公开(公告)号：US07432238B2

公开(公告)日：2008-10-07

申请号：US11107643

申请日：2005-04-15

Applicant: Walter Kisiel ,  Hitendra S. Chand

Inventor： Walter Kisiel ,  Hitendra S. Chand

IPC: A01N37/18

CPC classification number: C07K14/8114 ,  A61K38/00

Abstract: A human Kunitz-type inhibitor polypeptide with enhanced antifibrinolytic activity, methods of making, and methods of use. The novel polypeptide is structurally similar to the KD1 domain of human tissue factor pathway inhibitor-2 (TFPI-2).

Abstract translation: 具有增强的抗纤维蛋白溶解活性的人Kunitz型抑制剂多肽，制备方法和使用方法。 新型多肽在结构上类似于人组织因子途径抑制剂-2（TFPI-2）的KD1结构域。

公开(公告)号：US20080107652A1

公开(公告)日：2008-05-08

申请号：US11893699

申请日：2007-08-17

Applicant: Ravi Durvasula ,  Subba Durvasula

Inventor： Ravi Durvasula ,  Subba Durvasula

IPC: A61K35/66 ,  A61K39/00 ,  A61K39/395 ,  A61K31/70 ,  A61P43/00

CPC classification number: A61K39/12 ,  A01N25/00 ,  A01N65/03 ,  A61K39/00 ,  A61K39/02 ,  A61K39/107 ,  A61K2039/517 ,  A61K2039/552 ,  C12N1/12 ,  C12N15/79 ,  C12N15/8257 ,  C12N15/8258 ,  C12N2710/18034

Abstract: The invention discloses paratransgenesis methods for prevention, amelioration or treatment of a disease or disorder in an aquatic animal. The method comprises providing a genetically modified micro algae that expresses a recombinant molecule that specifically targets one or more key epitopes of a pathogen that infects the aquatic animal and ii) feeding the aquatic animal directly or indirectly with the genetically modified unicellular algae.

Abstract translation: 本发明公开了用于预防，改善或治疗水生动物疾病或病症的副作用方法。 该方法包括提供表达特异性靶向感染水生动物的病原体的一个或多个关键表位的重组分子的遗传修饰的微藻，以及ii）直接或间接地向遗传修饰的单细胞藻类喂养水生动物。

公开(公告)号：US07329871B2

公开(公告)日：2008-02-12

申请号：US11346229

申请日：2006-02-03

Applicant: Wenjun Fan ,  Shuang Zhang ,  Kevin J. Malloy ,  Steven R. J. Brueck

Inventor： Wenjun Fan ,  Shuang Zhang ,  Kevin J. Malloy ,  Steven R. J. Brueck

IPC: G01J5/02

CPC classification number: G01J5/02 ,  G01J5/022 ,  G01J5/08 ,  G01J5/0837 ,  G01J5/10

Abstract: Electromagnetic radiation detector elements and methods for detecting electromagnetic radiation, in particular, infrared radiation, are provided. The electromagnetic radiation detector element can include an electromagnetic radiation detector and a plasmonic antenna disposed over the electromagnetic radiation detector. The plasmonic antenna can include a metal film, a sub-wavelength aperture in the metal film, and a plurality of circular corrugations centered around the sub-wavelength aperture.

Abstract translation: 提供了用于检测电磁辐射的电磁辐射探测器元件和方法，特别是红外线辐射。 电磁辐射检测器元件可以包括设置在电磁辐射探测器上的电磁辐射探测器和等离子体激元。 等离子体激元天线可以包括金属膜，金属膜中的亚波长孔，以及以亚波长孔为中心的多个圆形波纹。

公开(公告)号：US07316320B2

公开(公告)日：2008-01-08

申请号：US10666116

申请日：2003-09-18

Applicant: Scott Sibbett ,  Gabriel P. Lopez

Inventor： Scott Sibbett ,  Gabriel P. Lopez

IPC: B03C9/00 ,  B01D59/38

CPC classification number: B03C5/026

Abstract: Charged particles may undergo two different separations within a single device, without manual intervention to effect the transfer of the particles between separations. In some embodiments, the device may be a Micro-Electro-Mechanical System.

Abstract translation: 带电粒子可以在单个装置内经历两个不同的分离，而无需手动干预来实现分离之间的颗粒转移。 在一些实施例中，该装置可以是微机电系统。

公开(公告)号：US12163953B2

公开(公告)日：2024-12-10

申请号：US16707501

申请日：2019-12-09

Applicant: STC.UNM

Inventor： David G. Whitten ,  Harry Craig Pappas ,  Eric H. Hill ,  Yue Zhang ,  Eva Yung Hua Chi ,  Arjun Thapa ,  Ying Wang ,  Patrick L Donabedian ,  Kiran Bhaskar

IPC: C12N1/20 ,  C07K14/65 ,  C08G61/02 ,  C12Q1/44 ,  C12Q1/46 ,  G01N33/52

Abstract: Various embodiments relate to p-phenylene ethynylene compounds as bioactive and detection agents. In various embodiments, the present invention provides a method of inducing germination of microbial spores including contacting the microbial spores with a p-phenylene ethynylene compound. In various embodiments, the present invention provides a method for detecting an enzyme, a method of protein analysis, or a method of detecting a chemical agent, including introducing a p-phenylene ethylylene compound to a composition including an enzyme substrate, and analyzing the fluorescence of the p-phenylene ethynylene compound. Various embodiments provide sensors that include a p-phenylene ethynylene compound and an enzyme substrate.

公开(公告)号：US11592399B2

公开(公告)日：2023-02-28

申请号：US17272527

申请日：2019-08-29

Applicant: STC.UNM ,  Aaron Kurt Neumann ,  Anatoliy O. Pinchuk

Inventor： Aaron Kurt Neumann ,  Anatoliy O Pinchuk

IPC: G01J3/44 ,  G01N21/65 ,  A61B10/00

Abstract: Highly sensitive assays for pathogen detection, identification and/or analysis including, but not limited to, sensing of metabolite patterns associated with high-risk drug resistance phenotypes.

公开(公告)号：US11434516B2

公开(公告)日：2022-09-06

申请号：US16333665

申请日：2017-09-18

Applicant: STC.UNM ,  NATIONAL TECHNOLOGY & ENGINEERING SOLUTIONS OF SANDIA, LLC

Inventor： Aaron Kurt Neumann ,  Matthew S Graus ,  Jerilyn A Timlin

IPC: C12Q1/04 ,  G01N21/64 ,  C12N1/16

Abstract: Methods and apparatus for rapid, culture free pathogen detection. The methods utilize optical spectroscopy techniques to identify and/or characterize pathogens in a sample via the detection of unique properties and/or analytes that are specific to particular pathogens.

公开(公告)号：US11188813B2

公开(公告)日：2021-11-30

申请号：US15909918

申请日：2018-03-01

Applicant: STC.UNM

Inventor： Alireza Goudarzi ,  Darko Stefanovic ,  Steven Wayde Graves ,  Daniel Kalb

IPC: G06N3/04 ,  G06N3/08 ,  G16H50/20

Abstract: The invention is directed to a hybrid architecture that comprises a stacked autoencoder and a deep echo state layer for temporal pattern discovery in high-dimensional sequence data. The stacked autoencoder plays a preprocessing role that exploits spatial structure in data and creates a compact representation. The compact representation is then fed to the echo state layer in order to generate a short-term memory of the inputs. The output of the network may be trained to generate any target output.

公开(公告)号：US11132178B2

公开(公告)日：2021-09-28

申请号：US16856887

申请日：2020-04-23

Applicant: STC.UNM

Inventor： James Plusquellic

IPC: G06F7/58 ,  H04L9/00 ,  H04L9/08 ,  G09C1/00

Abstract: This disclosure describes techniques for analyzing statistical quality of bitstrings produced by a physical unclonable function (PUF). The PUF leverages resistance variations in the power grid wires of an integrated circuit. Temperature and voltage stability of the bitstrings are analyzed. The disclosure also describes converting a voltage drop into a digital code, wherein the conversion is resilient to simple and differential side-channel attacks.

公开(公告)号：US11028318B2

公开(公告)日：2021-06-08

申请号：US16133844

申请日：2018-09-18

Applicant: National Technology & Engineering Solutions of Sandia, LLC ,  CARBO Ceramics Inc. ,  STC.UNM

Inventor： Chad Cannan ,  Terrence Palisch ,  Richard A. Kemp ,  Timothy J. Boyle ,  Bernadette A. Hernandez-Sanchez ,  James E. Miller

IPC: C09K8/80 ,  E21B47/11 ,  E21B43/267

Abstract: Proppant compositions for use in hydraulic fracturing and methods of using same are disclosed herein. The proppant compositions include a plurality of proppant particulates and at least one particulate of the plurality of proppant particulates containing at least one tracer, wherein the at least one tracer separates from the at least one particulate located inside a fracture of a subterranean formation after a period of time.