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公开(公告)号:US20170196914A1
公开(公告)日:2017-07-13
申请号:US15415745
申请日:2017-01-25
发明人: Gregory McKenzie , Mary-Jane Lombardo McKenzie , David N. Cook , Marin Vulic , Geoffrey von Maltzahn , Brian Goodman , John Grant Aunins , Matthew R. Henn , David Arthur Berry , Jonathan Winkler
IPC分类号: A61K35/742 , A61K45/06 , A61K9/00 , A61K9/48 , A61K35/37
CPC分类号: A61K35/741 , A61K9/0053 , A61K9/48 , A61K9/4816 , A61K35/37 , A61K35/74 , A61K35/742 , A61K35/744 , A61K35/745 , A61K35/747 , A61K45/06 , C12N1/20 , Y02A50/402 , Y02A50/469 , Y02A50/473 , Y02A50/475 , Y02A50/478 , Y02A50/48 , Y02A50/481
摘要: Disclosed herein are therapeutic compositions containing non-pathogenic, germination-competent bacterial spores, for the prevention, control, and treatment of gastrointestinal diseases, disorders and conditions and for general nutritional health.
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公开(公告)号:US09682171B2
公开(公告)日:2017-06-20
申请号:US14833354
申请日:2015-08-24
发明人: Robert G Matheny
IPC分类号: A61F13/00 , A61K35/12 , A61K35/34 , A61L33/00 , A61L27/36 , A61L31/00 , A61L27/38 , A61F2/00 , A61L27/34 , A61F2/02 , A61L27/54 , A61L31/16 , A61L27/50 , A61L31/14 , A61N1/375 , A61L27/22 , A61K35/38 , A61K35/22 , A61F2/24 , A61K38/00 , A61K35/42
CPC分类号: A61L27/3629 , A61F2/0077 , A61F2/02 , A61F2/24 , A61F2002/0086 , A61F2210/0076 , A61K35/12 , A61K35/22 , A61K35/37 , A61K35/38 , A61K35/42 , A61K38/005 , A61K38/1825 , A61L27/227 , A61L27/34 , A61L27/3604 , A61L27/362 , A61L27/3625 , A61L27/3633 , A61L27/3679 , A61L27/3683 , A61L27/38 , A61L27/3804 , A61L27/3834 , A61L27/50 , A61L27/54 , A61L31/005 , A61L31/041 , A61L31/14 , A61L31/16 , A61L2300/20 , A61L2300/23 , A61L2300/25 , A61L2300/252 , A61L2300/40 , A61L2300/404 , A61L2300/406 , A61L2300/41 , A61L2300/412 , A61L2300/414 , A61L2300/418 , A61L2300/434 , A61L2300/45 , A61L2300/64 , A61L2400/02 , A61L2400/12 , A61L2400/18 , A61L2430/20 , A61N1/375 , A61N1/3752
摘要: A bioremodelable encasement structure comprising a pouch formed from at least one sheet of bioremodelable material, the pouch including an internal region that is configured to receive a device therein, the bioremodelable material comprising mesothelial tissue.
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公开(公告)号:US09682108B2
公开(公告)日:2017-06-20
申请号:US15260207
申请日:2016-09-08
申请人: Crestovo LLC
发明人: Thomas Julius Borody
IPC分类号: A01N63/00 , A01N65/00 , A61K39/08 , A61K35/742 , A61K35/74 , A61K38/48 , A61K35/741 , A61K35/744 , A61K35/747 , A61K36/062 , A61K45/06 , A61K38/14 , A61K31/341 , A61K31/41 , A61K31/495 , A61K31/7034 , A23L2/52 , A61K35/745 , A61K35/38 , A61K35/24 , A61K9/00 , A23C9/123 , A61K9/48 , A23C9/13 , A23L33/135 , A23C9/127 , A61K9/19 , A61K35/37 , A61K31/545 , A61K39/00 , A61K35/76 , A61K31/43 , A61K38/00 , A61K31/7048 , A61K9/50 , A61K39/39 , A61K51/12 , A61K35/00
CPC分类号: A61K35/742 , A23C9/123 , A23C9/127 , A23C9/13 , A23L2/52 , A23L33/135 , A23V2002/00 , A61K9/0031 , A61K9/0053 , A61K9/19 , A61K9/48 , A61K9/4891 , A61K9/50 , A61K9/5005 , A61K9/5078 , A61K31/341 , A61K31/41 , A61K31/43 , A61K31/495 , A61K31/545 , A61K31/7034 , A61K31/7048 , A61K35/24 , A61K35/37 , A61K35/38 , A61K35/74 , A61K35/741 , A61K35/744 , A61K35/745 , A61K35/747 , A61K35/76 , A61K36/062 , A61K38/00 , A61K38/14 , A61K38/4893 , A61K39/00 , A61K39/39 , A61K45/06 , A61K51/1217 , A61K2035/115 , C12N2795/00032 , Y02A50/401 , Y02A50/469 , Y02A50/473 , A61K2300/00
摘要: The present invention relates to pharmaceutical compositions suitable for the treatment of chronic diseases associated with the presence of abnormal or an abnormal distribution of microflora in the gastrointestinal tract of a mammalian host, which compositions comprise viable non-pathogenic or attenuated pathogenic Clostridia. The compositions further comprise one or more additional viable non-pathogenic or attenuated pathogenic microorganisms selected from the group consisting of Bacteroides, Eubacteria, Fusobacteria, Propionibacteria, Lactobacilli, anaerobic cocci, Ruminococcus, E. coli, Gemmiger, Desulfomonas, Peptostreptococcus, and fungi. The present invention also provides pharmaceutical compositions suitable for the treatment of the same chronic diseases comprising viable non-pathogenic or attenuated pathogenic Escherichia coli, at least one strain of viable non-pathogenic or attenuated pathogenic Bacteroides and at least one strain of viable non-pathogenic or attenuated pathogenic microorganism.
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公开(公告)号:US09669133B2
公开(公告)日:2017-06-06
申请号:US14833404
申请日:2015-08-24
发明人: Robert G Matheny
IPC分类号: A61F2/00 , A61K35/37 , A61K35/12 , A61L33/00 , A61L27/36 , A61L31/00 , A61L27/38 , A61L27/34 , A61F2/02 , A61L27/54 , A61L31/16 , A61L27/50 , A61L31/14 , A61N1/375 , A61L27/22 , A61K35/38 , A61K35/22 , A61F2/24 , A61K38/00 , A61K35/42
CPC分类号: A61L27/3629 , A61F2/0077 , A61F2/02 , A61F2/24 , A61F2002/0086 , A61F2210/0076 , A61K35/12 , A61K35/22 , A61K35/37 , A61K35/38 , A61K35/42 , A61K38/005 , A61K38/1825 , A61L27/227 , A61L27/34 , A61L27/3604 , A61L27/362 , A61L27/3625 , A61L27/3633 , A61L27/3679 , A61L27/3683 , A61L27/38 , A61L27/3804 , A61L27/3834 , A61L27/50 , A61L27/54 , A61L31/005 , A61L31/041 , A61L31/14 , A61L31/16 , A61L2300/20 , A61L2300/23 , A61L2300/25 , A61L2300/252 , A61L2300/40 , A61L2300/404 , A61L2300/406 , A61L2300/41 , A61L2300/412 , A61L2300/414 , A61L2300/418 , A61L2300/434 , A61L2300/45 , A61L2300/64 , A61L2400/02 , A61L2400/12 , A61L2400/18 , A61L2430/20 , A61N1/375 , A61N1/3752
摘要: A pouch structure formed from extracellular matrix (ECM) derived from small intestine submucosa (SIS) that includes an internal region configured to receive a medical device therein. The pouch structure is configured to modulate inflammation of damaged biological tissue and induce cell and tissue proliferation, bioremodeling of the damaged biological tissue, and regeneration of tissue structures with site-specific structural and functional properties, when implanted in a subject.
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公开(公告)号:US09662418B2
公开(公告)日:2017-05-30
申请号:US14685755
申请日:2015-04-14
发明人: Robert G Matheny
IPC分类号: A61F2/00 , A61K35/37 , A61K35/12 , A61L27/36 , A61L31/00 , A61L27/38 , A61L27/34 , A61F2/02 , A61L27/54 , A61L31/16 , A61L27/50 , A61L31/14 , A61N1/375 , A61L27/22 , A61K35/38 , A61K35/22 , A61F2/24 , A61K38/00 , A61K35/42
CPC分类号: A61L27/3629 , A61F2/0077 , A61F2/02 , A61F2/24 , A61F2002/0086 , A61F2210/0076 , A61K35/12 , A61K35/22 , A61K35/37 , A61K35/38 , A61K35/42 , A61K38/005 , A61K38/1825 , A61L27/227 , A61L27/34 , A61L27/3604 , A61L27/362 , A61L27/3625 , A61L27/3633 , A61L27/3679 , A61L27/3683 , A61L27/38 , A61L27/3804 , A61L27/3834 , A61L27/50 , A61L27/54 , A61L31/005 , A61L31/041 , A61L31/14 , A61L31/16 , A61L2300/20 , A61L2300/23 , A61L2300/25 , A61L2300/252 , A61L2300/40 , A61L2300/404 , A61L2300/406 , A61L2300/41 , A61L2300/412 , A61L2300/414 , A61L2300/418 , A61L2300/434 , A61L2300/45 , A61L2300/64 , A61L2400/02 , A61L2400/12 , A61L2400/18 , A61L2430/20 , A61N1/375 , A61N1/3752
摘要: A bioremodelable encasement structure comprising a pouch formed from at least one sheet of bioremodelable material, the pouch including an internal region that is configured to receive a device therein, the bioremodelable material comprising mesothelial tissue.
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公开(公告)号:US09610308B2
公开(公告)日:2017-04-04
申请号:US15178539
申请日:2016-06-09
申请人: Crestovo LLC
发明人: Thomas Julius Borody
IPC分类号: A61K39/00 , A61K39/38 , A61K39/02 , A61K39/08 , A61K39/108 , A61K35/741 , A61K35/74 , A61K38/48 , A61K35/742 , A61K35/744 , A61K35/747 , A61K36/062 , A61K45/06 , A61K38/14 , A61K31/341 , A61K31/41 , A61K31/495 , A61K31/7034 , A23L2/52 , A61K35/745 , A61K35/38 , A61K35/24 , A61K9/00 , A23C9/123 , A61K9/48 , A23C9/13 , A23L33/135 , A23C9/127 , A61K31/545 , A61K35/76 , A61K31/43 , A61K38/00 , A61K31/7048 , A61K9/50 , A61K39/39 , A61K51/12 , A61K35/00
CPC分类号: A61K35/742 , A23C9/123 , A23C9/127 , A23C9/13 , A23L2/52 , A23L33/135 , A23V2002/00 , A61K9/0031 , A61K9/0053 , A61K9/19 , A61K9/48 , A61K9/4891 , A61K9/50 , A61K9/5005 , A61K9/5078 , A61K31/341 , A61K31/41 , A61K31/43 , A61K31/495 , A61K31/545 , A61K31/7034 , A61K31/7048 , A61K35/24 , A61K35/37 , A61K35/38 , A61K35/74 , A61K35/741 , A61K35/744 , A61K35/745 , A61K35/747 , A61K35/76 , A61K36/062 , A61K38/00 , A61K38/14 , A61K38/4893 , A61K39/00 , A61K39/39 , A61K45/06 , A61K51/1217 , A61K2035/115 , C12N2795/00032 , Y02A50/401 , Y02A50/469 , Y02A50/473 , A61K2300/00
摘要: The present invention relates to pharmaceutical compositions suitable for the treatment of chronic diseases associated with the presence of abnormal or an abnormal distribution of microflora in the gastrointestinal tract of a mammalian host, which compositions comprise viable non-pathogenic or attenuated pathogenic Clostridia. The compositions further comprise one or more additional viable non-pathogenic or attenuated pathogenic microorganisms selected from the group consisting of Bacteroides, Eubacteria, Fusobacteria, Propionibacteria, Lactobacilli, anaerobic cocci, Ruminococcus, E. coli, Gemmiger, Desulfomonas, Peptostreptococcus, and fungi. The present invention also provides pharmaceutical compositions suitable for the treatment of the same chronic diseases comprising viable non-pathogenic or attenuated pathogenic Escherichia coli, at least one strain of viable non-pathogenic or attenuated pathogenic Bacteroides and at least one strain of viable non-pathogenic or attenuated pathogenic microorganism.
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公开(公告)号:US20160375068A1
公开(公告)日:2016-12-29
申请号:US15260207
申请日:2016-09-08
申请人: Crestovo LLC
发明人: Thomas Julius BORODY
IPC分类号: A61K35/742 , A61K35/37 , A61K35/741 , A61K35/747 , A61K35/745 , A61K9/00 , A61K9/19
CPC分类号: A61K35/742 , A23C9/123 , A23C9/127 , A23C9/13 , A23L2/52 , A23L33/135 , A23V2002/00 , A61K9/0031 , A61K9/0053 , A61K9/19 , A61K9/48 , A61K9/4891 , A61K9/50 , A61K9/5005 , A61K9/5078 , A61K31/341 , A61K31/41 , A61K31/43 , A61K31/495 , A61K31/545 , A61K31/7034 , A61K31/7048 , A61K35/24 , A61K35/37 , A61K35/38 , A61K35/74 , A61K35/741 , A61K35/744 , A61K35/745 , A61K35/747 , A61K35/76 , A61K36/062 , A61K38/00 , A61K38/14 , A61K38/4893 , A61K39/00 , A61K39/39 , A61K45/06 , A61K51/1217 , A61K2035/115 , C12N2795/00032 , Y02A50/401 , Y02A50/469 , Y02A50/473 , A61K2300/00
摘要: The present invention relates to pharmaceutical compositions suitable for the treatment of chronic diseases associated with the presence of abnormal or an abnormal distribution of microflora in the gastrointestinal tract of a mammalian host, which compositions comprise viable non-pathogenic or attenuated pathogenic Clostridia. The compositions further comprise one or more additional viable non-pathogenic or attenuated pathogenic microorganisms selected from the group consisting of Bacteroides, Eubacteria, Fusobacteria, Propionibacteria, Lactobacilli, anaerobic cocci, Ruminococcus, E. coli, Gemmiger, Desulfomonas, Peptostreptococcus, and fungi. The present invention also provides pharmaceutical compositions suitable for the treatment of the same chronic diseases comprising viable non-pathogenic or attenuated pathogenic Escherichia coli, at least one strain of viable non-pathogenic or attenuated pathogenic Bacteroides and at least one strain of viable non-pathogenic or attenuated pathogenic microorganism.
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公开(公告)号:US20160279178A1
公开(公告)日:2016-09-29
申请号:US15178537
申请日:2016-06-09
申请人: Crestovo LLC
发明人: Thomas Julius BORODY
IPC分类号: A61K35/742 , A61K35/741 , A61K9/48 , A61K9/00
CPC分类号: A61K35/742 , A23C9/123 , A23C9/127 , A23C9/13 , A23L2/52 , A23L33/135 , A23V2002/00 , A61K9/0031 , A61K9/0053 , A61K9/19 , A61K9/48 , A61K9/4891 , A61K9/50 , A61K9/5005 , A61K9/5078 , A61K31/341 , A61K31/41 , A61K31/43 , A61K31/495 , A61K31/545 , A61K31/7034 , A61K31/7048 , A61K35/24 , A61K35/37 , A61K35/38 , A61K35/74 , A61K35/741 , A61K35/744 , A61K35/745 , A61K35/747 , A61K35/76 , A61K36/062 , A61K38/00 , A61K38/14 , A61K38/4893 , A61K39/00 , A61K39/39 , A61K45/06 , A61K51/1217 , A61K2035/115 , C12N2795/00032 , Y02A50/401 , Y02A50/469 , Y02A50/473 , A61K2300/00
摘要: The present invention relates to pharmaceutical compositions suitable for the treatment of chronic diseases associated with the presence of abnormal or an abnormal distribution of microflora in the gastrointestinal tract of a mammalian host, which compositions comprise viable non-pathogenic or attenuated pathogenic Clostridia. The compositions further comprise one or more additional viable non-pathogenic or attenuated pathogenic microorganisms selected from the group consisting of Bacteroides, Eubacteria, Fusobacteria, Propionibacteria, Lactobacilli, anaerobic cocci, Ruminococcus, E. coli, Gemmiger, Desulfomonas, Peptostreptococcus, and fungi. The present invention also provides pharmaceutical compositions suitable for the treatment of the same chronic diseases comprising viable non-pathogenic or attenuated pathogenic Escherichia coli, at least one strain of viable non-pathogenic or attenuated pathogenic Bacteroides and at least one strain of viable non-pathogenic or attenuated pathogenic microorganism.
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公开(公告)号:US09446080B2
公开(公告)日:2016-09-20
申请号:US15068438
申请日:2016-03-11
发明人: Gregory McKenzie , Mary-Jane Lombardo McKenzie , David N. Cook , Marin Vulic , Geoffrey von Maltzahn , Brian Goodman , John Grant Aunins , Matthew R. Henn , David Arthur Berry , Jonathan Winkler
IPC分类号: A01N63/00 , A61K35/741 , A61K35/74 , A61K35/742 , A61K35/744 , A61K35/745 , A61K35/747 , A61K9/48 , C12N1/20
CPC分类号: A61K35/741 , A61K9/0053 , A61K9/48 , A61K9/4816 , A61K35/37 , A61K35/74 , A61K35/742 , A61K35/744 , A61K35/745 , A61K35/747 , A61K45/06 , C12N1/20 , Y02A50/402 , Y02A50/469 , Y02A50/473 , Y02A50/475 , Y02A50/478 , Y02A50/48 , Y02A50/481
摘要: Disclosed herein are therapeutic compositions containing non-pathogenic, germination-competent bacterial spores, for the prevention, control, and treatment of gastrointestinal diseases, disorders and conditions and for general nutritional health.
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公开(公告)号:US20160199423A1
公开(公告)日:2016-07-14
申请号:US14884655
申请日:2015-10-15
发明人: Gregory McKenzie , Mary-Jane Lombardo McKenzie , David N. Cook , Marin Vulic , Geoffrey von Maltzahn , Brian Goodman , John Grant Aunins , Matthew R. Henn , David Arthur Berry , Jonathan Winkler
IPC分类号: A61K35/742 , A61K45/06 , A61K9/00
CPC分类号: A61K35/741 , A61K9/0053 , A61K9/48 , A61K9/4816 , A61K35/37 , A61K35/74 , A61K35/742 , A61K35/744 , A61K35/745 , A61K35/747 , A61K45/06 , C12N1/20 , Y02A50/402 , Y02A50/469 , Y02A50/473 , Y02A50/475 , Y02A50/478 , Y02A50/48 , Y02A50/481
摘要: Disclosed herein are therapeutic compositions containing non-pathogenic, germination-competent bacterial spores, for the prevention, control, and treatment of gastrointestinal diseases, disorders and conditions and for general nutritional health.
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