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公开(公告)号:US08053456B2
公开(公告)日:2011-11-08
申请号:US11807327
申请日:2007-05-25
申请人: Lijun Sun , Weiwen Ying , Junghyun Chae , Teresa Przewloka , Shijie Zhang , Dinesh U. Chimmanamada , Kevin Foley , Zhenjian Du , Hao Li , David James , Howard P. Ng , Zachary Demko , Dan Zhou , Shuzhen Qin
发明人: Lijun Sun , Weiwen Ying , Junghyun Chae , Teresa Przewloka , Shijie Zhang , Dinesh U. Chimmanamada , Kevin Foley , Zhenjian Du , Hao Li , David James , Howard P. Ng , Zachary Demko , Dan Zhou , Shuzhen Qin
IPC分类号: A61K31/4196 , C07D249/12
CPC分类号: C07D403/04 , A61K31/4196 , A61K31/422 , A61K31/4439 , A61K31/475 , A61K31/496 , A61K31/5377 , A61K45/06 , C07D249/12 , C07D401/04 , C07D401/14 , C07D403/12 , C07D405/04 , C07D405/14 , C07D413/14 , C07D487/04
摘要: The present invention relates to substituted triazole compounds and compositions comprising substituted triazole compounds. The invention further relates to methods of inhibiting the activity of Hsp90 in a subject in need thereof and methods for preventing or treating hyperproliferative disorders, such as cancer, in a subject in need thereof comprising administering to the subject a substituted triazole compound of the invention, or a composition comprising such a compound.
摘要翻译: 本发明涉及取代的三唑化合物和包含取代的三唑化合物的组合物。 本发明还涉及在有需要的受试者中抑制Hsp90的活性的方法和在有需要的受试者中预防或治疗过度增殖性疾病如癌症的方法,其包括向受试者施用本发明的取代的三唑化合物, 或包含这种化合物的组合物。
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公开(公告)号:US20110105749A1
公开(公告)日:2011-05-05
申请号:US12815322
申请日:2010-06-14
申请人: Weiwen YING , David James , Shijie Zhang , Teresa Przewloka , Junghyun Chae , Dinesh U. Chimmanamada , Chi-Wan Lee , Elena Kostik , Howard P. Ng , Kevin Foley , Zhenjian Du , James Barsoum
发明人: Weiwen YING , David James , Shijie Zhang , Teresa Przewloka , Junghyun Chae , Dinesh U. Chimmanamada , Chi-Wan Lee , Elena Kostik , Howard P. Ng , Kevin Foley , Zhenjian Du , James Barsoum
IPC分类号: C07D403/10 , C07D417/10 , C07D413/10 , C07D405/10 , C07D401/10 , C07D249/14 , C07D249/12 , C07D473/34 , C07D413/12 , C07F9/6518
CPC分类号: C07D249/08 , A61K31/4196 , C07D249/12 , C07D401/04 , C07D403/04 , C07D403/10 , C07D405/04 , C07D409/04 , C07D413/04 , C07D417/04 , C07D473/00 , C07D473/34
摘要: The present invention relates to substituted triazole compounds and compositions comprising substituted triazole compounds. The invention further relates to methods of inhibiting the activity of Hsp90 in a subject in need thereof and methods for preventing or treating hyperproliferative disorders, such as cancer, in a subject in need thereof comprising administering to the subject a substituted triazole compound of the invention, or a composition comprising such a compound.
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公开(公告)号:US20110009397A1
公开(公告)日:2011-01-13
申请号:US12604970
申请日:2009-10-23
申请人: Weiwen Ying , David James , Shijie Zhang , Teresa Przewloka , Junghyun Chae , Dinesh U. Chimmanamada , Chi-Wan Lee , Elena Kostik , Howard P. Ng , Kevin Foley , Zhenjian Du , James Barsoum
发明人: Weiwen Ying , David James , Shijie Zhang , Teresa Przewloka , Junghyun Chae , Dinesh U. Chimmanamada , Chi-Wan Lee , Elena Kostik , Howard P. Ng , Kevin Foley , Zhenjian Du , James Barsoum
IPC分类号: A61K31/4196 , A61K31/4709 , A61K31/4439 , A61K31/4725 , A61K31/5377 , A61K31/538 , C12N5/00
CPC分类号: C07D249/08 , A61K31/4196 , C07D249/12 , C07D401/04 , C07D403/04 , C07D403/10 , C07D405/04 , C07D409/04 , C07D413/04 , C07D417/04 , C07D473/00 , C07D473/34
摘要: The present invention relates to substituted triazole compounds and compositions comprising substituted triazole compounds. The invention further relates to methods of inhibiting the activity of Hsp90 in a subject in need thereof and methods for preventing or treating hyperproliferative disorders, such as cancer, in a subject in need thereof comprising administering to the subject a substituted triazole compound of the invention, or a composition comprising such a compound.
摘要翻译: 本发明涉及取代的三唑化合物和包含取代的三唑化合物的组合物。 本发明还涉及在有需要的受试者中抑制Hsp90的活性的方法和在有需要的受试者中预防或治疗过度增殖性疾病如癌症的方法,其包括向受试者施用本发明的取代的三唑化合物, 或包含这种化合物的组合物。
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公开(公告)号:US20100256768A1
公开(公告)日:2010-10-07
申请号:US12816476
申请日:2010-06-16
申请人: Roy Lim , Kevin Foley
发明人: Roy Lim , Kevin Foley
CPC分类号: A61B17/8858 , A61B17/025 , A61B2017/0256 , A61B2017/2939
摘要: A device to space vertebral members that may include a deploying device with a first member with an elongated first shaft and a first body at an end of the first shaft, a second member with an elongated second shaft that extends around the first shaft and a second body at an end of the second shaft, and a third member with an elongated third shaft that extends around the second shaft and a third body at an end of the second shaft. The device may include a first plate positioned on a first side of the deploying device, and a second plate positioned on a second side of the deploying device. First, second, and third jointed linkages may be spaced apart along the deploying device and each having a pair of links and each having a first end attached to the first plate, a second end attached to the second plate, and an intermediate joint connecting the pair of links together and being attached to the deploying device.
摘要翻译: 一种用于将脊椎构件放置的装置,其可以包括具有第一构件的展开装置,所述第一构件具有细长的第一轴和在所述第一轴的端部处的第一主体,第二构件,具有围绕所述第一轴延伸的细长的第二轴, 主体在第二轴的端部,以及第三构件,其具有围绕第二轴延伸的细长的第三轴和在第二轴的端部处的第三主体。 该装置可以包括位于展开装置的第一侧上的第一板和位于展开装置的第二侧上的第二板。 第一,第二和第三接合连杆可以沿着展开装置间隔开,并且每个具有一对连杆,并且每个连接件具有连接到第一板的第一端,附接到第二板的第二端和连接到第二板的中间接头 一对链接在一起并被附接到部署设备。
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公开(公告)号:US20100093670A1
公开(公告)日:2010-04-15
申请号:US12310950
申请日:2007-09-13
申请人: Yaming Wu , Kevin Foley , Christopher Borella
发明人: Yaming Wu , Kevin Foley , Christopher Borella
IPC分类号: A61K31/675 , A61K31/42 , A61K31/4192 , A61K31/425
CPC分类号: A61K31/00 , A61K31/4192 , A61K31/42 , A61K31/422 , A61K31/425 , A61K31/427 , A61K31/675
摘要: The invention relates to isoxazole, isothiazole, and triazole compounds that are useful for treating or inhibiting angiogenesis.
摘要翻译: 本发明涉及可用于治疗或抑制血管发生的异恶唑,异噻唑和三唑化合物。
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公开(公告)号:US20100069442A1
公开(公告)日:2010-03-18
申请号:US12559155
申请日:2009-09-14
申请人: Weiwen Ying , Shijie Zhang , Zhenjian Du , Kevin Foley
发明人: Weiwen Ying , Shijie Zhang , Zhenjian Du , Kevin Foley
IPC分类号: A61K31/4439 , C12N5/00 , A61K31/415 , A61P35/00
CPC分类号: C07D231/20 , C07D231/18 , C07D231/38 , C07D403/04
摘要: Compounds of formula (I), pharmaceutical compositions comprising compounds of formula (I) and methods of inhibiting Hsp90 in a cell, treating or preventing a proliferation disorder in a mammal and treating cancer in a mammal comprising administering a compound of formula (I) to a patient or a cell. Variable R5 is an optionally substituted heteroaryl; an optionally substituted 6 to 14-membered aryl; a bicyclic 9-member heterocycle optionally substituted at any substitutable nitrogen or carbon atoms; or a substituent R18, defined herein. Ring A is an aryl or a heteroaryl optionally further substituted with one or more substituents in addition to R3. Substituent R3 is defined herein.
摘要翻译: 式(I)化合物,包含式(I)化合物的药物组合物和抑制细胞中Hsp90的方法,治疗或预防哺乳动物中的增殖病症并治疗哺乳动物的癌症,其包括给予式(I)化合物至 患者或细胞。 变量R5是任选取代的杂芳基; 任选取代的6至14元芳基; 任选在任何可取代的氮或碳原子上取代的双环9元杂环; 或本文定义的取代基R18。 环A是除了R3之外任选进一步被一个或多个取代基取代的芳基或杂芳基。 取代基R 3在本文中定义。
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公开(公告)号:US07662813B2
公开(公告)日:2010-02-16
申请号:US11506185
申请日:2006-08-17
申请人: Weiwen Ying , David James , Shijie Zhang , Teresa Przewloka , Elena Kostik , Junghyun Chae , Howard P Ng , Zhenjian Du , James Barsoum , Dinesh Chimmanamada , Chi-Wan Lee , Kevin Foley
发明人: Weiwen Ying , David James , Shijie Zhang , Teresa Przewloka , Elena Kostik , Junghyun Chae , Howard P Ng , Zhenjian Du , James Barsoum , Dinesh Chimmanamada , Chi-Wan Lee , Kevin Foley
IPC分类号: A61K31/4196 , A61K31/4025 , A61K31/4523 , A61K31/506 , A61K31/5377 , A61K31/541 , C07D249/08 , C07D207/04 , C07D401/02 , C07D403/02 , C07D413/02
CPC分类号: C07D249/08 , C07D403/10 , C07D403/12 , C07D413/12
摘要: The present invention relates to substituted triazole compounds and compositions comprising substituted triazole compounds. The invention further relates to methods of inhibiting the activity of Hsp90 in a subject in need thereof and methods for preventing or treating hyperproliferative disorders, such as cancer, in a subject in need thereof comprising administering to the subject a substituted triazole compound of the invention, or a composition comprising such a compound.
摘要翻译: 本发明涉及取代的三唑化合物和包含取代的三唑化合物的组合物。 本发明还涉及在有需要的受试者中抑制Hsp90的活性的方法和在有需要的受试者中预防或治疗过度增殖性疾病如癌症的方法,其包括向受试者施用本发明的取代的三唑化合物, 或包含这种化合物的组合物。
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公开(公告)号:US20080176840A1
公开(公告)日:2008-07-24
申请号:US11807327
申请日:2007-05-25
申请人: Lijun Sun , Weiwen Ying , Junghyun Chae , Teresa Przewloka , Shijie Zhang , Dinesh U. Chimmanamada , Kevin Foley , Zhenjian Du , Hao Li , David James , Howard P. Ng , Zachary Demko , Dan Zhou , Shuzhen Qin
发明人: Lijun Sun , Weiwen Ying , Junghyun Chae , Teresa Przewloka , Shijie Zhang , Dinesh U. Chimmanamada , Kevin Foley , Zhenjian Du , Hao Li , David James , Howard P. Ng , Zachary Demko , Dan Zhou , Shuzhen Qin
IPC分类号: A61K31/4196 , C07D401/14 , A61K31/4439 , C07D471/04 , A61K31/538 , A61K31/496 , A61P37/00 , A61P29/00 , A61P31/00 , A61P35/00 , A61K31/5377 , C07D413/14 , A61K31/52 , A61K31/4709 , C07D403/02
CPC分类号: C07D403/04 , A61K31/4196 , A61K31/422 , A61K31/4439 , A61K31/475 , A61K31/496 , A61K31/5377 , A61K45/06 , C07D249/12 , C07D401/04 , C07D401/14 , C07D403/12 , C07D405/04 , C07D405/14 , C07D413/14 , C07D487/04
摘要: The present invention relates to substituted triazole compounds and compositions comprising substituted triazole compounds. The invention further relates to methods of inhibiting the activity of Hsp90 in a subject in need thereof and methods for preventing or treating hyperproliferative disorders, such as cancer, in a subject in need thereof comprising administering to the subject a substituted triazole compound of the invention, or a composition comprising such a compound.
摘要翻译: 本发明涉及取代的三唑化合物和包含取代的三唑化合物的组合物。 本发明还涉及在有需要的受试者中抑制Hsp90的活性的方法和在有需要的受试者中预防或治疗过度增殖性疾病如癌症的方法,其包括向受试者施用本发明的取代的三唑化合物, 或包含这种化合物的组合物。
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公开(公告)号:US20080109083A1
公开(公告)日:2008-05-08
申请号:US12004647
申请日:2007-12-21
申请人: James Van Hoeck , Troy McDonald , Bradley Coates , Regis Haid , Stephen Heim , Kevin Foley , Eugene Eckstein
发明人: James Van Hoeck , Troy McDonald , Bradley Coates , Regis Haid , Stephen Heim , Kevin Foley , Eugene Eckstein
IPC分类号: A61F2/44
CPC分类号: A61F2/442 , A61F2/30724 , A61F2/30767 , A61F2/4455 , A61F2/4611 , A61F2002/2817 , A61F2002/2835 , A61F2002/30062 , A61F2002/30112 , A61F2002/30153 , A61F2002/30187 , A61F2002/30261 , A61F2002/30271 , A61F2002/30677 , A61F2002/3092 , A61F2002/30929 , A61F2002/4475 , A61F2002/4623 , A61F2002/4627 , A61F2210/0004 , A61F2230/0004 , A61F2230/0019 , A61F2230/0034 , A61F2230/0082 , A61F2310/00161 , A61F2310/00293 , A61F2310/00491 , A61F2310/00544 , A61F2310/00796 , A61L31/024 , A61L31/026 , A61L31/044 , A61L31/047 , A61L31/048 , A61L31/06 , A61L2430/38 , Y10S606/907 , Y10S606/908
摘要: One embodiment of a hollow spinal spacer (10) includes a curved anterior wall (11) having opposite ends (12, 13), a posterior wall (15) having opposite ends (16, 17), two lateral walls (20, 21), each integrally connected between the opposite ends (12, 13, 16, 17) of the anterior (11) and posterior (15) walls to define a chamber (30). The walls (11, 15, 20, 21) include a superior face (35) and an inferior face (40). The superior face (35) defines a first opening (36) in communication with the chamber (30) and includes a first vertebral engaging surface (37). The inferior face (40) defines a second opening (41) in communication with the chamber (30) and includes a second vertebral engaging surface (42).
摘要翻译: 空心脊椎间隔件(10)的一个实施例包括具有相对端(12,13)的弯曲前壁(11),具有相对端(16,17)的后壁(15),两个侧壁(20,21) ,每个整体连接在前(11)和后(15)壁的相对端(12,13,16,17)之间,以限定室(30)。 壁(11,15,20,21)包括上表面(35)和下表面(40)。 上表面(35)限定与腔室(30)连通的第一开口(36)并且包括第一椎骨接合表面(37)。 下表面(40)限定与腔室(30)连通的第二开口(41)并且包括第二椎骨接合表面(42)。
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公开(公告)号:US20080004277A1
公开(公告)日:2008-01-03
申请号:US11807331
申请日:2007-05-25
申请人: Dinesh Chimmanamada , Weiwen Ying , Teresa Przewloka , Shijie Zhang , Kevin Foley , Zhenjian Du , Dan Zhou , Shuzhen Qin
发明人: Dinesh Chimmanamada , Weiwen Ying , Teresa Przewloka , Shijie Zhang , Kevin Foley , Zhenjian Du , Dan Zhou , Shuzhen Qin
IPC分类号: A61K31/4196 , A61K31/4439 , A61K31/496 , A61K31/5377 , A61P29/00 , A61P31/00 , A61P35/00 , A61P37/00 , C07D249/12 , C07D401/06 , C07D403/12 , C07D413/06
CPC分类号: C07D249/12 , C07D401/06 , C07D403/06 , C07D403/10 , C07D403/12 , C07D405/06 , C07D405/12 , C07D407/10 , C07D413/10 , C07F9/6518
摘要: The present invention relates to substituted triazole compounds and compositions comprising substituted triazole compounds. The invention further relates to methods of inhibiting the activity of Hsp90 in a subject in need thereof and methods for preventing or treating hyperproliferative disorders, such as cancer, in a subject in need thereof comprising administering to the subject a substituted triazole compound of the invention, or a composition comprising such a compound.
摘要翻译: 本发明涉及取代的三唑化合物和包含取代的三唑化合物的组合物。 本发明还涉及在有需要的受试者中抑制Hsp90的活性的方法和在有需要的受试者中预防或治疗过度增殖性疾病如癌症的方法,其包括向受试者施用本发明的取代的三唑化合物, 或包含这种化合物的组合物。
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