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    SORTING A DROPLET INCLUDING A BIOLOGIC SAMPLE
    124.
    发明申请
    SORTING A DROPLET INCLUDING A BIOLOGIC SAMPLE 有权

    公开(公告)号：US20220323958A1

    公开(公告)日：2022-10-13

    申请号：US17634787

    申请日：2019-12-04

    Applicant: HEWLETT-PACKARD DEVELOPMENT COMPANY, L.P.

    Inventor： Alexander Govyadinov ,  Viktor SHKOLNIKOV

    IPC: B01L3/00 ,  B01L7/00 ,  C12Q1/6844

    Abstract: Examples herein involve sorting a droplet including a biologic sample. In a particular example, sorting a droplet including a biologic sample includes generating a droplet including a biologic sample and a pH sensitive surfactant, and heating a nucleic acid molecule in the biologic sample. The pH sensitive surfactant may change the surface tension of the droplet responsive to amplification of the nucleic acid molecule. The droplet may be sorted into one of a plurality of sorting lanes based on the surface tension of the droplet, where a sorting lane among the plurality of sorting lanes is associated with droplets including the amplified nucleic acid molecule. A determination of whether the droplet includes the amplified nucleic acid molecule may be performed by detecting passage of the droplet in one of the plurality of sorting lanes.

    Microfluidic devices
    125.
    发明授权
    Microfluidic devices 有权

    公开(公告)号：US11364498B2

    公开(公告)日：2022-06-21

    申请号：US16493402

    申请日：2017-04-07

    Applicant: Hewlett-Packard Development Company, L.P.

    Inventor： Alexander Govyadinov ,  Adam Higgins ,  Pavel Kornilovich

    IPC: B01L3/00 ,  B01L7/00

    Abstract: The present disclosure is drawn to microfluidic devices. In one example, a microfluidic device can include a first covered fluid feed slot in fluid communication with a first microfluidic channel and a second covered fluid feed slot in fluid communication with a second microfluidic channel. The first microfluidic channel can be formed adjacent to the second microfluidic channel but not in fluid communication with the second microfluidic channel. The first covered fluid feed slot can include a first fluid feed hole for filling a fluid into the first covered fluid feed slot. The second covered fluid feed slot can also include a second fluid feed hole for filling a fluid into the second covered fluid feed slot.

    CELL TRAPPING ARRAYS WITH SELECTIVE EJECTION
    127.
    发明申请
    CELL TRAPPING ARRAYS WITH SELECTIVE EJECTION 有权

    公开(公告)号：US20220143594A1

    公开(公告)日：2022-05-12

    申请号：US17415161

    申请日：2019-07-25

    Applicant: Hewlett-Packard Development Company, L.P.

    Inventor： Alexander Govyadinov ,  Viktor Shkolnikov

    IPC: B01L3/02 ,  B01L3/00 ,  G01N15/14

    Abstract: In example implementations, a cell trapping array is provided. The cell trapping array includes a plurality of plates coupled along adjacent edges to form a channel. A plurality of orifices are formed in a first plate of the plurality of plates of the channel. The plurality of orifices is shaped to create a meniscus of a fluid in the channel in the plurality of orifices that is to attract a single cell from cells flowing through the channel in the fluid. The cell trapping array includes a selective ejection system coupled to a second plate located opposite the first plate of the channel. The selective ejection system is to selectively eject the single cell from one of the plurality of orifices.

    FLUID ANALYSIS WITH CHANNELS FORMED IN LIDS
    128.
    发明申请
    FLUID ANALYSIS WITH CHANNELS FORMED IN LIDS 有权

    公开(公告)号：US20220080414A1

    公开(公告)日：2022-03-17

    申请号：US17417609

    申请日：2019-05-07

    Applicant: Hewlett-Packard Development Company, L.P.

    Inventor： Silam J. Choy ,  Alexander Govyadinov ,  Erik D. Torniainen ,  Tod Woodford

    IPC: B01L3/00 ,  G01N21/64

    Abstract: In one example in accordance with the present disclosure, a fluid analysis device is described. The device includes a substrate, a die adhered to the substrate, and at least one fluid analysis element disposed on the die. A lid is adhered to the substrate and includes a channel formed thereinto be seated over the die. The device also includes an inlet port to the channel and an outlet from the channel. The inlet port and the outlet port are formed on at least one of the substrate and the lid. A number of electrical traces couple the die to a controller.

    CELL MARKING SYSTEMS
    130.
    发明申请
    CELL MARKING SYSTEMS 有权

    公开(公告)号：US20220072550A1

    公开(公告)日：2022-03-10

    申请号：US17417344

    申请日：2019-02-01

    Applicant: Hewlett-Packard Development Company, L.P.

    Inventor： Alexander Govyadinov ,  Viktor Shkolnikov

    IPC: B01L3/00

    Abstract: In one example in accordance with the present disclosure, a cell marking system is described. The cell marking system includes a microfluidic channel to serially feed individual cells from a volume of cells into at least one marking chamber. The at least one marking chambers hold an individual cell to be marked. The cell marking system also includes a marker application device per marking chamber to selectively apply a marker to the individual cell disposed within a respective marking chamber.

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