公开(公告)号：US08338532B2

公开(公告)日：2012-12-25

申请号：US13038378

申请日：2011-03-01

Applicant: Guillermo C. Bazan ,  Bin Liu

Inventor： Guillermo C. Bazan ,  Bin Liu

IPC: C08G63/91 ,  C08G63/00 ,  C12Q1/68

CPC classification number: C08G61/02 ,  C08G61/122 ,  C08G61/123 ,  C12Q1/6818 ,  C12Q1/6837 ,  G01N21/6428 ,  G01N21/6452 ,  G01N2021/6419 ,  G01N2021/6439 ,  C12Q2563/131 ,  C12Q2537/119 ,  C12Q2525/107

Abstract: The invention further relates to multichromophores, which may be conjugated polymers, and methods, articles and compositions employing them as described herein. In some aspects, the invention relates to methods, articles and compositions for the detection and analysis of biomolecules in a sample. Provided assays include those determining the presence of a target biomolecule in a sample or its relative amount, or the assays may be quantitative or semi-quantitative. The methods can be performed on a substrate. The methods can be performed in an array format on a substrate, which can be a sensor. In some embodiments, detection assays are provided employing sensor biomolecules that do not comprise a fluorophore that can exchange energy with the cationic multichromophore. In some aspects biological assays are provided in which energy is transferred between one or more of the multichromophore, a label on the target biomolecule, a label on the sensor biomolecule, and/or a fluorescent dye specific for a polynucleotide, in all permutations. The multichromophore may interact at least in part electrostatically with the sensor and/or the target, and an increase in energy transfer with the polymer may occur upon binding of the sensor and the target. Other variations of the inventions are described further herein.

Abstract translation: 本发明还涉及可以是共轭聚合物的多色素，以及如本文所述使用它们的方法，制品和组合物。 在一些方面，本发明涉及用于检测和分析样品中生物分子的方法，制品和组合物。 提供的测定包括确定样品中靶生物分子的存在或其相对量的那些，或者测定可以是定量或半定量的。 该方法可以在衬底上进行。 这些方法可以以阵列格式在基底上进行，其可以是传感器。 在一些实施方案中，使用不包含能够与阳离子多重色素交换能量的荧光团的传感器生物分子来提供检测测定。 在一些方面，提供生物测定，其中在所有置换中，能量在一个或多个多色素，目标生物分子上的标记，传感器生物分子上的标记和/或多核苷酸特异的荧光染料之间转移。 多重色淀可以至少部分地与传感器和/或靶相互作用，并且当传感器和目标物结合时，聚合物的能量传递的增加可能发生。 本文进一步描述了本发明的其它变型。

公开(公告)号：US08265748B2

公开(公告)日：2012-09-11

申请号：US12350749

申请日：2009-01-08

Applicant: Bin Liu ,  Hu Luo

Inventor： Bin Liu ,  Hu Luo

IPC: A61N1/34

CPC classification number: A61N1/046 ,  A61N1/0472 ,  A61N1/0492 ,  A61N1/3925 ,  A61N1/3993

Abstract: A defibrillator includes a defibrillator mainframe and a defibrillating electrode. The defibrillator mainframe includes a main control unit and a master device electrically connected to the main control unit. The defibrillating electrode comprises a slave device supporting a bus protocol, the master device and slave device being interconnected through a bus.

Abstract translation: 除颤器包括除颤器主机和去纤颤电极。 除颤器主机包括主控制单元和与主控制单元电连接的主设备。 除颤电极包括支持总线协议的从设备，主设备和从设备通过总线互连。

公开(公告)号：US08208856B2

公开(公告)日：2012-06-26

申请号：US12686623

申请日：2010-01-13

Applicant: Mark Hahm ,  Wei Luo ,  Thirunathan Sutharsan ,  Andrew du Preez ,  Bin Liu ,  Jun Wu ,  Severine Catreux-Erceg ,  Shuangquan Wang

Inventor： Mark Hahm ,  Wei Luo ,  Thirunathan Sutharsan ,  Andrew du Preez ,  Bin Liu ,  Jun Wu ,  Severine Catreux-Erceg ,  Shuangquan Wang

IPC: H04B1/00

CPC classification number: H04B1/71075 ,  H04B1/7115 ,  H04B1/712 ,  H04B2201/70702

Abstract: Aspects of a method and system for a programmable interference suppression module may include receiving a communication signal comprising one or more desired signal, and one or more undesired signals. The communication signal may be utilized to generate estimated channel state information. The estimated channel state information may be formatted for use in interference suppression. A reduced interference signal may be generated from a delayed version of said communications signal and the estimated channel state information, wherein the one or more undesired signals may be attenuated. The reduced interference signal may be formatted for post-processing. The desired signals may comprise WCDMA and/or HSDPA signals, and the undesired signals may be inter-cell and/or intra-cell interference. Further processing may comprise HSDPA processing and/or RAKE finger processing. The communication signal may be a Universal Mobile Telecommunication System (UMTS) compliant signal.

Abstract translation: 用于可编程干扰抑制模块的方法和系统的方面可以包括接收包括一个或多个期望信号的通信信号以及一个或多个不需要的信号。 通信信号可用于产生估计的信道状态信息。 估计的信道状态信息可以被格式化以用于干扰抑制。 可以从所述通信信号的延迟版本和所估计的信道状态信息产生减小的干扰信号，其中所述一个或多个不需要的信号可以被衰减。 减小的干扰信号可以被格式化用于后处理。 期望的信号可以包括WCDMA和/或HSDPA信号，并且不期望的信号可以是小区间和/或小区内干扰。 进一步的处理可以包括HSDPA处理和/或RAKE手指处理。 通信信号可以是符合通用移动通信系统（UMTS）的信号。

公开(公告)号：US08185155B2

公开(公告)日：2012-05-22

申请号：US13026234

申请日：2011-02-12

Applicant: Eric Chang ,  David Dehghan ,  Stanley Sun ,  Bin Liu

Inventor： Eric Chang ,  David Dehghan ,  Stanley Sun ,  Bin Liu

IPC: H04B1/38

CPC classification number: H04M1/72527

Abstract: A universal smart interface and peripheral management system for portable devices such as mobile phones. The smart system includes a connector interface that connects peripherals to a phone and/or personal digital assistant (PDA), through the smart system. The smart system includes a cradle for receiving a cell phone and interfacing the phone to external systems such as peripherals, networks and other systems through a USB hub and other suitable connector interfaces. The peripheral devices to which the smart system can interface include, but are not limited to, large displays (e.g., television), external monitors, input devices such as mice and keyboards, external storage devices, and networks (wired and/or wireless). The smart system also facilitates connectivity to large display systems such as TVs, computer displays and monitors.

Abstract translation: 通用智能接口和便携式设备（如手机）的外设管理系统。 智能系统包括通过智能系统将外围设备连接到电话和/或个人数字助理（PDA）的连接器接口。 该智能系统包括用于接收蜂窝电话并通过USB集线器和其他合适的连接器接口将电话与诸如外围设备，网络和其他系统的外部系统接口的支架。 智能系统可以接口的外围设备包括但不限于大型显示​​器（例如电视机），外部监视器，诸如鼠标和键盘的输入设备，外部存储设备和网络（有线和/或无线） 。 智能系统还有助于连接大型显示系统，如电视机，电脑显示器和显示器。

公开(公告)号：US08110673B2

公开(公告)日：2012-02-07

申请号：US12711233

申请日：2010-02-23

Applicant: Guillermo C. Bazan ,  Bin Liu

Inventor： Guillermo C. Bazan ,  Bin Liu

IPC: C07H21/04

CPC classification number: G01N21/6486 ,  C08G61/02 ,  C08G61/123 ,  C12Q1/6818 ,  C12Q1/6825 ,  G01N33/542 ,  G01N33/54373 ,  Y10T436/143333 ,  C12Q2565/113 ,  C12Q2563/173 ,  C12Q2565/101

Abstract: This invention relates to an aggregation sensor useful for the detection and analysis of aggregants in a sample, and methods, articles and compositions relating to such a sensor. The sensor comprises first and second optically active units, where energy may be transferred from an excited state of the first optically active unit to the second optically active unit. The second optically active unit is present in a lesser amount, but its relative concentration is increased upon aggregation, increasing its absorption of energy from the first optically active units. This increase in energy transfer can be detected in variety of formats to produce an aggregation sensing system for various aggregants, including for quantitation. Other variations of the inventions are described further herein.

Abstract translation: 本发明涉及可用于检测和分析样品中的聚集体的聚集传感器，以及与这种传感器相关的方法，制品和组合物。 传感器包括第一和第二光学有源单元，其中能量可以从第一光学活性单元的激发状态转移到第二光学活性单元。 第二光学活性单元以较小的量存在，但是其聚集时其相对浓度增加，从而增加其从第一光学活性单元的能量吸收。 可以以各种格式检测能量转移的这种增加，以产生用于各种聚合物的聚集感测系统，包括用于定量。 本文进一步描述了本发明的其它变型。

公开(公告)号：US20110103530A1

公开(公告)日：2011-05-05

申请号：US12611810

申请日：2009-11-03

Applicant: Wei Luo ,  Karthik Rajagopalan ,  Andrew du Preez ,  Bin Liu ,  Shuangquan Wang

Inventor： Wei Luo ,  Karthik Rajagopalan ,  Andrew du Preez ,  Bin Liu ,  Shuangquan Wang

IPC: H04B1/10

CPC classification number: H04B1/7107

Abstract: Aspects of a method and system for compensation of interference cancellation delay are provided. In this regard, a wireless communication device may receive one or more signals and may be operable to select, whether dynamically or statically, a processing path for processing the one or more received signals. The selected processing path may comprise one of an interference cancellation processing path and a pass-through processing path. A delay introduced by the pass-through processing path may be approximately equal to a processing delay introduced by the interference cancellation processing path. The one or more received signals may comprise HSDPA signals. The selection of processing path may be based on a measure of interference present in the one or more received signals.

Abstract translation: 提供了一种用于补偿干扰消除延迟的方法和系统。 在这方面，无线通信设备可以接收一个或多个信号，并且可以可操作地动态地或静态地选择用于处理一个或多个接收信号的处理路径。 所选择的处理路径可以包括干扰消除处理路径和直通处理路径之一。 由直通处理路径引入的延迟可以近似等于由干扰消除处理路径引入的处理延迟。 一个或多个接收信号可以包括HSDPA信号。 处理路径的选择可以基于存在于一个或多个接收信号中的干扰的度量。

公开(公告)号：US20110075708A1

公开(公告)日：2011-03-31

申请号：US12575879

申请日：2009-10-08

Applicant: Mark Hahm ,  Wei Luo ,  Bin Liu ,  Jun Wu ,  Severine Catreux-Erceg ,  Shuangquan Wang

Inventor： Mark Hahm ,  Wei Luo ,  Bin Liu ,  Jun Wu ,  Severine Catreux-Erceg ,  Shuangquan Wang

IPC: H04L1/02 ,  H04B1/707

CPC classification number: H04B1/711 ,  H04B1/71072 ,  H04B1/712 ,  H04J13/0044

Abstract: A wireless system may receive a plurality of multipath signals from a plurality of transmitters and allocate per-cell modules for generating an interference suppressed signal from the multipath signals. Data symbols may be sequentially processed in the received multipath signals utilizing the per-cell modules and subtracting the processed symbols from a residual buffer storing the received multipath signals. Desired information received from one or more of the transmitters may be recovered utilizing the interference suppressed signal. Timing of the data symbols may be correlated utilizing a cell chip combiner. The data symbols may be descrambled utilizing conjugated scrambling codes associated with one of the plurality of transmitters. Orthogonal variable spreading factor (OVSF) codes may be generated utilizing a Walsh transform on the data symbols. Power levels of the OVSF codes may be estimated and estimated signals may be generated based on the OVSF codes and the estimated power levels.

Abstract translation: 无线系统可以从多个发射机接收多个多径信号，并且分配用于从多路径信号产生干扰抑制信号的每小区模块。 数据符号可以利用每个单元模块在所接收的多路径信号中被顺序地处理，并且从存储所接收的多径信号的残差缓冲器中减去经处理的符号。 可以使用干扰抑制信号来恢复从一个或多个发射机接收到的期望信息。 数据符号的定时可以利用单元芯片组合器进行相关。 数据符号可以利用与多个发射机之一相关联的共轭扰码进行解扰。 可以使用对数据符号的沃尔什变换来生成正交可变扩展因子（OVSF）码。 可以估计OVSF码的功率电平，并且可以基于OVSF码和估计功率电平来生成估计信号。

公开(公告)号：US07897684B2

公开(公告)日：2011-03-01

申请号：US11329495

申请日：2006-01-10

Applicant: Guillermo C. Bazan ,  Bin Liu

Inventor： Guillermo C. Bazan ,  Bin Liu

IPC: C08G63/91 ,  C08G63/00 ,  C12Q1/68

CPC classification number: C08G61/02 ,  C08G61/122 ,  C08G61/123 ,  C12Q1/6818 ,  C12Q1/6837 ,  G01N21/6428 ,  G01N21/6452 ,  G01N2021/6419 ,  G01N2021/6439 ,  C12Q2563/131 ,  C12Q2537/119 ,  C12Q2525/107

Abstract: The invention further relates to polycationic multichromophores, which may be conjugated polymers, and methods, articles and compositions employing them as described herein. In some aspects, the invention relates to methods, articles and compositions for the detection and analysis of biomolecules in a sample. Provided assays include those determining the presence of a target biomolecule in a sample or its relative amount, or the assays may be quantitative or semi-quantitative. The methods can be performed on a substrate. The methods can be performed in an array format on a substrate, which can be a sensor. In some embodiments, detection assays are provided employing sensor biomolecules that do not comprise a fluorophore that can exchange energy with the cationic multichromophore. In some aspects biological assays are provided in which energy is transferred between one or more of the multichromophore, a label on the target biomolecule, a label on the sensor biomolecule, and/or a fluorescent dye specific for a polynucleotide, in all permutations. The multichromophore may interact at least in part electrostatically with the sensor and/or the target, and an increase in energy transfer with the polymer may occur upon binding of the sensor and the target. Other variations of the inventions are described further herein.

Abstract translation: 本发明还涉及可以是共轭聚合物的阳离子多色素，以及如本文所述使用它们的方法，制品和组合物。 在一些方面，本发明涉及用于检测和分析样品中生物分子的方法，制品和组合物。 提供的测定包括确定样品中靶生物分子的存在或其相对量的那些，或者测定可以是定量或半定量的。 该方法可以在衬底上进行。 这些方法可以以阵列格式在基底上进行，其可以是传感器。 在一些实施方案中，使用不包含能够与阳离子多重色素交换能量的荧光团的传感器生物分子来提供检测测定。 在一些方面，提供生物测定，其中在所有置换中，能量在一个或多个多色素，目标生物分子上的标记，传感器生物分子上的标记和/或多核苷酸特异的荧光染料之间转移。 多重色淀可以至少部分地与传感器和/或靶相互作用，并且当传感器和目标物结合时，聚合物的能量传递的增加可能发生。 本文进一步描述了本发明的其它变型。

公开(公告)号：US07786145B2

公开(公告)日：2010-08-31

申请号：US10900706

申请日：2004-07-28

Applicant: Jie Fei Cheng ,  Bin Liu ,  Thomas Arrhenius ,  Mark E. Wilson ,  Alex M. Nadzan ,  Gary D. Lopaschuk ,  Jason R. Dyck ,  Rossy Serafimov

Inventor： Jie Fei Cheng ,  Bin Liu ,  Thomas Arrhenius ,  Mark E. Wilson ,  Alex M. Nadzan ,  Gary D. Lopaschuk ,  Jason R. Dyck ,  Rossy Serafimov

IPC: A61K31/4406 ,  A61K31/428 ,  A61K31/4025 ,  C07D417/12 ,  C07D277/72 ,  C07D207/14

CPC classification number: C07D277/70 ,  A61K31/428 ,  A61K31/4439 ,  A61K31/4745 ,  A61K31/506 ,  C07D417/12

Abstract: The present invention provides methods for the use of compounds as depicted by structure I, pharmaceutical compositions containing the same, and methods for the prophylaxis, management and treatment of metabolic diseases and diseases modulated by MCD inhibition. The compounds disclosed in this invention are useful for the prophylaxis, management and treatment of diseases involving in malonyl-CoA regulated glucose/fatty acid metabolism pathway. In particular, these compounds and pharmaceutical composition containing the same are indicated in the prophylaxis, management and treatment of cardiovascular diseases, diabetes, cancer and obesity.

Abstract translation: 本发明提供了使用结构I所示化合物的方法，含有该化合物的药物组合物，以及预防，治疗和治疗由MCD抑制调节的代谢疾病和疾病的方法。 本发明公开的化合物可用于预防，管理和治疗涉及丙二酰辅酶A调节的葡萄糖/脂肪酸代谢途径的疾病。 特别地，这些化合物和含有它们的药物组合物在心血管疾病，糖尿病，癌症和肥胖症的预防，治疗和治疗中被指出。

公开(公告)号：US20100003267A1

公开(公告)日：2010-01-07

申请号：US12432528

申请日：2009-04-29

Applicant: Venkata Ramana Doppalapudi ,  Jing-Yu Lai ,  Bin Liu ,  Dingguo Liu ,  Joel Desharnais ,  Abhijit Suresh Bhat ,  Yanwen Fu ,  Bryan Douglas Oates ,  Gang Chen ,  Curt William Bradshaw

Inventor： Venkata Ramana Doppalapudi ,  Jing-Yu Lai ,  Bin Liu ,  Dingguo Liu ,  Joel Desharnais ,  Abhijit Suresh Bhat ,  Yanwen Fu ,  Bryan Douglas Oates ,  Gang Chen ,  Curt William Bradshaw

IPC: A61K39/395 ,  C07K14/00 ,  C07K19/00

CPC classification number: A61K47/48215 ,  A61K47/48246 ,  A61K47/48415 ,  A61K47/48507 ,  A61K47/60 ,  A61K47/64 ,  A61K47/6811 ,  A61K47/6835 ,  C07K14/71

Abstract: The present invention provides VEGF binding peptides. In addition, the invention provides VEGF peptides conjugated to antibodies alone and in conjunction with other anti-angiogenic molecules. Various uses of the peptides and compounds are provided, including methods to treat disorders associated with abnormal angiogenesis.

Abstract translation: 本发明提供VEGF结合肽。 此外，本发明提供了与单独的抗体和其它抗血管生成分子结合的VEGF肽。 提供肽和化合物的各种用途，包括治疗与异常血管发生相关的疾病的方法。