公开(公告)号：US07601356B2

公开(公告)日：2009-10-13

申请号：US11780627

申请日：2007-07-20

Applicant: Hong Jin ,  Bin Liu

Inventor： Hong Jin ,  Bin Liu

IPC: A61K39/145 ,  C12N7/04 ,  C12N15/44

CPC classification number: C12N7/00 ,  A61K39/12 ,  A61K39/145 ,  C07K14/005 ,  C12N2760/16121 ,  C12N2760/16122 ,  C12N2760/16134

Abstract: In certain aspects, the present invention provides methods for increasing the replication capacity of influenza viruses in hens' eggs and/or cell culture, recombinant and/or reassortant influenza viruses with increased replication capacity, and immunogenic and vaccine compositions comprising such recombinant and/or reassortant influenza viruses. In other aspects, the invention further provides nucleic acids encoding influenza genes associated with increased replication capacity, expression vectors comprising the nucleic acids of the invention, methods for making influenza viruses with increased replication capacity, and kits useful for practice of the methods.

Abstract translation: 在某些方面，本发明提供了增加在具有增加的复制能力的母鸡卵和/或细胞培养物，重组和/或重配流感病毒中的流感病毒的复制能力的方法，以及包含这种重组和/或 重配流感病毒。 在其它方面，本发明还提供编码与增加的复制能力相关的流感基因的核酸，包含本发明的核酸的表达载体，具有增加的复制能力的制备流感病毒的方法，以及可用于实施该方法的试剂盒。

公开(公告)号：US07582736B2

公开(公告)日：2009-09-01

申请号：US11972130

申请日：2008-01-10

Applicant: Bin Liu ,  James D. Marks

Inventor： Bin Liu ,  James D. Marks

IPC: C12P21/08

CPC classification number: C07K16/3069 ,  A61K2039/505 ,  C07K2317/622 ,  C07K2317/73 ,  C07K2317/77

Abstract: This invention provides novel prostate cancer specific internalizing human antibodies. The antibodies are useful by themselves to prevent growth and/or proliferation of prostate cancer cells. The antibodies can also be formulated as chimeric molecules to direct an effector (e.g. a cytotoxin, an imaging reagent, a drug, etc.) to a prostate tumor site.

Abstract translation: 本发明提供了新型前列腺癌特异性内化人抗体。 抗体本身可用于预防前列腺癌细胞的生长和/或增殖。 抗体还可以配制成嵌合分子以将效应物（例如细胞毒素，成像试剂，药物等）引导至前列腺肿瘤部位。

公开(公告)号：US20080280891A1

公开(公告)日：2008-11-13

申请号：US11819494

申请日：2007-06-27

Applicant: Martha Kelly ,  Younghee Lee ,  Bin Liu ,  Ted Fujimoto ,  Joel Freundlich ,  Bruce D. Dorsey ,  Gary A. Flynn ,  Arifa Husain ,  William R. Moore, Jr.

Inventor： Martha Kelly ,  Younghee Lee ,  Bin Liu ,  Ted Fujimoto ,  Joel Freundlich ,  Bruce D. Dorsey ,  Gary A. Flynn ,  Arifa Husain ,  William R. Moore, Jr.

IPC: A61K31/541 ,  A61K31/404 ,  C07D209/42 ,  C07D401/02 ,  C07D417/14 ,  A61K31/44 ,  A61P35/00 ,  A61K31/4439 ,  A61K31/5377 ,  C07D413/14

CPC classification number: A61K31/404 ,  A61K31/44 ,  A61K31/4439 ,  A61K31/5377 ,  A61K31/541 ,  C07D213/74 ,  C07D231/56 ,  C07D401/12 ,  C07D401/14 ,  C07D403/12 ,  C07D405/12 ,  C07D409/10 ,  C07D413/12 ,  C07D498/04

Abstract: The present invention is in the area of novel compounds and salts thereof, their syntheses, and their use as anti-cancer agents. The compounds include compounds of Formula I: and solvates, hydrates and pharmaceutically-acceptable salts thereof, wherein A1 is N or CR1; A3 is N or CR3; A5 is N or CR5; R1, R3-R6 and L are defined in the specification; n is 0 or 1; and X is an optionally-substituted aryl group having 6-10 carbons in the ring portion, an optionally-substituted 6-membered heteroaryl group having 1-3 nitrogen atoms in the ring portion, an optionally-substituted 5-membered heteroaryl group having 0-4 nitrogen atoms in the ring portion and optionally having 1 sulfur atom or 1 oxygen atom in the ring portion, or an optionally-substituted heteroaryl group in which a 6-membered ring is fused either to a 5-membered ring or to a 6-membered ring, wherein in each case 1, 2, 3 or 4 ring atoms are heteroatoms independently selected from nitrogen, oxygen and sulfur. They are effective against a broad range of cancers, especially leukemia, prostate, non-small cell lung and colon. They are additionally useful in the treatment of proliferative retinopathies such as diabetic neuropathy and macular degeneration.

Abstract translation: 本发明涉及新型化合物及其盐，其合成及其作为抗癌剂的用途。 化合物包括式I化合物及其溶剂合物，水合物及其药学上可接受的盐，其中A 1是N或CR 1; N 3或N 3是N或CR 3; A <5>为N或CR 5; 在说明书中定义了R 1，R 3，R 6和L 6; n为0或1; 并且X是在环部分中具有6-10个碳的任选取代的芳基，在环部分中具有1-3个氮原子的任选取代的6元杂芳基，任选取代的5元杂芳基具有0 -4个氮原子，并且在环部分中任选具有1个硫原子或1个氧原子，或任选取代的杂芳基，其中6元环稠合到5元环或6元环 其中在每种情况下，1,2,3或4个环原子是独立地选自氮，氧和硫的杂原子。 它们对广泛的癌症尤其是白血病，前列腺，非小细胞肺和结肠有效。 它们还可用于治疗增殖性视网膜病变，例如糖尿病性神经病变和黄斑变性。

公开(公告)号：US07356594B2

公开(公告)日：2008-04-08

申请号：US10678976

申请日：2003-10-03

Applicant: Charbel Khawand ,  Jianping W. Miller ,  Jean Khawand ,  Bin Liu

Inventor： Charbel Khawand ,  Jianping W. Miller ,  Jean Khawand ,  Bin Liu

IPC: G06F15/173 ,  G06F13/00

CPC classification number: H04L67/14 ,  H04L69/329

Abstract: An IPC protocol/network allows for intelligent targeting of nodes in order to reduce overhead and provide for improved power management. The IPC server keeps track of the IPC network's node activity and using an operational state table (2000) it can determine which node can handle a service request (e.g., MP3 decode). By keeping track of the current operational condition of the nodes within the network, the processors can have better battery life and application latency can be improved. The IPC server will keep track not only of which nodes can handle which services, but it will also know which node can handle the service request given its knowledge of the operational state of each of the nodes.

Abstract translation: IPC协议/网络允许节点的智能目标，以减少开销并提供改进的电源管理。 IPC服务器跟踪IPC网络的节点活动并使用操作状态表（2000），它可以确定哪个节点可以处理服务请求（例如，MP3解码）。 通过跟踪网络中节点的当前操作条件，处理器可以具有更好的电池寿命并且可以提高应用延迟。 IPC服务器不仅将跟踪哪些节点可以处理哪些服务，而且还将知道哪个节点可以处理服务请求，因为它知道每个节点的操作状态。

公开(公告)号：US07335744B2

公开(公告)日：2008-02-26

申请号：US11021438

申请日：2004-12-21

Applicant: Bin Liu ,  James D. Marks

Inventor： Bin Liu ,  James D. Marks

IPC: C12P21/08

CPC classification number: C07K16/3069 ,  A61K2039/505 ,  C07K2317/622 ,  C07K2317/73 ,  C07K2317/77

Abstract: This invention provides novel prostate cancer specific internalizing human antibodies. The antibodies are useful by themselves to prevent growth and/or proliferation of prostate cancer cells. The antibodies can also be formulated as chimeric molecules to direct an effector (e.g. a cytotoxin, an imaging reagent, a drug, etc.) to a prostate tumor site.

Abstract translation: 本发明提供了新型前列腺癌特异性内化人抗体。 抗体本身可用于预防前列腺癌细胞的生长和/或增殖。 抗体还可以配制成嵌合分子以将效应物（例如细胞毒素，成像试剂，药物等）引导至前列腺肿瘤部位。

公开(公告)号：US20070284501A1

公开(公告)日：2007-12-13

申请号：US11735246

申请日：2007-04-13

Applicant: Bin Liu

Inventor： Bin Liu

IPC: B60S9/02

CPC classification number: B66F5/00 ,  B60B33/0002 ,  B60B33/001 ,  B60B33/0021 ,  B60B33/0039 ,  B60B33/0049 ,  B60B33/0057 ,  B60B33/0068 ,  B60B33/0073 ,  B60B33/045 ,  B60G3/01 ,  B60G11/16 ,  B66F13/00 ,  F16F1/127

Abstract: A shock-absorbing wheel mounting structure used in a horizontal jack is disclosed. The wheel mounting structure includes an axial sleeve (4) affixed to a rear wheel mount (5) of the horizontal jack (100), and a shaft (2), vertically slideably mounted in the axial sleeve (4) and riveted to a bracket (1). The bracket (1) supports a wheel (71). A compression spring (3) is sleeved onto the shaft (2) and stopped between a stop flange around the periphery of the shaft (2) and the top wall of the axial sleeve (4). This arrangement serves to impart a downward pressure to the shaft (2) relative to the axial sleeve (4).

Abstract translation: 公开了一种在水平千斤顶中使用的减震轮安装结构。 车轮安装结构包括固定到水平千斤顶（100）的后轮安装件（5）上的轴向套筒（4）和可垂直地可滑动地安装在轴向套筒（4）中并铆接到支架 （1）。 支架（1）支撑轮（71）。 压缩弹簧（3）套在轴（2）上并且停在围绕轴（2）的周边的止动凸缘和轴向套筒（4）的顶壁之间。 这种布置用于相对于轴向套筒（4）向轴（2）施加向下的压力。

公开(公告)号：US07271753B1

公开(公告)日：2007-09-18

申请号：US11436824

申请日：2006-05-18

Applicant: Pradeep Padukone ,  Bin Liu

Inventor： Pradeep Padukone ,  Bin Liu

IPC: H03M1/62

CPC classification number: G11B5/58 ,  G11B5/6005 ,  G11B5/6029 ,  H03M1/1014 ,  H03M1/12

Abstract: Methods of calibrating an analog front end (AFE) of a read/write channel include measuring a first magnitude of a test signal, measuring a second magnitude of an output signal of the AFE generated in response to the test signal, and comparing the first magnitude and the second magnitude to generate a measure of a gain of the AFE at a frequency of the test signal. A data storage device includes a read/write head configured to generate an analog input signal, an AFE coupled to the read/write head and configured to amplify and filter the analog input signal, a test signal generator configured to generate a test signal having a frequency substantially equal to a fundamental frequency of the analog input signal or any of its harmonics, and an attenuator coupled between the test signal generator and the AFE.

Abstract translation: 校准读/写通道的模拟前端（AFE）的方法包括测量测试信号的第一幅度，测量响应于测试信号产生的AFE的输出信号的第二幅度，并且比较第一幅度 以及第二幅度以产生在测试信号的频率处的AFE的增益的量度。 数据存储装置包括被配置为产生模拟输入信号的读/写头，耦合到读/写头并被配置为放大和滤波模拟输入信号的AFE，被配置为产生测试信号的测试信号发生器， 频率基本上等于模拟输入信号或其任何谐波的基频，以及耦合在测试信号发生器和AFE之间的衰减器。

公开(公告)号：US07230011B2

公开(公告)日：2007-06-12

申请号：US10466969

申请日：2002-01-17

Applicant: Sandra Ann Filla ,  Michael Edward Flaugh ,  James Ronald Gillig ,  Lawrence Joseph Heinz ,  Joseph Herman Krushinski, Jr. ,  Bin Liu ,  Marta Maria Pineiro-Nunez ,  John Mehnert Schaus ,  John Stanley Ward

Inventor： Sandra Ann Filla ,  Michael Edward Flaugh ,  James Ronald Gillig ,  Lawrence Joseph Heinz ,  Joseph Herman Krushinski, Jr. ,  Bin Liu ,  Marta Maria Pineiro-Nunez ,  John Mehnert Schaus ,  John Stanley Ward

IPC: A61K31/454 ,  A61K31/4545 ,  C07D401/04 ,  C07D401/14

CPC classification number: C07D401/04 ,  C07D401/14 ,  C07D487/04

Abstract: The present invention relates to compounds of formula I: which are antagonists of 5-HT6 receptor.

Abstract translation: 本发明涉及式I化合物，它是5-HT 6受体的拮抗剂。

公开(公告)号：US20060183140A1

公开(公告)日：2006-08-17

申请号：US11329495

申请日：2006-01-10

Applicant: Guillermo Bazan ,  Bin Liu

Inventor： Guillermo Bazan ,  Bin Liu

IPC: C12Q1/68 ,  C08G63/91

CPC classification number: C08G61/02 ,  C08G61/122 ,  C08G61/123 ,  C12Q1/6818 ,  C12Q1/6837 ,  G01N21/6428 ,  G01N21/6452 ,  G01N2021/6419 ,  G01N2021/6439 ,  C12Q2563/131 ,  C12Q2537/119 ,  C12Q2525/107

Abstract: The invention further relates to polycationic multichromophores, which may be conjugated polymers, and methods, articles and compositions employing them as described herein. In some aspects, the invention relates to methods, articles and compositions for the detection and analysis of biomolecules in a sample. Provided assays include those determining the presence of a target biomolecule in a sample or its relative amount, or the assays may be quantitative or semi-quantitative. The methods can be performed on a substrate. The methods can be performed in an array format on a substrate, which can be a sensor. In some embodiments, detection assays are provided employing sensor biomolecules that do not comprise a fluorophore that can exchange energy with the cationic multichromophore. In some aspects biological assays are provided in which energy is transferred between one or more of the multichromophore, a label on the target biomolecule, a label on the sensor biomolecule, and/or a fluorescent dye specific for a polynucleotide, in all permutations. The multichromophore may interact at least in part electrostatically with the sensor and/or the target, and an increase in energy transfer with the polymer may occur upon binding of the sensor and the target. Other variations of the inventions are described further herein.

Abstract translation: 本发明还涉及可以是共轭聚合物的阳离子多色素，以及如本文所述使用它们的方法，制品和组合物。 在一些方面，本发明涉及用于检测和分析样品中生物分子的方法，制品和组合物。 提供的测定包括确定样品中靶生物分子的存在或其相对量的那些，或者测定可以是定量或半定量的。 该方法可以在衬底上进行。 这些方法可以以阵列格式在基底上进行，其可以是传感器。 在一些实施方案中，使用不包含能够与阳离子多重色素交换能量的荧光团的传感器生物分子来提供检测测定。 在一些方面，提供生物测定，其中在所有置换中，能量在一个或多个多色素，目标生物分子上的标记，传感器生物分子上的标记和/或多核苷酸特异的荧光染料之间转移。 多重色淀可以至少部分地与传感器和/或靶相互作用，并且当传感器和目标物结合时，聚合物的能量传递的增加可能发生。 本文进一步描述了本发明的其它变型。

公开(公告)号：US20060154922A1

公开(公告)日：2006-07-13

申请号：US10546910

申请日：2004-03-12

Applicant: Jennifer Allen ,  Stephen Hitchcock ,  William Turner ,  Bin Liu

Inventor： Jennifer Allen ,  Stephen Hitchcock ,  William Turner ,  Bin Liu

IPC: A61K31/54 ,  A61K31/537 ,  C07D279/12 ,  C07D211/06 ,  C07D265/30 ,  A61K31/445

CPC classification number: C07D409/12 ,  C07D207/22 ,  C07D211/72 ,  C07D239/14 ,  C07D263/28 ,  C07D265/08 ,  C07D277/18 ,  C07D279/06

Abstract: The present invention relates to compounds of Formula (I): which are agonists of the M-1 muscarinic receptor.

Abstract translation: 本发明涉及式（I）化合物：它是M-1毒蕈碱受体的激动剂。