公开(公告)号：US20240423790A1

公开(公告)日：2024-12-26

申请号：US18825316

申请日：2024-09-05

Applicant: EDWARDS LIFESCIENCES CORPORATION

Inventor： Anatoly Dvorsky ,  Michael Bukin ,  Nikolai Gurovich ,  Eran Grosu

IPC: A61F2/24

Abstract: This disclosure is directed to prosthetic heart valves and actuators for prosthetic heart valves. In some examples, the actuator can comprise an internally threaded bore that engages an externally threaded portion of the frame component, such as a stationary post. In some examples, the actuator can comprise an externally threaded end portion that engages an internally threaded bore in a frame component, such as a stationary post.

公开(公告)号：US20240366371A1

公开(公告)日：2024-11-07

申请号：US18777392

申请日：2024-07-18

Applicant: EDWARDS LIFESCIENCES CORPORATION

Inventor： Michael Bukin ,  Giolnara Pinhas ,  Elena Sherman ,  Nikolai Gurovich

IPC: A61F2/24

Abstract: Sealing members for an outer skirt of a prosthetic heart valve are disclosed. As one example, a prosthetic heart valve can include an annular frame, a plurality of leaflets arranged within an interior of the frame, and an outer skirt disposed around an outer surface of the frame. The outer skirt can comprise at least one folded portion and stitches extending through the folded portion to form a radially protruding rib.

公开(公告)号：US20240358981A1

公开(公告)日：2024-10-31

申请号：US18765944

申请日：2024-07-08

Applicant: EDWARDS LIFESCIENCES CORPORATION

Inventor： Tomer Saar ,  Michael Bukin ,  Dudu Haimovich ,  Roee Haimovich ,  Ohad Yakobovitch

IPC: A61M25/10 ,  A61F2/24 ,  A61F2/958 ,  A61M5/31 ,  A61M5/315 ,  A61M39/22

CPC classification number: A61M25/10182 ,  A61F2/2433 ,  A61M25/10186 ,  A61M39/22 ,  A61F2/958 ,  A61M2005/3128 ,  A61M2005/31598

Abstract: Disclosed herein are inflators and methods of using the inflators for inflating inflatable devices, such as balloons, used in medical procedures. Such procedures include angioplasty and the transcatheter delivery of prosthetic heart valves and stents. The inflators overcome the resistances typically generated during such procedures and reduces the force required to fully inflate the balloon.

公开(公告)号：US20240358503A1

公开(公告)日：2024-10-31

申请号：US18767437

申请日：2024-07-09

Applicant: EDWARDS LIFESCIENCES CORPORATION

Inventor： Nikolai Gurovich ,  Michael Bukin ,  Alexey Tsypenyuk ,  Elena Sherman ,  Dikla Kersh ,  Boaz Manash ,  Liron Tayeb ,  Ziv Yohanan ,  Alexander Barash ,  Yair A. Neumann ,  Tomer Saar

IPC: A61F2/24

CPC classification number: A61F2/2418 ,  A61F2220/0033 ,  A61F2220/0075 ,  A61F2220/0091 ,  A61F2230/0069

Abstract: A prosthetic heart valve includes an annular frame including a plurality of strut members, the frame being radially collapsible to a collapsed configuration and radially expandable to an expanded configuration. A leaflet structure is situated at least partially within the frame, the leaflet structure including a plurality of leaflets, each leaflet having opposing commissure tab portions on opposite sides of the leaflet, each commissure tab portion being paired with an adjacent commissure tab portion of an adjacent leaflet to form a commissure, the commissure tab portions of each leaflet being folded such that each commissure tab portion forms a plurality of layers. A reinforcement member of a plurality of reinforcement members is positioned between the layers of each commissure tab portion. Each commissure tab portion of each leaflet is positioned entirely within the frame.

公开(公告)号：US20240285400A1

公开(公告)日：2024-08-29

申请号：US18656741

申请日：2024-05-07

Applicant: EDWARDS LIFESCIENCES CORPORATION

Inventor： Eran Grosu ,  Nikolai Gurovich ,  Michael Bukin ,  Anatoly Dvorsky ,  Noam Nir ,  Joseph Mordechai Leichner ,  Ziv Yohanan

IPC: A61F2/24 ,  A61F2/00

CPC classification number: A61F2/2418 ,  A61F2/243 ,  A61F2002/0081 ,  A61F2230/0017 ,  A61F2250/001

Abstract: Examples of prosthetic heart valves and frames for use in prosthetic heart valve are disclosed herein. The prosthetic heart valves comprise frames that are movable between a radially compressed configuration and a radially-expanded configuration and comprise a row of inlet cells, a row of outlet cells, and a row of intermediate cells. The frames of the prosthetic heart valves include actuation members and locking mechanisms configured to secure the frame in one or more radially-expanded configurations. In some examples, the actuation members and locking members are integrally formed with the frame. The frames of the prosthetic heart valves can be coupled to one or more shafts of a delivery apparatus via a threaded connection or a non-threaded connection.

公开(公告)号：US20240173123A1

公开(公告)日：2024-05-30

申请号：US18433626

申请日：2024-02-06

Applicant: EDWARDS LIFESCIENCES CORPORATION

Inventor： Noam Nir ,  Elena Sherman ,  Tamir S. Levi ,  Michael Bukin

IPC: A61F2/24 ,  B29C65/00 ,  B29C65/62 ,  B29L31/00

CPC classification number: A61F2/2415 ,  A61F2/2418 ,  B29C65/62 ,  B29C66/1142 ,  A61F2220/0075 ,  A61F2240/001 ,  B29L2031/7534

Abstract: Assembly methods for installing a leaflet assembly to an expandable frame of a prosthetic heart valve are described. The leaflet assembly comprises a plurality of leaflets coupled together at adjacent tabs, which form respective commissure tab assemblies. The commissure tab assemblies are inserted into corresponding windows of support members of the expandable frame. One or more wedge members are inserted into the commissure tab assembly, e.g., between the adjacent tabs or with the adjacent tabs therebetween, to restrain radial motion of the commissure tab assembly with respect to the window. The window can be a closed window, and the wedge member insertion can be after the commissure tab assembly is inserted into the window. Alternatively, the window can be an open window or channel, and the wedge member insertion can be before the commissure tab assembly is installed in the window.

公开(公告)号：US20240164898A1

公开(公告)日：2024-05-23

申请号：US18430453

申请日：2024-02-01

Applicant: EDWARDS LIFESCIENCES CORPORATION

Inventor： Noam Nir ,  Michael Bukin ,  Eran Goldberg

IPC: A61F2/24 ,  A61B17/00

CPC classification number: A61F2/243 ,  A61B17/00234 ,  A61B2017/00243 ,  A61B2017/0046 ,  A61F2220/0025

Abstract: A prosthetic heart valve includes an annular frame that is movable between a radially expanded state and a radially compressed state. The prosthetic heart valve includes one or more compliant actuators coupled to the annular frame. Each compliant actuator is configured to produce radial expansion of the annular frame and retain the annular frame in the radially expanded state. The prosthetic heart valve can be coupled to a handle of a delivery apparatus for delivery to an implantation site.

公开(公告)号：US20240148497A1

公开(公告)日：2024-05-09

申请号：US18408174

申请日：2024-01-09

Applicant: EDWARDS LIFESCIENCES CORPORATION

Inventor： Michael Bukin ,  Nikolai Gurovich ,  Ziv Yohanan ,  Anatoly Dvorsky ,  Eran Grosu

IPC: A61F2/24

CPC classification number: A61F2/2418 ,  A61F2/2433 ,  A61F2/2436 ,  A61F2220/0025

Abstract: Described herein are annular frames for prosthetic heart valves that include commissure portions that are radially offset and/or are radially flexible relative to the rest of the frame. The commissure portions can extend radially outwardly from the rest of the frame such that they are positioned at a greater radius than the adjacent struts of the frame. The commissure portions can be cantilevered from the frame, such that only one axial end of the commissure portion is attached to the rest of the frame, allowing the commissure portions to flex radially inwardly and outwardly relative to the rest of the frame. Lateral arms can also couple upper ends of the commissure portions to adjacent apices to pull them in at larger diameters. The radial position of the commissure portions relative to the rest of the frame can affect the positioning of the leaflets and the effectiveness of the valve.

公开(公告)号：US20240074851A1

公开(公告)日：2024-03-07

申请号：US18235720

申请日：2023-08-18

Applicant: EDWARDS LIFESCIENCES CORPORATION

Inventor： Noam Nir ,  Michael Bukin ,  Boaz Manash

IPC: A61F2/24

CPC classification number: A61F2/2418 ,  A61F2/2415 ,  A61F2/243 ,  A61F2/2436 ,  A61F2/9517 ,  A61F2220/0033 ,  A61F2220/0075 ,  A61F2220/0091

Abstract: In one embodiment, a prosthetic valve assembly includes an annular frame being radially expandable and compressible between a radially compressed configuration and a radially expanded configuration, a valvular structure comprising a plurality of leaflets mounted inside the annular frame, a plurality of posts mounted on an interior surface of the annular frame, and a pair of commissure attachment members extending outwardly from each post and away from each other. Each two adjacent leaflets can form a pair of commissure tabs. Each pair of commissure tabs can be attached to a corresponding pair of the commissure attachment members.

公开(公告)号：US20240000565A1

公开(公告)日：2024-01-04

申请号：US18369734

申请日：2023-09-18

Applicant: EDWARDS LIFESCIENCES CORPORATION

Inventor： Nikolai Gurovich ,  Michael Bukin ,  Anatoly Dvorsky ,  Eran Grosu

IPC: A61F2/24

CPC classification number: A61F2/2418 ,  A61F2220/0025 ,  A61F2240/001 ,  A61F2250/0058

Abstract: A prosthetic heart valve has a frame and a valvular structure supported by the frame. The frame has cells distributed circumferentially around the frame and formed by struts. The struts includes a support arm, which has a fixed end portion extending from an axial end portion of the frame and a free end portion disposed toward an opposite axial end portion of the frame relative to the fixed end portion. The fixed end portion has a rotational position that is rotationally offset relate to that of the free end portion. When the frame is in a radially-compressed configuration, a second locking member of the struts is spaced apart from a first locking member of the free end portion of the support arm. When the frame is in the radially-expanded configuration, the second locking member engages the first locking member, thereby restricting the frame from moving from the radially-expanded configuration.