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公开(公告)号：US20210331165A1
公开(公告)日：2021-10-28
申请号：US16606287
申请日：2018-04-25
Applicant: HEWLETT-PACKARD DEVELOPMENT COMPANY, L.P.
Inventor： Viktor Shkolnikov , Chien-Hua Chen
Abstract: An example system includes a microfluidic cavity; a retaining feature within the microfluidic cavity, and a releasing feature. The retaining feature is to position capsules at a predetermined location in the microfluidic cavity. The capsules have a thermally degradable shell enclosing a material therein. The releasing feature is to selectively cause degradation of the shell to release the material into the microfluidic opening. The releasing feature is to generate heat to facilitate degradation of the shell. In some examples, the retaining feature is a physical barrier sized to prevent flow of the capsule and to allow flow of the released materials through the microfluidic cavity.
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公开(公告)号：US20210277350A1
公开(公告)日：2021-09-09
申请号：US16605985
申请日：2018-03-27
Applicant: HEWLETT-PACKARD DEVELOPMENT COMPANY, L.P.
Inventor： Viktor Shkolnikov , Alexander Govyadinov
IPC: C12M1/00 , G01N33/543 , G01N33/569
Abstract: An example system includes an input channel to receive particles through a first end, a separation chamber, at least two output channels, an integrated pump to facilitate flow through the separation chamber and a cell analysis portion. The separation chamber is in fluid communication with a second end of the input channel. The separation chamber has a passive separation structure including an array of columns spaced apart to facilitate separation of particles into at least two flow paths based on a size of the particles. The size associated with a first flow path of the at least two flow paths corresponds to a cell. A first output channel is to receive the first flow path corresponding to a cell. The cell analysis portion is coupled to the first output channel and is to perform at least one analysis associated with cells in the first output channel.
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公开(公告)号：US20210270721A1
公开(公告)日：2021-09-02
申请号：US17255761
申请日：2018-10-01
Applicant: Hewlett-Packard Development Company, L.P.
Inventor： Fausto D'Apuzzo , Viktor Shkolnikov , Yang Lei
Abstract: A system and a method for sorting particles are provided. An example of a particle sorting system includes an array that includes a number of microfluidic ejectors. An optical sensor is focused on the array. A controller is used to identify a target particle proximate to a microfluidic ejector, and activate the microfluidic ejector to eject the target particle into a collection vessel.
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公开(公告)号：US20210262913A1
公开(公告)日：2021-08-26
申请号：US17256324
申请日：2018-10-01
Applicant: Hewlett-Packard Development Company, L.P.
Inventor： Fausto D'Apuzzo , Viktor Shkolnikov , Yang Lei
Abstract: A system and a method for the batch sorting of particles are provided. An example of a batch sorting system includes a microfluidic ejector, a flow channel fluidically coupled to the microfluidic ejector at one end, and a reservoir coupled to an opposite end of the flow channel from the microfluidic ejector. A counter is disposed in the flow channel upstream of the microfluidic ejector to count particles prior to ejection from the microfluidic ejector. An optical sensor is to image the flow channel. A controller is configured to locate a target particle in the flow channel based, at least in part, on the image and capture the target particle in a collection vessel based, at least in part, on a count from the counter.
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公开(公告)号：US20210239958A1
公开(公告)日：2021-08-05
申请号：US17255808
申请日：2018-10-01
Applicant: Hewlett-Packard Development Company, L.P.
Inventor： Fausto D'Apuzzo , Viktor Shkolnikov
Abstract: A system and a method for imaging microfluidic ejectors during operation. An example provides a microscopy system, that includes a plurality of microfluidic ejectors. A mirror is disposed in a droplet path of the plurality of microfluidic ejectors, wherein the droplet path passes through an opening in the mirror. An optical system is focused on the plurality of microfluidic ejectors through the minor, wherein the optical system comprises a camera.
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Patent Agency Ranking
公开(公告)号：US11067513B2
公开(公告)日：2021-07-20
申请号：US16710819
申请日：2019-12-11
Applicant: Hewlett-Packard Development Company, L.P.
Inventor： Francesco Aieta , Anita Rogacs , Viktor Shkolnikov
Abstract: In an example, an apparatus is described that includes a light source, a holographic optical element, a sampling apparatus, and a detector. The light source is configured to emit a beam of excitation light. The holographic optical element is arranged to convert the beam of excitation light into a plurality of beams of excitation light. The sampling apparatus is arranged to project the plurality of beams of excitation light onto a surface outside the apparatus as a two-dimensional pattern of projection points. The sampling apparatus is further arranged to collect scattered radiation emitted by the surface in response to the two-dimensional pattern of projection points. The detector detects a frequency shift in the scattered radiation.
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公开(公告)号：US20210154672A1
公开(公告)日：2021-05-27
申请号：US17047353
申请日：2018-08-10
Applicant: Hewlett-Packard Development Company, L.P.
Inventor： Viktor Shkolnikov , Alexander Govyadinov
Abstract: In one example in accordance with the present disclosure, a cellular analytic system is described. The cellular analytic system includes a series of analytic devices. Each analytic device includes 1) a separator to separate a cellular particle from a surrounding fluid, 2) an analyzer coupled to a first outlet of the separator to analyze the surrounding fluid, and 3) at least one lysing device coupled to at least a second outlet of the separator to rupture a membrane of the cellular particle. An outlet of the lysing device is fluidly coupled to a separator of a downstream analytic device.
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公开(公告)号：US20210121883A1
公开(公告)日：2021-04-29
申请号：US16605927
申请日：2018-03-27
Applicant: HEWLETT-PACKARD DEVELOPMENT COMPANY, L.P.
Inventor： Viktor Shkolnikov , Alexander Govyadinov
Abstract: An example system includes an input channel to flow nucleic segments therethrough, a mixing portion coupled to the input channel, a separation chamber in fluid communication with the second end of the input channel, at least two output channels coupled to the chamber, and an integrated pump to facilitate flow through the separation chamber. The mixing portion is to include at least two different categories of beads having different sizes from each other and having a probe to attach to a corresponding nucleic acid segment. The separation chamber has a passive separation structure including an array of columns spaced apart to facilitate separation of the different categories of beads and attached corresponding nucleic acid segment into at least two flow paths based on a size of the category of the beads. Each output channel is to receive separated categories of beads and attached nucleic acid segments.
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公开(公告)号：US20210018466A1
公开(公告)日：2021-01-21
申请号：US16606013
申请日：2018-04-11
Applicant: HEWLETT-PACKARD DEVELOPMENT COMPANY, L.P.
Inventor： Viktor Shkolnikov , Steven Barcelo
Abstract: The present disclosure is drawn to a photoacoustic explosives detector, including a sample chamber, an aerosolizing ejector, a light source, and a pressure differential sensor. The sample chamber can include a photoreaction region, and the aerosolizing ejector can be positioned to eject 3 pL to 10 nL droplets of a liquid sample into the photoreaction region. A light source can be directed to emit focused light through the photoreaction region, and a pressure differential sensor can be positioned with respect to the photoreaction region to sense degradation of the droplets exposed to the focused light.
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公开(公告)号：US20210009931A1
公开(公告)日：2021-01-14
申请号：US16606841
申请日：2018-04-04
Applicant: HEWLETT-PACKARD DEVELOPMENT COMPANY, L.P.
Inventor： Viktor Shkolnikov , Daixi Xin
Abstract: The present disclosure is drawn to microfluidic cellular membrane modification devices. In one example, a microfluidic cellular membrane modification device can include a microfluidic channel including a pumping portion and an electric field portion. An electrode pair can be positioned about the electric field portion. A bidirectional pump can be in fluid communication with the microfluidic channel at the pumping portion to move fluid backward and forward through the electric field portion.
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