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公开(公告)号：US11590850B2
公开(公告)日：2023-02-28
申请号：US17165463
申请日：2021-02-02
申请人： Toyota Motor Engineering & Manufacturing North America, Inc. , The Regents of the University of Michigan
发明人： Yanghe Liu , Qunfang Wu , Mengqi Wang , Weiyang Zhou , Chungchih Chou
摘要： A vehicle power system includes a coil that, in a first operational mode, receives power wirelessly from an external source, a first battery connected to the coil to receive power transferred from the coil while the coil is in the first operational mode, a second battery that receives power from the first battery, and a switch that switches the coil between the first operational mode and a second operational mode in which the coil receives power from the second battery and wirelessly transfers power from the second battery to an electrical load in the vehicle.
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公开(公告)号：US20230056534A1
公开(公告)日：2023-02-23
申请号：US17743878
申请日：2022-05-13
摘要： An acoustic lens to steer an acoustic beam includes a first structure, a second structure spaced from the first structure, an array of projections disposed between the first and second structures, each projection of the array of projections extending from the first structure toward the second structure to define a respective gap between the projection and the second structure, and an actuator configured to move the first structure, the second structure, or the array of projections for collective adjustment of the respective gaps of the array of projections. Each projection is configured to define one or more respective unit cells, each unit cell having a sub-wavelength size relative to the acoustic beam to establish an effective refractive index profile for the acoustic beam between the first and second structures. The actuator is configured such that the collective adjustment of the respective gaps varies across the array of projections to spatially modify the effective refractive index profile to steer the acoustic beam.
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公开(公告)号：US20230053687A1
公开(公告)日：2023-02-23
申请号：US17889563
申请日：2022-08-17
发明人： Tyler S. WORMAN , Huei PENG , Gregory J. McGUIRE
IPC分类号： G06T11/00
摘要： An augmented virtual vehicle testing system and method for presenting graphics to a vehicle operator during operation of a vehicle. The method includes: determining a position of a vehicle operator within a vehicle testing environment; executing an augmentative simulation of the vehicle testing environment, wherein the augmentative simulation is used to provide a position of one or more virtual objects within the vehicle testing environment; generating graphics representing the one or more virtual objects based on the position of the vehicle operator and the position of the one or more virtual objects within the vehicle testing environment; and presenting the graphics on an electronic display and to the vehicle operator during operation of the vehicle.
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公开(公告)号：US20230051263A1
公开(公告)日：2023-02-16
申请号：US17791790
申请日：2021-01-11
发明人： Xudong FAN , Wen XUE , Xiaotian TAN , Mark A. ILGEN , Girish KULKARNI , Maung Kyaw KHAING OO
摘要： An automated microfluidic bioreactor device and methods to rapidly detect drugs of abuse from human sweat are provided. The bioreactor can perform either single-plexed measurements (detecting only one target analyte at a time) or multiplexed measurement (detecting multiple analytes simultaneously). The bioreactor device has a cartridge comprising a capillary array that employs competitive enzyme-linked immunosorbent assay (ELISA) to detect the presence of various drugs or metabolite compounds. For example, four common drugs, methadone, methamphetamine, amphetamine, and tetrahydrocannabinol, were detected rapidly and quantitatively in about 16 minutes with a low sweat sample volume (about 4 μL per analyte) and a large dynamic range (methadone: 0.0016 ng/mL-1 ng/mL; METH: 0.016 ng/mL-25 ng/mL; amphetamine: 0.005 ng/mL-10 ng/mL; THC: 0.02 ng/mL-1000 ng/mL).
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公开(公告)号：US20230046569A1
公开(公告)日：2023-02-16
申请号：US17729836
申请日：2022-04-26
发明人： Tomasz Cierpicki , Jolanta Grembecka , Huang Huang , Sergei Zari , Hyo Je Cho , Mykhaylo Potopnyk , Sergii Dudkin , Wenbing Chen , Yassir Adam , Christina Howard , EunGi Kim
IPC分类号： A61K31/428 , A61P35/00
摘要： Provided herein are small molecule inhibitors of NSD1, NSD2 and/or NSD3 activity, and methods of use thereof for the treatment of disease, including leukemia, breast cancer, osteosarcoma, lung and prostate cancers and other solid tumors as well as other diseases dependent on the activity of NSD1, NSD2 and/or NSD3.
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136.发明申请公开(公告)号：US20230044649A1
公开(公告)日：2023-02-09
申请号：US17840276
申请日：2022-06-14
发明人： Olga Shalev , Max Shtein , Shreya Raghavan , Geeta Mehta
IPC分类号： A61K9/70 , A61K31/192 , A61K31/522 , C23C14/12 , A61K31/138 , A61K31/167 , A61L31/16 , A61K45/06 , A61K31/277 , A61K31/352 , A61L27/54 , C23C14/22 , C23C14/04 , A61K31/275 , A61K31/65
摘要： Solid films and articles having a surface with discrete regions patterned with a deposited low molecular weight organic compound, such as pharmaceutical actives and new chemical entities, are provided. The organic compound may be present at ≥ about 99 mass % in the one or more discrete regions and may be crystalline or amorphous. The deposited organic compound may be deposited as a film having high surface area. The deposited organic compound exhibits enhanced solubility and bioavailability, by way of non-limiting example. Methods of organic vapor jet printing deposition method of such a low molecular weight organic compound in an inert gas stream are also provided.
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公开(公告)号：US11555041B2
公开(公告)日：2023-01-17
申请号：US16927844
申请日：2020-07-13
发明人： Tao Wu , Liansheng Li , Yi Wang , Pingda Ren , Jolanta Grembecka , Tomasz Cierpicki , Szymon Klossowski , Jonathan Pollock , Dmitry Borkin
IPC分类号： C07D495/04 , A61K31/445 , A61P35/02
摘要： The present disclosure provides compounds of Formula (I-A) for inhibiting the interaction of menin with MLL1, MLL2 and MLL-fusion oncoproteins. The compounds are useful for the treatment of leukemia, solid cancers, diabetes and other diseases dependent on activity of MLL1, MLL2, MLL fusion proteins, and/or menin.
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公开(公告)号：US11548277B2
公开(公告)日：2023-01-10
申请号：US16901556
申请日：2020-06-15
发明人： Lai Yu Leo Tse , Ethan John McMillan , Kira Barton
摘要： A printer is configured to provide a jet of extraction gas that extracts a printing fluid from a printing nozzle in the presence of an electric field that accelerates the extracted printing fluid toward a printing substrate. The printer is also configured to selectively turn the electric field and the jet of extraction gas off and on to enable printing in gas-extraction mode, an e-assisted gas-extraction mode, or an e-jet mode. The jet of gas can be provided by a second nozzle concentric with the printing nozzle. A third nozzle can discharge a focusing gas around the extracted printing fluid.
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公开(公告)号：US11543465B2
公开(公告)日：2023-01-03
申请号：US16841323
申请日：2020-04-06
发明人： Scott Green , Yogesh B. Gianchandani , Richard Kwon , Grace Elta , Jiqing Jiang , Ramprasad Nambisan
摘要： Encapsulation packages for stent-deployable monitoring devices formed of resonator sensors and allowing for magnetic biasing elements that exhibit a targeted impact on the mechanical characteristics of a stent are provided. Encapsulation packages are formed of different types and include a longitudinal shield and curved end on profile for aligning the shield within the deployable stent, the shield having perforations such that a resonator can be positioned adjacent the perforations for allowing particulate within the stent to collect and be measured by the resonator during deployment.
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公开(公告)号：US20220409960A1
公开(公告)日：2022-12-29
申请号：US17623920
申请日：2020-06-30
申请人： University of Florida Research Foundation, Inc. , THE REGENTS OF THE UNIVERSITY OF MICHIGAN OFFICE OF TECHNOLOGY TRANSFER
摘要： Systems and methods are disclosed for human balance training. The systems and methods involve intermittently occluding the vision of a subject while the subject is engaged in a balance activity, such as walking on a balance beam, for example. Creating a brief period of continuous visual occlusion results in posterior parietal cortex activation, leading to enhanced balance training. The end result is much greater improvement in balance compared to physical training alone.
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