公开(公告)号：US08841281B2

公开(公告)日：2014-09-23

申请号：US13653883

申请日：2012-10-17

Applicant: Virginia Tech Intellectual Properties, Inc.

Inventor： Joseph S. Merola

IPC: A61K31/66 ,  C07D207/00

CPC classification number: C07F15/0033 ,  C07F15/0073 ,  C07F17/02

Abstract: The present invention relates to the fields of chemistry and pharmaceuticals. Embodiments of the present invention provide transition metal complexes of amino acids. Transition metal complexes of embodiments of the invention according to Categories I, II, III, and/or IV may be used as antimicrobial, anti-malarial, and anti-cancer agents, as well as catalysts in chemical reactions. Such compounds of the invention are particularly useful for combating multi-drug resistance against a broad range of microbials (such as MRSA and mycobacteria), including gram positive and gram negative bacteria, as well as can be used as anti-cancer agents against bladder cancer, breast cancer, colon cancer, rectal cancer, endometrial cancer, kidney cancer, leukemia, lung cancer, melanoma, non-Hodgkin's lymphoma, pancreatic cancer, prostate cancer, and thyroid cancer, to name a few.

Abstract translation: 本发明涉及化学和药物领域。 本发明的实施方案提供氨基酸的过渡金属络合物。 根据类别I，II，III和/或IV的本发明的实施方案的过渡金属络合物可以用作抗微生物剂，抗疟剂和抗癌剂以及化学反应中的催化剂。 本发明的这些化合物特别可用于抵抗广泛范围的微生物（如MRSA和分枝杆菌）（包括革兰氏阳性菌和革兰氏阴性细菌）的多药耐药性，并且可用作抗膀胱癌的抗癌剂 ，乳腺癌，结肠癌，直肠癌，子宫内膜癌，肾癌，白血病，肺癌，黑素瘤，非霍奇金淋巴瘤，胰腺癌，前列腺癌和甲状腺癌。

公开(公告)号：US20140039489A1

公开(公告)日：2014-02-06

申请号：US14017210

申请日：2013-09-03

Applicant: Virginia Tech Intellectual Properties, Inc.

Inventor： Rafael V. Davalos ,  John H. Rossmeisl ,  Paulo A. Garcia

IPC: A61B18/12 ,  A61B18/14

CPC classification number: A61B18/1206 ,  A61B18/14 ,  A61B18/1477 ,  A61B2018/00446 ,  A61B2018/00577 ,  A61B2018/00613 ,  A61B2034/104 ,  A61N1/05 ,  A61N1/327 ,  C12N13/00

Abstract: A method is provided for ablating brain tissue of a living mammal comprising: placing first and second electrodes in a brain of the living mammal; applying a plurality of electrical pulses through the first and second placed electrodes which are predetermined to: cause irreversible electroporation (IRE) of brain tissue of the mammal within a target ablation zone; and cause a temporary disruption of a blood brain barrier (BBB) within a surrounding zone that surrounds the target ablation zone to allow material in a blood vessel to be transferred to the surrounding zone through the temporarily disrupted BBB. Such methods are useful for delivering large molecule material within a blood vessel of the brain across the BBB, where the large molecule is otherwise blocked by the BBB from passing through the blood vessel into the brain.

Abstract translation: 提供了一种用于消融活体哺乳动物的脑组织的方法，包括：将第一和第二电极放置在活的哺乳动物的脑中; 施加多个电脉冲通过所述第一和第二放置的电极，所述电脉冲预定为：引起所述哺乳动物在靶消融区内的脑组织的不可逆电穿孔（IRE）; 并引起围绕目标消融区域的周围区域内的血脑屏障（BBB）的暂时中断，以允许血管中的物质通过暂时中断的BBB转移到周围区域。 这种方法可用于在大脑血管内的BBB上输送大分子物质，其中大分子另外被BBB阻断以通过血管进入大脑。

公开(公告)号：US20140032148A1

公开(公告)日：2014-01-30

申请号：US13954014

申请日：2013-07-30

Applicant: Virginia Tech Intellectual Properties, Inc. ,  Huntington Ingalls, Inc.

Inventor： Jacob Verhulst ,  Mohamed Belkhayat ,  Zhiyu Shen ,  Marko Jaksic ,  Paolo Mattavelli ,  Dushan Boroyevich

IPC: G01R27/16

CPC classification number: G01R29/26 ,  G01R27/02 ,  G01R27/16

Abstract: A method for impedance measurement in a three-phase AC system is provided. The method includes injecting a shunt perturbation signal into the three-phase AC system and collecting a response to the shunt perturbation signal, and injecting a series perturbation signal into the three-phase AC system and collecting a response to the series perturbation signal. The response to the shunt perturbation signal and the response to the series perturbation signal are then transferred from abc coordinate to dq coordinates. At least one impedance of the three-phase AC system is calculated based on the response to the shunt perturbation signal and the response to the series perturbation signal.

Abstract translation: 提供了一种三相交流系统中的阻抗测量方法。 该方法包括将分流扰动信号注入到三相交流系统中并收集对分流扰动信号的响应，并将一系列扰动信号注入到三相交流系统中并收集对串联扰动信号的响应。 对分流扰动信号的响应和对串联扰动信号的响应然后从abc坐标传递到dq坐标。 基于对分流扰动信号的响应和对串联扰动信号的响应，计算三相AC系统的至少一个阻抗。

公开(公告)号：US20130178614A1

公开(公告)日：2013-07-11

申请号：US13661028

申请日：2012-10-25

Applicant: Virginia Tech Intellectual Properties, Inc.

Inventor： Kevin Edgar ,  Daiqiang Xu ,  Xueyan Zheng

IPC: C08B3/24 ,  C08B3/06 ,  C08B3/08

CPC classification number: C08B3/24 ,  C08B3/00 ,  C08B3/06 ,  C08B3/08 ,  C08B3/16 ,  C08J5/18 ,  C08J2301/10 ,  C08L1/10

Abstract: Embodiments of the invention provide regioselectively substituted carbohydrate and polysaccharide derivatives, such as cellulose esters, and methods for preparing them. Particular methods of the invention include deacylation of esters using tetrabutylammonium fluoride to obtain selective substitution at desired hydroxyl position(s) of the ester. Preferred is deacylation of an ester, which shows selectivity for removal of acyl groups from the ester of the secondary alcohols at C-2 and C-3, and which affords cellulose-6-O-esters with high regioselectivity by a simple one-step process employing no protective groups. Inventive regioselectively substituted cellulose esters can be prepared by such methods to obtain esters with the following anhydroglucose repeating units: wherein R1, R2, and R3 are each independently chosen from a hydrogen atom, and, whether substituted or unsubstituted, branched or unbranched, an alkanoyl group, an aroyl group, and a heteroaroyl group. In embodiments, the alkanoyl, aroyl and heteroaroyl groups can comprise from 1-20 carbon atoms.

公开(公告)号：US20030170270A1

公开(公告)日：2003-09-11

申请号：US10314512

申请日：2002-12-09

Applicant: Virginia Tech Intellectual Properties, Inc.

Inventor： Xiang-Jin Meng ,  Martijn Fenaux ,  Patrick G. Halbur

IPC: C12P021/06 ,  A61K048/00 ,  A01N063/00 ,  A61K039/12 ,  C12N015/00 ,  C12N015/09 ,  C12N015/63 ,  C12N015/70 ,  C12N015/74

CPC classification number: C07K14/005 ,  A61K2039/5254 ,  A61K2039/5256 ,  A61K2039/53 ,  C12N7/00 ,  C12N2750/10022 ,  C12N2750/10034 ,  C12N2750/10061

Abstract: The present invention relates to infectious DNA clones, infectious chimeric DNA clones of porcine circovirus (PCV), vaccines and means of protecting pigs against viral infection or postweaning multisystemic wasting syndrome (PMWS) caused by PCV2. The new chimeric infectious DNA clone and its derived, avirulent chimeric virus are constructed from the nonpathogenic PCV1 in which the immunogenic ORF gene of the pathogenic PCV2 replaces a gene of the nonpathogenic PCV1, preferably in the same position. The chimeric virus advantageously retains the nonpathogenic phenotype of PCV1 but elicits specific immune responses against the pathogenic PCV2. The invention further embraces the immunogenic polypeptide expression products.

Abstract translation: 本发明涉及感染性DNA克隆，猪圆环病毒感染性嵌合DNA克隆（PCV），疫苗和保护猪免受病毒感染或PCV2引起的断奶后多系统消耗综合征（PMWS）的方法。 新的嵌合感染性DNA克隆及其衍生的无毒性嵌合病毒由非致病性PCV1构建，其中病原性PCV2的免疫原性ORF基因替代非致病性PCV1的基因，优选在相同的位置。 嵌合病毒有利地保留了PCV1的非病原性表型，但引发针对致病性PCV2的特异性免疫应答。 本发明还包括免疫原性多肽表达产物。

公开(公告)号：US20020058779A1

公开(公告)日：2002-05-16

申请号：US09887979

申请日：2001-06-22

Applicant: Johnson & Johnson Vision Products, Inc., and Virginia Tech Intellectual Properties, Inc.

Inventor： Hosadurga K. Shobha ,  Venkat Sekharipuram ,  James E. McGrath ,  Atul Bhatnagar

IPC: C08G079/02

CPC classification number: C08G79/04

Abstract: High refractive index, melt processable polyphosphonates and methods for preparing the same are provided. These polymers are particularly useful for optical and ophthalmic parts, such as lenses. A method of preparing optical and ophthalmic lenses by injection molding the polymers of the present invention into the form of the optical or ophthalmic lenses is also provided.

Abstract translation: 提供高折射率，可熔融加工的聚膦酸盐及其制备方法。 这些聚合物特别适用于光学和眼科部件，例如透镜。 还提供了通过将本发明的聚合物注射成光学或眼科镜片的形式来制备光学和眼科镜片的方法。

公开(公告)号：US12293297B2

公开(公告)日：2025-05-06

申请号：US18135259

申请日：2023-04-17

Applicant: Virginia Tech Intellectual Properties, Inc.

Inventor： Timothy James O'Shea

IPC: G06N3/086 ,  G06N3/045 ,  G06N3/08 ,  G06N20/00 ,  H04B17/30 ,  H04W24/08

Abstract: Methods, systems, and apparatus, including computer programs encoded on computer storage media, for training and deploying machine-learned compact representations of radio frequency (RF) signals. One of the methods includes: determining a first RF signal to be compressed; using an encoder machine-learning network to process the first RF signal and generate a compressed signal; calculating a measure of compression in the compressed signal; using a decoder machine-learning network to process the compressed signal and generate a second RF signal that represents a reconstruction of the first RF signal; calculating a measure of distance between the second RF signal and the first RF signal; and updating at least one of the encoder machine-learning network or the decoder machine-learning network based on (i) the measure of distance between the second RF signal and the first RF signal, and (ii) the measure of compression in the compressed signal.

公开(公告)号：US12285910B2

公开(公告)日：2025-04-29

申请号：US16954124

申请日：2018-12-15

Applicant: Virginia Tech Intellectual Properties, Inc.

Inventor： Nicholas Chartrain ,  Viswanath Meenakshisundaram ,  Christopher B. Williams

IPC: B29C64/255 ,  B29C64/124 ,  B29C64/135 ,  B29C64/209 ,  B29C64/245 ,  B29C64/264 ,  B29C64/295 ,  B33Y10/00 ,  B33Y30/00 ,  B33Y70/00 ,  C08F120/68 ,  C08F283/00 ,  C08F283/06 ,  C08L5/00 ,  B29K33/00 ,  B29K75/00 ,  B29K105/00 ,  B29L31/52

Abstract: In various aspects, top-down stereolithography apparatus and methods of use thereof are provided herein that allow for additive manufacturing of an article from a high-viscosity resin. The apparatus and methods can print resins having viscosities higher than conventional systems, e.g. viscosities up to about 100 Pa·s at the elevated temperature. The resin may have a room temperature viscosity of about 100 Pa·s, about 250 Pa·s, about 1000 Pa·s, or more. In some aspects, the resin is a solid at room temperature. The apparatus and methods do not rely upon solvents or other viscosity modifiers being added to the resin, and are capable of top-down additive manufacturing approaches which provide reduced stress on the printed article.

公开(公告)号：US20250126834A1

公开(公告)日：2025-04-17

申请号：US18486880

申请日：2023-10-13

Applicant: Virginia Tech Intellectual Properties, Inc.

Inventor： Yuhao Zhang ,  Yuan Qin

IPC: H01L29/78 ,  H01L29/20 ,  H01L29/808 ,  H01L29/861

Abstract: A device may include a substrate. A device may include a first semiconductor region of a first conductivity type having a first doping concentration, the first semiconductor region including a base surface, a buffer region positioned between the substrate and the first semiconductor region. A device may include a second semiconductor region of the first conductivity type and having a second doping concentration that is less than the first doping concentration, the second semiconductor region positioned over the base surface of the first semiconductor region. A device may include at least one first device terminal positioned over the base surface of the first semiconductor region. A device may include a third semiconductor region of a second conductivity type disposed over at least one sidewall of the second semiconductor region.

公开(公告)号：US12269744B2

公开(公告)日：2025-04-08

申请号：US17415445

申请日：2019-12-17

Applicant: VIRGINIA TECH INTELLECTUAL PROPERTIES, INC.

Inventor： Roop L. Mahajan ,  Seul-Yi Lee

IPC: C01B32/198 ,  B01J19/14 ,  C01B32/194 ,  C01B32/196

Abstract: Methods of making graphene oxide and reduced graphene oxide are provided. The methods can include a simple one-pot synthesis of graphene oxide from a purified coal powder using a mild oxidizing acid. The methods provide for an improved, more cost-effective, and simpler process than conventional methods such as Hummers methods. In some aspects, placing the purified coal powder in the mild oxidation atmosphere includes contacting the purified coal powder with a mild oxidizing acid such as nitric acid, nitrous acid, sulfuric acid, phosphoric acid, benzoic acid, or a combination thereof. In some aspects, the mild oxidizing acid consists essentially of nitric acid. Graphene oxides and reduced graphene oxides prepared by the methods are also provided.