公开(公告)号：US20090093585A1

公开(公告)日：2009-04-09

申请号：US12278159

申请日：2007-02-02

申请人： Daniel J. Smith ,  Horst Ring

发明人： Daniel J. Smith ,  Horst Ring

IPC分类号： C08L75/04 ,  B29C47/00

CPC分类号： B32B5/26 ,  B32B5/022 ,  B32B5/08 ,  B32B2250/20 ,  B32B2255/02 ,  B32B2255/24 ,  B32B2255/26 ,  B32B2262/02 ,  B32B2262/0207 ,  B32B2262/0215 ,  B32B2262/0246 ,  B32B2262/0292 ,  B32B2262/14 ,  B32B2307/726 ,  B32B2307/728 ,  B32B2535/00 ,  B32B2555/02 ,  D01D5/0007 ,  D01D5/0985 ,  D01F1/10 ,  D04H1/4374 ,  D04H1/44 ,  D04H1/56

摘要： The present invention relates to liquid entrapping devices (e.g., absorbent non-woven fibrous mats) and to a process for preparing such devices. More particularly, the present invention relates to mechanically strong absorbent materials made from such liquid entrapping devices (e.g., non-woven fibrous mats) and to a method for preparing same. In one embodiment, a liquid entrapping device of the present invention comprises at least one hydrophilic elastomeric fibrous component (HEFC) and at least one wetting agent component. In another embodiment, a liquid entrapping device of the present invention comprise at least one hydrophilic elastomeric fibrous component (HEFC), at least one absorbent component, and at least one wetting agent component. In one instance, the wetting agent component of the present invention is contained on and/or within the fibers and/or nanofibers that form the liquid entrapping device (e.g., a non-woven fibrous mat) of the present invention.

摘要翻译： 本发明涉及液体截留装置（例如，吸收性非织造纤维垫）和制备这种装置的方法。 更具体地说，本发明涉及由这种液体截留装置（例如非织造纤维垫）制成的机械强吸收材料及其制备方法。 在一个实施方案中，本发明的液体截留装置包含至少一种亲水弹性纤维组分（HEFC）和至少一种润湿剂组分。 在另一个实施方案中，本发明的液体截留装置包含至少一种亲水弹性纤维组分（HEFC），至少一种吸收组分和至少一种润湿剂组分。 在一种情况下，本发明的润湿剂组分包含在形成本发明的液体捕获装置（例如无纺纤维垫）的纤维和/或纳米纤维之上和/或内部。

公开(公告)号：US20090057592A1

公开(公告)日：2009-03-05

申请号：US11845884

申请日：2007-08-28

申请人： Haresh C. Lakhan ,  Bruce A. Helget ,  Daniel J. Smith

发明人： Haresh C. Lakhan ,  Bruce A. Helget ,  Daniel J. Smith

IPC分类号： F16K1/00

CPC分类号： F16K3/32 ,  F16K3/265 ,  F16K3/267

摘要： A metering valve for controlling the flow rate of a fluid has a substantially rigid housing having an internal cylindrical wall defining a cavity. The cavity has a first opening at one end and a spaced second opening in the cylindrical wall. A substantially rigid valve element that fits closely within the cavity has an internal bore extending axially from a first end toward a second end. A metering aperture penetrates the valve element wall between the outer surface of the valve element and the valve element bore. Moving the valve element within the housing cavity to a first position places a portion of the second opening within the cavity's second opening at a first position to allow a first rate of fluid flow between the first chamber and the second chamber. Moving the valve element to a second position places the metering aperture at a second position different from the first position to allow a second rate of fluid flow between the first and second chambers. The flow has an axial flow vector within the valve element bore and a radial flow vector through the metering aperture.

摘要翻译： 用于控制流体流速的计量阀具有基本上刚性的壳体，其具有限定空腔的内部圆柱形壁。 空腔在一端具有第一开口，在圆柱形壁中具有间隔开的第二开口。 紧密配合在空腔内的基本上刚性的阀元件具有从第一端向第二端轴向延伸的内孔。 计量孔穿透阀元件的外表面和阀元件孔之间的阀元件壁。 将壳体腔内的阀元件移动到第一位置将第二开口的一部分置于空腔的第二开口内的第一位置处，以允许第一室和第二室之间的第一流体流量流动。 将阀元件移动到第二位置将测量孔放置在与第一位置不同的第二位置，以允许第一和第二腔之间的第二流体流量流动。 流体在阀元件孔内具有轴向流动矢量，并且通过计量孔径具有径向流动矢量。

公开(公告)号：US07465859B2

公开(公告)日：2008-12-16

申请号：US11446079

申请日：2006-06-01

申请人： Kevin M. Kroeger ,  Meaulnes Laberge ,  Timothy P. Shaw ,  Daniel J. Smith

发明人： Kevin M. Kroeger ,  Meaulnes Laberge ,  Timothy P. Shaw ,  Daniel J. Smith

IPC分类号： G10D3/00 ,  G10D1/08

CPC分类号： G10D3/06

摘要： A headblock and fingerboard support assembly for a stringed instrument includes a fingerboard support assembly for mounting to a neck and fingerboard of the stringed instrument. The fingerboard support assembly further includes a plate having an integrated rail structure. A headblock has an integrated channel for receiving the integrated rail structure. The headblock is adapted to secure to the fingerboard support assembly. A method of assembling a stringed instrument includes mounting a plate structure to a neck and fingerboard of the stringed instrument, where the plate includes an integrated rail, and mounting a headblock to an interior surface of a body of the stringed instrument, where the headblock has an integrated channel structure for receiving the integrated rail of the plate structure.

摘要翻译： 用于弦乐器的头枕和指板支撑组件包括用于安装到弦乐器的颈部和指板的指板支撑组件。 指板支撑组件还包括具有集成轨道结构的板。 头块具有用于接收集成轨道结构的集成通道。 头枕适于固定到指板支撑组件。 组装弦乐器的方法包括将板结构安装到弦乐器的颈部和指板上，其中板包括集成导轨，并且将头块安装到弦乐器的主体的内表面，其中头带具有 用于接收板结构的集成轨道的集成通道结构。

公开(公告)号：US20080027531A1

公开(公告)日：2008-01-31

申请号：US10597901

申请日：2005-02-14

申请人： Darrell H. Reneker ,  Daniel J. Smith ,  Woraphon Kataphinan

发明人： Darrell H. Reneker ,  Daniel J. Smith ,  Woraphon Kataphinan

IPC分类号： A61F2/06

CPC分类号： A61F2/82 ,  A61B17/12022 ,  A61B17/12118 ,  A61B2017/00889 ,  A61B2017/00893 ,  A61F2250/0067 ,  A61L29/085 ,  A61L29/16 ,  A61L31/10 ,  A61L31/14 ,  A61L31/16 ,  A61L2300/418 ,  A61L2400/04 ,  A61L2420/04 ,  A61M25/1027 ,  A61M2025/1088

摘要： The present invention is directed to a medical device, such as a stent, having a coating comprising a release component and an insoluble fibrous component. The release component is capable of being degraded thus leaving a gap between the stent and the insoluble fibrous component. Further, the insoluble fibrous component is capable of being wrapped about the stent, and capable of moving substantially freely about the stent upon degradation of the release component. This capacity enables the insoluble fibrous component to form a reinforced thrombus plug in, for instance, an aneurysm or fistula.

摘要翻译： 本发明涉及具有包含释放组分和不溶性纤维组分的涂层的医疗装置，例如支架。 释放组分能够降解，从而在支架和不溶性纤维组分之间留下间隙。 此外，不溶性纤维组分能够缠绕在支架上，并且能够在释放组分降解时能够基本上自由地围绕支架移动。 该能力使得不溶性纤维组分在例如动脉瘤或瘘中形成增强的血栓塞。

公开(公告)号：US07261723B2

公开(公告)日：2007-08-28

申请号：US10706559

申请日：2003-11-12

申请人： Daniel J. Smith ,  Jonathan B. Gabel ,  Henri A. M. Decloux

发明人： Daniel J. Smith ,  Jonathan B. Gabel ,  Henri A. M. Decloux

IPC分类号： A61F2/04 ,  A61B17/12

CPC分类号： A61B17/06109 ,  A61B17/0469 ,  A61B2017/00805 ,  A61F2/0045

摘要： A surgical assembly is provided including a surgical passer having a wire portion coupled to a handle, with the wire portion having a free distal end, an outer periphery, and at least one recess therein in a distal end region. The assembly further includes a tube element having a proximal end, a tissue penetrating distal end, and a channel extending therein from an opening at the proximal end and defined by an inner periphery. The channel has at least one projection projecting outwardly into the channel in a distal end region thereof. The outer periphery of the surgical passer is dimensioned relative to the inner periphery of the channel of the tube element so that the surgical passer is positionable within the tube element, and when so positioned, the at least one tube element projection engages the at least one surgical passer recess to removably couple the surgical passer to the tube element.

摘要翻译： 提供了一种手术组件，其包括具有联接到手柄的线部分的外科路径，其中线部分具有自由远端，外周边以及远端区域中的至少一个凹部。 组件还包括具有近端，组织穿透远端的管元件和从近端的开口延伸并由内周限定的通道。 通道具有在其远端区域中向外突出到通道中的至少一个突起。 手术路人的外周相对于管元件的通道的内周尺寸设定，使得手术路径器可定位在管元件内，并且当这样定位时，至少一个管元件突出物接合至少一个 手术通道凹槽，以可移除地将外科路口耦合到管元件。

公开(公告)号：US06821479B1

公开(公告)日：2004-11-23

申请号：US09879386

申请日：2001-06-12

申请人： Daniel J. Smith ,  Woraphon Kataphinan ,  Darrell H. Reneker ,  Sally Dabney

发明人： Daniel J. Smith ,  Woraphon Kataphinan ,  Darrell H. Reneker ,  Sally Dabney

IPC分类号： B01D1700

CPC分类号： C12N9/0065 ,  A61K9/70 ,  C12N9/6427 ,  C12N9/6429 ,  C12Y304/21005

摘要： A method of preserving a biological material includes the steps of providing at least one fiber-forming material, mixing at least one biological material, and optionally, one or more additives, to the at least one fiber-forming material to form a mixture, and forming at least one fiber from the mixture, wherein the resulting fiber has a diameter between 0.3 nanometers and about 25 microns. A biological material preserved by this method is also disclosed.

摘要翻译： 保存生物材料的方法包括以下步骤：提供至少一种纤维形成材料，将至少一种生物材料和任选的一种或多种添加剂混合至至少一种纤维形成材料以形成混合物;以及 从混合物形成至少一种纤维，其中所得纤维的直径在0.3纳米至约25微米之间。 还公开了通过该方法保存的生物材料。

公开(公告)号：US06451337B1

公开(公告)日：2002-09-17

申请号：US09576096

申请日：2000-05-22

申请人： Daniel J. Smith ,  Sibel Yazici

发明人： Daniel J. Smith ,  Sibel Yazici

IPC分类号： A61L1500

CPC分类号： A61K47/61

摘要： A chitosan-based polymeric nitric oxide donor composition comprising a modified chitosan polymer and a nitric oxide [N2O2] dimer, wherein the nitric oxide [N2O2] dimer is bonded directly to the backbone of the modified chitosan polymer without further binding through a nucleophile residue or moiety. The chitosan-based polymeric nitric oxide donor composition is capable of site specific delivery and controlled release of nitric oxide under physiological conditions. The chitosan-based polymeric nitric oxide donor composition further provides a carrier having medically beneficial properties. A method is further included for preparing a chitosan-based polymeric nitric oxide donor composition comprising reacting a nitric oxide dimer (80-100 p.s.i.) with a modified chitosan polymer in the presence of sodium methoxide at room temperature. The chitosan-based polymeric nitric oxide composition can be incorporated into dry powder inhalers, wound dressings, implants, injectables, condoms, wound dressings and prosthesis coatings for use in a variety of medical applications in which an effective dosage of nitric oxide is indicated as a preferred method of treatment.

摘要翻译： 一种壳聚糖基聚合一氧化氮供体组合物，其包含改性的壳聚糖聚合物和一氧化氮[N2O2]二聚体，其中所述一氧化氮[N 2 O 2]二聚体直接键合到所述改性壳聚糖聚合物的主链上，而不通过亲核残基进一步结合，或 部分。 基于壳聚糖的聚合一氧化氮供体组合物能够在生理条件下进行位点特异性递送和一氧化氮的控制释放。 基于壳聚糖的聚合一氧化氮供体组合物还提供具有医学上有益的性质的载体。 进一步包括一种制备基于壳聚糖的聚合一氧化氮供体组合物的方法，该组合物包括在室温下在甲醇钠存在下使一氧化氮二聚体（80-100p.s.i）与改性壳聚糖聚合物反应。 基于壳聚糖的聚合一氧化氮组合物可以掺入用于各种医疗应用的干粉吸入器，伤口敷料，植入物，注射剂，避孕套，伤口敷料和假体涂层中，其中将有效剂量的一氧化氮指示为 优选的治疗方法。

公开(公告)号：US6147068A

公开(公告)日：2000-11-14

申请号：US157856

申请日：1998-09-21

申请人： Daniel J. Smith ,  Dominick Roselle

发明人： Daniel J. Smith ,  Dominick Roselle

IPC分类号： A61K31/15 ,  A61K31/22 ,  A61K31/575 ,  C07C243/42 ,  C07C291/08 ,  A61K31/13 ,  A61K31/195 ,  C07C229/26

CPC分类号： A61K31/22 ,  A61K31/15 ,  A61K31/575 ,  C07C243/42 ,  C07C291/08

摘要： A pharmaceutical composition of matter for delivering nitric oxide. The composition is an amine that was reacted with nitric oxide. The composition of matter is lipophilic and insoluble and therefore delivers nitric oxide to the specific area of the body where it is introduced. Also, a method of synthesizing an amine and reacting it with nitric oxide to form the pharmaceutical composition of matter. Finally, a method of using the pharmaceutical composition of matter to deliver nitric oxide to the body.

摘要翻译： 用于输送一氧化氮的物质的药物组合物。 该组合物是与一氧化氮反应的胺。 物质的组成是亲脂性和不溶性的，因此将一氧化氮递送到其被引入的身体的特定区域。 另外，合成胺并使其与一氧化氮反应形成物质的药物组合物的方法。 最后，使用物质的药物组合物将一氧化氮输送到身体的方法。

公开(公告)号：US5613022A

公开(公告)日：1997-03-18

申请号：US295900

申请日：1995-03-13

申请人： Jefferson E. Odhner ,  Daniel J. Smith ,  Shailesh S. Bhat ,  Donald L. Cullen ,  Ken G. Wasson

发明人： Jefferson E. Odhner ,  Daniel J. Smith ,  Shailesh S. Bhat ,  Donald L. Cullen ,  Ken G. Wasson

IPC分类号： G02B5/18 ,  G02B5/32 ,  G02B27/42 ,  G09F9/37 ,  H04N9/31 ,  H04R17/08 ,  G02B6/34 ,  G03H1/00

CPC分类号： G09F9/375 ,  G03H1/0244 ,  G03H1/0272 ,  H04R17/08 ,  Y10S385/901

摘要： The present invention is directed to a diffractive display suitable for presenting graphic and the like displays. Broadly, the novel display is realized from a diffraction pattern (132) carried by (e.g. embossed) a film or element (138) connected to an energy source which is energizable for movement of the film (138). Movement of the patterned film (138) generates a display using the diffracted light from the embossed pattern (132). Electroactive films are known in the art, including, for example, piezoelectric films, electrostrictive films, electromotive films, and electrostatic films. Magnetoactive films also are known in the art. Any of these films (138) can carry the diffraction pattern (132) and be energized for movement to generate from the resulting diffracted light.

摘要翻译： PCT No.PCT / US94 / 07584第 371日期1995年3月13日 102（e）1995年3月13日PCT PCT 1994年7月12日PCT公布。 公开号WO95 / 02838 日期1995年1月26日本发明涉及适用于呈现图形等的显示器的衍射显示器。 广泛地，新颖的显示是通过由（例如压花）携带的衍射图案（132）实现的，所述衍射图案连接到可激活胶片（138）移动的能量源的膜或元件（138）。 图案化膜（138）的运动使用来自压印图案（132）的衍射光产生显示。 电活性膜是本领域已知的，包括例如压电膜，电致伸缩膜，电动膜和静电膜。 磁性膜也是本领域已知的。 这些膜（138）中的任何一个可以承载衍射图案（132）并且被激发以便从所得到的衍射光中移动以产生。

公开(公告)号：US4889530A

公开(公告)日：1989-12-26

申请号：US223086

申请日：1988-07-22

申请人： Daniel J. Smith ,  Sanjay R. Patel

发明人： Daniel J. Smith ,  Sanjay R. Patel

IPC分类号： A61L26/00 ,  C08F20/36

CPC分类号： C08F20/36 ,  A61L26/0014 ,  A61L26/008

摘要： Acrylate and methacrylate monoesters and diesters having the following formula (I) ##STR1## wherein R.sub.1, R.sub.2, R.sub.3 are as defined in the specification, are disclosed. These monomers are polymerizable into hydrogen polymers which are extremely hydrophilic. These hydrogel polymers are useful in the preparation of wound dressings. These polymers form complexes with polyvalent metal ions such as Ca, Mg, Mn and Cu, and possess macrophage stimulating activity in addition to the useful properties possessed by other acrylate and methacrylate hydrogel polymers.

摘要翻译： 公开了具有下式（I）的丙烯酸酯和甲基丙烯酸酯单酯和二酯：其中R1，R2，R3如说明书中所定义。 这些单体可聚合成非常亲水的氢聚合物。 这些水凝胶聚合物可用于制备伤口敷料。 这些聚合物与多价金属离子如Ca，Mg，Mn和Cu形成络合物，除了其它丙烯酸酯和甲基丙烯酸酯水凝胶聚合物具有的有用特性之外，还具有巨噬细胞刺激活性。