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公开(公告)号:US20230234028A1
公开(公告)日:2023-07-27
申请号:US18070525
申请日:2022-11-29
CPC分类号: B01J20/265 , B01J20/28028 , B01J20/3085 , C08F20/06 , C08J11/28 , C02F1/285 , B01D53/0407 , C08F2810/00 , C08J2333/02 , C02F2101/32
摘要: Articles comprising pressure-sensitive adhesives and methods of their use for removing micro- and nanoplastic particles from various media, including wastewater effluent, laundry effluent, and indoor air, are disclosed.
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公开(公告)号:US20230228715A1
公开(公告)日:2023-07-20
申请号:US18154348
申请日:2023-01-13
发明人: Jan P. Stegemann , Cheri X. Deng , Eric C. Hobson
IPC分类号: G01N29/02 , G01N29/04 , G01N33/02 , G01N33/487 , G01N33/483
CPC分类号: G01N29/02 , G01N29/04 , G01N33/02 , G01N33/487 , G01N33/4833 , G01N2291/106 , G01N2291/022 , G01N2291/023
摘要: Techniques for performing an acoustic rheology measurement of a sample are provided. A first set of acoustic pulses is provided by a focused ultrasound transducer to induce surface oscillations of the sample. A second set of acoustic pulses is provided by a detection transducer to interrogate the sample and detect the echo pulses reflected by the sample surface as a function of time. The detection ultrasound transducer system converts the echo signals to an electrical signal associated with the detected echo pulses, and a processor determines a dynamic displacement of the interface of the sample as a function of time. The processor also determines the spectrum, resonant surface oscillation frequency, and damping coefficient. Viscoelastic properties of the material are determined from these measurements, with applications for the characterization of the blood clotting process, the identification of a blood clot, gelation process, tumor, or fibrosis based on the viscoelastic properties.
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103.
公开(公告)号:US20230225839A1
公开(公告)日:2023-07-20
申请号:US17996565
申请日:2021-04-15
发明人: Junying Li , Hom-Lay Wang , Zhaozhao Chen
IPC分类号: A61C9/00 , A61C11/02 , A61C19/045 , A61C19/05 , A61C7/00
CPC分类号: A61C9/0053 , A61C11/02 , A61C19/045 , A61C19/05 , A61C7/002
摘要: The present invention relates to methods and systems for generating a 3-D dental impression with a corresponding hinge axis position and, in certain embodiments, a condylar guide inclination. In some embodiments, an intraoral scanner and a computer processing system are employed to: i) generate upper and lower jaw models, and first and second occlusal 3-D models with different mouth openings (MOs) or functional positions (FPs), ii) align the models to generate a composite 3-D model, iii) calculate a hinge axis position from the composite 3-D model based on the difference in said MOs or FPs, and iv) mount the 3-D dental impression on a virtual articulator (VA) by aligning the hinge axis position to the hinge axis position of the VA.
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公开(公告)号:US11698683B1
公开(公告)日:2023-07-11
申请号:US17742795
申请日:2022-05-12
发明人: Wonhee Michael Kim , Paul W. Alexander , Diann Brei , Jonathan E. Luntz , Koray Benli , Laura Alejandra Giner Munoz , James Menno Nykamp
CPC分类号: G06F3/016 , G06F3/0414 , G06F3/0416 , G06F2203/04103
摘要: A distributed inflatable touch sensing system is provided. The distributed inflatable touch sensing system includes a sensing bladder array, the sensing bladder array having a plurality of bladders, passageways, and ports in fluid communication. The system further includes a pressure regulator in fluid communication with one of the plurality of ports for regulating a pressure in the sensing bladder array. The system further includes a plurality of sensors, each in fluid communication with one of the plurality of ports, for measuring the pressure in the sensing bladder array. The system further includes a processor in communication with the plurality of sensors. The processor is configured to determine which of the plurality of bladders has been depressed by a user.
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105.
公开(公告)号:US20230212123A1
公开(公告)日:2023-07-06
申请号:US17920794
申请日:2021-04-20
IPC分类号: C07D213/64 , C07D213/65 , C07D213/40 , C07D213/68 , C07D401/06 , C07D213/61 , A61K45/06
CPC分类号: C07D213/64 , A61K45/06 , C07D213/40 , C07D213/61 , C07D213/65 , C07D213/68 , C07D401/06
摘要: Glucosylceramide synthase inhibitors and compositions containing the same are disclosed. Methods of using the glucosylceramide synthase inhibitors in the treatment of diseases and conditions wherein inhibition of glucosylceramide synthase provides a benefit, like Gaucher disease and Fabry disease, also are disclosed.
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公开(公告)号:US11691989B2
公开(公告)日:2023-07-04
申请号:US17047423
申请日:2019-11-20
申请人: ASCENTAGE PHARMA (SUZHOU) CO., LTD. , THE REGENTS OF THE UNIVERSITY OF MICHIGAN , ASCENTAGE PHARMA GROUP CORP LIMITED
发明人: Hao Chen , Wenming Chen , Chao Li , Dongbo Li , Yu Jing , Guozhi Tang , Yunlong Zhou , Shaomeng Wang , Chao-Yie Yang
IPC分类号: C07D497/22 , C07D515/22 , C07D231/12 , A61K31/395 , A61P35/00
CPC分类号: C07D515/22 , A61P35/00
摘要: Disclosed is compound of formula I and the pharmaceutically acceptable salts and solvates thereof, wherein R, R1a, R1b, R1h, L2, L3, #, #, # are as defined as set forth in the re) specification. Disclosed is compound of formula I for use to treat a condition or disorder responsive to Mcl-1 inhibition such as cancer.
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公开(公告)号:US20230201354A1
公开(公告)日:2023-06-29
申请号:US17998761
申请日:2021-05-14
发明人: Hakan Demirci , Nicholas Kotov , Yichun Wang
CPC分类号: A61K47/52 , A61K9/0019 , A61K45/06 , A61K9/0092 , A61K49/0095 , A61K49/0017 , A61K47/6929 , C01B32/159 , C01B2202/36 , C01B2202/34 , B82Y5/00
摘要: Disclosed herein are compositions and methods for injecting compounds into a vitreous body. Carbon nanotubes can be functionalized with a variety of agents, such as therapeutic agents and/or diagnostic agents, which can be injected into a vitreous body for treatment or detection of ocular tumors such as retinoblastoma. The carbon nanotubes can effectively penetrate the ocular tumor, making them effective carriers for the therapeutic and/or diagnostic agents.
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公开(公告)号:US11680143B2
公开(公告)日:2023-06-20
申请号:US16738872
申请日:2020-01-09
发明人: Mark H. Tuszynski , Jeffrey S. Sakamoto , Kendell M. Pawelec , Yacov M. Koffler , Michael Sailor , Jonathan Zuidema
CPC分类号: C08J5/18 , A61F2/02 , A61M31/002 , C08K3/36 , A61F2002/30316 , C08J2367/04 , C08K3/042 , C08K2003/325 , C08K2201/011
摘要: Provided herein is technology relating to materials having microscale and/or nanoscale features and particularly, but not exclusively, to porous materials comprising microscale features, methods for producing porous materials comprising microscale features, drug delivery vehicles, and related kits, systems, and uses.
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公开(公告)号:US20230179182A1
公开(公告)日:2023-06-08
申请号:US18077759
申请日:2022-12-08
发明人: Xin Zan , Al-Thaddeus Avestruz
摘要: A pulse shaping device includes an inductor that is selectively output-coupled to a first port of a capacitor. The inductor is charged to a selected current throughput and then coupled to the first port to generate a first characteristic within the current flowing at a second port of the capacitor. The capacitor is charged until reaching a clamping voltage at the first port. A voltage clamp of the shaping device clamps the first port of the capacitor at the clamping voltage to generate a second characteristic within the current flowing at a second port of the capacitor.
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公开(公告)号:US20230173768A1
公开(公告)日:2023-06-08
申请号:US17870418
申请日:2022-07-21
发明人: Fengchao LIU , Pingsha DONG
CPC分类号: B29C66/742 , B29C65/1429 , B29C65/44 , B29C66/022 , B29C66/43 , B29C66/30326
摘要: A method of directly joining a polymer to a metal along a joint interface through the formation of C—O—M chemical bonds, where M represents an element in the metal to be joined. The method includes heating the metal to a predetermined temperature above a glass transition temperature of the polymer and less than a flash ignition temperature of the polymer and less than a metal melting temperature of the metal; and applying force to the joint interface of the metal and the polymer to generate intimate atomic contact between the metal and the polymer to create C—O—M chemical bonds between the metal and the polymer.
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