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101.发明公开公开(公告)号：US20230256201A1
公开(公告)日：2023-08-17
申请号：US18296906
申请日：2023-04-06
Applicant: Wake Forest University Health Sciences
Inventor： James D. Turner , Sean Dobson
CPC classification number: A61M25/0113 , A61B34/20 , A61B8/0841 , A61B2034/2063
Abstract: A medical device is provided that can be held and operated with a single hand to cause a catheter to be placed at a selected location in a patient's body. The user's other hand is free to perform other tasks, such as operating an ultrasound probe, for example. The medical device may also include a valve that can be operated with the same hand that holds the medical device to open a port to cause a fluid, such as a nerve block agent, for example, to be injected into the patient's body at the selected location.
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公开(公告)号：US20230227477A1
公开(公告)日：2023-07-20
申请号：US18002535
申请日：2021-06-24
Applicant: WAKE FOREST UNIVERSITY HEALTH SCIENCES
Inventor： John C. Lukesh, III , Katherine Virginia Ambrose
IPC: C07F5/02
CPC classification number: C07F5/02
Abstract: Provided herein according to some embodiments of the invention are aryl boronate and/or aryl diaminoboryl compounds. Also provided are methods of detecting the presence of hydrogen peroxide (H2O2) and/or other reactive oxygen species (ROS) in a cell and/or tissue by contacting the cell and/or tissue with aryl boronate and/or aryl diaminoboryl compounds. Also provided according to embodiments of the invention are methods of producing persulfides in the presence of hydrogen peroxide (H2O2) and/or other reactive oxygen species (ROS) in a cell and/or tissue by contacting the cell and/or tissue with aryl boronate and/or aryl diaminoboryl compounds.
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公开(公告)号：US11648335B2
公开(公告)日：2023-05-16
申请号：US14610902
申请日：2015-01-30
Applicant: WAKE FOREST UNIVERSITY HEALTH SCIENCES
Inventor： Giuseppe Orlando , Shay Soker
CPC classification number: A61L27/3633 , A61L27/3604 , A61L27/3687 , A61L27/3808 , A61L27/3834 , A61L27/54 , A61L2300/256 , A61L2300/42 , A61L2430/26 , A61L2430/28 , A61L2430/40
Abstract: Methods for decellularizing organs and tissues in vitro and in vivo are provided, as are methods of maintaining organ and tissue frameworks and methods of recellularizing organs and tissues, thereby providing an approach to needed organs or tissues.
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公开(公告)号：US11583698B2
公开(公告)日：2023-02-21
申请号：US16657377
申请日：2019-10-18
Applicant: Duke University , Wake Forest University Health Sciences
Inventor： Fang-Fang Yin , Qingrong Jackie Wu , Lulin Yuan , Yaorong Ge
Abstract: According to an aspect, a method includes receiving data about a patient, computing geometric characterization of one or more organs at risk proximate to a target volume of a patient or vice versa, and selecting relevant treatment knowledge and experience. The method also includes generating, based on the received data, computed geometric characterization, and available knowledge and experience, a first set of radiation treatment planning parameters that will lead to a high quality plan for the patient. Further, the method includes model-based prediction, based on the data, a second set or more of radiation treatment planning parameters that will lead to alternative achievable plans with different organ sparing objectives for treating the patient. The multiple sets for parameters can be used separately or in conjunction to generate treatment plans.
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公开(公告)号：US20220117472A1
公开(公告)日：2022-04-21
申请号：US17431675
申请日：2020-02-18
Applicant: WAKE FOREST UNIVERSITY HEALTH SCIENCES
Inventor： Keith WALTER , Kenneth WEINLANDER
Abstract: Ophthalmic endoscopes are provided that overcome deficiencies associated with current approaches to implanting ophthalmic stents and shunts for treatment of glaucoma. In various aspects, ophthalmic endoscopes are provided having an elongated body, an instrument port, a micro fiber-optic camera, and in some aspects an irrigation port, wherein the irrigation port extends at least the length of the elongated body from the proximal end to the distal end. The use of the fiber-optic camera and the angle of the irrigation port can allow the device to be operated with a single hand and to overcome the difficult positioning associated with conventional implantation procedures. Ophthalmic endoscopy systems are also provided including the endoscope and a video processor. Methods of implanting an ophthalmic implant using the ophthalmic endoscopes and endoscopy systems are also provided.
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Patent Agency Ranking
公开(公告)号：US20220062376A1
公开(公告)日：2022-03-03
申请号：US17527835
申请日：2021-11-16
Applicant: Wake Forest University Health Sciences
Inventor： Waldemar Debinski , Jill Wykosky , Denise Mazess Herpai
IPC: A61K38/17 , A61K49/00 , C07K14/52 , A61K47/64 , A61K47/68 , A61K38/20 , A61K45/06 , C07K14/705 , A61K38/45
Abstract: The present invention provides compounds, compositions, and methods for detecting, diagnosing and treating cancers such as glioblastoma multiforme.
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公开(公告)号：US11229682B2
公开(公告)日：2022-01-25
申请号：US16496117
申请日：2018-03-29
Applicant: Wake Forest University Health Sciences
Inventor： James K. Williams
Abstract: The present disclosure provides compositions and methods for treatment of a kidney disease with chemokine protein stromal cell-derived factor 1 (SDF-1), such as methods of treating a subject afflicted with or at risk of developing a kidney disease, comprising administering SDF-1 to a kidney of the subject in a treatment-effective amount.
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公开(公告)号：US11207380B2
公开(公告)日：2021-12-28
申请号：US15957445
申请日：2018-04-19
Applicant: Wake Forest University Health Sciences
Inventor： Waldemar Debinski , Jill Wykosky , Denise Mazess Herpai
IPC: A61K47/64 , A61P35/00 , A61K38/17 , A61K49/00 , C07K14/52 , A61K47/68 , A61K38/20 , A61K45/06 , C07K14/705 , A61K38/45 , A61K38/00
Abstract: The present invention provides compounds, compositions, and methods for detecting, diagnosing and treating cancers such as glioblastoma multiforme.
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公开(公告)号：US20210395324A1
公开(公告)日：2021-12-23
申请号：US17465145
申请日：2021-09-02
Applicant: Wake Forest University Health Sciences
Inventor： Waldemar Debinski , Hetal Pandya , Denise Gibo
IPC: C07K14/54 , A61K47/64 , C07K14/34 , G01N33/50 , G01N33/532 , G01N33/68 , C07K14/21 , C07K19/00 , C07K14/005 , C07K14/195
Abstract: A compound comprising, in combination: a cell surface binding ligand or internalizing factor, such as an IL-13Rα2 binding ligand; at least one effector molecule (e.g., one, two, three or more effector molecules); optionally but preferably, a cytosol localization element covalently coupled between said binding ligand and said at least one effector molecule; and a subcellular compartment localization signal element covalently coupled between said binding ligand and said at least one effector molecule (and preferably with said cytosol localization element between said binding ligand and said subcellular compartment localization signal element). Methods of using such compounds and formulations containing the same are also described.
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公开(公告)号：US20210275783A1
公开(公告)日：2021-09-09
申请号：US17194053
申请日：2021-03-05
Applicant: UNIVERSITY OF UTAH RESEARCH FOUNDATION , Wake Forest University Health Sciences , Certus Critical Care, Inc.
Inventor： Michael Austin Johnson , Adam de Havenon , Guillaume Hoareau , Lucas Neff , Timothy Williams , Melanie McWade , David Poisner
IPC: A61M25/10
Abstract: Disclosed are systems and methods for reducing blood pressure variability in a patient. The system includes an endovascular catheter having an expandable element and one or more blood pressure sensors, and a computer/processing unit configured to receive blood pressure measurements and determine a blood pressure variability metric. Upon determining that the blood pressure variability metric exceeds a given blood pressure variability threshold or falls outside a predefined range, the computer/processing unit directs a catheter controller to adjust the size of the expandable element of the catheter, thereby modulating blood pressure and reducing blood pressure variability.
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