公开(公告)号：US06749553B2

公开(公告)日：2004-06-15

申请号：US09858816

申请日：2001-05-16

申请人： Richard A. Brauckman ,  Jack C. White ,  Glenn A. Dill ,  Michael R. Moody

发明人： Richard A. Brauckman ,  Jack C. White ,  Glenn A. Dill ,  Michael R. Moody

IPC分类号： A61N500

CPC分类号： A61N5/1027 ,  A61N2005/1023 ,  A61N2005/1025

摘要： Radiation delivery devices useful in brachytherapy which employ radioactive palladium-103 as the radiation source material are disclosed. Certain embodiments of the disclosed radiation delivery devices have the advantages that they can be fabricated with the desired specific activity, that the self-shielding effects of the devices are minimized, that the radioactive source material is bonded to a substrate in a manner which substantially prevents it from becoming detached, and that a variety of customizable radiation delivery devices can be made using the concepts of the invention. Also disclosed are processes for bonding radiation source material to various substrates using electroless plating, chemical vapor deposition and polymer matrices. These processes have the advantage that they can be applied to bond the radiation source material to a wide variety of substrates including different substrate materials and differently shaped substrates, thereby providing the ability to tailor the radiation delivery devices to the specific requirements of a particular brachytherapy treatment.

摘要翻译： 公开了使用放射性钯-103作为辐射源材料的用于近距离放射治疗的辐射递送装置。 所公开的辐射递送装置的某些实施例具有这样的优点：它们可以以期望的比活度制造，使得装置的自屏蔽作用最小化，放射源材料以基本上防止的方式结合到基底 它变得分离，并且可以使用本发明的概念制造各种可定制的辐射递送装置。 还公开了使用化学镀，化学气相沉积和聚合物基质将辐射源材料粘合到各种基底的方法。 这些方法具有这样的优点：它们可以用于将辐射源材料粘合到包括不同基底材料和不同形状的基底的各种基底上，从而提供根据特定近距离放射疗法治疗的具体要求来定制辐射递送装置的能力 。

公开(公告)号：US20040102671A1

公开(公告)日：2004-05-27

申请号：US10705133

申请日：2003-11-10

发明人： Richard A. Terwilliger ,  Gary A. Lamoureux

IPC分类号： A61N005/00

CPC分类号： A61N5/1027 ,  A61N2005/1023 ,  A61N2005/1024 ,  B29C47/0023 ,  B29C47/021 ,  B29C47/028 ,  G21G4/08

摘要： A delivery system and method for interstitial radiation therapy comprising substantially axially stiff and radially flexible elongated members made of material which is bioabsorbable in living tissue and a plurality of radioactive seeds dispersed in a predetermined array within the elongate member. The radioactive seeds can be dispersed within assembled half-shells made of the same material. The housing for the radiation seeds can also be manufactured from extruded material. A system for manufacturing the interstitial radiation therapy seed strands that automatically makes the seed strands is also provided. The delivery system and method further customize the member based on a prescription.

公开(公告)号：US20040097779A1

公开(公告)日：2004-05-20

申请号：US10702942

申请日：2003-11-06

发明人： Gregory Mclntire ,  Robert Snow ,  Edward Bacon ,  Morten Eriksen ,  Auden Tornes ,  Geraldine Cooney ,  Virginia Ann Gates ,  Joel Cornacoff ,  Christopher Black

IPC分类号： A61N005/00

CPC分类号： G21G4/08 ,  A61B2090/3925 ,  A61N5/1027 ,  A61N2005/1024

摘要： Radioactive sources, preferably radioactive seeds, for use in brachytherapy comprising a radioisotope within a sealed biocompatible container, wherein at least one part of a surface of the container is roughened, shaped or otherwise treated so that it is no longer smooth. The surface treatment may enhance the ultrasound visibility of the source and/or reduce the tendency of the source to migrate once implanted in a patient's body. Preferred radioisotopes are palladium-103 and iodine-125.

公开(公告)号：US06716156B2

公开(公告)日：2004-04-06

申请号：US10066918

申请日：2002-02-04

申请人： Helmut Menuhr ,  Eberhard Fritz ,  Mark Shilton

发明人： Helmut Menuhr ,  Eberhard Fritz ,  Mark Shilton

IPC分类号： A61N500

CPC分类号： A61N5/1027 ,  A61N2005/1024

摘要： A radioactive or activatable seed for use in brachytherapy, and a method for producing the seed, the seed comprising a closed and self-supported casing consisting of (a) a radioactive or activatable metallic material selected from the group consisting of a metal, an alloy and a metal composite or mixtures thereof, optionally in combination with (b) a non-radioactive, non-activatable metallic material; wherein (a) comprises a radioactive nuclide selected from the group consisting of Pd-103, Tm-170, Sr-90, Y-90, Yb-169, P-32, Ge-71, Se-75, Cl-36, Ta-182, Tl-204, Re-188, W-188, Ce-144, Pr-144, Sn-123, Ru-106, Rh-106 and mixtures thereof, and/or an activatable precursor nuclide thereof selected from the group consisting of Pd-102, Rh-103, Tm-169, Y-89, Yb-168, P-31, Ge-70, Se-74, Cl-35, Ta-181, Tl-203, W-186, Sn-122 and mixtures thereof, excluding metallic Pd with natural abundance of Pd-102.

摘要翻译： 一种用于近距离放射治疗的放射性或可激活的种子，以及一种用于生产种子的方法，该种子包括一个封闭的和自支撑的壳体，该壳体由（a）放射性或可激活的金属材料组成，该金属材料选自金属，合金 和金属复合材料或其混合物，任选地与（b）非放射性不可激活的金属材料组合; 其中（a）包括选自Pd-103，Tm-170，Sr-90，Y-90，Yb-169，P-32，Ge-71，Se-75，Cl-36， Ta-182，Tl-204，Re-188，W-188，Ce-144，Pr-144，Sn-123，Ru-106，Rh-106及其混合物，和/或其可活化的前体核素， 由Pd-102，Rh-103，Tm-169，Y-89，Yb-168，P-31，Ge-70，Se-74，Cl-35，Ta-181，Tl-203，W-186组成的组 ，Sn-122及其混合物，不包括Pd-102天然丰度的金属Pd。

公开(公告)号：US06712782B2

公开(公告)日：2004-03-30

申请号：US09853459

申请日：2001-05-09

申请人： John C. Ford

发明人： John C. Ford

IPC分类号： A61M3700

CPC分类号： A61M37/0069 ,  A61N5/1007 ,  A61N5/1027 ,  A61N2005/1011 ,  A61N2005/1023

摘要： A brachytherapy apparatus is composed of a tubular needle with forwardly protruding cutting edges at its tip, a holder supporting the needle and a driver for electromechanically causing the needle to undergo a continuous or oscillatory rotary motion around its axis and/or a reciprocating linear motion in the longitudinal direction such that its front opening at its tip can reliably reach a specified position inside a patient's tissue without being deflected or bowing when it encounters an obstruction such as a calcification or a small bone. Such motions may be provided by a piezoelectric hammer and a piezoelectric tamper. After the needle is thus correctly positioned, a brachytherapy device such as a radioactive seed or a reflector may be pushed through and out of the needle by means of a pusher as the needle is retracted to leave a track inside the tissue. A quickly hardening liquid may be thereafter injected through the needle to immobilize the deposited brachytherapy device. Another brachytherapy device may be deposited similarly after the needle is retracted by a specified distance. A plurality of brachytherapy devices may be preliminarily prepared as a unit having them linearly arranged inside a hardened liquid and mutually separated by specified distances such that they can be pushed together through the needle, or they may be injected together with a quickly hardening liquid.

摘要翻译： 近距离放射治疗装置由其尖端处具有向前突出的切割边缘的管状针，支撑针的保持器和用于机电地使针在其轴线周围进行连续或振荡的旋转运动的驱动器和/或往复线性运动 纵向方向使得其尖端处的前开口可以可靠地到达患者组织内的指定位置，而不会在遇到诸如钙化或小骨之类的阻塞时被偏转或弯曲。 这样的动作可以由压电锤和压电篡改器来提供。 在针被如此正确定位之后，当针被缩回以在组织内留下轨道时，诸如放射性种子或反射器的近距离放射治疗装置可以通过推动器被推入和移出。 然后可以通过针头注入快速硬化液体，以固定沉积的近距离放射治疗装置。 在针回缩指定距离之后，可以类似地沉积另一近距离放射治疗装置。 可以预先制备多个近程放射治疗装置作为其单元，其中它们线性地布置在硬化液体的内部并相互分开一定距离，使得它们可以通过针被推到一起，或者它们可以用快速硬化液体一起注入。

公开(公告)号：US06709381B2

公开(公告)日：2004-03-23

申请号：US10160881

申请日：2002-05-31

申请人： John J. Munro, III

发明人： John J. Munro, III

IPC分类号： A61N500

CPC分类号： A61N5/1001 ,  A61N5/1027 ,  A61N2005/1011 ,  A61N2005/1023

摘要： A system for brachytherapy is provided. The system includes an implantation device having a tubular member, a radioactive source within the member, and a socket at opposing ends of the tubular member. A plurality of implantation devices may be joined into an assembly by use of a spacer positioned within the sockets of adjoining devices. The device may be deployed at an implantation site by use of a delivery mechanism, such as needle. The presence of the tubular members and spacers minimizes movement of the radioactive source subsequent to deployment, so as not to alter dose distribution for subsequent irradiation.

摘要翻译： 提供一种近距离放射治疗系统。 该系统包括具有管状构件，构件内的放射源和在管状构件的相对端处的插座的植入装置。 多个植入装置可以通过使用位于相邻装置的插座内的间隔件连接到组件中。 该装置可以通过使用诸如针的递送机构来部署在植入位置。 管状构件和隔离物的存在使放射源在展开后的移动最小化，以便不改变随后照射的剂量分布。

公开(公告)号：US06695760B1

公开(公告)日：2004-02-24

申请号：US10269555

申请日：2002-10-11

申请人： Rance A. Winkler ,  Timothy J. Patrick ,  Carribeth B. Ramey

发明人： Rance A. Winkler ,  Timothy J. Patrick ,  Carribeth B. Ramey

IPC分类号： A61N500

CPC分类号： A61F2/446 ,  A61F2002/30777 ,  A61F2002/30785 ,  A61F2002/30858 ,  A61F2002/4475 ,  A61M25/10 ,  A61M29/02 ,  A61M2210/1003 ,  A61N5/1027 ,  A61N2005/1005 ,  A61N2005/1021

摘要： A radiotherapy system, and preferably a brachytherapy system, for delivering radiation to tissue surrounding an interstitial space is provided. While the system can be used for a variety of purposes, the system is preferably used to treat spinal metastases. In general, the system includes a catheter member having a proximal end, a distal end, and an inner lumen extending therethrough, and a structural support adapted to fit within an interstitial space in load bearing portion of a patient's body and having an internal space for removably receiving the distal end of the catheter member. At least one anchoring element can be disposed proximate to the distal end of the catheter. The anchoring element is preferably adapted to fit within the internal space in the structural support so as to anchor the distal end of the catheter therein. The system further includes a radiation source disposable within the internal space of the structural support through the lumen in the catheter for delivering radiation to tissue surrounding the interstitial space.

公开(公告)号：US06673006B2

公开(公告)日：2004-01-06

申请号：US09882506

申请日：2001-06-15

申请人： Rance A. Winkler

发明人： Rance A. Winkler

IPC分类号： A61N500

CPC分类号： A61N5/1027 ,  A61B90/04 ,  A61B2017/00867 ,  A61B2090/0427 ,  A61M37/0069 ,  A61N2005/1094

摘要： A spacing apparatus for use with radiation therapy devices, and in particular, for use with a brachytherapy device. The spacing apparatus is useful in that the instrument is effective to limit the amount of radiation that comes into contact with the sensitive tissue proximate to the extraction site, and thereby protect sensitive tissue from overheating or hotspots, and/or protect against radiation exposure outside of the patient's body which may affect healthcare providers or others who might come close to the patient. In particular, the spacing apparatus is effective to control the proximity of a brachytherapy device to the outer surface of the sensitive tissue proximate to a surgical extraction site.

摘要翻译： 一种用于放射线治疗装置的间隔装置，特别是与近距离放射治疗装置一起使用。 间隔装置是有用的，因为该仪器有效地限制与接近提取部位的敏感组织接触的辐射量，从而保护敏感组织免于过热或热点，和/或防止辐射暴露在 患者的身体可能会影响医护人员或其他可能接近病人的身体。 特别地，间隔装置有效地控制近距离放射治疗装置邻近手术切除部位的敏感组织的外表面。

公开(公告)号：US20030225437A1

公开(公告)日：2003-12-04

申请号：US10407843

申请日：2003-04-04

发明人： Patrick J. Ferguson

IPC分类号： A61B017/06

CPC分类号： A61M37/0069 ,  A61B17/3468 ,  A61B90/03 ,  A61N5/1027 ,  A61N2005/1011

摘要： A stopple for retaining material within a hollow needle/push rod assembly is made of a synthetic absorbable material and is configured to fit snugly within the hollow needle of the needle/push rod assembly. The stopple is typically circular in shape, having a diameter that is substantially similar to the inner diameter of the hollow needle. The stopple prevents inadvertent ejection of material stored in the hollow needle/push rod assembly.

摘要翻译： 用于将材料保持在中空针/推杆组件内的止动件由合成的可吸收材料制成并且构造成紧密地配合在针/推杆组件的中空针内。 该止动件通常为圆形，其直径基本上类似于中空针的内径。 塞子防止无意中弹出存储在中空针/推杆组件中的材料。

公开(公告)号：US20030212302A1

公开(公告)日：2003-11-13

申请号：US10350357

申请日：2003-01-24

发明人： Anatoly Rozenfeld ,  Marc Zaider

IPC分类号： A61N005/00

CPC分类号： A61N5/1048 ,  A61N5/1007 ,  A61N5/1027 ,  A61N5/1071 ,  A61N2005/1072

摘要： The present invention provides a method of determining the dose rate of a radiation source comprising locating three or more detectors in the vicinity of said source, each for providing an output indicative of the amount of radiation received from said source; and determining the location of said source from at least some of said detector outputs, wherein as many of said detector outputs is required to provide an acceptably accurate result are used in determining said location; whereby the dose of radiation from said source can be determined from said determined location of said source and either a known activity of said source or a measure of the activity of said source determined by means of said detectors.

摘要翻译： 本发明提供了一种确定辐射源的剂量率的方法，包括在所述源附近定位三个或更多个检测器，每个检测器用于提供指示从所述源接收的辐射量的输出; 以及从所述检测器输出中的至少一些确定所述源的位置，其中在确定所述位置时使用需要提供可接受的精确结果的所述检测器输出的数量; 从而可以从所述源的所述确定位置和所述源的已知活动或通过所述检测器确定的所述源的活动的度量来确定来自所述源的辐射的剂量。