公开(公告)号：US06964966B2

公开(公告)日：2005-11-15

申请号：US10128996

申请日：2002-04-23

Applicant: Noel John De Souza ,  Mahesh Vithalbhai Patel ,  Prasad Keshav Deshpande ,  Shiv Kumar Agarwal ,  Shrikant V. Gupte ,  Dilip J. Upadhyay ,  Satish B. Bhawsar ,  Rupinder K. Beri ,  Kandepu Sreenivas ,  Sheela Chandrasekharan Nair ,  Milind Chintaman Shukla ,  Yati Chugh ,  Nitin Shetty ,  Ravindra D. Yeole ,  M. Madhav Reddy

Inventor： Noel John De Souza ,  Mahesh Vithalbhai Patel ,  Prasad Keshav Deshpande ,  Shiv Kumar Agarwal ,  Shrikant V. Gupte ,  Dilip J. Upadhyay ,  Satish B. Bhawsar ,  Rupinder K. Beri ,  Kandepu Sreenivas ,  Sheela Chandrasekharan Nair ,  Milind Chintaman Shukla ,  Yati Chugh ,  Nitin Shetty ,  Ravindra D. Yeole ,  M. Madhav Reddy

IPC: A61K31/095 ,  A61K31/191 ,  A61K31/47 ,  A61K31/4709 ,  A61K45/06 ,  A61P3/04 ,  A61P11/00 ,  A61P13/10 ,  A61P13/12 ,  A61P19/02 ,  A61P27/16 ,  A61P29/00 ,  A61P31/00 ,  A61P31/04 ,  C07D215/22 ,  C07D215/233 ,  C07D401/04 ,  C07D401/14 ,  C07D413/12 ,  C07D455/04 ,  C07D471/04 ,  C07D471/08 ,  C07D519/00 ,  A61K31/497 ,  C07D215/36 ,  C07D279/12 ,  C07D401/00 ,  C07F5/02

CPC classification number: C07D215/233 ,  A61K31/47 ,  A61K45/06 ,  C07D401/04 ,  C07D401/14 ,  C07D413/12 ,  C07D455/04 ,  C07D471/04 ,  C07D471/08

Abstract: This invention relates to new generation triple-targeting, chiral, broad-spectrum antimicrobial 7-substituted piperidino-quinolone carboxylic acid derivatives, to their optical isomers, diastereomers or enantiomers, as well as pharmaceutically acceptable salts, hydrates, prodrugs, polymorphs and pseudopolymorphs thereof, to their preparation, to their compositions and to their use.

Abstract translation: 本发明涉及新一代三靶向，手性，广谱抗微生物7-取代的哌啶子基 - 喹诺酮羧酸衍生物，其旋光异构体，非对映异构体或对映异构体，以及其药学上可接受的盐，水合物，前药，多晶型物和假多晶型物 ，准备，组合和使用。

公开(公告)号：US06878713B2

公开(公告)日：2005-04-12

申请号：US10318367

申请日：2002-12-12

Applicant: Noel John De Souza ,  Mahesh Vithalbhai Patel ,  Prasad Keshav Deshpande ,  Shiv Kumar Agarwal ,  Kandepu Sreenivas ,  Sheela Chandrasekharan Nair ,  Yati Chugh ,  Milind Chintaman Shukla

Inventor： Noel John De Souza ,  Mahesh Vithalbhai Patel ,  Prasad Keshav Deshpande ,  Shiv Kumar Agarwal ,  Kandepu Sreenivas ,  Sheela Chandrasekharan Nair ,  Yati Chugh ,  Milind Chintaman Shukla

IPC: A61K31/47 ,  A61K45/06 ,  C07D215/22 ,  C07D215/233 ,  C07D401/04 ,  C07D401/14 ,  C07D413/12 ,  C07D455/04 ,  C07D471/04 ,  C07D471/08 ,  C07D519/00 ,  A61K31/497 ,  A61K31/44 ,  C07D215/16 ,  C07D455/06

CPC classification number: A61K31/47 ,  A61K45/06 ,  C07D215/233 ,  C07D401/04 ,  C07D401/14 ,  C07D413/12 ,  C07D455/04 ,  C07D471/04 ,  C07D471/08 ,  Y10S514/859

Abstract: This invention relates to new generation triple-targeting, chiral, broad-spectrum antimicrobial 7-substituted piperidino-quinolone carboxylic acid derivatives, to their optical isomers, diastereomers or enantiomers, as well as pharmaceutically acceptable salts, hydrates, prodrugs, polymorphs and pseudopolymorphs thereof, to their preparation, to their compositions and to their use.

公开(公告)号：US06794401B2

公开(公告)日：2004-09-21

申请号：US10356113

申请日：2003-01-31

Applicant: Bishwajit Nag ,  Abhijeet Nag ,  Debendranath Dey ,  Shiv Kumar Agarwal

Inventor： Bishwajit Nag ,  Abhijeet Nag ,  Debendranath Dey ,  Shiv Kumar Agarwal

IPC: A61K31425

CPC classification number: C07D263/44 ,  A61K31/421 ,  A61K31/422 ,  A61K31/426 ,  A61K31/427 ,  C07D277/34

Abstract: Novel amino acid phenyl ethers are provided which exhibit activity for the treatment of immunological diseases, inflammation, obesity, hyperlipidemia, hypertension, neurological diseases and diabetes.

Abstract translation: 提供了新的氨基酸苯基醚，其表现出用于治疗免疫疾病，炎症，肥胖症，高脂血症，高血压，神经疾病和糖尿病的活性。

公开(公告)号：US06664058B2

公开(公告)日：2003-12-16

申请号：US09898210

申请日：2001-07-03

Applicant: Shiv Kumar ,  Satyam Nampalli ,  Constantin Neagu ,  Mark McDougall ,  David Loakes ,  Dan Brown

Inventor： Shiv Kumar ,  Satyam Nampalli ,  Constantin Neagu ,  Mark McDougall ,  David Loakes ,  Dan Brown

IPC: C12Q168

CPC classification number: C07D487/04 ,  C07F9/6561 ,  C07H19/23 ,  C12Q2525/117 ,  G01N33/58

Abstract: The present invention describes novel compounds of the formula Wherein Q is H or a sugar or a sugar analogue or a nucleic acid backbone or backbone analogue, Y=O, S, NR10, where R10 is H, alkyl alkenyl, alkynyl, X is H, alkyl, alkenyl, alkynyl, aryl, heteroaryl or a combination thereof or, preferably, a reporter group. The novel compounds are suitable for incorporation in oligonucleotides and polynucleotides.

Abstract translation: 本发明描述了新颖的式化合物，其中Q是H或糖或糖类似物或核酸主链或主链类似物，Y = O，S，NR 10，其中R 10是H，烷基烯基， 炔基，X是H，烷基，烯基，炔基，芳基，杂芳基或其组合，或优选报道基团。 新型化合物适用于掺入寡核苷酸和多核苷酸。

公开(公告)号：US06337095B1

公开(公告)日：2002-01-08

申请号：US09538893

申请日：2000-03-30

Applicant: Dharam Chand Jain ,  Neerja Pant ,  Madan Mohan Gupta ,  Rajendra Singh Bhakuni ,  Ram Kishor Verma ,  Sudeep Tandon ,  Shiv Kumar Gupta ,  Amit Tewari ,  Atul Prakash Kahol ,  Sushil Kumar

Inventor： Dharam Chand Jain ,  Neerja Pant ,  Madan Mohan Gupta ,  Rajendra Singh Bhakuni ,  Ram Kishor Verma ,  Sudeep Tandon ,  Shiv Kumar Gupta ,  Amit Tewari ,  Atul Prakash Kahol ,  Sushil Kumar

IPC: A01N6500

CPC classification number: C07D311/16

Abstract: The invention relates to a process for the isolation of compound scopoletin which is used as nitric oxide synthesis inhibitor from Artemisia annua and other plant families, said process comprising extraction of dried powdered material of different plant parts with an aqueous acetonitrite solvent in the ratio of 1:5 for 6 to 8 hrs., concentration of the extracted solvent upto 30% of its original extract under vacuum, partitioning the concentrated extract with halogenated solvent to transfer scopoletin in the non-polar halogenated solvent, drying halogenated solvent over anhydrous sodium sulphate and evaporating the solvent, crystallizing the residues in methanol and filtering the crystals, concentrating the filtrate and chromatographed on silica gel, eluting scopoletin in chloroform methanol mixture; and crystallization of the fractions containing the scopoletin to get the pure scopoletin compound.

Abstract translation: 本发明涉及一种用于分离化合物番茄酱的方法，其用作来自青蒿和其他植物家族的一氧化氮合成抑制剂，所述方法包括用比例为1的丙酮酸溶剂萃取不同植物部分的干燥粉末材料 5℃6〜8小时，真空浓缩提取溶剂至30％原始萃取液，用卤代溶剂分配浓缩萃取液，在非极性卤代溶剂中转移香料，用无水硫酸钠干燥卤代溶剂， 蒸发溶剂，结晶甲醇残余物并过滤晶体，浓缩滤液并在硅胶上进行色谱分离，用氯仿甲醇混合物洗脱; 并将含有scopoletin的级分结晶，得到纯的scopoletin化合物。

公开(公告)号：US06242257B1

公开(公告)日：2001-06-05

申请号：US08862004

申请日：1997-05-22

Applicant: Rakesh Tuli ,  Alok Kumar Srivastava ,  Shiv Kumar Gupta

Inventor： Rakesh Tuli ,  Alok Kumar Srivastava ,  Shiv Kumar Gupta

IPC: C12N502

CPC classification number: C12N15/8201 ,  A01H4/005 ,  A01H4/008 ,  C12N5/04

Abstract: The present invention relates to a tissue culture process for producing a large number of viable cotton plants in vitro from a specified tissue of cotton plant. The invention provides genotype independent, direct, multiple shoot proliferation and opens up new possibilities for micropropagation, selection of mutants and for producing genetically improved cotton plants by modern methods of agrobiotechnology and genetic engineering. The protocol provides an important step in the success of cotton improvement programmed, utilizing tissue culture technology.

Abstract translation: 本发明涉及从棉花植物的指定组织体外生产大量活的棉花植物的组织培养方法。 本发明提供基因型独立，直接，多枝增生，并通过现代农业生物技术和遗传工程方法开辟了微繁殖，突变体选择和生产遗传改良棉花植物的新可能。 该方案为使用组织培养技术编程的棉花改良成功提供了重要的一步。