公开(公告)号：US20170298037A1

公开(公告)日：2017-10-19

申请号：US15510152

申请日：2015-09-10

Applicant: Temple University-Of the Commonwealth system of Higher Education

Inventor： Daniel J. Canney ,  Benjamin E. Blass ,  Rong Gao ,  Magid Abou-Gharbia

IPC: C07D307/33 ,  C07D307/94 ,  C07D405/06 ,  C07D405/12

CPC classification number: C07D307/33 ,  C07D307/28 ,  C07D307/94 ,  C07D405/06 ,  C07D405/12 ,  C07D405/14

Abstract: Pharmaceutical compositions of the invention comprise functionalized lactone derivatives having a disease-modifying action in the treatment of diseases associated with dysregulation of 5-hydroxytryptamine receptor 7 activity.

公开(公告)号：US20170246139A1

公开(公告)日：2017-08-31

申请号：US15521623

申请日：2015-10-30

Applicant: UNIVERSITY OF ROCHESTER ,  TEMPLE UNIVERSITY -- OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION

Inventor： Paul M. Dunman ,  Wayne Childers

IPC: A61K31/341 ,  A61K31/17 ,  A61K31/381 ,  A61K31/497 ,  A61K31/343 ,  A61K31/415 ,  A61K31/4409 ,  A61K31/4045 ,  A61K31/4184 ,  A61K31/47 ,  A61K31/44 ,  A61K45/06 ,  A61K31/351 ,  A61K47/10 ,  A61K9/06 ,  A61K9/00 ,  A61K31/443

CPC classification number: A61K31/341 ,  A61K9/0043 ,  A61K9/06 ,  A61K31/136 ,  A61K31/17 ,  A61K31/343 ,  A61K31/351 ,  A61K31/381 ,  A61K31/4045 ,  A61K31/415 ,  A61K31/4184 ,  A61K31/44 ,  A61K31/4409 ,  A61K31/443 ,  A61K31/47 ,  A61K31/497 ,  A61K45/06 ,  A61K47/10 ,  A61K2300/00

Abstract: Synergistic pharmaceutical compositions including an RNase P inhibitor and a tRNA synthetase inhibitor are provided, as well as methods for their use in treating infections. Also provided herein are methods of using the compositions to inhibit a bacterial tRNA synthetase in a cell and to decolonize bacteria on a surface.

公开(公告)号：US09724304B2

公开(公告)日：2017-08-08

申请号：US13918019

申请日：2013-06-14

Applicant: Temple University—Of The Commonwealth System of Higher Education

Inventor： Ho Lun Wong ,  Mayuri Narvekar ,  Hui Yi Xue

IPC: A61K9/16 ,  A61K31/203 ,  A61K31/405 ,  A61K9/51

CPC classification number: A61K9/16 ,  A61K9/5123 ,  A61K9/5153 ,  A61K31/203 ,  A61K31/405

Abstract: Provided is a nanosphere for delivery of a therapeutic agent comprising: a polymer matrix; discrete liquid oil droplets dispersed in the polymer matrix; and a therapeutic agent dissolved or dispersed in the oil. In some embodiments, the nanosphere is pegylated. In some embodiments, the nanosphere has a diameter of from about 100 nm to about 300 nm. In further preferred embodiments, the nanosphere has a diameter of from about 150 nm to about 250 nm. In yet further embodiments, the nanosphere has a diameter of from about 180 nm to about 220 nm. In some embodiments, the oil comprises a lipid or a phospholipid. In further embodiments, the lipid or the phospholipid has a melting point below 20° C. In some embodiments, the polymer is a natural, modified or synthetic polymer. In further embodiments, the polymer is biodegradable.

公开(公告)号：US20170179524A1

公开(公告)日：2017-06-22

申请号：US15129342

申请日：2015-03-20

Applicant: Temple University- of The Commonwealth System of Higher Education

Inventor： Michael J. Zdilla ,  Stephanie L. Wunder ,  Parameswara Rao Chinnam

IPC: H01M10/0565 ,  H01M6/36 ,  H01M6/16 ,  H01M4/02 ,  H01M6/14

CPC classification number: H01M10/0565 ,  H01M4/02 ,  H01M6/14 ,  H01M6/16 ,  H01M6/36 ,  H01M10/052 ,  H01M10/056 ,  H01M2300/0017 ,  H01M2300/0085

Abstract: The present invention relates to compositions comprising ionic compounds surrounded by organic matrices, and methods for producing such compositions. In various embodiments, the compositions of the present invention are co-crystals of an organic compound and a salt. The organic compound forms matrices with channel structures, wherein the organic matrices interact relatively poorly with the salt, thus allowing for excellent ion mobility through the channel structures. In one embodiment, the compositions are soft-solid electrolytes, comprising ions such as lithium or sodium, which can be used in batteries or other electrochemical devices. The electrolyte compositions of the present invention exhibit relatively high ionic conductivities with a negligible activation barrier for ion migration, i.e., the compositions exhibit barrierless ion conduction. In addition, the compositions exhibit good conductivities at very low temperatures, making them useful in a variety of low temperature applications. In one embodiment, the present invention further relates to free-standing films comprising the co-crystals of the present invention, and methods for preparing such films.

公开(公告)号：US20170176408A1

公开(公告)日：2017-06-22

申请号：US15129353

申请日：2015-03-24

Applicant: Temple University-Of The Commonwealth System of Higher Education ,  The Johns Hopkins University

Inventor： Salim Merali ,  Carlos A. Barrerro ,  Kamel Khalili ,  Jay Rappaport ,  Norman J. Haughey ,  Ned Sacktor

IPC: G01N33/487 ,  G01N30/88

CPC classification number: G01N33/487 ,  G01N30/88 ,  G01N33/5308 ,  G01N2030/8813 ,  G01N2800/2814 ,  G01N2800/52 ,  G01N2800/56

Abstract: Provided is a method of detecting mild neurocognitive disturbance (MNCD) or HIV associated dementia (HAD) in a patient comprising detecting the level of acetyl spermine and/or acetyl spermidine from a cerebrospinal fluid test sample of the patient; and comparing the level of acetyl spermine and/or acetyl spermidine in the test sample to the level of the acetyl spermine and/or acetyl spermidine in a cerebrospinal fluid control sample or to a control value for lack of neurocognitive impairment, MNCD or HAD; wherein an elevated level of acetyl spermine and/or acetyl spermidine in the test sample as compared to the level in the control sample or a control value for lack of neurocognitive impairment, or a level of acetyl spermine and/or acetyl spermidine that is similar to that of a control value for MNCD or HAD, indicates that the patient suffers from MNCD or HAD. Also provided are methods for measuring the progression of an HIV-1-associated neurocognitive disorder, as well as methods for staging such a disorder.

公开(公告)号：US09680182B2

公开(公告)日：2017-06-13

申请号：US14399433

申请日：2013-03-14

Applicant: TEMPLE UNIVERSITY—OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION

Inventor： Stephanie L. Wunder ,  Parameswara Rao Chinnam

IPC: H01M10/0565 ,  H01M10/0525

CPC classification number: H01M10/0565 ,  H01M10/0525 ,  H01M2220/10 ,  H01M2220/20 ,  H01M2220/30 ,  H01M2300/0082

Abstract: A composition suitable as a solid polymer electrolyte for a lithium ion battery comprises a mixture of polyoctahedral silsesquioxane-phenyl7(BF3Li)3 and a poly(ethylene oxide).

公开(公告)号：US20170128525A1

公开(公告)日：2017-05-11

申请号：US15363119

申请日：2016-11-29

Applicant: Temple University-Of The Commonwealth System of Higher Education

Inventor： George P. Tuszynski ,  John F. Wong ,  Taffy Williams

IPC: A61K38/17 ,  A61K38/18 ,  C12N5/0786

CPC classification number: A61K38/177 ,  A61K38/1709 ,  A61K38/18 ,  A61K38/1808 ,  A61K38/1825 ,  A61K38/185 ,  C12N5/0645 ,  C12N2501/50 ,  C12N2506/30

Abstract: Methods are presented for the therapeutic administration of angiocidin in the treatment of cancers such as glioma, breast cancer, and leukemia. Methods are also presented for inducing growth arrest and/or apoptosis of tumor cells, as well as inducing differentiation of tumor cells to inhibit tumorigenicity and to confer a non-tumor or healthy phenotype.

公开(公告)号：US09622995B2

公开(公告)日：2017-04-18

申请号：US14711355

申请日：2015-05-13

Applicant: TEMPLE UNIVERSITY—OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION ,  DUKE UNIVERSITY ,  RESEARCH TRIANGLE INSTITUTE

Inventor： Mary E. Abood ,  Pingwei Zhao ,  Lawrence S. Barak ,  Herbert H. Seltzman

IPC: A61K31/194 ,  A61K31/191

CPC classification number: A61K31/194 ,  A61K31/191

Abstract: Compounds are provided having agonistic activity against G protein-coupled receptor 35 (GPR35). The compounds are useful for providing antinociception, providing neuroprotection in case of stroke or ischemia, or treating gastric inflammation.

公开(公告)号：US20160367967A1

公开(公告)日：2016-12-22

申请号：US15121593

申请日：2015-02-27

Applicant: TEMPLE UNIVERSITY-OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION

Inventor： Rominder P.S. Suri

IPC: B01J20/34 ,  C02F1/28 ,  B01J20/32

CPC classification number: B01J20/3458 ,  B01J20/3204 ,  B01J20/3274 ,  B01J20/3425 ,  C02F1/281 ,  C02F1/285 ,  C02F1/288 ,  C02F2101/305 ,  C02F2101/345 ,  C02F2101/36 ,  C02F2303/16

Abstract: The present invention relates to systems and methods for regenerating β-cyclodextrin (β-CD) adsorbent after it has been used in a water decontamination process. The regeneration process of the present invention is based on treating β-CD with ozone gas, i.e., ozonation. In one embodiment, the regeneration process of the present invention comprises the steps of providing a β-CD adsorbent that has been used in a water decontamination process and removing at least a portion of the contaminants from the β-CD adsorbent by contacting the contaminants bound to the β-CD adsorbent with a gas comprising ozone.

Abstract translation: 本发明涉及在β-去环糊精（β-CD）吸附剂用于水净化过程中再生的系统和方法。 本发明的再生方法是用臭氧气体处理β-CD，即臭氧化。 在一个实施方案中，本发明的再生方法包括以下步骤：提供已经用于水去污过程中的β-CD吸附剂，并通过使结合的污染物接触从β-CD吸附剂中除去至少一部分污染物 与包含臭氧的气体接触到β-CD吸附剂。

公开(公告)号：US09517230B2

公开(公告)日：2016-12-13

申请号：US14744205

申请日：2015-06-19

Applicant: UNIVERSITY OF ROCHESTER ,  BOARD OF REGENTS OF THE UNIVERSITY OF NEBRASKA ,  TEMPLE UNIVERSITY—OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION

Inventor： Paul M. Dunman ,  Patrick D. Olson ,  Wayne Childers

IPC: A61K31/427 ,  C07D307/68 ,  C07D307/56 ,  C07D405/06 ,  C07D417/06 ,  A61K31/341 ,  A61K45/06 ,  A61K31/402 ,  C07D207/337 ,  C12Q1/44

CPC classification number: A61K31/427 ,  A61K31/341 ,  A61K31/402 ,  A61K45/06 ,  C07D207/337 ,  C07D307/56 ,  C07D307/68 ,  C07D405/06 ,  C07D417/06 ,  C12Q1/44 ,  G01N2333/922 ,  G01N2500/04 ,  G01N2500/10 ,  A61K2300/00

Abstract: Small molecule inhibitors of bacterial ribonuclease (e.g., RnpA) and methods for their synthesis and use are described herein. The methods of using the compounds include treating and preventing microbial infections and inhibiting bacterial ribonuclease.