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195 条记录 (耗时 0.031 秒)

    Continuous open-cell polymeric foams containing living cells
    131.
    发明授权
    Continuous open-cell polymeric foams containing living cells 失效
    含活细胞的连续开孔聚合物泡沫

    公开(公告)号：US5677355A

    公开(公告)日：1997-10-14

    申请号：US475218

    申请日：1995-06-07

    申请人： Shalaby W. Shalaby ,  Susan L. Roweton

    发明人： Shalaby W. Shalaby ,  Susan L. Roweton

    IPC分类号： A61K9/12 ,  A61L27/16 ,  A61L27/18 ,  A61L27/38 ,  A61L27/56 ,  B01D67/00 ,  B01D69/14 ,  B29C67/20 ,  C08J9/26 ,  A61K9/14

    CPC分类号： A61L27/3839 ,  A61K9/122 ,  A61L27/16 ,  A61L27/18 ,  A61L27/38 ,  A61L27/3847 ,  A61L27/3852 ,  A61L27/56 ,  B01D67/003 ,  B01D69/141 ,  B29C67/202 ,  C08J9/26 ,  B01D2323/21 ,  B01D2325/48 ,  C08J2201/042 ,  C08J2205/05 ,  Y10T428/249958 ,  Y10T428/31504 ,  Y10T428/31725 ,  Y10T428/31931 ,  Y10T428/31938

    摘要： A polymeric foam with continuous, open-cell pores containing living cells suitable for medical applications and methods for preparing these foams. The microporous foams are of controlled pore size that may be utilized in a variety of applications. In general, the foams are characterized in that the pores are continuous and open-celled. In preparing the foams, an organic polymer is melted and combined with a selected solid crystalline fugitive compound, that melts above about 25.degree. C. and/or that sublimates at above about 25.degree. C. or can be extracted, to produce a substantially isotropic solution. The solution is cooled under controlled conditions to produce a foam precursor containing the solidified fugitive composition dispersed through a matrix of the organic polymer. Crystals of fugitive composition are then removed by solvent extraction and/or sublimation, or a like process to produce microcellular foams having a continuous, open-cell structure. After removing the fugitive composition, living cells capable of producing biologically active products are added to the pores to produce a foam containing living cells.

    摘要翻译： 具有连续的开孔细胞孔的聚合物泡沫，其含有适用于医学应用的活细胞和用于制备这些泡沫的方法。 微孔泡沫具有受控的孔径，可用于各种应用中。 通常，泡沫的特征在于孔是连续的和开孔的。 在制备泡沫体时，将有机聚合物熔化并与选定的固体晶体化合物混合，熔融高于约25℃，和/或在高于约25℃升华或可提取，以产生基本上各向同性 解。 将溶液在受控条件下冷却以产生包含通过有机聚合物基质分散的固化的缓冲组合物的泡沫前体。 然后通过溶剂萃取和/或升华或类似方法除去挥发性组合物的晶体，以产生具有连续的开孔结构的微孔泡沫。 除去挥发性组合物后，将能够生产生物活性物质的活细胞加入到孔中以产生含有活细胞的泡沫。

    Ionic molecular conjugates of biodegradable polyesters and bioactive polypeptides
    132.
    发明授权
    Ionic molecular conjugates of biodegradable polyesters and bioactive polypeptides 失效
    生物降解聚酯和生物活性多肽的离子分子共轭物

    公开(公告)号：US5672659A

    公开(公告)日：1997-09-30

    申请号：US464735

    申请日：1995-06-29

    申请人： Shalaby W. Shalaby ,  Steven A. Jackson ,  Jacques-Pierre Moreau

    发明人： Shalaby W. Shalaby ,  Steven A. Jackson ,  Jacques-Pierre Moreau

    IPC分类号： A61K9/52 ,  A61K38/00 ,  A61K47/48 ,  C07K7/23 ,  A61K9/16 ,  A61K37/02

    CPC分类号： A61K47/482 ,  A61K47/48284 ,  C07K7/23 ,  A61K38/00 ,  Y10S514/80 ,  Y10S514/806 ,  Y10S514/807 ,  Y10S514/808 ,  Y10S514/809 ,  Y10S514/963

    摘要： A composition including a polyester containing one or more free COOH groups ionically conjugated with a bioactive polypeptide comprising at least one effective ionogenic amine, wherein the polyester contains a member selected from the group of L-lactic acid, D-lactic acid, DL-lactic acid, .epsilon.-caprolactone, p-dioxanone, .epsilon.-caprolic acid, alkylene oxalate, cycloalkylene oxalate, alkylene succinate, .beta.-hydroxybutyrate, substituted or unsubstituted trimethylene carbonate, 1,5-dioxopan-2-one, 1,4-dioxepan-2-one, glycolide, glycolic acid, L-lactide, D-lactide, DL-lactide, meso-lactide, and any optically active isomers, racemates or copolymers thereof, and at least 50%, by weight, of the polypeptide present in the composition is ionically conjugated to said polyester.

    摘要翻译： PCT No.PCT / US94 / 00148 Sec。 371日期：1995年6月29日 102（e）日期1995年6月29日PCT 1994年1月5日PCT PCT。 出版物WO94 / 15587 日期1994年7月21日包含含有一种或多种游离COOH基团的组合物的组合物，所述游离COOH基团与包含至少一种有效的离子型胺的生物活性多肽离子地缀合，其中所述聚酯包含选自L-乳酸，D-乳酸 酸，DL-乳酸，ε-己内酯，对二恶烷酮，ε-己内酯，草酸亚烷基酯，草酸亚环烷基酯，琥珀酸亚烷基酯，β-羟基丁酸酯，取代或未取代的三亚甲基碳酸亚乙酯，1,5-二氧杂戊-2-酮，1 ，4-二氧杂环庚烷-2-酮，乙交酯，乙醇酸，L-丙交酯，D-丙交酯，DL-丙交酯，内消旋丙交酯及其任何光学活性异构体，外消旋体或其共聚物，和至少50重量％ 存在于组合物中的多肽与所述聚酯离子共轭。

    Isomorphic copolyoxalates and sutures thereof
    138.
    发明授权
    Isomorphic copolyoxalates and sutures thereof 失效
    同构共聚阴离子及其缝线

    公开(公告)号：US4208511A

    公开(公告)日：1980-06-17

    申请号：US915500

    申请日：1978-06-14

    申请人： Shalaby W. Shalaby ,  Dennis D. Jamiolkowski

    发明人： Shalaby W. Shalaby ,  Dennis D. Jamiolkowski

    IPC分类号： A61B17/00 ,  A61B17/06 ,  A61L17/10 ,  C08G63/199 ,  C08G63/18

    CPC分类号： C08G63/199 ,  A61B17/06133 ,  A61B17/06166 ,  A61L17/105 ,  A61B2017/00004

    摘要： Synthetic absorbable sutures are prepared from copolyoxalate polymers having isomorphic sequences. The polymers are derived from mixtures of cyclic and linear diols, each having the same carbon chain length of 6 or 8 atoms. The cyclic diol may be aliphatic or aromatic. The diols are polymerized with dialkyl oxalate, preferably in the presence of an inorganic or organometallic catalyst, to obtain a highly crystalline isomorphic copolyoxalate polymer which is melt extruded and drawn to form oriented filaments. The filaments are characterized by good initial tensile and knot strength and a high order of softness and flexibility. When implanted in living animal tissue, the fibers have good strength retention over a period of at least 21 days and eventually absorb with a minimal degree of adverse tissue reaction.

    摘要翻译： 合成可吸收缝线由具有同构序列的共聚草酸酯聚合物制备。 聚合物衍生自环状和线性二醇的混合物，每一种具有相同的碳链长度为6或8个原子。 环状二醇可以是脂肪族或芳香族的。 二醇与草酸二烷基酯进行聚合，优选在无机或有机金属催化剂的存在下进行聚合，得到熔融挤出和拉伸形成定向长丝的高度结晶的同晶共聚草酸酯聚合物。 长丝的特征在于初始拉伸强度和结强度高，柔软度高的柔顺性。 当植入活的动物组织中时，纤维在至少21天的时间内具有良好的强度保留，并且最终以最小程度的不良组织反应吸收。

    Isomorphic copolyoxalates and sutures thereof
    140.
    发明授权
    Isomorphic copolyoxalates and sutures thereof 失效
    同构共聚阴离子及其缝线

    公开(公告)号：US4141087A

    公开(公告)日：1979-02-27

    申请号：US752374

    申请日：1977-01-19

    申请人： Shalaby W. Shalaby ,  Dennis D. Jamiolkowski

    发明人： Shalaby W. Shalaby ,  Dennis D. Jamiolkowski

    IPC分类号： A61B17/00 ,  A61B17/06 ,  A61L17/10 ,  A61L27/18 ,  A61F1/24 ,  A61F1/00 ,  A61L17/00 ,  C08G63/18

    CPC分类号： A61L17/105 ,  A61B17/06133 ,  A61B17/06166 ,  A61L27/18 ,  A61B2017/00004

    摘要： Synthetic absorbable sutures are prepared from copolyoxalate polymers having isomorphic sequences. The polymers are derived from mixtures of cyclic and linear diols, each having the same carbon chain length of 6 or 8 atoms. The cyclic diol may be aliphatic or aromatic. The diols are polymerized with dialkyl oxalate, preferably in the presence of an inorganic or organometallic catalyst, to obtain a highly crystalline isomorphic copolyoxalate polymer which is melt extruded and drawn to form oriented filaments. The filaments are characterized by good initial tensile and knot strength and a high order of softness and flexibility. When implanted in living animal tissue, the fibers have good strength retention over a period of at least 21 days and eventually absorb with a minimal degree of adverse tissue reaction.

    摘要翻译： 合成可吸收缝线由具有同构序列的共聚草酸酯聚合物制备。 聚合物衍生自环状和线性二醇的混合物，每一种具有相同的碳链长度为6或8个原子。 环状二醇可以是脂肪族或芳香族的。 二醇与草酸二烷基酯进行聚合，优选在无机或有机金属催化剂的存在下进行聚合，得到熔融挤出和拉伸形成定向长丝的高度结晶的同态共聚草酸酯聚合物。 长丝的特征在于初始拉伸强度和结强度高，柔软度高的柔顺性。 当植入活的动物组织中时，纤维在至少21天的时间内具有良好的强度保留，并且最终以最小程度的不良组织反应吸收。