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    PATCH
    132.
    发明申请
    PATCH 审中-公开
    补丁

    公开(公告)号：US20140322300A1

    公开(公告)日：2014-10-30

    申请号：US14363559

    申请日：2012-12-06

    Applicant: Hisamitsu Pharmaceutical Co., Inc.

    Inventor： Masaru Kijima ,  Yasuhisa Kose ,  Takaaki Yoshinaga

    IPC: A61K31/196 ,  A61K47/10 ,  A61K47/02 ,  A61K9/70

    CPC classification number: A61K9/7061 ,  A61K9/7069 ,  A61K31/196 ,  A61K47/02 ,  A61K47/10

    Abstract: A patch comprising a support layer and an adhesive agent layer, wherein the adhesive agent layer contains diclofenac or a pharmaceutically acceptable salt thereof, glycerin, butylene glycol, and poly(ethylene glycol)monooleate, and a mass ratio between the butylene glycol and the poly(ethylene glycol)monooleate (mass of butylene glycol:mass of poly(ethylene glycol)monooleate) is 1:1 to 4:1.

    Abstract translation: 一种贴剂，包括支持层和粘合剂层，其中所述粘合剂层包含双氯芬酸或其药学上可接受的盐，甘油，丁二醇和聚（乙二醇）单油酸酯，并且所述丁二醇和聚 （乙二醇）单油酸酯（丁二醇的质量：聚（乙二醇）单油酸酯的质量）为1:1至4:1。

    LIDOCAINE-CONTAINING PATCH
    133.
    发明申请
    LIDOCAINE-CONTAINING PATCH 有权

    公开(公告)号：US20250082591A1

    公开(公告)日：2025-03-13

    申请号：US18960714

    申请日：2024-11-26

    Applicant: HISAMITSU PHARMACEUTICAL CO., INC.

    Inventor： Kentaro NAKASHIMA ,  Yusuke TANAKA ,  Keiichiro TSURUSHIMA

    IPC: A61K31/167 ,  A61K9/70 ,  A61K47/10

    Abstract: Disclosed is a patch comprising an adhesive layer on a backing layer, wherein the adhesive layer comprises lidocaine or a pharmaceutically acceptable salt thereof, propylene glycol, a rubber adhesive base and a terpene resin, wherein the content of the lidocaine or pharmaceutically acceptable salt thereof in the adhesive layer is 3 mass % to 5 mass % with respect to the total mass of the adhesive layer, the content of the terpene resin in the adhesive layer is 5 mass % to 18 mass % with respect to the total mass of the adhesive layer, and the content of propylene glycol in the adhesive layer is 3 mass % to 7 mass % with respect to the total mass of the adhesive layer, wherein crystals are not precipitated in the patch, and wherein the adhesive layer has an adhesive surface, and requires a force of 1.3 N or less to release the adhesive surfaces during self-adhesion.

    Spray container
    137.
    外观设计
    Spray container 有权

    公开(公告)号：USD1014284S1

    公开(公告)日：2024-02-13

    申请号：US29723539

    申请日：2020-02-07

    Applicant: HISAMITSU PHARMACEUTICAL CO., INC.

    Designer： Michiaki Tsuji ,  Hiroyuki Nagashima

    Abstract: FIG. 1 is a front perspective view of a spray container.
    FIG. 2 is a rear perspective view thereof.
    FIG. 3 is a front view thereof.
    FIG. 4 is a rear view thereof.
    FIG. 5 is a top plan view thereof.
    FIG. 6 is a bottom plan view thereof.
    FIG. 7 is a right side view thereof.
    FIG. 8 is a left side view thereof.
    FIG. 9 is an enlarged sectional view taken along the line 9-9 in FIG. 5 with the unclaimed bottle portion partially removed for ease of illustration.
    FIG. 10 is a reference front perspective view showing the unlocked state thereof; and,
    FIG. 11 is a reference rear perspective view showing the unlocked state thereof.
    The broken lines show portions of a spray container that form no part of the claimed design.
    The alternate long and short dash lines are merely the boundary lines between the claimed portions and the non-claimed portions.

    METHOD FOR INHIBITING ASENAPINE DEGRADATION
    138.
    发明公开
    METHOD FOR INHIBITING ASENAPINE DEGRADATION 审中-公开

    公开(公告)号：US20230414530A1

    公开(公告)日：2023-12-28

    申请号：US18035951

    申请日：2021-11-08

    Applicant: HISAMITSU PHARMACEUTICAL CO., INC.

    Inventor： Yuka TAKAGI ,  Nao IWAMOTO

    IPC: A61K9/70 ,  A61K47/18 ,  A61K31/407

    CPC classification number: A61K9/7046 ,  A61K47/18 ,  A61K31/407

    Abstract: Disclosed is a method for inhibiting degradation of asenapine or a pharmaceutically acceptable salt thereof in a patch. The patch comprises an adhesive layer on a base, and the adhesive layer contains an adhesive base and asenapine or a pharmaceutically acceptable salt thereof. The method includes incorporating at least one amine compound selected from the group consisting of monoethanolamine, diethanolamine, diisopropanolamine, isopropanolamine, triethanolamine and meglumine in the adhesive layer.

    LIDOCAINE-CONTAINING PATCH
    139.
    发明公开
    LIDOCAINE-CONTAINING PATCH 审中-公开

    公开(公告)号：US20230346720A1

    公开(公告)日：2023-11-02

    申请号：US18083793

    申请日：2022-12-19

    Applicant: HISAMITSU PHARMACEUTICAL CO., INC.

    Inventor： Kentaro NAKASHIMA ,  Yusuke TANAKA ,  Keiichiro TSURUSHIMA

    IPC: A61K9/70 ,  A61K31/167 ,  A61K47/10

    CPC classification number: A61K31/167 ,  A61K9/7046 ,  A61K47/10

    Abstract: Disclosed is a patch comprising an adhesive layer on a backing layer, wherein the adhesive layer comprises lidocaine or a pharmaceutically acceptable salt thereof, propylene glycol, a rubber adhesive base and a terpene resin, wherein the content of the lidocaine or a pharmaceutically acceptable salt thereof in the adhesive layer in terms of free form is 2 mass% to 6 mass% with respect to the total mass of the adhesive layer, wherein the ratio of the mass of the lidocaine or a pharmaceutically acceptable salt thereof in terms of free form to the mass of propylene glycol in the adhesive layer is 1:0.6 to 1:1.8, and wherein the content of the terpene resin in the adhesive layer is 5 mass% to 18 mass% with respect to a total mass of the adhesive layer.

    ASENAPINE-CONTAINING PATCH
    140.
    发明公开
    ASENAPINE-CONTAINING PATCH 审中-公开

    公开(公告)号：US20230310340A1

    公开(公告)日：2023-10-05

    申请号：US18036203

    申请日：2021-11-08

    Applicant: HISAMITSU PHARMACEUTICAL CO., INC.

    Inventor： Yuka TAKAGI ,  Nao IWAMOTO

    IPC: A61K9/70 ,  A61K31/407 ,  A61K47/18

    CPC classification number: A61K9/7069 ,  A61K31/407 ,  A61K47/183

    Abstract: Disclosed is a patch in which degradation of asenapine or a pharmaceutically acceptable salt thereof is inhibited. The patch comprises an adhesive layer on a base, wherein the adhesive layer contains an adhesive base, asenapine or a pharmaceutically acceptable salt thereof, and at least one basic amino acid selected from the group consisting of lysine, arginine and histidine, or a pharmaceutically acceptable salt of said basic amino acid.

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