公开(公告)号：US09682254B2

公开(公告)日：2017-06-20

申请号：US14216788

申请日：2014-03-17

Applicant: Vladimir Balakin ,  Pavel Balakin

Inventor： Vladimir Balakin ,  Pavel Balakin

IPC: A61N5/10 ,  H01J37/141 ,  G21K1/093 ,  G21K5/04

CPC classification number: A61N5/1082 ,  A61N5/1044 ,  A61N5/1067 ,  A61N5/107 ,  A61N5/1077 ,  A61N5/1081 ,  A61N2005/1087 ,  A61N2005/1097 ,  G21K1/093 ,  G21K5/04 ,  H01J37/141 ,  H01J2237/0815 ,  H05H2007/007

Abstract: The invention comprises a charged particle cancer therapy system used to seal a periphery of a tumor, such as through use of a proton or carbon ion beam searing the outer edges of the tumor, which prevents/hinders nutrient delivery to the tumor resultant in stunted growth of the tumor, halted growth of the tumor, and/or starvation/necrosis of the tumor. Optionally, a tumor sealing layer is formed using multiple passes, of a treatment beam of the charged particle cancer therapy system, across a tumor/healthy tissue boundary layer or voxel.

公开(公告)号：US09649510B2

公开(公告)日：2017-05-16

申请号：US15228514

申请日：2016-08-04

Applicant: Vladimir Balakin

Inventor： Vladimir Balakin

IPC: A61N5/10 ,  H05H13/04 ,  H05H7/00 ,  H05H7/08 ,  H05H7/12 ,  H05H7/10

CPC classification number: A61N5/1077 ,  A61N5/1037 ,  A61N5/1043 ,  A61N5/1067 ,  A61N5/1068 ,  A61N5/107 ,  A61N2005/1059 ,  A61N2005/1061 ,  A61N2005/1074 ,  A61N2005/1087 ,  A61N2005/1097 ,  H05H7/001 ,  H05H7/08 ,  H05H7/10 ,  H05H7/12 ,  H05H13/04 ,  H05H2007/082 ,  H05H2007/087 ,  H05H2007/125

Abstract: The invention comprises a multi-axis charged particle irradiation method and apparatus. The multi-axis controls includes separate or independent control of one or more of horizontal position, vertical position, energy control, and intensity control of the charged particle irradiation beam. Optionally, the charged particle beam is additionally controlled in terms of timing. Timing is coordinated with patient respiration and/or patient rotational positioning. Combined, the system allows multi-axis and multi-field charged particle irradiation of tumors yielding precise and accurate irradiation dosages to a tumor with distribution of harmful proximal distal energy about the tumor.

公开(公告)号：US20170087381A1

公开(公告)日：2017-03-30

申请号：US15232512

申请日：2016-08-09

Applicant: Vladimir Balakin

Inventor： Vladimir Balakin

IPC: A61N5/10

CPC classification number: A61N5/10 ,  A61N5/1069 ,  A61N5/107 ,  A61N5/1077 ,  A61N5/1082 ,  A61N2005/1087 ,  A61N2005/1097

Abstract: A patient positioning/constraint apparatus and method of use thereof is described in combination with a charged particle cancer therapy system. In one embodiment, a patient is tilted about a longitudinal axis, such as rotation about a head-to-foot axis of the patient where the head-to-foot axis of the patient is horizontal. Optional side support constraints are optionally used to constrain radial movement of the patient on the tilted patient support. The side support constraints are optionally pre-formed to or coupled to a radially outer shape of an individual patient, such as the dexter or sinister side of the individual's head, arm, torso, hip, and/or leg. Patient tilt is optionally combined with rotation of the patient about a vertical axis, rotation of the entire patient about an axis not overlapped by the patient, and/or dynamic control of angles of incident charged particles directed by beamline magnets of the charged particle therapy system.

公开(公告)号：US09579525B2

公开(公告)日：2017-02-28

申请号：US14493322

申请日：2014-09-22

Applicant: Vladimir Balakin

Inventor： Vladimir Balakin

IPC: A61N5/10 ,  H05H7/08 ,  H05H13/04

CPC classification number: A61N5/1077 ,  A61N5/1037 ,  A61N5/1043 ,  A61N5/1067 ,  A61N5/1068 ,  A61N5/107 ,  A61N2005/1059 ,  A61N2005/1061 ,  A61N2005/1074 ,  A61N2005/1087 ,  A61N2005/1097 ,  H05H7/001 ,  H05H7/08 ,  H05H7/10 ,  H05H7/12 ,  H05H13/04 ,  H05H2007/082 ,  H05H2007/087 ,  H05H2007/125

Abstract: The invention comprises a multi-axis charged particle irradiation method and apparatus. The multi-axis controls includes separate or independent control of one or more of horizontal position, vertical position, energy control, and intensity control of the charged particle irradiation beam. Optionally, the charged particle beam is additionally controlled in terms of timing. Timing is coordinated with patient respiration and/or patient rotational positioning. Combined, the system allows multi-axis and multi-field charged particle irradiation of tumors yielding precise and accurate irradiation dosages to a tumor with distribution of harmful proximal distal energy about the tumor.

Abstract translation: 本发明包括多轴带电粒子照射方法和装置。 多轴控制包括对带电粒子照射束的水平位置，垂直位置，能量控制和强度控制中的一个或多个的单独或独立的控制。 可选地，带电粒子束根据定时被附加地控制。 时间与患者呼吸和/或患者旋转定位相协调。 综合起来，该系统允许肿瘤的多轴和多场带电粒子照射产生精确和准确的辐照剂量，使肿瘤附近有害的近端远端能量分布。

公开(公告)号：US20170043182A1

公开(公告)日：2017-02-16

申请号：US15157263

申请日：2016-05-17

Applicant: Vladimir Balakin

Inventor： Vladimir Balakin

IPC: A61N5/10 ,  A61B6/00 ,  A61B6/02

CPC classification number: A61N5/1039 ,  A61B6/025 ,  A61B6/03 ,  A61B6/4028 ,  A61B6/4216 ,  A61B6/4258 ,  A61B6/5205 ,  A61N5/1044 ,  A61N5/1047 ,  A61N5/1067 ,  A61N5/107 ,  A61N5/1071 ,  A61N5/1075 ,  A61N5/1077 ,  A61N5/1081 ,  A61N5/1082 ,  A61N2005/1074 ,  A61N2005/1087 ,  A61N2005/1097 ,  G21K1/087 ,  G21K1/093 ,  G21K5/04

Abstract: The invention relates to a method and apparatus of control and/or determination of energy and/or velocity of a beam of a charged particles extracted from a synchrotron, the synchrotron using a radio frequency field to redirect the charged particles through an extraction material. The method and apparatus for extracting a group of charged particles at a known and controlled energy is optionally used in conjunction with any apparatus and/or technique coupled to a synchrotron, such as a charged particle cancer therapy system. For example, the knowledge/control of the charged particle beam delivery energy is used in conjunction with a multi-axes and/or a multi-field tumor irradiation system in combination with a tumor treatment plan to accurately ablate or irradiate a tumor.

Abstract translation: 本发明涉及一种用于控制和/或确定从同步加速器提取的带电粒子的能量和/或速度的方法和装置，所述同步加速器使用射频场将带电粒子重新引导通过提取材料。 用于以已知和受控能量提取一组带电粒子的方法和装置任选地与耦合到同步加速器（例如带电粒子癌症治疗系统）的任何装置和/或技术结合使用。 例如，带电粒子束输送能量的知识/控制与多轴和/或多场肿瘤辐射系统结合使用以准确地烧蚀或照射肿瘤的肿瘤治疗计划结合使用。

公开(公告)号：US09155911B1

公开(公告)日：2015-10-13

申请号：US14223604

申请日：2014-03-24

Applicant: Vladimir Balakin

Inventor： Vladimir Balakin

IPC: H01J21/18 ,  A61N5/10

CPC classification number: A61N5/1082 ,  A61N5/1044 ,  A61N5/1067 ,  A61N5/107 ,  A61N5/1077 ,  A61N5/1081 ,  A61N2005/1087 ,  A61N2005/1097 ,  G21K1/093 ,  G21K5/04 ,  H01J37/141 ,  H01J2237/0815 ,  H05H2007/007 ,  H05H2007/082

Abstract: As part of a charged particle cancer therapy system, a negative ion source is used to generate and accelerate an anion, such a C−, and to convert the anion to a cation, such as C6+, through use of one or more electron extraction subsystems. Initially, an electric field is pulsed across a magnetic field to generate the C− anion. Subsequent to extraction of the C− anion from a plasma region using pulsed electrodes, one or both of a hydrogen gas electron stripping system and a carbon foil electron stripping system converts the carbon anion into the cation. The resultant cation is accelerated in a synchrotron, transported along a beam-line, and targeted to a tumor resulting in ablation of the tumor.

Abstract translation: 作为带电粒子癌治疗系统的一部分，使用负离子源来产生和加速阴离子，例如C-，并通过使用一个或多个电子提取子系统将阴离子转化成阳离子，例如C6 + 。 最初，电场通过磁场脉冲产生C-阴离子。 在使用脉冲电极从等离子体区域中提取C-阴离子之后，氢气电子剥离系统和碳箔电子剥离系统中的一个或两个将碳阴离子转化为阳离子。 所得阳离子在同步加速器中加速，沿着束线传输，并靶向肿瘤，导致肿瘤的消融。

公开(公告)号：US20150265854A1

公开(公告)日：2015-09-24

申请号：US14223604

申请日：2014-03-24

Applicant: Vladimir Balakin

Inventor： Vladimir Balakin

IPC: A61N5/10

CPC classification number: A61N5/1082 ,  A61N5/1044 ,  A61N5/1067 ,  A61N5/107 ,  A61N5/1077 ,  A61N5/1081 ,  A61N2005/1087 ,  A61N2005/1097 ,  G21K1/093 ,  G21K5/04 ,  H01J37/141 ,  H01J2237/0815 ,  H05H2007/007 ,  H05H2007/082

Abstract: As part of a charged particle cancer therapy system, a negative ion source is used to generate and accelerate an anion, such a C−, and to convert the anion to a cation, such as C6+, through use of one or more electron extraction subsystems. Initially, an electric field is pulsed across a magnetic field to generate the C− anion. Subsequent to extraction of the C− anion from a plasma region using pulsed electrodes, one or both of a hydrogen gas electron stripping system and a carbon foil electron stripping system converts the carbon anion into the cation. The resultant cation is accelerated in a synchrotron, transported along a beam-line, and targeted to a tumor resulting in ablation of the tumor.

Abstract translation: 作为带电粒子癌治疗系统的一部分，使用负离子源来产生和加速阴离子，例如C-，并通过使用一个或多个电子提取子系统将阴离子转化成阳离子，例如C 6+ 。 最初，电场通过磁场脉冲产生C-阴离子。 在使用脉冲电极从等离子体区域中提取C-阴离子之后，氢气电子剥离系统和碳箔电子剥离系统中的一个或两个将碳阴离子转化为阳离子。 所得阳离子在同步加速器中加速，沿着束线传输，并靶向肿瘤，导致肿瘤的消融。

公开(公告)号：US20150258350A1

公开(公告)日：2015-09-17

申请号：US14216788

申请日：2014-03-17

Applicant: Vladimir Balakin ,  Pavel Balakin

Inventor： Vladimir Balakin ,  Pavel Balakin

IPC: A61N5/10

CPC classification number: A61N5/1082 ,  A61N5/1044 ,  A61N5/1067 ,  A61N5/107 ,  A61N5/1077 ,  A61N5/1081 ,  A61N2005/1087 ,  A61N2005/1097 ,  G21K1/093 ,  G21K5/04 ,  H01J37/141 ,  H01J2237/0815 ,  H05H2007/007

Abstract: The invention comprises a charged particle cancer therapy system used to seal a periphery of a tumor, such as through use of a proton or carbon ion beam searing the outer edges of the tumor, which prevents/hinders nutrient delivery to the tumor resultant in stunted growth of the tumor, halted growth of the tumor, and/or starvation/necrosis of the tumor. Optionally, a tumor sealing layer is formed using multiple passes, of a treatment beam of the charged particle cancer therapy system, across a tumor/healthy tissue boundary layer or voxel.

Abstract translation: 本发明包括用于密封肿瘤周边的带电粒子癌症治疗系统，例如通过使用灼伤肿瘤外缘的质子或碳离子束来阻止/阻碍营养物向肿瘤产生的发育迟缓的生长 的肿瘤，停止肿瘤的生长和/或肿瘤的饥饿/坏死。 任选地，肿瘤密封层是通过穿过肿瘤/健康组织边界层或体素的多次通过带电粒子癌症治疗系统的治疗束形成的。

公开(公告)号：US20150217140A1

公开(公告)日：2015-08-06

申请号：US14493322

申请日：2014-09-22

Applicant: Vladimir Balakin

Inventor： Vladimir Balakin

IPC: A61N5/10 ,  A61B5/00 ,  A61B5/113

CPC classification number: A61N5/1077 ,  A61N5/1037 ,  A61N5/1043 ,  A61N5/1067 ,  A61N5/1068 ,  A61N5/107 ,  A61N2005/1059 ,  A61N2005/1061 ,  A61N2005/1074 ,  A61N2005/1087 ,  A61N2005/1097 ,  H05H7/001 ,  H05H7/08 ,  H05H7/10 ,  H05H7/12 ,  H05H13/04 ,  H05H2007/082 ,  H05H2007/087 ,  H05H2007/125

Abstract: The invention comprises a multi-axis charged particle irradiation method and apparatus. The multi-axis controls includes separate or independent control of one or more of horizontal position, vertical position, energy control, and intensity control of the charged particle irradiation beam. Optionally, the charged particle beam is additionally controlled in terms of timing. Timing is coordinated with patient respiration and/or patient rotational positioning. Combined, the system allows multi-axis and multi-field charged particle irradiation of tumors yielding precise and accurate irradiation dosages to a tumor with distribution of harmful proximal distal energy about the tumor.

Abstract translation: 本发明包括多轴带电粒子照射方法和装置。 多轴控制包括对带电粒子照射束的水平位置，垂直位置，能量控制和强度控制中的一个或多个的单独或独立的控制。 可选地，带电粒子束根据定时被附加地控制。 时间与患者呼吸和/或患者旋转定位相协调。 综合起来，该系统允许肿瘤的多轴和多场带电粒子照射产生精确和准确的辐照剂量，使肿瘤附近有害的近端远端能量分布。

公开(公告)号：US09095040B2

公开(公告)日：2015-07-28

申请号：US13282135

申请日：2011-10-26

Applicant: Vladimir Balakin

Inventor： Vladimir Balakin

IPC: H01J1/50 ,  H05H13/04 ,  H05H7/10 ,  H05H7/04

CPC classification number: H05H13/04 ,  H05H7/10 ,  H05H2007/045 ,  H05H2277/11

Abstract: The invention comprises a charged particle beam acceleration and optional extraction method and apparatus used in conjunction with charged particle beam radiation therapy of cancerous tumors. Novel design features of a synchrotron are described. Particularly, turning magnets, edge focusing magnets, concentrating magnetic field magnets, and extraction elements are described that minimize the overall size of the synchrotron, provide a tightly controlled proton beam, directly reduce the size of required magnetic fields, directly reduces required operating power, and allow continual acceleration of protons in a synchrotron even during a process of extracting protons from the synchrotron.

Abstract translation: 本发明包括带电粒子束加速度和与癌性肿瘤的带电粒子束放射治疗结合使用的任选的提取方法和装置。 描述了同步加速器的新颖设计特征。 特别地，描述了转子磁体，边缘聚焦磁体，集中磁场磁体和提取元件，其使得同步加速器的总体尺寸最小化，提供严格控制的质子束，直接减小所需磁场的尺寸，直接减少所需的操作功率， 并且即使在从同步加速器提取质子的过程中也允许同步加速器中的质子的持续加速。