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101.发明授权公开(公告)号：US08649853B2
公开(公告)日：2014-02-11
申请号：US13168531
申请日：2011-06-24
CPC分类号： A61N1/36514 , A61B5/02133 , A61B5/026 , A61N1/08 , A61N1/36142 , A61N1/36578
摘要： Systems and methods to monitor cardiac function using information indicative of lead motion are described. In an example, a system including an implantable medical device can include a receiver circuit configured to be electrically coupled to conductor comprising a portion of an implantable lead and be configured to obtain information indicative of a movement of the implantable lead due at least in part to a motion of a heart. The system can include a sensing circuit configured to obtain information indicative of cardiac electrical activity. The system can include a processor circuit configured to construct a template representative of a contraction of the heart, where the template can be constructed using the information indicative of the movement of the implantable lead due at least in part to the motion of the heart during the contraction, and using the information indicative of the cardiac electrical activity sensed during the contraction.
摘要翻译： 描述使用指示引导运动的信息来监测心脏功能的系统和方法。 在一个示例中，包括可植入医疗装置的系统可以包括被配置为电耦合到导体的接收器电路，该导体包括可植入引线的一部分，并且被配置为获得指示可植入引线的移动的信息， 一个心脏的动作。 该系统可以包括被配置为获得指示心脏电活动的信息的感测电路。 该系统可以包括配置成构造代表心脏收缩的模板的处理器电路，其中可以使用指示可植入导线的运动的信息构造模板，至少部分地由于心脏的运动 并且使用指示在收缩期间感测到的心脏电活动的信息。
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102.发明授权Refractory and blanking intervals in the context of multi-site left ventricular pacing 有权多站点左心室起搏背景下的耐火和消隐间隔公开(公告)号：US08611999B2
公开(公告)日：2013-12-17
申请号：US13327400
申请日：2011-12-15
IPC分类号： A61N1/05
CPC分类号： A61N1/3627 , A61N1/3684
摘要： A refractory period for a pacemaker sensing channel refers to a period of time during which the sensing channel is either blind to incoming electrical signals, termed a blanking interval, and/or during which the device is configured to ignore such signals for purposes of sense event detection. Methods and devices for implementing refractory periods in the context of multi-site left ventricular pacing are described.
摘要翻译： 用于起搏器感测通道的不适期是指感测通道对于被称为消隐间隔的输入电信号而言是盲目的，和/或在该时间段期间，设备被配置为忽略这些信号以用于感觉事件 检测。 描述了在多站点左心室起搏背景下实施不应期的方法和装置。
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103.发明授权公开(公告)号：US08535235B2
公开(公告)日：2013-09-17
申请号：US13605397
申请日：2012-09-06
IPC分类号： A61B5/02
CPC分类号： A61B5/021 , A61N1/36564 , A61N1/36578 , A61N1/375
摘要： An implantable device and method for monitoring S1 heart sounds with a remotely located accelerometer. The device includes a transducer that converts heart sounds into an electrical signal. A control circuit is coupled to the transducer. The control circuit is configured to receive the electrical signal, identify an S1 heart sound, and to convert the S1 heart sound into electrical information. The control circuit also generates morphological data from the electrical information. The morphological data relates to a hemodynamic metric, such as left ventricular contractility. A housing may enclose the control circuit. The housing defines a volume coextensive with an outer surface of the housing. The transducer is in or on the volume defined by the housing.
摘要翻译： 一种用远程位置加速度计监测S1心音的可植入装置和方法。 该装置包括将心音转换为电信号的换能器。 控制电路耦合到换能器。 控制电路被配置为接收电信号，识别S1心音，并将S1心音转换为电信息。 控制电路还从电信息生成形态数据。 形态学数据涉及血流动力学指标，如左心室收缩力。 壳体可以包围控制电路。 壳体限定与壳体的外表面共同延伸的体积。 传感器位于由外壳限定的体积中。
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104.发明授权公开(公告)号：US08301267B2
公开(公告)日：2012-10-30
申请号：US12876426
申请日：2010-09-07
申请人： Allan C. Shuros , Dan Li , Krzysztof Z. Siejko , John H. Tangren
发明人： Allan C. Shuros , Dan Li , Krzysztof Z. Siejko , John H. Tangren
IPC分类号： A61N1/05
CPC分类号： A61B5/02158 , A61B5/02133 , A61B5/02405 , A61N1/36514 , A61N1/36578
摘要： An apparatus comprises an implantable sensor and a signal analyzer circuit communicatively coupled to the implantable sensor. The implantable sensor is configured for coupling to an implantable lead and the implantable sensor provides an electrical vibration sensor signal representative of mechanical vibration of the implantable lead. The signal analyzer circuit is configured to determine a baseline of the vibration sensor signal, detect a change in the vibration sensor signal from the baseline vibration sensor signal, and provide an indication of the change to a user or process.
摘要翻译： 一种装置包括可植入传感器和通信地耦合到可植入传感器的信号分析器电路。 可植入传感器被配置为联接到可植入引线，并且可植入传感器提供表示可植入引线的机械振动的电振动传感器信号。 信号分析器电路被配置为确定振动传感器信号的基线，从基线振动传感器信号检测振动传感器信号的变化，并且向用户或过程提供变化的指示。
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公开(公告)号：US08285373B2
公开(公告)日：2012-10-09
申请号：US12835288
申请日：2010-07-13
IPC分类号： A61N1/00
CPC分类号： A61N1/36139 , A61B5/0255 , A61B5/0816 , A61B5/0823 , A61B5/1107 , A61B5/6869 , A61B2562/0219 , A61B2562/043 , A61N1/36053 , A61N1/36114 , A61N1/36117 , A61N1/36578
摘要： An embodiment uses an accelerometer to sense heart sounds, and determines heart rate info nation using the sensed heart sounds. An embodiment uses an accelerometer to sense respiratory activity. An embodiment delivers a programmed neural stimulation therapy with a programmed duty cycle, where the programmed duty cycle includes a stimulation ON portion followed by a stimulation OFF portion. An electrode electrically connected to the implanted neural stimulation device is used to remotely detect cardiac activity. The remotely detected cardiac activity is used to detect heart rate information during the stimulation ON portion and to detect heart rate information during the stimulation OFF portion. The detected heart rate information and/or the detected respiration information are used to control a neural stimulation therapy performed by the neural stimulator device and/or are used to provide diagnostic information for the patient's condition.
摘要翻译： 一个实施例使用加速度计来感测心脏声音，并且使用所感测到的心脏声音来确定心率信息国家。 一个实施例使用加速计来感测呼吸活动。 实施例以编程的占空比递送编程的神经刺激疗法，其中编程的占空比包括刺激开启部分，随后是刺激关闭部分。 电连接到植入的神经刺激装置的电极用于远程检测心脏活动。 远程检测到的心脏活动用于在刺激ON部分期间检测心率信息，并在刺激OFF部分期间检测心率信息。 检测到的心率信息和/或检测到的呼吸信息用于控制由神经刺激器装置执行的神经刺激治疗和/或用于提供患者状况的诊断信息。
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公开(公告)号：US20120245656A1
公开(公告)日：2012-09-27
申请号：US13487877
申请日：2012-06-04
IPC分类号： A61N1/36
CPC分类号： A61N1/3727 , A61B5/02405 , A61B5/4035 , A61B5/4839 , A61N1/36114 , A61N1/36117 , A61N1/36139 , A61N1/362 , A61N1/37264
摘要： Described herein are methods and devices that utilize electrical neural stimulation to treat heart failure by modulating a patient's autonomic balance in a manner that inhibits sympathetic activity and/or augments parasympathetic activity. Because other therapies for treating heart failure may also affect a patient's autonomic balance, a device for delivering neural stimulation is configured to appropriately titrate such therapy in either an open-loop or closed-loop fashion.
摘要翻译： 本文描述了利用电神经刺激来以抑制交感神经活动和/或增加副交感神经活动的方式调节患者的自主神经平衡来治疗心力衰竭的方法和装置。 因为用于治疗心力衰竭的其它治疗也可能影响患者的自主平衡，用于递送神经刺激的装置被配置为以开环或闭环方式适当地滴定这种治疗。
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公开(公告)号：US08257271B2
公开(公告)日：2012-09-04
申请号：US12776557
申请日：2010-05-10
IPC分类号： A61B5/04
CPC分类号： A61B5/00 , A61B5/053 , A61B5/746 , A61B7/023 , A61N1/3627 , A61N1/36514
摘要： Systems and methods using constant false alarm rate techniques for event detection. One example of an event detection method includes collecting a first distribution of measurements for a first physiological parameter. In another example, the first distribution of measurements includes only non-event measurements. One or more values are determined corresponding to at least a first tail area of the first distribution from at least one measurement of the first physiological parameter toward an end point of the distribution. A threshold is established based on a specified false alarm rate. The one or more values are compared to the threshold. The method includes determining if the measurement is representative of a detected event using the comparison.
摘要翻译： 用于事件检测的常数误报率技术的系统和方法。 事件检测方法的一个示例包括收集第一生理参数的测量的第一分布。 在另一示例中，测量的第一分布仅包括非事件测量。 从第一生理参数的至少一个测量到分布的终点，确定对应于第一分布的至少第一尾区的一个或多个值。 基于指定的虚警率建立阈值。 将一个或多个值与阈值进行比较。 该方法包括使用比较来确定测量是否表示检测到的事件。
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108.发明申请公开(公告)号：US20120158084A1
公开(公告)日：2012-06-21
申请号：US13327428
申请日：2011-12-15
IPC分类号： A61N1/365
CPC分类号： A61N1/368
摘要： One way in which cardiac resynchronization therapy may be delivered is to only deliver paces to the left ventricle. If left ventricular pacing is inhibited during a cardiac cycle, it may be desirable to deliver a right ventricular safety pace to prevent asystole. Methods and devices for implementing right ventricular safety pacing in the context of multi-site left ventricular-only pacing are described.
摘要翻译： 进行心脏再同步治疗的一种方法是仅向左心室输送步伐。 如果在心动周期期间左心室起搏被抑制，则可能需要递送右心室安全步速以防止心搏停止。 描述了在多局部左心室起搏背景下实施右心室安全起搏的方法和装置。
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109.发明申请CARDIAC CONTRACTION DETECTION USING INFORMATION INDICATIVE OF LEAD MOTION 有权使用指示铅运动的信息进行CARDIAC承包检测公开(公告)号：US20110319776A1
公开(公告)日：2011-12-29
申请号：US13168507
申请日：2011-06-24
IPC分类号： A61B5/0245 , A61B5/042 , A61N1/365
CPC分类号： A61N1/36514 , A61B5/02133 , A61B5/026 , A61N1/08 , A61N1/36142 , A61N1/36578
摘要： Systems and methods for cardiac contraction detection using information indicative of lead motion are described. In an example, an implantable medical device can include a receiver circuit configured to be electrically coupled to conductor comprising a portion of an implantable lead and be configured to obtain information indicative of a movement of the implantable lead due at least in part to a motion of a heart. The device can include a processor circuit configured to determine whether a cardiac mechanical contraction occurred during a specified interval included in the obtained information indicative of the movement of the implantable lead. The processor circuit can be configured to determine information about the cardiac mechanical contraction using the obtained information indicative of the movement of the implantable lead.
摘要翻译： 描述使用指示引导运动的信息进行心脏收缩检测的系统和方法。 在一个示例中，可植入医疗设备可以包括被配置为电耦合到导体的接收器电路，该导体包括可植入引线的一部分，并被配置为获得指示可植入引线的运动的信息，至少部分地由 一个心脏。 该装置可以包括处理器电路，该处理器电路被配置为确定在所获得的指示可植入引线的运动的信息中包括的指定间隔期间是否发生心脏机械收缩。 处理器电路可以被配置为使用获得的指示可植入引线的移动的信息来确定关于心脏机械收缩的信息。
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110.发明授权公开(公告)号：US08007442B2
公开(公告)日：2011-08-30
申请号：US12703533
申请日：2010-02-10
IPC分类号： A61B5/02
CPC分类号： A61B5/021 , A61N1/36564 , A61N1/36578 , A61N1/375
摘要： An implantable device and method for monitoring S1 heart sounds with a remotely located accelerometer. The device includes a transducer that converts heart sounds into an electrical signal. A control circuit is coupled to the transducer. The control circuit is configured to receive the electrical signal, identify an S1 heart sound, and to convert the S1 heart sound into electrical information. The control circuit also generates morphological data from the electrical information. The morphological data relates to a hemodynamic metric, such as left ventricular contractility. A housing may enclose the control circuit. The housing defines a volume coextensive with an outer surface of the housing. The transducer is in or on the volume defined by the housing.
摘要翻译： 一种用远程位置加速度计监测S1心音的可植入装置和方法。 该装置包括将心音转换为电信号的换能器。 控制电路耦合到换能器。 控制电路被配置为接收电信号，识别S1心音，并将S1心音转换为电信息。 控制电路还从电信息生成形态数据。 形态学数据涉及血流动力学指标，如左心室收缩力。 壳体可以包围控制电路。 壳体限定与壳体的外表面共同延伸的体积。 传感器位于由外壳限定的体积中。
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