal direction is connected to the fabric band A1, the other end of the fabric band B is connected to the fabric band A2, an interior angle between the fabric band A1 and the fabric band B when the lower-limb orthotic device is worn is 30° to 90°, and at least one of the fabric bands has an extension ratio at a load of 100 N/5 cm of 0.5% or more and 50% or less in a width direction and a longitudinal direction or in either one of the width direction and the longitudinal direction.