公开(公告)号：US08339921B2

公开(公告)日：2012-12-25

申请号：US12453538

申请日：2009-05-14

申请人： Yusuke Nakamura

发明人： Yusuke Nakamura

IPC分类号： G11B7/00

CPC分类号： G11B20/1426 ,  G11B7/0065 ,  G11B2020/1457 ,  G11B2020/1469 ,  G11B2220/2504

摘要： An optical information recording/reproducing apparatus using holography comprises a signal generation unit that modulates input data, adds at least one control bit to each group of N bits, performs an NRZI-modulation on the modulated data, determines the at least one control bit such that a digital sum value of the NRZI-modulated data is 0, performs NRZI modulation on the data whose at least one control bit was determined, and rearranges the data to generate 2-dimensional data; a pickup that records the 2-dimensional data in a hologram disc and reproduces the 2-dimensional data from the hologram disc; and a signal processing unit that corrects the 2-dimensional data reproduced by the pickup, performs NRZI-modulation on the 2-dimensional data that has undergone a binarization operation, removes the at least one control bit added during the recording, and demodulates the data according to a modulation rule used during the recording.

摘要翻译： 使用全息术的光学信息记录/再现装置包括：信号产生单元，其对输入数据进行调制;将至少一个控制位加到每一组N位;对调制数据执行NRZI调制;确定至少一个控制位， NRZI调制数据的数字和值为0，对确定了至少一个控制位的数据执行NRZI调制，并重新排列数据以生成二维数据; 记录全息图盘中的二维数据的拾取器，并再现来自全息图盘的二维数据; 以及信号处理单元，其校正由拾取器再现的2维数据，对经过二值化操作的二维数据执行NRZI调制，去除在记录期间添加的至少一个控制位，并解调数据 根据记录期间使用的调制规则。

公开(公告)号：US20120201111A1

公开(公告)日：2012-08-09

申请号：US13447975

申请日：2012-04-16

申请人： Yusuke Nakamura ,  Masakazu Ikeda ,  Koichiro Nishimura

发明人： Yusuke Nakamura ,  Masakazu Ikeda ,  Koichiro Nishimura

IPC分类号： G11B27/36 ,  G11B7/00

CPC分类号： G11B20/10009 ,  G11B20/10037 ,  G11B20/10046 ,  G11B20/10222 ,  G11B20/10425 ,  G11B20/14 ,  G11B20/22 ,  G11B2220/2537

摘要： An optical disk reproducing device for controlling false detection of synchronization signals due to intersymbol interference, and stably improving accuracy of frequency acquisition of a phase locked loop (PLL) even when offset and so on occur. A signal width close to an original mark length is obtained to use for frequency acquisition of the PLL by, for example, using two different slice thresholds and taking a width between a rising of a result of slicing at one threshold and a falling of a result of slicing at the other threshold as a synchronization signal width. When asymmetric properties due to offset, asymmetry, etc. occur, an amount of corrections on the slice threshold is calculated, and it is reflected on a threshold previously set to always obtain a correct synchronization signal width.

摘要翻译： 一种用于控制由于符号间干扰导致的同步信号的错误检测的光盘再现装置，并且即使发生偏移等也能稳定地提高锁相环（PLL）的频率获取的精度。 获得接近原始标记长度的信号宽度，以便通过例如使用两个不同的切片阈值并且在一个阈值的切片结果的上升与结果的下降之间的宽度来使用PLL的频率采集 在另一阈值处切片为同步信号宽度。 当发生由于偏移，不对称等引起的不对称性质时，计算切片阈值上的校正量，并将其反映在预先设定为始终获得正确的同步信号宽度的阈值上。

公开(公告)号：US08221993B2

公开(公告)日：2012-07-17

申请号：US10586987

申请日：2005-01-21

申请人： Yusuke Nakamura ,  Yoichi Furukawa

发明人： Yusuke Nakamura ,  Yoichi Furukawa

IPC分类号： C12N9/10 ,  C12Q1/48 ,  G01N33/573

CPC分类号： C12Q1/48 ,  G01N33/57419 ,  G01N33/57438 ,  G01N2333/91011 ,  G01N2500/02

摘要： The invention features a method for determining methyl transferase activity of a polypeptide and screening for modulators of methyl transferase activity. The invention further provides a method or pharmaceutical composition for prevention or treating of colorectal cancer or hepatocellular carcinoma using the modulator.

摘要翻译： 本发明的特征在于确定多肽的甲基转移酶活性并筛选甲基转移酶活性调节剂的方法。 本发明还提供了一种使用该调节剂预防或治疗结肠直肠癌或肝细胞癌的方法或药物组合物。

公开(公告)号：US20120176880A1

公开(公告)日：2012-07-12

申请号：US13424480

申请日：2012-03-20

申请人： Yusuke Nakamura

发明人： Yusuke Nakamura

IPC分类号： G11B7/127 ,  G11B7/1374

CPC分类号： G11B7/1374 ,  G11B7/0065 ,  G11B7/128

摘要： An optical information recording/reproducing apparatus and an optical information recording/reproducing method that record information using holography, wherein the optical information recording/reproducing apparatus includes a signal generation unit that generates two-dimensional data by a two-dimensional encoding method in which a lower-limit value of a number of continuous ON/OFF pixels in an array in one direction of pixels in a two-dimensional spatial light modulator is K(K≧2, K: natural number); and a pickup that records the two-dimensional data, generated by the signal generation unit, on a hologram disc.

摘要翻译： 一种使用全息记录信息的光学信息记录/再现装置和光学信息记录/再现方法，其中光学信息记录/再现装置包括：信号生成单元，其通过二维编码方法生成二维数据，其中 二维空间光调制器中的一个像素方向的阵列中连续的ON / OFF像素的数量的下限值为K（K≥2，K：自然数）; 以及将由信号生成单元生成的二维数据记录在全息图盘上的拾取器。

公开(公告)号：US08174951B2

公开(公告)日：2012-05-08

申请号：US12625633

申请日：2009-11-25

申请人： Yutaka Nagai ,  Yusuke Nakamura

发明人： Yutaka Nagai ,  Yusuke Nakamura

IPC分类号： G11B7/00

CPC分类号： G11B7/0065 ,  G03H1/182 ,  G11B7/083

摘要： In a recording apparatus capable of performing a curing process at high speed by curing a plurality of books at a time during recording and capable of performing recording of a recordable type, when recording is stopped once, the unit of books to be cured at a time is set smaller than that during continuous recording, in order to realize inexpensively both performing a curing process at high speed in hologram recording and realizing recording of a recordable type freely in a book unit. It is therefore possible to terminate recording in the unit of arbitrary books irrespective of the unit of books to be cured, and perform recording of a recordable type without loss.

摘要翻译： 在能够通过在记录期间固化多本书并且能够执行可记录类型的记录来高速执行固化处理的记录装置中，当一次停止记录时，一次要固化的书籍单位 设定为小于连续记录时的设定，以便廉价地实现在全息记录中高速地进行固化处理，并在书本单元中实现可记录型的记录。 因此，可以以任意书籍为单位终止记录，而不管要修复的书籍单位如何，并且不损失地执行可记录类型的记录。

公开(公告)号：US08158351B2

公开(公告)日：2012-04-17

申请号：US12304559

申请日：2007-06-15

申请人： Toshihiro Tanaka ,  Yusuke Nakamura ,  Aritoshi Iida ,  Kouichi Ozaki ,  Masatsugu Hori

发明人： Toshihiro Tanaka ,  Yusuke Nakamura ,  Aritoshi Iida ,  Kouichi Ozaki ,  Masatsugu Hori

IPC分类号： C12Q1/68 ,  C07H21/02 ,  C07H21/04

CPC分类号： G01N33/6893 ,  A61K31/7088 ,  C12Q1/6883 ,  C12Q2600/136 ,  C12Q2600/156 ,  C12Q2600/158 ,  C12Q2600/172 ,  G01N2500/00 ,  G01N2800/324

摘要： It is an object of the present invention to provide a method for determining inflammatory diseases including myocardial infarction as a typical example, which involves identifying polymorphisms associated with myocardial infarction and using the gene polymorphisms, an oligonucleotide that can be used for the method, a kit for diagnosing inflammatory diseases, a therapeutic agent for inflammatory diseases, and the like. The present invention provides a method for determining an inflammatory disease, which comprises detecting at least one type of gene polymorphism existing in a proteasome subunit α type 6 gene.

摘要翻译： 本发明的目的是提供一种用于确定包括心肌梗塞在内的炎性疾病的方法，其中包括鉴定与心肌梗塞相关的多态性和使用基因多态性，可用于该方法的寡核苷酸，试剂盒 用于诊断炎性疾病，炎症性疾病的治疗剂等。 本发明提供一种测定炎性疾病的方法，其包括检测存在于蛋白酶体亚单位α6型基因中的至少一种基因多态性。

公开(公告)号：US08138167B2

公开(公告)日：2012-03-20

申请号：US12278763

申请日：2006-02-10

申请人： Yusuke Nakamura ,  Yataro Daigo

发明人： Yusuke Nakamura ,  Yataro Daigo

IPC分类号： A01N43/00

CPC分类号： G01N33/57423 ,  A61K31/47 ,  A61K31/517 ,  A61K31/519 ,  A61K31/5377 ,  A61K49/0004

摘要： The present invention provided methods for treating lung cancers using therapeutic agents for lung cancers comprising erbB receptor inhibitors as active ingredients. Methods for examining the responsiveness of lung cancer patients to erbB receptor inhibitors by using blood amphiregulin (AREG) as an indicator were provided. Furthermore, methods for treating lung cancers in which responsiveness to an erbB receptor inhibitor is determined based on blood AREG concentration, and in which therapeutic agents are selectively administered to patients expected to be responsive, were also provided. Advanced therapeutic effects can be expected by administering an erbB receptor inhibitor to patients predicted to be responsive. The present invention contributes to the improvement of therapeutic effects of gefitinib (Product name: Iressa®) and such on lung cancers.

摘要翻译： 本发明提供了使用包含erbB受体抑制剂作为活性成分的肺癌治疗剂治疗肺癌的方法。 提供了通过使用血液两性调节蛋白（AREG）作为指标来检查肺癌患者对erbB受体抑制剂的反应性的方法。 此外，还提供了治疗肺癌的方法，其中基于血液AREG浓度确定对erbB受体抑制剂的反应性，并且其中治疗剂被选择性地施用于预期具有反应性的患者。 通过对预测具有反应性的患者施用erbB受体抑制剂，可以预期先进的治疗效果。 本发明有助于改善吉非替尼（商品名：Iressa）等对肺癌的治疗效果。

公开(公告)号：US08124341B2

公开(公告)日：2012-02-28

申请号：US12699711

申请日：2010-02-03

申请人： Yusuke Nakamura ,  Yoichi Furukawa

发明人： Yusuke Nakamura ,  Yoichi Furukawa

IPC分类号： C12Q1/68 ,  G01N33/53

CPC分类号： C07K16/303 ,  A61K38/00 ,  C07K14/4748 ,  C07K16/3046 ,  G01N33/57419 ,  G01N33/57438 ,  G01N33/6893 ,  G01N2500/00

摘要： The present application provides novel human genes WDRPUH and KRZFPUH, and PPIL1 whose expression is markedly elevated in a great majority of HCCs and colorectal cancers, respectively, compared to corresponding non-cancerous tissues, as well as novel human gene APCDD1 whose expression is elevated in primary colon cancers and down-regulated in response to the transduction of wild-type APC1 into colon-cancer cells. The genes and polypeptides encoded by the genes can be used, for example, in the diagnosis of a cell proliferative disease, and as target molecules for developing drugs against the disease.

摘要翻译： 本申请提供了新的人类基因WDRPUH和KRZFPUH，和PPIL1，其表达在大多数HCC和结肠直肠癌中分别与相应的非癌组织相比显着升高，以及新型人基因APCDD1，其表达升高 原发性结肠癌并且响应于野生型APC1转导入结肠癌细胞而下调。 由该基因编码的基因和多肽可用于例如细胞增殖性疾病的诊断，以及用于开发针对该疾病的药物的靶分子。

公开(公告)号：US20120028262A1

公开(公告)日：2012-02-02

申请号：US13079274

申请日：2011-04-04

申请人： Yusuke Nakamura ,  Toyomasa Katagiri

发明人： Yusuke Nakamura ,  Toyomasa Katagiri

IPC分类号： C12Q1/68 ,  C12Q1/02 ,  G01N33/566

CPC分类号： G01N33/57438 ,  A61K38/00 ,  C07K14/47 ,  C07K14/82 ,  C12Q1/6837 ,  C12Q1/6886 ,  C12Q2600/112 ,  C12Q2600/118 ,  C12Q2600/136 ,  C12Q2600/158 ,  Y02A90/26

摘要： The present application provides novel human genes C1958V1 or C1958V2 whose expression is markedly elevated in pancreatic cancers compared to corresponding non-cancerous tissues. The genes and polypeptides encoded by the genes can be used, for example, in the diagnosis of pancreatic cancer, and as target molecules for developing drugs against the disease.

摘要翻译： 本申请提供了新的人基因C1958V1或C1958V2，与相应的非癌组织相比，其在胰腺癌中的表达显着升高。 由该基因编码的基因和多肽可用于例如胰腺癌的诊断，以及作为用于开发针对该疾病的药物的靶分子。

公开(公告)号：US20120022128A1

公开(公告)日：2012-01-26

申请号：US12674664

申请日：2008-08-20

申请人： Yusuke Nakamura ,  Hidewaki Nakagawa ,  Shuichi Nakatsuru

发明人： Yusuke Nakamura ,  Hidewaki Nakagawa ,  Shuichi Nakatsuru

IPC分类号： A61K31/713 ,  C12N15/63 ,  C12Q1/68 ,  A61P35/00 ,  C40B30/04 ,  C07K16/44 ,  C07K16/18 ,  G01N33/566 ,  C12N15/113 ,  G01N33/574

CPC分类号： A61K31/70 ,  A61K48/00 ,  C07K14/47 ,  C12N15/113 ,  C12N2310/111 ,  C12N2310/14

摘要： The invention features methods for detecting prostate cancer, especially hormone-refractory prostate cancer (HRPC) or castration-resistant prostate cancer (CRPC), by detecting over-expression of PKIB or NAALADL2 compared the normal organs. Also disclosed are methods of identifying compounds for treating and preventing prostate cancer including HRPC, based on the over-expression of PKIB or NAALADL2 in the prostate cancer, the cell proliferation function of PKIB or NAALADL2, the intracellular localization of PKIB or NAALADL2 or the interaction between PKIB and PKA-C. Also, provided are a method for treating prostate cancer by administering a double-stranded molecule against the PKIB or NAALADL2 gene. The invention also provides products, including the double-stranded molecules and vectors encoding them, as well as compositions comprising the molecules or vectors, useful in the provided methods.

摘要翻译： 本发明通过检测PKIB或NAALADL2的过表达来检测前列腺癌，特别是激素难治性前列腺癌（HRPC）或去势抗性前列腺癌（CRPC）的方法。 还公开了基于前列腺癌中PKIB或NAALADL2的过度表达，PKIB或NAALADL2的细胞增殖功能，PKIB或NAALADL2的细胞内定位或相互作用的鉴定，鉴定用于治疗和预防前列腺癌包括HRPC的化合物的方法 PKIB和PKA-C之间。 此外，提供了通过对PKIB或NAALADL2基因施用双链分子来治疗前列腺癌的方法。 本发明还提供了包括双链分子和编码它们的载体的产物，以及可用于所提供的方法中的包含分子或载体的组合物。