公开(公告)号：US08012937B2

公开(公告)日：2011-09-06

申请号：US11526183

申请日：2006-09-22

申请人： Arthur B. Raitano ,  Wangmag Ge ,  Aya Jakobovits ,  Pia M. Challita-Eid ,  Mary Faris

发明人： Arthur B. Raitano ,  Wangmag Ge ,  Aya Jakobovits ,  Pia M. Challita-Eid ,  Mary Faris

IPC分类号： A61K39/00

CPC分类号： C07K14/47

摘要： A novel gene 098P4B6 (also designated STEAP-2) and its encoded protein, and variants thereof, are described wherein 98P4B6 exhibits tissue specific expression in normal adult tissue, and is aberrantly expressed in the cancers listed in Table I. Consequently, 98P4B6 provides a diagnostic, prognostic, prophylactic and/or therapeutic target for cancer. The 98P4B6 gene or fragment thereof, or its encoded protein, or variants thereof, or a fragment thereof, can be used to elicit a humoral or cellular immune response; antibodies or T cells reactive with 98P4B6 can be used in active or passive immunization.

摘要翻译： 描述了一种新型基因098P4B6（也称为STEAP-2）及其编码的蛋白及其变体，其中98P4B6在正常成人组织中表现出组织特异性表达，并且在表I中列出的癌症中异常表达。因此，98P4B6提供了 诊断，预后，预防和/或治疗靶标。 98P4B6基因或其片段或其编码的蛋白质或其变体或其片段可用于引发体液或细胞免疫应答; 与98P4B6反应的抗体或T细胞可用于主动或被动免疫。

公开(公告)号：US07968090B2

公开(公告)日：2011-06-28

申请号：US12820279

申请日：2010-06-22

申请人： Arthur B. Raitano ,  Pia M. Challita-Eid ,  Aya Jakobovits ,  Mary Faris ,  Wangmao Ge

发明人： Arthur B. Raitano ,  Pia M. Challita-Eid ,  Aya Jakobovits ,  Mary Faris ,  Wangmao Ge

IPC分类号： A61K39/395

CPC分类号： C07K14/47 ,  A61K38/00 ,  A61K39/00 ,  Y02A50/466

摘要： A novel gene 191P4D12(b) and its encoded protein, and variants thereof, are described wherein 191P4D12(b) exhibits tissue specific expression in normal adult tissue, and is aberrantly expressed in the cancers listed in Table I. Consequently, 191P4D12(b) provides a diagnostic, prognostic, prophylactic and/or therapeutic target for cancer. The 191P4D12(b) gene or fragment thereof, or its encoded protein, or variants thereof, or a fragment thereof, can be used to elicit a humoral or cellular immune response; antibodies or T cells reactive with 191P4D12(b) can be used in active or passive immunization.

摘要翻译： 描述了一种新颖的基因191P4D12（b）及其编码的蛋白及其变体，其中191P4D12（b）在正常成人组织中表现出组织特异性表达，并且在表I中列出的癌症中异常表达。因此，191P4D12（b） 提供癌症的诊断，预后，预防和/或治疗靶标。 191P4D12（b）基因或其片段或其编码的蛋白质或其变体或其片段可用于引发体液或细胞免疫应答; 与191P4D12（b）反应的抗体或T细胞可用于主动或被动免疫。

公开(公告)号：US20100256068A1

公开(公告)日：2010-10-07

申请号：US11648757

申请日：2006-12-29

申请人： Aya Jakobovits ,  Soudabeh Etessami ,  Pia M. Challita-Eid ,  Juan J. Perez-Villar ,  Karen J. Morrison ,  Xiao-Chi Jia ,  Mary Faris ,  Jean Gudas ,  Arthur B. Raitano

发明人： Aya Jakobovits ,  Soudabeh Etessami ,  Pia M. Challita-Eid ,  Juan J. Perez-Villar ,  Karen J. Morrison ,  Xiao-Chi Jia ,  Mary Faris ,  Jean Gudas ,  Arthur B. Raitano

IPC分类号： A61K38/16 ,  C07K14/00 ,  A61P35/00

CPC分类号： C07K14/4748 ,  A01K67/0271 ,  A61K38/00 ,  A61K39/00 ,  A61K51/1045 ,  A61K2039/505 ,  C07K14/705 ,  C07K14/723 ,  C07K16/30 ,  C07K2317/34 ,  C07K2317/77 ,  C07K2319/00 ,  C12N9/0091 ,  G01N33/57484

摘要： Antibodies and molecules derived therefrom that bind to novel STEAP-1 protein, and variants thereof, are described wherein STEAP-1 exhibits tissue specific expression in normal adult tissue, and is aberrantly expressed in the cancers listed in Table I. Consequently, STEAP-1 provides a diagnostic, prognostic, prophylactic and/or therapeutic target for cancer. The STEAP-1 gene or fragment thereof, or its encoded protein, or variants thereof, or a fragment thereof, can be used to elicit a humoral or cellular immune response; antibodies or T cells reactive with STEAP-1 can be used in active or passive immunization.

摘要翻译： 描述了结合于新型STEAP-1蛋白质的抗体和衍生自其的变体及其变体，其中STEAP-1在正常成人组织中显示组织特异性表达，并且在表I中列出的癌症中异常表达。因此，STEAP-1 提供癌症的诊断，预后，预防和/或治疗靶标。 STEAP-1基因或其片段或其编码的蛋白质或其变体或其片段可用于引发体液或细胞免疫应答; 与STEAP-1反应的抗体或T细胞可用于主动或被动免疫。

公开(公告)号：US20100168214A1

公开(公告)日：2010-07-01

申请号：US12687768

申请日：2010-01-14

申请人： Pia M. Challita-Eid ,  Arthur B. Raitano ,  Mary Faris ,  Rene S. Hubert ,  Karen Jane Meyrick Morrison ,  Robert Kendall Morrison ,  Wangmao Ge ,  Aya Jakobovits

发明人： Pia M. Challita-Eid ,  Arthur B. Raitano ,  Mary Faris ,  Rene S. Hubert ,  Karen Jane Meyrick Morrison ,  Robert Kendall Morrison ,  Wangmao Ge ,  Aya Jakobovits

IPC分类号： A61K31/7088 ,  C07H21/04 ,  C12N15/83 ,  C12N5/00 ,  C12P21/06

CPC分类号： C07K14/47 ,  A61K38/00 ,  C12N9/78 ,  Y10T436/25

摘要： A novel gene (designated 151P3D4) and its encoded protein, and variants thereof, are described wherein 151P3D4 exhibits tissue specific expression in normal adult tissue, and is aberrantly expressed in the cancers listed in Table I. Consequently, 151P3D4 provides a diagnostic, prognostic, prophylactic and/or therapeutic target for cancer. The 151P3D4 gene or fragment thereof, or its encoded protein, or variants thereof, or a fragment thereof, can be used to elicit a humoral or cellular immune response; antibodies or T cells reactive with 151P3D4 can be used in active or passive immunization.

摘要翻译： 描述了一种新型基因（称为151P3D4）及其编码的蛋白及其变体，其中151P3D4在正常成人组织中表现出组织特异性表达，并且在表I中列出的癌症中异常表达。因此，151P3D4提供诊断，预后， 癌症的预防和/或治疗靶标。 151P3D4基因或其片段或其编码的蛋白质或其变体或其片段可用于引发体液或细胞免疫应答; 与151P3D4反应的抗体或T细胞可用于主动或被动免疫。

公开(公告)号：US07667018B2

公开(公告)日：2010-02-23

申请号：US11655822

申请日：2007-01-19

申请人： Aya Jakobovits ,  Arthur B. Raitano ,  Mary Faris ,  Rene S. Hubert ,  Wangmao Ge ,  Karen Jane Meyrick Morrison ,  Robert Kendall Morrison ,  Pia M. Challita-Eid

发明人： Aya Jakobovits ,  Arthur B. Raitano ,  Mary Faris ,  Rene S. Hubert ,  Wangmao Ge ,  Karen Jane Meyrick Morrison ,  Robert Kendall Morrison ,  Pia M. Challita-Eid

IPC分类号： C07H21/00 ,  C12N15/00 ,  C12N1/20

CPC分类号： C07K16/30 ,  A61K31/7088 ,  A61K39/00 ,  A61K51/1045 ,  A61K2039/505 ,  C07K14/47 ,  C07K16/18 ,  C07K16/3023 ,  C07K16/303 ,  C07K16/3038 ,  C07K16/3046 ,  C07K16/3061 ,  C07K16/3069 ,  C07K16/40 ,  C07K2317/20 ,  C07K2317/33 ,  C07K2317/34 ,  C07K2317/54 ,  C07K2317/55 ,  C07K2317/73 ,  C07K2317/76 ,  C07K2317/77 ,  C07K2319/30 ,  C12N9/16 ,  C12Q1/6886 ,  C12Q2600/158 ,  G01N33/57492 ,  Y02A50/466

摘要： A novel gene 0161P2F10B (also designated 161P2F10B) and its encoded protein, and variants thereof, are described wherein 161P2F10B exhibits tissue specific expression in normal adult tissue, and is aberrantly expressed in the cancers listed in Table I. Consequently, 161P2F10B provides a diagnostic, prognostic, prophylactic and/or therapeutic target for cancer. The 161P2F10B gene or fragment thereof, or its encoded protein, or variants thereof, or a fragment thereof, can be used to elicit a humoral or cellular immune response; antibodies or T cells reactive with 161P2F10B can be used in active or passive immunization.

摘要翻译： 描述了新颖的基因0161P2F10B（也称为161P2F10B）及其编码的蛋白质及其变体，其中161P2F10B在正常成人组织中表现出组织特异性表达，并且在表I中列出的癌症中异常表达。因此，161P2F10B提供了诊断， 癌症的预后，预防和/或治疗靶标。 161P2F10B基因或其片段或其编码的蛋白质或其变体或其片段可用于引发体液或细胞免疫应答; 与161P2F10B反应的抗体或T细胞可用于主动或被动免疫。

公开(公告)号：US07501502B2

公开(公告)日：2009-03-10

申请号：US11489907

申请日：2006-07-19

申请人： Arthur B. Raitano ,  Mary Faris ,  Rene S. Hubert ,  Daniel Afar ,  Wangmao Ge ,  Pia M. Challita-Eid ,  Aya Jakobovits

发明人： Arthur B. Raitano ,  Mary Faris ,  Rene S. Hubert ,  Daniel Afar ,  Wangmao Ge ,  Pia M. Challita-Eid ,  Aya Jakobovits

IPC分类号： C07H21/04 ,  C12N7/00 ,  C12N15/09 ,  C12N15/63 ,  C12P21/06 ,  C07K1/02 ,  C07K14/005

CPC分类号： C07K14/47

摘要： A novel gene (designated 85P1B3) and its encoded protein are described. While 85P1B3 exhibits tissue specific expression in normal adult tissue, it is aberrantly expressed in multiple cancers including set forth in Table 1. Consequently, 85P1B3 provides a diagnostic and/or therapeutic target for cancers. The 85P1B3 gene or fragment thereof, or its encoded protein or a fragment thereof, can be used to elicit an immune response.

摘要翻译： 描述了一种新型基因（命名为85P1B3）及其编码的蛋白质。 虽然85P1B3在正常成人组织中表现出组织特异性表达，但是在多种癌症中异常表达，如表1所示。因此，85P1B3为癌症提供了诊断和/或治疗靶点。 85P1B3基因或其片段或其编码的蛋白质或其片段可用于引发免疫应答。

公开(公告)号：US07279556B2

公开(公告)日：2007-10-09

申请号：US10859643

申请日：2004-06-02

申请人： Pia M. Challita-Eid ,  Arthur B. Raitano ,  Mary Faris ,  Rene S. Hubert ,  Karen Jane Meyrick Morrison ,  Aya Jakobovits

发明人： Pia M. Challita-Eid ,  Arthur B. Raitano ,  Mary Faris ,  Rene S. Hubert ,  Karen Jane Meyrick Morrison ,  Aya Jakobovits

IPC分类号： C07K1/00

CPC分类号： C07K14/47 ,  A61K39/00 ,  C07K16/40 ,  C12N9/16 ,  C12Q1/6886 ,  C12Q2600/158 ,  Y02A50/466

摘要： A gene (designated 161P2F10B) and its encoded protein are described wherein 161P2F10B exhibits tissue specific expression in normal adult tissue, it is aberrantly expressed in the cancers listed in Table I. Consequently, 161P2F10B provides a diagnostic, prognostic, prophylactic and/or therapeutic target for cancer. The 161P2F10B gene or fragment thereof, or its encoded protein or a fragment thereof, can be used to elicit a humoral or cellular immune response.

公开(公告)号：US07217799B2

公开(公告)日：2007-05-15

申请号：US09942052

申请日：2001-08-28

申请人： Arthur B. Raitano ,  Mary Faris ,  Rene S. Hubert ,  Daniel E. Afar ,  Wangmao Ge ,  Pia M. Challita-Eid ,  Aya Jakobovits

发明人： Arthur B. Raitano ,  Mary Faris ,  Rene S. Hubert ,  Daniel E. Afar ,  Wangmao Ge ,  Pia M. Challita-Eid ,  Aya Jakobovits

IPC分类号： C07K16/00 ,  C12P21/08 ,  A61K39/395 ,  C12P21/04 ,  C12N15/02 ,  C12N5/06 ,  C07H21/04

CPC分类号： C07K14/47

摘要： A novel gene (designated 85P1B3) and its encoded protein are described. While 85P1B3 exhibits tissue specific expression in normal adult tissue, it is aberrantly expressed in multiple cancers including set forth in Table 1. Consequently, 85P1B3 provides a diagnostic and/or therapeutic target for cancers. The 85P1B3 gene or fragment thereof, or its encoded protein or a fragment thereof, can be used to elicit an immune response.

摘要翻译： 描述了一种新型基因（命名为85P1B3）及其编码的蛋白质。 虽然85P1B3在正常成人组织中表现出组织特异性表达，但是在多种癌症中异常表达，如表1所示。因此，85P1B3为癌症提供了诊断和/或治疗靶点。 85P1B3基因或其片段或其编码的蛋白质或其片段可用于引发免疫应答。

公开(公告)号：US07115727B2

公开(公告)日：2006-10-03

申请号：US10435751

申请日：2003-05-09

申请人： Mary Faris ,  Pia M. Challita-Eid ,  Aya Jakobovits ,  Arthur B. Raitano ,  Wangmao Ge

发明人： Mary Faris ,  Pia M. Challita-Eid ,  Aya Jakobovits ,  Arthur B. Raitano ,  Wangmao Ge

IPC分类号： C07H21/02

CPC分类号： C12N5/0693 ,  A01K2217/05 ,  A01K2217/075 ,  A61K38/00 ,  A61K47/6851 ,  A61K2039/505 ,  C07K14/435 ,  C07K14/47 ,  C07K2319/00 ,  G01N33/57484 ,  Y02A50/466

摘要： A novel gene 282P1G3 and its encoded protein, and variants thereof, are described wherein 282P1G3 exhibits tissue specific expression in normal adult tissue, and is aberrantly expressed in the cancers listed in Table I. Consequently, 282P1G3 provides a diagnostic, prognostic, prophylactic and/or therapeutic target for cancer. The 282P1G3 gene or fragment thereof, or its encoded protein, or variants thereof, or a fragment thereof, can be used to elicit a humoral or cellular immune response; antibodies or T cells reactive with 282P1G3 can be used in active or passive immunization.

公开(公告)号：US07582448B2

公开(公告)日：2009-09-01

申请号：US11594275

申请日：2006-11-07

申请人： Aya Jakobovits ,  Daniel E. H. Afar ,  Pia M. Challita-Eid ,  Elena Levin ,  Steven Chappell Mitchell ,  Rene S. Hubert

发明人： Aya Jakobovits ,  Daniel E. H. Afar ,  Pia M. Challita-Eid ,  Elena Levin ,  Steven Chappell Mitchell ,  Rene S. Hubert

IPC分类号： C07H21/02

CPC分类号： C07K14/47 ,  A01K2217/05 ,  A61K38/00 ,  A61K39/00 ,  Y02A50/466

摘要： A novel gene (designated 84P2A9) and its encoded protein is described. While 84P2A9 exhibits prostate and testis specific expression in normal adult tissue, it is aberrantly expressed multiple cancers including prostate, testis, kidney, brain, bone, skin, ovarian, breast, pancreas, colon, lymphocytic and lung cancers. Consequently, 84P2A9 provides a diagnostic and/or therapeutic target for cancers, and the 84P2A9 gene or fragment thereof, or its encoded protein or a fragment thereof used to elicit an immune response.

摘要翻译： 描述了一种新型基因（称为84P2A9）及其编码的蛋白质。 虽然84P2A9在正常成人组织中表现出前列腺和睾丸特异性表达，但是异常表达多种癌症，包括前列腺，睾丸，肾，脑，骨，皮肤，卵巢，乳腺，胰腺，结肠，淋巴细胞和肺癌。 因此，84P2A9提供了用于癌症的诊断和/或治疗靶标，以及用于引发免疫应答的84P2A9基因或其片段或其编码的蛋白质或其片段。