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    METHOD FOR PRODUCING CYCLOMETALATED IRIDIUM COMPLEX
    142.
    发明申请
    METHOD FOR PRODUCING CYCLOMETALATED IRIDIUM COMPLEX 审中-公开

    公开(公告)号：US20200181181A1

    公开(公告)日：2020-06-11

    申请号：US16344315

    申请日：2017-12-04

    Applicant: NATIONAL INSTITUTE OF ADVANCED INDUSTRIAL SCIENCE AND TECHNOLOGY ,  TANAKA KIKINZOKU KOGYO K.K.

    Inventor： Hideo KONNO ,  Junichi TANIUCHI ,  Rumi KOBAYASHI ,  Yasushi MASAHIRO

    IPC: C07F15/00

    Abstract: The present invention provides a method for producing a cyclometalated iridium complex, the method including producing a cyclometalated iridium complex by reacting a cyclometalated iridium complex raw material including an organoiridium compound with an aromatic heterocyclic bidentate ligand capable of forming an iridium-carbon bond and an iridium-nitrogen bond, and using as the raw material an organoiridium compound including a substructure represented by the following General Formula (1). The present invention is capable of producing a cyclometalated iridium complex with a high yield without by-production of a halogen-crosslinked iridium dimer. (in General Formula (1), Ir represents an iridium atom, and O represents an oxygen atom).

    GENE EXPRESSION SYSTEM USING STEALTHY RNA, AND GENE INTRODUCTION/EXPRESSION VECTOR INCLUDING SAID RNA
    147.
    发明申请
    GENE EXPRESSION SYSTEM USING STEALTHY RNA, AND GENE INTRODUCTION/EXPRESSION VECTOR INCLUDING SAID RNA 审中-公开

    公开(公告)号：US20200157571A1

    公开(公告)日：2020-05-21

    申请号：US16703092

    申请日：2019-12-04

    Applicant: NATIONAL INSTITUTE OF ADVANCED INDUSTRIAL SCIENCE AND TECHNOLOGY ,  TOKIWA-BIO INC.

    Inventor： Mahito Nakanishi ,  Minoru Iijima

    IPC: C12N15/86 ,  C12N5/14 ,  C12N15/09 ,  C07K16/28 ,  C07K16/32 ,  C07K16/46 ,  C12N5/074 ,  C12N9/12

    Abstract: The present invention enables simultaneous and stable expression of a plurality of foreign genes by using a stealthy RNA gene expression system that is a complex that does not activate the innate immune mechanism and is formed from an RNA-dependent RNA polymerase, a single-strand RNA binding protein, and negative-sense single-strand RNAs including the following (1) to (8): (1) a target RNA sequence that codes for any protein or functional RNA; (2) an RNA sequence forming a noncoding region and derived from mRNA expressed in animal cells; (3) a transcription initiation signal sequence recognized by the RNA-dependent RNA polymerase; (4) a transcription termination signal sequence recognized by the polymerase; (5) an RNA sequence containing a replication origin recognized by the polymerase; (6) an RNA sequence that codes for the polymerase and of which codons are optimized for the species from which an introduction target cell is derived; (7) an RNA sequence that codes for a protein for regulating the activity of the polymerase and of which codons are optimized for the species from which the introduction target cell is derived; and (8) an RNA sequence that codes for the single-strand RNA binding protein and of which codons are optimized for the species from which the introduction target cell is derived.

    Cell-spreading device and method for detecting rare cell
    148.
    发明授权
    Cell-spreading device and method for detecting rare cell 有权

    公开(公告)号：US10584367B2

    公开(公告)日：2020-03-10

    申请号：US14411191

    申请日：2013-07-01

    Applicant: Konica Minolta, Inc. ,  National Institute of Advanced Industrial Science and Technology

    Inventor： Jungo Araki ,  Kumiko Hoshi ,  Shohei Yamamura ,  Shouki Yatsushiro ,  Masatoshi Kataoka

    IPC: C12Q1/24 ,  B01L3/00

    Abstract: A cell-spreading device may include a microchamber chip having a microchamber capable of enclosing and retaining a cell, a channel-forming frame united with the microchamber chip to form a channel on the microchamber, an inlet provided in the channel-forming frame to allow a cell suspension to flow into the channel, and an outlet provided in the channel-forming frame to allow the cell suspension, which has been allowed to flow into the channel through the inlet, to flow out from the channel. When an aperture of the microchamber is projected perpendicularly to a longitudinal width of the microchamber chip, the void ratio that is a ratio of the sum total of voids to the longitudinal width is not more than 5%, the void being a length of a portion where the projected aperture of the microchamber is not present against the longitudinal width.

    ELECTRODE ACTIVE MATERIAL FOR NONAQUEOUS SECONDARY BATTERIES, AND NONAQUEOUS SECONDARY BATTERY USING SAME
    149.
    发明申请
    ELECTRODE ACTIVE MATERIAL FOR NONAQUEOUS SECONDARY BATTERIES, AND NONAQUEOUS SECONDARY BATTERY USING SAME 审中-公开

    公开(公告)号：US20200067095A1

    公开(公告)日：2020-02-27

    申请号：US16462653

    申请日：2017-11-24

    Applicant: National Institute of Advanced Industrial Science and Technology

    Inventor： Masaru Yao ,  Hisanori Ando

    IPC: H01M4/60 ,  H01M10/0525

    Abstract: An electrode active material for non-aqueous secondary batteries containing a compound represented by formula (1) is a material that is less likely to dissolve in an electrolyte during charge and discharge, and that exhibits an excellent discharge capacity and excellent charge-and-discharge cycle characteristics: the compound represented by formula (1) wherein Y1 and Y2 are identical or different and represent an oxygen atom, a sulfur atom, or a selenium atom, R1 to R8 are identical or different and represent an oxygen atom or a group represented by —OLi, R9 to R12 are identical or different and represent a hydrogen atom or an organic group, and bonds that are each represented by a solid line and a dashed line indicate a single bond or a double bond.

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