摘要:
An organic semiconductor inverting circuit includes at least three organic transistors, an output terminal (110, 210, 310, 410), a reference supply voltage input (115, 215, 315, 415), a first positive supply voltage input (120, 220, 320, 420), and a negative supply voltage input (125, 225, 325, 425). One of the three organic transistors is an input transistor having a gate to which is coupled an input terminal (105, 205, 305, 405). The output terminal (110, 210, 310, 410) is coupled to a first electrode of at least one of the at least three organic transistors.
摘要:
Disclosed is a pharmaceutical composition for extended release of an erythromycin derivative in the gastrointestinal environment. The composition comprises an erythromycin derivative and a pharmaceutically acceptable polymer so that, when ingested orally, the composition induces statistically significantly lower Cmax in the plasma than an immediate release composition of the erythromycin derivative while maintaining bioavailability and minimum concentration substantially equivalent to that of the immediate release composition of the erythromycin derivative upon multiple dosing. The compositions of the invention have an improved taste profile and reduced gastrointestinal side effects as compared to those for the immediate release composition.
摘要:
In a system for monitoring stability of an on-frequency repeater, a wide-band signature (WBS) signal associated with the repeater is generated, and inserted into an output RF signal transmitted by the repeater. Signal components corresponding to the WBS signal in an input RF signal received by the repeater are detected and analyzed to estimate a feedback path loss L.
摘要:
A method and system for improving the efficiency of a database processing system for evaluating candidate data items representing search listings that are submitted for inclusion into a search engine database. Candidate search listings are automatically assessed for quality, style, and relevance to evaluate risk of unfavorable reception by a user and of potential exposure volume. Search listings which are higher-risk or higher-volume are routed through manual editorial review while lower-risk, lower-volume search listings are routed for immediate inclusion in the search database without manual editorial evaluation. Accordingly, human editorial efforts can be devoted to manual review of high-risk or high-volume search listings while efficiency is simultaneously improved in the processing system as a whole.
摘要:
The invention concerns E2F oligonucleotide decoy molecules with improved properties. In particular, the invention concerns a double-stranded E2F decoy oligodeoxynucleotide (dsODN) molecule comprising a core sequence that is capable of specific binding to an E2F transcription factor, flanked by 5′ and 3′ sequences, wherein (i) the core sequence consists of about 5 to 12 base pairs; (ii) the molecule comprises an about 12 to 28 base-pair long double-stranded region composed of two fully complementary strands; and (iii) the E2F dsODN binds to said E2F transcription factor with a binding affinity that is at least about 5-fold of the binding affinity of a reference decoy molecule shown in FIG. 1 (SEQ ID NOS: 1 and 2), as determined by a competitive gel mobility shift binding assay performed on nuclear extract from THP-1 cells.
摘要翻译:本发明涉及具有改进性质的E2F寡核苷酸诱饵分子。 特别地,本发明涉及双链E2F诱饵寡脱氧核苷酸(dsODN)分子,其包含能够与侧翼为5'和3'序列的E2F转录因子特异性结合的核心序列,其中(i)核心序列组成 约5至12个碱基对; (ii)分子包含由两个完全互补的链组成的约12至28个碱基对长双链区域; 和(iii)E2F dsODN以与图1所示的参考诱饵分子的结合亲和力的至少约5倍的结合亲和力结合所述E2F转录因子。 1(SEQ ID NO:1和2),其通过对来自THP-1细胞的核提取物进行的竞争性凝胶迁移率转移结合测定法测定。
摘要:
The present invention provides compounds which inhibit poly(ADP-ribose) polymerase (“PARP”), compositions containing these compounds and methods for using these PARP inhibitors to treat, prevent and/or ameliorate the effects of the conditions described herein.
摘要:
The present invention is directed to a method and system for delivering a drug into the systemic circulation. The method comprises establishing a drug depot in a patient's skin and/or sub-skin tissues by applying a transdermal drug delivery system on the patients skin, for a predetermined time so that a drug depot is formed in said user's skin and/or sub-skin tissues. A heating source is placed proximate to the skin area to rapidly release a bolus of the drug from the depot into the systemic circulation when there is a need to rapidly increase the drug's concentrations in the systemic circulation.
摘要:
A semiconductor device formed of a flexible or rigid substrate (10) having a gate electrode (11), a source electrode (12), and a drain electrode (13) formed thereon and organic semiconductor material (14) disposed at least partially thereover. With appropriate selection of material, the gate electrode (11) will form a Schottky junction and an ohmic contact will form between the organic semiconductor material (14) and each of the source electrode (12) and drain electrode (13). In many of the embodiments, any of the above elements can be formed through contact or non-contact printing. Sizing of the resultant device can be readily scaled to suit various needs.