公开(公告)号：US20230221333A1

公开(公告)日：2023-07-13

申请号：US18155299

申请日：2023-01-17

Applicant: Genentech, Inc. ,  Universiteit Utrecht Holding B.V.

Inventor： Wendy Noel Sandoval ,  Tomislav Caval ,  Albert J.R. Heck ,  Elizabeth Sara Hecht

IPC: G01N33/68

CPC classification number: G01N33/6848 ,  G01N33/6824 ,  G01N2560/00 ,  G01N2333/96466

Abstract: This disclosure relates to new methods for antibody characterization sequencing, such as middle down antibody characterization and sequencing, for example, for de novo antibody sequencing, identifying known antibodies in a sample, or verifying the sequence of antibodies in a sample. In some embodiments, the methods involve exposing antibodies to cathepsin D, cathepsin L, and/or cathepsin D and L, followed by mass spectrometry and sequence identification and deconvolution.

公开(公告)号：US20230220491A1

公开(公告)日：2023-07-13

申请号：US18157597

申请日：2023-01-20

Applicant: Genentech, Inc.

Inventor： YounJeong CHOI ,  Omar Kabbarah ,  Doris Kim

IPC: C12Q1/6886 ,  A61K39/395 ,  C07K16/30 ,  A61K31/517 ,  C07K16/18 ,  G01N33/574 ,  C07K16/28 ,  A61K45/06

CPC classification number: C12Q1/6886 ,  A61K39/39558 ,  C07K16/3038 ,  A61K31/517 ,  C07K16/18 ,  G01N33/57407 ,  C07K16/2863 ,  A61K45/06 ,  G01N2333/71 ,  C12Q2600/158 ,  C12Q2600/118 ,  C12Q2600/106 ,  G01N2800/52 ,  G01N2333/4748

Abstract: The invention provides methods and compositions to detect expression of one or more biomarkers, including FGFR3, TP53, and/or EGFR, for treating, diagnosing, and providing a prognosis for cancer, e.g., bladder cancer. The invention also provides kits and articles of manufacture for use in the methods.

公开(公告)号：US20230218782A1

公开(公告)日：2023-07-13

申请号：US18056856

申请日：2022-11-18

Applicant: Genentech, Inc.

Inventor： Jan MARIK ,  Joseph P. LYSSIKATOS ,  Simon Peter WILLIAMS

IPC: A61K51/04 ,  C07B59/00 ,  C07D487/04

CPC classification number: A61K51/0459 ,  C07B59/002 ,  C07D487/04 ,  C07B2200/05

Abstract: The present invention relates to deuterated and optionally detectably labeled compounds of formula (I) and formula (V):










and salts thereof, wherein R1, R2, A, and X10-X19 have any of the values defined in the specification. Also included are pharmaceutical compositions comprising such compounds and salts, and methods of using such compounds and salts as imaging agents.

公开(公告)号：US20230206644A1

公开(公告)日：2023-06-29

申请号：US18176389

申请日：2023-02-28

Applicant: Genentech, Inc.

Inventor： Mark ZAK ,  Paul GIBBONS ,  Yun-Xing CHENG ,  Simon Charles GOODACRE

IPC: G06V20/52 ,  G06M11/00 ,  G08G1/005 ,  G08G1/04 ,  H04N7/18 ,  G06F3/147

CPC classification number: G06V20/53 ,  G06M11/00 ,  G08G1/005 ,  G08G1/04 ,  H04N7/188 ,  G06F3/147 ,  H04N7/181 ,  G09G2380/06

Abstract: Compounds and salts thereof that are useful as JAK kinase inhibitors are described herein. Also provided are pharmaceutical compositions that include such a JAK inhibitor and a pharmaceutically acceptable carrier, adjuvant or vehicle, and methods of treating or lessening the severity of a disease or condition responsive to the inhibition of a Janus kinase activity in a patient.

公开(公告)号：US20230201468A1

公开(公告)日：2023-06-29

申请号：US18116473

申请日：2023-03-02

Applicant: Genentech, Inc.

Inventor： Lionel Vedrine ,  Steven N. Roe ,  Mukund Patel

IPC: A61M5/315 ,  A61M5/24 ,  A61F9/00 ,  A61M5/31 ,  A61M5/32 ,  A61M5/36

CPC classification number: A61M5/31513 ,  A61M5/31586 ,  A61M5/31573 ,  A61M5/24 ,  A61M5/3157 ,  A61F9/0017 ,  A61M5/2448 ,  A61M5/2459 ,  A61M5/3137 ,  A61M5/3145 ,  A61M5/3146 ,  A61M5/31505 ,  A61M5/31528 ,  A61M5/31581 ,  A61M5/31596 ,  A61M5/3202 ,  A61M5/3298 ,  A61M5/36 ,  A61M2005/31508 ,  A61M5/284

Abstract: Apparatus and methods for medicament delivery. The apparatus may include, and the methods may involve, a delivery device for delivering a target amount of the medicament from a distal end of the device. The device may include a rod for moving a plunger that discharges the medicament from the distal end. The device may avoid or reduce deformation of the plunger during the discharge. The plunger motion may be stopped by detent that interacts with the rod. The apparatus and the methods may provide an operator indication of progress of stages of operation. The device may feature triggers corresponding to stages of medicament displacement from the device, such as pre-delivery stages, including priming.

公开(公告)号：US20230197278A1

公开(公告)日：2023-06-22

申请号：US17860939

申请日：2022-07-08

Applicant: Genentech, Inc. ,  Hoffmann-La Roche Inc

Inventor： Emily Piccione GRIFFIN ,  Bruce MCCALL ,  Tina Geritz NIELSEN ,  Anton BELOUSOV

IPC: G16H50/30 ,  G16H70/60

CPC classification number: G16H50/30 ,  G16H70/60 ,  G16H20/40

Abstract: Techniques are provided for predicting a risk of a subject experiencing a cytokine release syndrome of at least a threshold grade subsequent to receiving a treatment. The risk may be predicted based on (for example) a set of baseline characteristics, a risk-score generation model, an on-treatment cytokine level, and/or a treatment dosage. The risk may be used to generate an output corresponding to a recommendation as to whether to monitor the subject via in-patient monitoring.

公开(公告)号：US11674962B2

公开(公告)日：2023-06-13

申请号：US16041363

申请日：2018-07-20

Applicant: Genentech, Inc. ,  Foundation Medicine, Inc.

Inventor： Craig Anthony Cummings ,  Yan Li ,  Sarah Margaret Shagan ,  Erica Beth Schleifman ,  David Shames ,  David Fabrizio ,  Daniel Lieber ,  Geoffrey Alan Otto ,  Mark Kennedy ,  Travis Clark ,  Doron Lipson ,  Jie He ,  Shan Zhong

IPC: C12Q1/68 ,  C12Q1/6883 ,  G01N33/574 ,  C07K16/28 ,  G16H50/50 ,  G16H50/30 ,  G16H50/70 ,  G16H50/20 ,  A61P35/00 ,  G06F16/28 ,  C07K14/735 ,  A61K39/00

CPC classification number: G01N33/574 ,  A61P35/00 ,  C07K14/70535 ,  C07K16/2827 ,  C07K16/2896 ,  C12Q1/68 ,  C12Q1/6883 ,  G01N33/57492 ,  G06F16/285 ,  G16H50/20 ,  G16H50/30 ,  G16H50/50 ,  G16H50/70 ,  A61K2039/505 ,  A61K2039/55 ,  C07K2317/24 ,  C12Q2600/156 ,  G01N2333/70532 ,  G01N2800/52

Abstract: The present invention provides therapeutic, diagnostic, and prognostic methods for cancer. The invention provides methods of treating a cancer, methods of determining whether an individual having a cancer is likely to respond to a treatment including an immune checkpoint inhibitor (e.g., a PD-L1 axis binding antagonist), methods of predicting responsiveness of an individual having a cancer to a treatment including an immune checkpoint inhibitor (e.g., a PD-L1 axis binding antagonist), methods of selecting a therapy for an individual having a cancer, methods of providing a prognosis for an individual having a cancer, and methods of monitoring a response of an individual having a cancer, based on a blood tumor mutational burden (bTMB) score or a maximum somatic allele frequency (MSAF) from a sample (e.g., a whole blood sample, a plasma sample, a serum sample, or a combination thereof) from the individual.

公开(公告)号：US11666581B2

公开(公告)日：2023-06-06

申请号：US16194897

申请日：2018-11-19

Applicant: Genentech, Inc.

Inventor： Thomas Pillow ,  Jack Sadowsky ,  Leanna Staben ,  Steven Staben ,  Binqing Wei ,  Ingrid Wertz ,  Pragya Adhikari ,  Nicole Blaquiere ,  Peter Dragovich ,  Wayne Fairbrother

IPC: A61K31/551 ,  A61K47/54 ,  A61K47/68 ,  A61K47/65 ,  A61P37/06 ,  A61P35/00 ,  C07K16/28 ,  C07K16/32 ,  C12N9/00

CPC classification number: A61K31/551 ,  A61K47/545 ,  A61K47/65 ,  A61K47/68 ,  A61P35/00 ,  A61P37/06 ,  C07K16/2827 ,  C07K16/32 ,  C12N9/93 ,  C12Y203/02007

Abstract: The subject matter described herein is directed to antibody-PROTAC conjugates (PACs), to pharmaceutical compositions containing them, and to their use in treating diseases and conditions where targeted protein degradation is beneficial.

公开(公告)号：US20230167123A1

公开(公告)日：2023-06-01

申请号：US18063575

申请日：2022-12-08

Applicant: Genentech, Inc.

Inventor： Mark Edward Zak ,  Naomi S. Rajapaksa ,  Yun-Xing Cheng ,  Jessica Grandner ,  Daniel G.M. Shore ,  F. Anthony Romero ,  Marian C. Bryan

IPC: C07D487/04 ,  A61P37/06

CPC classification number: C07D487/04 ,  A61P37/06

Abstract: Compounds of formula (I)




wherein R1, R2, R3, R4, R5 and R6 are as defined herein, and salts thereof, that are useful as JAK kinase inhibitors are described herein. Also provided are pharmaceutical compositions that include such a JAK inhibitor and a pharmaceutically acceptable carrier, adjuvant or vehicle, and methods of treating or lessening the severity of a disease or condition responsive to the inhibition of a Janus kinase activity in a patient.

公开(公告)号：US20230159886A1

公开(公告)日：2023-05-25

申请号：US17954128

申请日：2022-09-27

Applicant: Genentech, Inc.

Inventor： Masaru Ken SHIRATORI ,  Robert David KISS ,  Hardayal PRASHAD ,  Raquel IVERSON ,  Justin BOURRET ,  Michael KIM ,  Salim CHARANIYA

IPC: C12N1/36 ,  C12N7/00

CPC classification number: C12N1/36 ,  C12N7/00 ,  C12N2750/14061 ,  C12N2760/12061 ,  C12N2760/16061 ,  C12N2760/18061 ,  C12N2760/20061 ,  C12N2770/16061 ,  C12N2770/32061 ,  C12N2770/36061

Abstract: The invention provides for methods of viral inactivation using high temperature short time (HTST) treatment and adjustment of various parameters such that generation of precipitate and depositions of precipitate are reduced and/or minimized.