Spacer with Height and Angle Adjustments for Spacing Vertebral Members
    134.
    发明申请
    Spacer with Height and Angle Adjustments for Spacing Vertebral Members 有权
    间隔脊椎成员的高度和角度调整的间隔

    公开(公告)号:US20100256768A1

    公开(公告)日:2010-10-07

    申请号:US12816476

    申请日:2010-06-16

    申请人: Roy Lim Kevin Foley

    发明人: Roy Lim Kevin Foley

    IPC分类号: A61F2/44 A61B17/56

    摘要: A device to space vertebral members that may include a deploying device with a first member with an elongated first shaft and a first body at an end of the first shaft, a second member with an elongated second shaft that extends around the first shaft and a second body at an end of the second shaft, and a third member with an elongated third shaft that extends around the second shaft and a third body at an end of the second shaft. The device may include a first plate positioned on a first side of the deploying device, and a second plate positioned on a second side of the deploying device. First, second, and third jointed linkages may be spaced apart along the deploying device and each having a pair of links and each having a first end attached to the first plate, a second end attached to the second plate, and an intermediate joint connecting the pair of links together and being attached to the deploying device.

    摘要翻译: 一种用于将脊椎构件放置的装置,其可以包括具有第一构件的展开装置,所述第一构件具有细长的第一轴和在所述第一轴的端部处的第一主体,第二构件,具有围绕所述第一轴延伸的细长的第二轴, 主体在第二轴的端部,以及第三构件,其具有围绕第二轴延伸的细长的第三轴和在第二轴的端部处的第三主体。 该装置可以包括位于展开装置的第一侧上的第一板和位于展开装置的第二侧上的第二板。 第一,第二和第三接合连杆可以沿着展开装置间隔开,并且每个具有一对连杆,并且每个连接件具有连接到第一板的第一端,附接到第二板的第二端和连接到第二板的中间接头 一对链接在一起并被附接到部署设备。

    PYRAZOLE COMPOUNDS THAT MODULATE HSP90 ACTIVITY
    136.
    发明申请
    PYRAZOLE COMPOUNDS THAT MODULATE HSP90 ACTIVITY 审中-公开
    调节HSP90活性的吡咯化合物

    公开(公告)号:US20100069442A1

    公开(公告)日:2010-03-18

    申请号:US12559155

    申请日:2009-09-14

    摘要: Compounds of formula (I), pharmaceutical compositions comprising compounds of formula (I) and methods of inhibiting Hsp90 in a cell, treating or preventing a proliferation disorder in a mammal and treating cancer in a mammal comprising administering a compound of formula (I) to a patient or a cell. Variable R5 is an optionally substituted heteroaryl; an optionally substituted 6 to 14-membered aryl; a bicyclic 9-member heterocycle optionally substituted at any substitutable nitrogen or carbon atoms; or a substituent R18, defined herein. Ring A is an aryl or a heteroaryl optionally further substituted with one or more substituents in addition to R3. Substituent R3 is defined herein.

    摘要翻译: 式(I)化合物,包含式(I)化合物的药物组合物和抑制细胞中Hsp90的方法,治疗或预防哺乳动物中的增殖病症并治疗哺乳动物的癌症,其包括给予式(I)化合物至 患者或细胞。 变量R5是任选取代的杂芳基; 任选取代的6至14元芳基; 任选在任何可取代的氮或碳原子上取代的双环9元杂环; 或本文定义的取代基R18。 环A是除了R3之外任选进一步被一个或多个取代基取代的芳基或杂芳基。 取代基R 3在本文中定义。