Method for manufacturing hydroxyethyl starch derivatives
    102.
    发明授权
    Method for manufacturing hydroxyethyl starch derivatives 有权
    羟乙基淀粉衍生物的制备方法

    公开(公告)号:US09181353B2

    公开(公告)日:2015-11-10

    申请号:US14127766

    申请日:2012-06-21

    摘要: A method for manufacturing a modified hydroxyethyl starch carrying a heptonic acid residue on at least one of its termini is disclosed. Within this method, the following steps are carried out: a) dissolving hydroxyethyl starch in water, b) adjusting the pH value to a value of 8.0 to 10.0, c) adding a cyanide compound to the hydroxyethyl starch solution, heating the solution to a temperature of 80 to 99° C. and keeping it at this temperature for a first time period, and d) adjusting the pH value to a value of 2.0 to 4.0, bringing the solution to a temperature of 50 to 90° C. and keeping it at this temperature for a second time period.

    摘要翻译: 公开了一种在其至少一个末端上制备带有庚糖残基的改性羟乙基淀粉的方法。 在该方法中,进行以下步骤:a)将羟乙基淀粉溶于水中,b)将pH值调节至8.0至10.0,c)将氰化物化合物加入到羟乙基淀粉溶液中,将溶液加热至 温度为80〜99℃,将其保持在该温度下第一次,d)将pH值调节至2.0〜4.0,使溶液温度达到50〜90℃,保持 它在这个温度下第二个时间段。

    ACIDIC GAS-PERMEATED CARBOXYALKYL STARCH PARTICLES, EXTRUDATES, AND PROCESS FOR MAKING THE SAME
    103.
    发明申请
    ACIDIC GAS-PERMEATED CARBOXYALKYL STARCH PARTICLES, EXTRUDATES, AND PROCESS FOR MAKING THE SAME 审中-公开
    酸性气体渗透的羧甲基淀粉颗粒,其制备方法及其制备方法

    公开(公告)号:US20150306568A1

    公开(公告)日:2015-10-29

    申请号:US14794954

    申请日:2015-07-09

    IPC分类号: B01J20/24 B01D15/08 B01J20/30

    摘要: The present disclosure relates to particles comprising carboxyalkyl starch that are permeated with an acidic gas and their uses as absorbent materials. It was discovered that superabsorbent materials could be obtained from carboxyalkyl starch particles permeated with the acidic gas and heated to a temperature of at least 100° C. until they reach an AUL at 0.7 psi. of at least 14 g/g and a CRC of at least 18 g/g. Moreover, it was discovered that the pH of alkaline starch extrudates can be adjusted by permeating particles of the extrudate with the acidic gas even with treating the particles to temperatures less than 100° C. The carboxyalkyl starch particles obtained by the methods described herein are characterized as having intramolecular ester bonds, which are greater in number at the surface of the particle than in the core, and the particles have a greater concentration of cation of the acidic gas at the surface than a the core.

    摘要翻译: 本公开涉及包含羧酸烷基淀粉的颗粒,其被酸性气体渗透并且其用作吸收材料。 已经发现超吸收材料可以从用酸性气体渗透的羧基烷基淀粉颗粒获得并加热到至少100℃的温度,直到它们在0.7psi下达到AUL。 至少为14g / g,CRC为至少18g / g。 此外,已经发现,即使将颗粒处理到低于100℃的温度,也可以通过用酸性气体渗透挤出物的颗粒来调节碱性淀粉挤出物的pH。通过本文所述的方法获得的羧基烷基淀粉颗粒被表征 具有分子内酯键,其在颗粒表面上的数量大于芯中的分子内酯键,并且颗粒在表面处具有比芯更高浓度的酸性气体的阳离子。

    Acidic gases permeated carboxyalkyl starch and alkaline starch extrudates and process for making the same
    104.
    发明授权
    Acidic gases permeated carboxyalkyl starch and alkaline starch extrudates and process for making the same 有权
    酸性气体透过羧基烷基淀粉和碱性淀粉挤出物,并制成相同的过程

    公开(公告)号:US09107975B2

    公开(公告)日:2015-08-18

    申请号:US13202456

    申请日:2010-02-22

    摘要: The present disclosure relates to particles comprising carboxyalkyl starch that are permeated with an acidic gas and their uses as absorbent materials. It was discovered that superabsorbent materials could be obtained from carboxyalkyl starch particles permeated with the acidic gas and heated to a temperature of at least 100° C. until they reach an AUL at 0.7 psi. of at least 14 g/g and a CRC of at least 18 g/g. Moreover, it was discovered that the pH of alkaline starch extrudates can be adjusted by permeating particles of the extrudate with the acidic gas even with treating the particles to temperatures less than 100° C. The carboxyalkyl starch particles obtained by the methods described herein are characterized as having intramolecular ester bonds, which are greater in number at the surface of the particle than in the core, and the particles have a greater concentration of cation of the acidic gas at the surface than a the core.

    摘要翻译: 本公开涉及包含羧酸烷基淀粉的颗粒,其被酸性气体渗透并且其用作吸收材料。 已经发现超吸收材料可以从用酸性气体渗透的羧基烷基淀粉颗粒获得并加热到至少100℃的温度,直到它们在0.7psi下达到AUL。 至少为14g / g,CRC为至少18g / g。 此外,已经发现,即使将颗粒处理到低于100℃的温度,也可以通过用酸性气体渗透挤出物的颗粒来调节碱性淀粉挤出物的pH。通过本文所述的方法获得的羧基烷基淀粉颗粒被表征 具有分子内酯键,其在颗粒表面上的数量大于芯中的分子内酯键,并且颗粒在表面处具有比芯更高浓度的酸性气体的阳离子。

    CONJUGATES COMPRISING HYDROXYALKYL STARCH AND A CYTOTOXIC AGENT AND PROCESS FOR THEIR PREPARATION
    107.
    发明申请
    CONJUGATES COMPRISING HYDROXYALKYL STARCH AND A CYTOTOXIC AGENT AND PROCESS FOR THEIR PREPARATION 审中-公开
    包含羟基烷基淀粉和细胞毒素的方法及其制备方法

    公开(公告)号:US20140073778A9

    公开(公告)日:2014-03-13

    申请号:US13809074

    申请日:2011-07-11

    IPC分类号: C08B31/10

    摘要: The present invention relates to hydroxyalkyl starch conjugates, a method for preparing the same, the hydroxyalkyl starch conjugate comprising a hydroxyalkyl starch derivative and a cytotoxic agent and the cytotoxic agent comprising at least one tertiary hydroxyl group, wherein the hydroxyalkyl starch is linked via said tertiary hydroxyl group to the cytotoxic agent. The conjugates according to the present invention have a structure according to the following formula HAS′(-L-M)n wherein M is a residue of the cytotoxic agent, L is a linking moiety, HAS′ is the residue of the hydroxyalkyl starch derivative, and n is greater than or equal to 1, and wherein the hydroxyalkyl starch derivative has a mean molecular weight (MW) above the renal threshold.

    摘要翻译: 本发明涉及羟烷基淀粉共轭物,其制备方法,包含羟烷基淀粉衍生物和细胞毒性剂的羟烷基淀粉缀合物和包含至少一个叔羟基的细胞毒性剂,其中羟烷基淀粉通过所述第三级 羟基对细胞毒性剂。 根据本发明的缀合物具有根据下式HAS'( - LM)n的结构,其中M是细胞毒性剂的残基,L是连接部分,HAS'是羟烷基淀粉衍生物的残基,以及 n大于或等于1,并且其中羟烷基淀粉衍生物具有高于肾阈值的平均分子量(MW)。

    METHOD FOR PREPARING HYDROXYALKYL STARCH
    110.
    发明申请
    METHOD FOR PREPARING HYDROXYALKYL STARCH 审中-公开
    制备羟基烷基淀粉的方法

    公开(公告)号:US20130225803A1

    公开(公告)日:2013-08-29

    申请号:US13882945

    申请日:2011-11-23

    IPC分类号: C08B31/10

    CPC分类号: C08B31/10 C08B30/12 C08B31/12

    摘要: The present invention relates to a method for preparing hydroxyalkyl starch. The method for preparing hydroxyalkyl starch comprises the steps of hydrolyzing starch, reducing the hydrolyzed starch, and substituting the reduced starch with hydroxyalkyl group in a dry process.

    摘要翻译: 本发明涉及一种制备羟烷基淀粉的方法。 制备羟烷基淀粉的方法包括水解淀粉,还原水解淀粉以及在干法中用羟基烷基取代还原淀粉的步骤。