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    AUTOMATED MACULAR PATHOLOGY DIAGNOSIS IN THREEDIMENSIONAL (3D) SPECTRAL DOMAIN OPTICAL COHERENCE TOMOGRAPHY (SD-OCT) IMAGES
    114.
    发明申请
    AUTOMATED MACULAR PATHOLOGY DIAGNOSIS IN THREEDIMENSIONAL (3D) SPECTRAL DOMAIN OPTICAL COHERENCE TOMOGRAPHY (SD-OCT) IMAGES 失效
    自动化宏观病理学诊断（3D）光谱域光学相干图像（SD-OCT）图像

    公开(公告)号：US20120184845A1

    公开(公告)日：2012-07-19

    申请号：US13294601

    申请日：2011-11-11

    申请人： Hiroshi Ishikawa ,  Gadi Wollstein ,  Joel S. Schuman ,  Yu-Ying Liu ,  James M. Rehg ,  Mei Chen

    发明人： Hiroshi Ishikawa ,  Gadi Wollstein ,  Joel S. Schuman ,  Yu-Ying Liu ,  James M. Rehg ,  Mei Chen

    IPC分类号： A61B3/14 ,  G06K9/00

    CPC分类号： A61B3/102 ,  G06K9/4642 ,  G06K2009/4666

    摘要： Systems and methods of analyzing an optical coherence tomography image of a retina are discussed. A 2-dimensional slice of the image can be aligned to produce an approximately horizontal image of the retina and an edge map based at least in part on the aligned slice. Also, at least one global representation can be determined based on a (multi-scale) spatial division, such as multi-scale spatial pyramid, on the slice and/or edge map. Creating the local features is based on the specified cell structure of the global representation. The local features can be constructed based on local binary pattern (LBP)-based features. Additionally, a slice can be categorized into one or more categories via one or more classifiers (e.g., support vector machines). Each category can be associated with at least one ocular pathology, and classifying can be based on the constructed global descriptors, which can include the LBP-based local descriptors.

    摘要翻译： 讨论了分析视网膜的光学相干断层图像的系统和方法。 图像的二维切片可以被对准以至少部分地基于对齐的切片来产生视网膜的近似水平的图像和边缘图。 此外，可以基于切片和/或边缘图上的（多尺度）空间划分（例如多尺度空间金字塔）来确定至少一个全局表示。 创建局部特征是基于全局表示的指定单元格结构。 可以基于局部二进制模式（LBP）的特征构建局部特征。 此外，切片可以经由一个或多个分类器（例如，支持向量机）被分类为一个或多个类别。 每个类别可以与至少一个眼部病理学相关联，并且分类可以基于构建的全局描述符，其可以包括基于LBP的局部描述符。

    METHODS FOR FORMING TOOTH ROOT AND PERIODONTAL TISSUE UNIT, AND REGENERATED TOOTH
    115.
    发明申请
    METHODS FOR FORMING TOOTH ROOT AND PERIODONTAL TISSUE UNIT, AND REGENERATED TOOTH 有权
    形成牙根和周围组织的方法和再生牙

    公开(公告)号：US20110212418A1

    公开(公告)日：2011-09-01

    申请号：US13040672

    申请日：2011-03-04

    申请人： Taka Nakahara ,  Hiroshi Ishikawa ,  Soh Sato ,  Masato Ohta

    发明人： Taka Nakahara ,  Hiroshi Ishikawa ,  Soh Sato ,  Masato Ohta

    IPC分类号： A61C8/00 ,  C12N5/071

    CPC分类号： A61L27/3604 ,  A61L27/3804 ,  A61L27/3865

    摘要： A method for forming at least a tooth root in a tooth containing a tooth crown, including: forming a culture core containing the tooth and a cell-containing base material, the tooth being wrapped with the cell-containing base material, and culturing the culture core in a medium to form at least the tooth root in the tooth contained therein, wherein the cell-containing base material contains at least one kind of cells selected from periodontal ligament-derived cells, bone marrow-derived cells, dental follicle-derived cells, dental pulp-derived cells and dental papilla-derived cells, and the medium contains a component contained in a conditioned medium of a serum-free-cultured cell line of a human uterocervical squamous carcinoma cell line; an additive containing at least one selected from IL-1β, IL-6, IL-8, IL-9, EGF, IGF-I, GH, PDGF-AB, VEGF, LIF, HGF, FGF-2, FGF-1, BMP-2, BMP-4, M-CSF, dexamethasone, insulin, thyroxine, thyrocalcitonin, ascorbic acid and β-glycerophosphate; or both of them.

    摘要翻译： 一种在含有牙冠的牙齿中至少形成齿根的方法，包括：形成含有牙齿的培养核和含细胞的基材，所述牙齿用含细胞的基材包裹，并培养培养物 在培养基中形成至少在其中含有的牙齿中的牙根，其中所述含细胞的基质材料含有选自牙周韧带衍生的细胞，骨髓来源的细胞，来自牙囊的细胞中的至少一种细胞 牙髓源细胞和来自乳头乳头的细胞，培养基含有人子宫颈鳞状细胞癌细胞系的无血清培养细胞系的条件培养基中所含的成分， 含有选自IL-1和bgr，IL-6，IL-8，IL-9，EGF，IGF-1，GH，PDGF-AB，VEGF，LIF，HGF，FGF-2，FGF-1中的至少一种的添加剂 ，BMP-2，BMP-4，M-CSF，地塞米松，胰岛素，甲状腺素，降钙素原，抗坏血酸和甘油磷酸酯; 或者他们两个。

    ESTABLISHING COMPATIBILITY BETWEEN TWO- AND THREE-DIMENSIONAL OPTICAL COHERENCE TOMOGRAPHY SCANS
    116.
    发明申请
    ESTABLISHING COMPATIBILITY BETWEEN TWO- AND THREE-DIMENSIONAL OPTICAL COHERENCE TOMOGRAPHY SCANS 有权
    建立两维和三维光学相干扫描仪之间的兼容性

    公开(公告)号：US20110176716A1

    公开(公告)日：2011-07-21

    申请号：US13056510

    申请日：2009-08-06

    申请人： Jong S. Kim ,  Hiroshi Ishikawa ,  Joel S. Schuman ,  Gadi Wollstein

    发明人： Jong S. Kim ,  Hiroshi Ishikawa ,  Joel S. Schuman ,  Gadi Wollstein

    IPC分类号： G06K9/00

    CPC分类号： G06T3/0075 ,  A61B3/102

    摘要： Advances in optical coherence tomography (OCT) have prompted a transition from time domain OCT, providing 2D OCT images, to spectral domain OCT, which has a 3D imaging capability. Yet conventional technology offers little toward the goal of inter-device compatibility between extant 2D OCT images and newer 3D OCT images for the same or comparable subjects, as in the context of ongoing monitoring the quantitative status of a patient's eyes. The inventive methodology is particularly useful to identify the scan location of tissue in a 2D OCT image within the 3D volumetric data, thereby allowing clinicians to image a patient via 3D OCT, based on available 2D OCT images, with minimal inter-device variation.

    摘要翻译： 光学相干断层扫描（OCT）的进展促使从具有3D成像能力的光谱域OCT向时域OCT提供2D OCT图像的转变。 然而，传统技术对于相同或可比较的对象的现有2D OCT图像和较新的3D OCT图像之间的设备间兼容性的目标几乎没有提供，如在持续监测患者眼睛的定量状态的情况下。 本发明的方法对于识别3D体积数据内的2D OCT图像中的组织的扫描位置特别有用，由此允许临床医生通过3D OCT基于可用的2D OCT图像以最小的装置间变化来对患者进行图像化。

    System simulation using multi-tasking computer code
    119.
    发明授权
    System simulation using multi-tasking computer code 有权
    使用多任务计算机代码进行系统仿真

    公开(公告)号：US07747426B2

    公开(公告)日：2010-06-29

    申请号：US11292775

    申请日：2005-12-02

    申请人： Hiroaki Nakamura ,  Naoto Sato ,  Naoshi Tabuchi ,  Hiroshi Ishikawa

    发明人： Hiroaki Nakamura ,  Naoto Sato ,  Naoshi Tabuchi ,  Hiroshi Ishikawa

    IPC分类号： G06F17/50

    CPC分类号： G06F17/5022 ,  G06F9/4843

    摘要： A system, such as hardware or software system having a number of modules, is simulated using multi-tasking computer code. Simulation computer code launches tasks simulating system execution, where each task corresponds to a module. Each task requests a processing delay to a common scheduler. Upon the common scheduler receiving a processing delay request, the common scheduler instructs a scheduling method processor to update a task-remaining time for at least one task. The scheduling method processor updates the task-remaining time for at least one task based at least on a scheduling approach. The common scheduler sends a wait request to a preexisting simulation system to delay a module that corresponds to the task by a length of time, based on the task-remaining time for the task and the scheduling approach. The preexisting simulation system delays the module that corresponds to the task by the length of time of the wait request.

    摘要翻译： 使用多任务计算机代码来模拟诸如具有多个模块的硬件或软件系统的系统。 模拟计算机代码启动模拟系统执行的任务，其中每个任务对应于一个模块。 每个任务向公共调度程序请求处理延迟。 在公共调度器接收到处理延迟请求时，公共调度器指示调度方法处理器更新至少一个任务的任务剩余时间。 调度方法处理器至少基于调度方法来更新至少一个任务的任务剩余时间。 公共调度器根据任务剩余时间和调度方式，向预先存在的模拟系统发送等待请求，以将与任务相对应的模块延迟一段时间。 预先存在的模拟系统将与任务相对应的模块延迟等待请求的时间长度。

    Optical waveguide-type wavelength domain switch
    120.
    发明申请
    Optical waveguide-type wavelength domain switch 有权
    光波导型波长域开关

    公开(公告)号：US20100067900A1

    公开(公告)日：2010-03-18

    申请号：US12585516

    申请日：2009-09-16

    申请人： Hiroshi Ishikawa ,  Toshifumi Hasama ,  Hitoshi Kawashima ,  Kenji Kintaka ,  Masahiko Mori ,  Hisato Uetsuka ,  Hiroyuki Tsuda ,  Keisuke Sorimoto

    发明人： Hiroshi Ishikawa ,  Toshifumi Hasama ,  Hitoshi Kawashima ,  Kenji Kintaka ,  Masahiko Mori ,  Hisato Uetsuka ,  Hiroyuki Tsuda ,  Keisuke Sorimoto

    IPC分类号： G02F2/00 ,  H04J14/00

    CPC分类号： G02F1/31 ,  G02B6/12014 ,  G02B6/12016 ,  G02B6/12021 ,  G02B6/2713 ,  G02B6/2793 ,  G02B6/30 ,  G02B6/3548 ,  G02B6/356 ,  G02F2203/58 ,  G02F2203/585

    摘要： An optical waveguide-type wavelength domain switch includes a waveguide-type multi/demultiplexing device laminate comprising three or more laminated waveguide-type multi/demultiplexing devices, a lens system positioned on a demultiplex side of the waveguide-type multi/demultiplexing device laminate, and a reflective optical phase-modulating cell positioned on an opposite side of the waveguide-type multi/demultiplexing device laminate to the lens system. The lens system includes a lens alignment composed of plural lenses in one-to-one correspondence with the waveguide-type multi/demultiplexing devices and having a light-collecting or collimating function in the lens-aligning direction, an image-magnifying optical system having an N:1 (N>1) image-magnifying function arranged on the optical phase-modulating cell side of the lens alignment, an f-f lens (Y) arranged on the optical phase-modulating cell side of the image-magnifying optical system, and having a light-collecting or collimating function in the same direction as the lens-aligning direction of the lens alignment, and an f-f lens (X) having a light-collecting or collimating function in a perpendicular direction to the lens-aligning direction of the lens alignment.

    摘要翻译： 光波导型波长域开关包括：波导型多路解复用器件层叠体，其包含三个或更多个层叠波导型多路解复用器件，位于波导型多路解复用器件层叠体的解复用侧的透镜系统， 以及反射光学相位调制单元，其位于与所述透镜系统的所述波导型多路解复用器件层叠体的相反侧。 透镜系统包括由多个透镜组成的透镜对准，与波导型多路/多路分离装置一一对应，并且在透镜对准方向上具有聚光或准直功能，图像放大光学系统具有 配置在透镜对准的光学相位调制单元侧的N：1（N> 1）图像放大功能，配置在图像放大光学系统的光学相位调制单元侧的ff透镜（Y） 并且在与透镜对准方向的透镜对准方向相同的方向上具有聚光或准直功能，以及在与透镜对准方向垂直的方向上具有聚光或准直功能的ff透镜（X） 镜头对准。