公开(公告)号：US20160066977A1

公开(公告)日：2016-03-10

申请号：US14940863

申请日：2015-11-13

Applicant: AngioDynamics, Inc.

Inventor： Robert Neal, II ,  Rafael V. Davalos

IPC: A61B18/12 ,  A61B18/14

CPC classification number: A61B18/1206 ,  A61B18/14 ,  A61B18/1477 ,  A61B18/18 ,  A61B34/10 ,  A61B2018/0016 ,  A61B2018/00577 ,  A61B2018/00613 ,  A61B2018/00666 ,  A61B2018/00672 ,  A61B2018/00678 ,  A61B2018/00767 ,  A61B2018/00875 ,  A61B2018/1425 ,  A61B2034/104 ,  C12N13/00

Abstract: A medical system for ablating a tissue site with real-time monitoring during an electroporation treatment procedure. A pulse generator generates a pre-treatment (PT) test signal having a frequency of at least 1 MHz prior to the treatment procedure and intra-treatment (IT) test signals during the treatment procedure. A treatment control module determines impedance values from the PT test signal and IT test signals and determines a progress of electroporation and an end point of treatment in real-time based on the determined impedance values while the treatment progresses.

Abstract translation: 一种用于在电穿孔治疗过程中实时监测组织部位的消融的医疗系统。 脉冲发生器在治疗过程之前产生具有至少1MHz的频率的治疗前（PT）测试信号，并且在治疗过程中处理（IT）测试信号。 治疗控制模块根据PT测试信号和IT测试信号确定阻抗值，并且在治疗进行时基于确定的阻抗值来实时确定电穿孔进程和终点治疗。

公开(公告)号：US20160022957A1

公开(公告)日：2016-01-28

申请号：US14872371

申请日：2015-10-01

Applicant: AngioDynamics, Inc.

Inventor： Eamonn Hobbs ,  William C. Hamilton, JR.

IPC: A61M25/00

CPC classification number: A61M25/0043 ,  A61B18/1492 ,  A61B2018/00357 ,  A61B2018/00386 ,  A61B2018/00613 ,  A61B2018/00839 ,  A61B2018/0097 ,  A61M2025/0019 ,  A61M2205/054 ,  A61N1/327

Abstract: An indwelling venous catheter and method capable of destroying undesirable cellular growth is provided. The catheter includes a shaft having at least one lumen and adapted to be placed inside a vein for long term use. A plurality of electrodes are positioned near a distal section of the shaft and are adapted to receive from a voltage generator a plurality of electrical pulses in an amount sufficient to cause destruction of cells in the undesirable cellular growth that have grown around the shaft. In one aspect of the invention, a probe is configured to be removably insertable into the at least one lumen and the electrodes are positioned near the distal section of the probe.

公开(公告)号：US20160008530A1

公开(公告)日：2016-01-14

申请号：US14857962

申请日：2015-09-18

Applicant: AngioDynamics, Inc.

Inventor： Karla Weaver ,  Jim Cuthane

IPC: A61M1/36 ,  A61M25/00 ,  A61M39/24

CPC classification number: A61M1/3653 ,  A61M1/3659 ,  A61M1/3661 ,  A61M25/0028 ,  A61M25/0029 ,  A61M39/22 ,  A61M39/24 ,  A61M2025/0031 ,  A61M2039/2433 ,  F16K15/147 ,  Y10T137/7882

Abstract: A valve for controlling material flow through a catheter, comprises a first flexible member including a first moveable element, wherein, when the first moveable element is in the open position, material may flow past the first flexible member through a first lumen of the catheter and, when the first moveable element is in the closed position, flow through the first lumen is prevented and a first biasing member coupled to the first flexible member for biasing the first moveable member toward the closed position.

公开(公告)号：US09161811B2

公开(公告)日：2015-10-20

申请号：US13683047

申请日：2012-11-21

Applicant: AngioDynamics, Inc.

Inventor： Nigel Cronin

IPC: A61B18/18

CPC classification number: A61B18/1815 ,  A61B18/18 ,  A61B2018/183 ,  A61B2018/1861 ,  A61B2018/1869 ,  A61B2018/1892

Abstract: A radiation applicator with a dielectric body (2) surrounding the antenna. The dielectric body (2) is comprised of three sections (3, 4 and 5) with different dielectric constants to provide broad-band matching of the applicator to surrounding material. Washers (10) and (11) are mounted on the antenna to act as reflectors.

Abstract translation: 具有围绕天线的电介质体（2）的辐射施加器。 介电体（2）由具有不同介电常数的三个部分（3,4和5）组成，以便将施加器与周围材料进行宽带匹配。 垫圈（10）和（11）安装在天线上作为反射器。

公开(公告)号：US20150230855A1

公开(公告)日：2015-08-20

申请号：US14535762

申请日：2014-11-07

Applicant: AngioDynamics, Inc.

Inventor： Victor Chornenky ,  Ali Jaafar

IPC: A61B18/14 ,  A61B18/12

CPC classification number: A61B18/14 ,  A61B18/1206 ,  A61B18/1445 ,  A61B18/1477 ,  A61B2018/0016 ,  A61B2018/00452 ,  A61B2018/0047 ,  A61B2018/00613 ,  A61B2018/1425 ,  A61B2018/143 ,  A61N1/0412

Abstract: An apparatus and method for performing noninvasive treatment of the human face and body by electroporation in lieu of cosmetic surgery is provided. The apparatus comprises a high voltage pulse generator and an applicator having two or more electrodes in close mechanical and electrical, contact with the patient's skin for applying the pulses to the patient's skin. The applicator may consist of two pieces with one electrode having a sharp tip and another having a flat surface. High voltage pulses delivered to the electrodes create at the tip of the sharp electrode an electric field high enough to cause death of relatively large subcutaneous fat cells by electroporation. Moving the electrode tip along the skin creates a line of necrotic subcutaneous fat cells, which later are metabolized by the body. Multiple applications of the electrode along predetermined lines on the face or neck create shrinkage of the skin and the subcutaneous fat volume underlying the treated area.

Abstract translation: 提供了一种用于通过电穿孔代替整容手术来对人体和身体进行无创处理的装置和方法。 该装置包括高压脉冲发生器和具有两个或更多个紧密机械和电气的电极的施用器，与患者的皮肤接触以将脉冲施加到患者皮肤。 施加器可以由具有一个尖端的一个电极和另一个具有平坦表面的两个部件组成。 输送到电极的高电压脉冲在尖锐的电极的尖端产生足够高的电场，以通过电穿孔引起相对较大的皮下脂肪细胞的死亡。 沿着皮肤移动电极尖端产生一系列坏死的皮下脂肪细胞，其随后被身体代谢。 电极沿着面部或颈部上的预定线的多次应用产生皮肤收缩和处理区域下面的皮下脂肪体积。

公开(公告)号：US09078665B2

公开(公告)日：2015-07-14

申请号：US13630135

申请日：2012-09-28

Applicant: AngioDynamics, Inc.

Inventor： Kevin Moss ,  Robert Pearson

IPC: A61B18/18 ,  A61B18/04 ,  A61B18/14 ,  A61B18/00 ,  A61B19/00

CPC classification number: A61B18/18 ,  A61B18/1477 ,  A61B18/1487 ,  A61B18/1815 ,  A61B2018/00029 ,  A61B2018/00083 ,  A61B2018/00273 ,  A61B2018/00529 ,  A61B2018/00577 ,  A61B2018/00589 ,  A61B2018/00613 ,  A61B2018/1467 ,  A61B2018/1475 ,  A61B2090/036

Abstract: An energy delivery probe and method of using the energy delivery probe to treat a patient is provided herein. The energy delivery probe has at least one probe body having a longitudinal axis and at least a first trocar and a second trocar. Each trocar comprises at least two electrodes that are electrically insulated from each other, and each electrode is independently selectively activatable. An insulative sleeve is positioned in a coaxially surrounding relationship to each of the first trocar and the second trocar. The probe also has a switching means for independently activating at least one electrode. The method involves independently and selectively activating the first and second electrodes to form an ablation zone, then repeating the ablation by delivering energy to a second set of electrodes, producing one or more overlapping ablation zone, and eliminating the need to reposition the ablation probes.

Abstract translation: 本文提供了能量递送探针和使用能量传递探针来治疗患者的方法。 能量传送探针具有至少一个具有纵向轴线的探针主体和至少第一套管针和第二套管针。 每个套管针包括彼此电绝缘的至少两个电极，并且每个电极独立地选择性地激活。 绝缘套管与第一套管针和第二套管针中的每一个同轴地围绕。 探头还具有用于独立地激活至少一个电极的开关装置。 该方法包括独立地和选择性地激活第一和第二电极以形成消融区，然后通过将能量传递到第二组电极来重复消融，产生一个或多个重叠的消融区，并且消除了重新定位消融探针的需要。

公开(公告)号：US20150126922A1

公开(公告)日：2015-05-07

申请号：US14591071

申请日：2015-01-07

Applicant: AngioDynamics, Inc.

Inventor： Jeffrey R. Willis

IPC: A61B18/14

CPC classification number: A61B18/1487 ,  A61B17/3417 ,  A61B17/3421 ,  A61B18/1477 ,  A61B18/1815 ,  A61B90/36 ,  A61B2018/00434 ,  A61B2018/00517 ,  A61B2018/00577 ,  A61B2018/00583 ,  A61B2018/00613 ,  A61B2018/00791 ,  A61B2018/00916 ,  A61B2018/00982 ,  A61B2090/0807 ,  A61B2090/3966 ,  A61N1/327

Abstract: An energy delivery probe for use in tissue ablation and method of use is presented. The energy delivery device has at least a first energy delivery member and a second energy delivery member that have handle members positioned along a longitudinal axis, each handle member having a proximal and distal end. The distal end of the first handle member is releasably coupled to the proximal end of the second handle member and a portion of each member is defined in a coaxially surrounding relationship to each other along the longitudinal axis. The method of using the probe involves identifying a tissue to be ablated, providing the energy delivery probe, inserting at least a portion of the energy delivery probe into the identified tissue, delivering electrical energy through the energy delivery probe to the identified tissue, and ablating the identified tissue such that at least a first ablation zone is formed.

Abstract translation: 提出了一种用于组织消融的能量输送探针和使用方法。 能量输送装置具有至少第一能量输送构件和第二能量输送构件，其具有沿着纵向轴线定位的把手构件，每个手柄构件具有近端和远端。 第一把手构件的远端可释放地联接到第二手柄构件的近端，并且每个构件的一部分沿着纵向轴线彼此同轴地围绕关系限定。 使用探针的方法包括识别要消融的组织，提供能量递送探针，将能量递送探针的至少一部分插入识别的组织中，将能量通过能量传递探针输送到识别的组织，以及消融 所述识别的组织使得至少形成第一消融区。

公开(公告)号：US08906006B2

公开(公告)日：2014-12-09

申请号：US14176889

申请日：2014-02-10

Applicant: AngioDynamics, Inc.

Inventor： Victor Chornenky ,  Ali Jaafar

IPC: A61B18/14 ,  C12N13/00 ,  A61N1/04 ,  A61B18/00

CPC classification number: A61B18/14 ,  A61B18/1445 ,  A61B18/1477 ,  A61B2018/00452 ,  A61B2018/00613 ,  A61B2018/1425 ,  A61B2018/143 ,  A61N1/0412

Abstract: An apparatus and method for performing non-invasive treatment of the human face and body by electroporation in lieu of cosmetic surgery is provided. The apparatus comprises a high voltage pulse generator and an applicator having two or more electrodes in close mechanical and electrical contact with the patient's skin for applying the pulses to the patient's skin. The applicator may consist of two pieces with one electrode having a sharp tip and another having a flat surface. High voltage pulses delivered to the electrodes create at the tip of the sharp electrode an electric field high enough to cause death of relatively large subcutaneous fat cells by electroporation. Moving the electrode tip along the skin creates a line of necrotic subcutaneous fat cells, which later are metabolized by the body. Multiple applications of the electrode along predetermined lines on the face or neck create shrinkage of the skin and the subcutaneous fat volume underlying the treated area.

Abstract translation: 提供了一种用于通过电穿孔代替整容手术来进行人脸和身体非侵入性治疗的装置和方法。 该装置包括高压脉冲发生器和具有两个或更多个电极的施加器，该电极与患者的皮肤紧密机械和电接触以将脉搏施加到患者皮肤。 施加器可以由具有一个尖端的一个电极和另一个具有平坦表面的两个部件组成。 输送到电极的高电压脉冲在尖锐的电极的尖端产生足够高的电场，以通过电穿孔引起相对较大的皮下脂肪细胞的死亡。 沿着皮肤移动电极尖端产生一系列坏死的皮下脂肪细胞，其随后被身体代谢。 电极沿着面部或颈部上的预定线的多次应用产生皮肤收缩和处理区域下面的皮下脂肪体积。

公开(公告)号：US08876797B2

公开(公告)日：2014-11-04

申请号：US14100671

申请日：2013-12-09

Applicant: AngioDynamics, Inc.

Inventor： Raymond Lareau ,  Benjamin Bell ,  J. Paul Santerre ,  Jeannette Ho

IPC: A61M25/098 ,  A61L29/18 ,  A61L29/04 ,  A61L33/06

CPC classification number: A61L29/041 ,  A61L29/049 ,  A61L29/14 ,  A61L29/18 ,  A61L33/062 ,  A61L33/064 ,  A61L2300/802 ,  A61M25/0017 ,  A61M25/0021 ,  A61M2025/0056 ,  C08L75/04 ,  C08L27/12

Abstract: The present invention provides catheter compositions that provide anti-thrombogenic properties while not adversely impacting mechanical properties. All embodiments of the present invention comprise a catheter that comprises a fluoropolymer additive with specific compositions and/or purity levels.

Abstract translation: 本发明提供了提供抗血栓形成性质而不会不利地影响机械性能的导管组合物。 本发明的所有实施方案包括导管，其包含具有特定组成和/或纯度水平的含氟聚合物添加剂。

公开(公告)号：US20140309579A1

公开(公告)日：2014-10-16

申请号：US14313647

申请日：2014-06-24

Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA ,  ANGIODYNAMICS, INC.

Inventor： BORIS RUBINSKY ,  ELAD MAOR ,  ANTONI IVORRA ,  JAMES J. MITCHELL ,  WILLIAM C. HAMILTON

IPC: A61B18/14 ,  A61M5/14 ,  A61N1/32

CPC classification number: A61M5/14 ,  A61B18/14 ,  A61B18/1492 ,  A61B2017/22038 ,  A61B2018/00166 ,  A61B2018/00214 ,  A61B2018/0022 ,  A61B2018/0041 ,  A61B2018/00613 ,  A61B2018/1435 ,  A61N1/327

Abstract: Restenosis or neointimal formation may occur following angioplasty or other trauma to an artery such as by-pass surgery. This presents a major clinical problem which narrows the artery. The invention provides a balloon catheter with a particular electrode configuration. Also provided is a method whereby vascular cells in the area of the artery subjected to the trauma are subjected to irreversible electroporation which is a non-thermal, non-pharmaceutical method of applying electrical pulses to the cells so that substantially all of the cells in the area are ablated while leaving the structure of the vessel in place and substantially unharmed due to the non-thermal nature of the procedure.

Abstract translation: 血管成形术或其他对动脉的创伤如旁路手术可能发生再狭窄或新内膜形成。 这是导致动脉狭窄的主要临床问题。 本发明提供了一种具有特定电极结构的球囊导管。 还提供了一种方法，其中经受创伤的动脉区域中的血管细胞经受不可逆电穿孔，其是对细胞施加电脉冲的非热非非药物方法，使得基本上所有细胞 由于该程序的非热性质，将容器的结构留在原位并且基本上没有受到伤害的区域被消融。