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    Process for making nonwoven articles
    3.
    发明申请
    Process for making nonwoven articles 审中-公开
    制造无纺布制品的方法

    公开(公告)号：US20060121099A1

    公开(公告)日：2006-06-08

    申请号：US11276191

    申请日：2006-02-17

    申请人： Daniel Solarek

    发明人： Daniel Solarek

    IPC分类号： A61K9/70 ,  A61F13/15 ,  B32B27/04

    CPC分类号： D06M23/06 ,  A61F13/15577 ,  A61F13/51113 ,  A61F13/8405 ,  A61F2013/51117 ,  C08B31/04 ,  C08B35/02 ,  C08L3/02 ,  C08L3/06 ,  C08L3/16 ,  D06M13/005 ,  D06M15/03 ,  D06M15/11 ,  D06M23/08 ,  D21H17/28 ,  D21H19/54 ,  D21H27/002 ,  Y10T442/2566

    摘要： Method for preparing an active-containing nonwoven article involving fixing active ingredients on the surface of non-woven webs and cellulosic mats. The active ingredients can be released (deposited) onto a surface by normal triggering mechanisms, which include the action of a liquid or by friction or rubbing. The fixative systems described herein provide the ability to control high load levels while not interfering with wettability of the fabric or paper. Additionally, ingredients incompatible and reactive with each other can be treated onto the same web and kept as separate particles fixed to the surface until released.

    摘要翻译： 制备含有活性物质的非织造制品的方法，其涉及将有效成分固定在无纺网和纤维素垫的表面上。 可以通过包括液体作用或摩擦或摩擦的正常触发机制将活性成分释放（沉积）到表面上。 本文所述的固定系统提供了控制高负载水平的能力，同时不干扰织物或纸的润湿性。 此外，彼此不相容和反应的成分可以处理在相同的纤维网上并保持为单独的颗粒固定到表面直到释放。

    Water-soluble antibiotic comprising an amino sugar, in the form of a polysaccharide conjugate
    4.
    发明申请
    Water-soluble antibiotic comprising an amino sugar, in the form of a polysaccharide conjugate 失效
    包含多糖缀合物形式的氨基糖的水溶性抗生素

    公开(公告)号：US20040180858A1

    公开(公告)日：2004-09-16

    申请号：US10481597

    申请日：2003-12-19

    发明人： Klaus Sommermeyer

    IPC分类号： A61K031/718 ,  C08B033/00

    CPC分类号： C08B35/06 ,  A61K47/61 ,  C08B31/00 ,  C08B31/04 ,  C08B31/08 ,  C08B31/125 ,  C08B31/16 ,  C08B33/00 ,  C08B33/02 ,  C08B33/04 ,  C08B33/06 ,  C08B35/00 ,  C08B35/02 ,  C08B35/04

    摘要： The invention relates to novel pharmaceutical forms for antibiotics containing amino sugar, amphotericin B, daunorubicin and doxorubicin, in which the known side effects are reduced and which can be used in a simple manner. The antimycotic agent B is nephrotoxic. The cytostatic agents daunorubicin and doxorubicin are highly cardiotoxic. The novel pharmaceutical forms are antibiotic-starch conjugates, wherein the antibiotic is combined with the polysaccharide at the reducing end thereof by means of a peptide bond. According to the invention, said bond is carried out by means of J2 oxidation of the starch derivative at the reducing end thereof in an aqueous alkaline solution, and by coupling the starch derivative oxidised thereby to the antibiotic in an organic solution. The conjugates obtained are less toxic. The polysaccharide part can be decomposed by serum-null-amylase and the peptide bond can be accessed by an enzymatic attack.

    摘要翻译： 本发明涉及含有氨基糖，两性霉素B，柔红霉素和多柔比星的抗生素的新型药物形式，其中已知的副作用减少并且可以以简单的方式使用。 抗真菌剂B是肾毒性的。 细胞抑制剂柔红霉素和多柔比星是高度心脏毒性的。 新型药物形式是抗生素 - 淀粉共轭物，其中抗生素通过肽键在其还原端与多糖结合。 根据本发明，通过在碱性水溶液中还原端的淀粉衍生物的J2氧化，将由此氧化的淀粉衍生物与抗生素偶联在有机溶液中进行。 获得的共轭物毒性较小。 多糖部分可以通过血清-α-淀粉酶分解，肽键可以通过酶促侵袭进入。

    Water-soluble antibiotic comprising an amino sugar, in the form of a polysaccharide conjugate
    8.
    发明授权
    Water-soluble antibiotic comprising an amino sugar, in the form of a polysaccharide conjugate 失效
    包含多糖缀合物形式的氨基糖的水溶性抗生素

    公开(公告)号：US07115576B2

    公开(公告)日：2006-10-03

    申请号：US10481597

    申请日：2002-06-19

    申请人： Klaus Sommermeyer

    发明人： Klaus Sommermeyer

    IPC分类号： A61K31/70 ,  C07H15/24 ,  C07H17/08

    CPC分类号： C08B35/06 ,  A61K47/61 ,  C08B31/00 ,  C08B31/04 ,  C08B31/08 ,  C08B31/125 ,  C08B31/16 ,  C08B33/00 ,  C08B33/02 ,  C08B33/04 ,  C08B33/06 ,  C08B35/00 ,  C08B35/02 ,  C08B35/04

    摘要： The invention relates to novel pharmaceutical forms for antibiotics containing amino sugar, amphotericin B, daunorubicin and doxorubicin, in which the known side effects are reduced and which can be used in a simple manner. The antimycotic agent B is nephrotoxic. The cytostatic agents daunorubicin and doxorubicin are highly cardiotoxic. The novel pharmaceutical forms are antibiotic-starch conjugates, wherein the antibiotic is combined with the polysaccharide at the reducing end thereof by means of a peptide bond. According to the invention, said bond is carried out by means of J2 oxidation of the starch derivative at the reducing end thereof in an aqueous alkaline solution, and by coupling the starch derivative oxidised thereby to the antibiotic in an organic solution. The conjugates obtained are less toxic. The polysaccharide part can be decomposed by serum-α-amylase and the peptide bond can be accessed by an enzymatic attack.

    摘要翻译： 本发明涉及含有氨基糖，两性霉素B，柔红霉素和多柔比星的抗生素的新型药物形式，其中已知的副作用降低并且可以以简单的方式使用。 抗真菌剂B是肾毒性的。 细胞抑制剂柔红霉素和多柔比星是高度心脏毒性的。 新型药物形式是抗生素 - 淀粉共轭物，其中抗生素通过肽键在其还原端与多糖结合。 根据本发明，所述键通过淀粉衍生物的还原端在碱性水溶液中的氧化作用进行，并将由此氧化的淀粉衍生物与抗生素偶联 一种有机溶液。 获得的共轭物毒性较小。 多糖部分可以通过血清-α-淀粉酶分解，肽键可以通过酶促侵袭进入。