公开(公告)号：US20180353639A1

公开(公告)日：2018-12-13

申请号：US16106324

申请日：2018-08-21

Applicant: KCI Licensing, Inc.

Inventor： Christopher Brian Locke ,  Timothy Mark Robinson ,  Breda Mary Cullen

IPC: A61L15/42 ,  A61L15/32 ,  A61H9/00 ,  A61L15/28 ,  A61L15/22

CPC classification number: A61L15/42 ,  A61H9/0057 ,  A61L15/225 ,  A61L15/28 ,  A61L15/325 ,  A61L15/425 ,  A61L2430/34

Abstract: Systems, methods, and apparatuses for modulating proteases including matrix metalloproteinase (MMP), elastase, and bacterial protease in a negative pressure therapy system are described. A mesh having a sacrificial substrate is included. The sacrificial substrate includes a plurality of collagen fibers reinforced with a supporting material and intersecting with each other to form a network of collagen fibers having a plurality openings. The openings of the plurality of openings have an average area between about 0.5 mm2 and about 20 mm2 to permit the flow of negative pressure through the mesh. The sacrificial substrate can also include oxidized regenerated cellulose.

公开(公告)号：US10064759B2

公开(公告)日：2018-09-04

申请号：US14135120

申请日：2013-12-19

Applicant: KCI Licensing, Inc.

Inventor： Christopher Brian Locke ,  Timothy Mark Robinson ,  Richard Daniel John Coulthard

IPC: A61F13/00 ,  A61F13/02 ,  A61M1/00 ,  A61M27/00

Abstract: Methods for promoting re-epithelialization and granulation as an aspect of wound healing are presented. A method for promoting granulation and re-epithelialization of a wound at the same time involves using a reduced-pressure treatment dressing and applying a moist, water-sensitive barrier to promote re-epithelialization and to inhibit granulation. Other methods are also presented.

公开(公告)号：US10010454B2

公开(公告)日：2018-07-03

申请号：US13937947

申请日：2013-07-09

Applicant: KCI Licensing, Inc.

Inventor： Rosella Kendrick ,  Colin John Hall ,  Elliott James Rider ,  Timothy Mark Robinson ,  Benjamin Stokes

IPC: A61M35/00 ,  A61F13/02 ,  A61L15/18 ,  A61L15/26 ,  A61L15/44 ,  A61L15/46

CPC classification number: A61F13/0246 ,  A61F13/02 ,  A61F13/0206 ,  A61F13/0209 ,  A61F13/0213 ,  A61F13/0216 ,  A61L15/18 ,  A61L15/26 ,  A61L15/44 ,  A61L15/46 ,  A61L2300/434 ,  C08L75/04 ,  C08L83/04

Abstract: Systems, methods, and devices are presented for treating a tissue site and managing hair proximate the tissue site. A composition is provided for inhibiting, removing, or weakening hair proximate the tissue site and for providing an improved fluid seal by a flexible film drape over the tissue site. In some example embodiments, a hair-modification agent is disposed at least proximate a peripheral edge of a treatment manifold between a drape and epidermis proximate a tissue site. The hair-modification agent can be configured to flow over imperfections on the epidermis and to form a fluid seal against the epidermis, and can further be configured to at least substantially weaken hair on the epidermis as the hair encounters the hair-modification agent.

公开(公告)号：US09974694B2

公开(公告)日：2018-05-22

申请号：US14708061

申请日：2015-05-08

Applicant: KCI Licensing, Inc.

Inventor： Christopher Brian Locke ,  Timothy Mark Robinson ,  Robert Tuck ,  Gareth Stephenson

IPC: A61F13/00 ,  A61M1/00

CPC classification number: A61F13/00068 ,  A61F13/00017 ,  A61F13/00042 ,  A61M1/0088

Abstract: Systems, apparatuses, and methods for closing an opening through a surface of a tissue site are described. The system includes a sealing member adapted to cover the opening to form a sealed space and a negative-pressure source adapted to be fluidly coupled to the sealed space to provide negative pressure to the sealed space. The system also includes a contracting layer adapted to be positioned adjacent the opening and formed from a material having a firmness factor and a plurality of holes extending through the contracting layer to form a void space. The holes have a perforation shape factor and a strut angle causing the plurality of holes to collapse in a direction substantially perpendicular to the opening. The contracting layer generates a closing force substantially parallel to the surface of the tissue site to close the opening in response to application of the negative pressure.

公开(公告)号：US09937079B2

公开(公告)日：2018-04-10

申请号：US14080285

申请日：2013-11-14

Applicant: KCI Licensing, Inc.

Inventor： Timothy Mark Robinson ,  Christopher Brian Locke

IPC: A61F13/02 ,  A61M27/00 ,  A61F13/00 ,  A61M1/00

CPC classification number: A61F13/0216 ,  A61F13/00068 ,  A61F13/0233 ,  A61F13/0246 ,  A61F13/0289 ,  A61M1/0088

Abstract: A system for treating a tissue site includes a pressure source to apply reduced pressure, and a manifold in fluid communication with the pressure source to provide reduced pressure to the tissue site. The system includes a drape for adhering to the tissue site to cover the tissue site and the manifold. The drape has a film layer having a thickness less than about 15 microns, and an adhesive coupled to the film layer. The adhesive seals the film layer to the tissue site to create a sealed space having the manifold therein. The adhesive is sufficiently thick to limit leaks between the film layer and the tissue site.

公开(公告)号：US09878077B2

公开(公告)日：2018-01-30

申请号：US14276853

申请日：2014-05-13

Applicant: KCI Licensing, Inc.

Inventor： Christopher Brian Locke ,  Timothy Mark Robinson ,  Aidan Marcus Tout

IPC: A61M1/00 ,  A61F13/00 ,  A61M25/00

CPC classification number: A61M1/0088 ,  A61F13/00068 ,  A61F2013/00174 ,  A61F2013/00536 ,  A61F2013/0054 ,  A61M1/00 ,  A61M1/0025 ,  A61M25/00 ,  A61M2205/3344

Abstract: Systems and methods for a reduced-pressure interface for providing reduced pressure through a sealing member to a distribution manifold includes a housing having a flange portion and a cavity wall portion such that the cavity wall portion forms a cavity having a tissue-facing cavity opening. A conduit port is coupled to the cavity wall and has a conduit aperture, such that the conduit port is adapted to receive a reduced-pressure delivery conduit. An attachment device is coupled to a tissue-facing side of the flange portion of the housing such that the attachment device couples the housing to the sealing member. Additionally, a cutting element is at least temporarily coupled to the housing proximate to the tissue-facing cavity opening such that the cutting element is adapted to form an aperture in the sealing member when the cutting element is driven into the sealing member with a driving force.

公开(公告)号：US09833363B2

公开(公告)日：2017-12-05

申请号：US14104630

申请日：2013-12-12

Applicant: KCI Licensing, Inc.

Inventor： Timothy Mark Robinson ,  Christopher Brian Locke

IPC: A61F13/02 ,  A61M1/00 ,  A61F13/00

CPC classification number: A61F13/022 ,  A61F13/00068 ,  A61F13/0216 ,  A61F13/0223 ,  A61M1/0088 ,  Y10T156/10

Abstract: A sealing drape may be suitable for use with a reduced-pressure treatment system for treating a tissue site. The sealing drape may have an interior surface adapted for positioning adjacent to a peripheral surface of the tissue site. The sealing drape may include a sealing material and an absorbent material. The sealing material may be hydrophobic and substantially free of hydrophilic components. Further, the sealing material may be positioned between the interior surface of the sealing drape and the absorbent material. The sealing drape may be used with a manifold for positioning at the tissue site, a reduced-pressure interface, and a reduced-pressure source. Methods of manufacture and treatment are also disclosed.

公开(公告)号：US09814485B2

公开(公告)日：2017-11-14

申请号：US14581646

申请日：2014-12-23

Applicant: KCI Licensing, Inc.

Inventor： Benjamin A. Pratt ,  Christopher Brian Locke ,  Timothy Mark Robinson ,  Kevin Higley ,  Tab Randolph ,  T. Blane Sanders

IPC: A61B17/322 ,  A61B17/00

CPC classification number: A61B17/322 ,  A61B2017/00761 ,  A61B2017/00774 ,  A61B2017/3225

Abstract: The present invention generally relates to devices and systems that utilize an inflatable bladder for generating, cutting, capturing, and/or transplanting one or more skin blisters. In some aspects, methods and devices in accordance with the present teachings can enable the harvesting of skin grafts from an increased variety of potential donor sites, such as areas of the body having uneven surfaces or a smaller radius of curvature (e.g., the arm) or large area donor sites where the creation of a vacuum may require a high power negative pressure source. In various aspects, systems, devices, and methods in accordance with the present teachings can also enable the efficient transplant of the grafts directly from the skin graft harvester to the recipient site without the transfer of the grafts generated by the harvester to another substrate prior to transplantation.

公开(公告)号：US20160325028A1

公开(公告)日：2016-11-10

申请号：US15147666

申请日：2016-05-05

Applicant: KCI Licensing, Inc.

Inventor： Christopher Brian Locke ,  Timothy Mark Robinson

IPC: A61M1/00 ,  A61B17/3203 ,  A61F13/00 ,  A61B17/32

CPC classification number: A61M1/0088 ,  A61B17/32 ,  A61B17/3203 ,  A61B2017/22008 ,  A61B2017/22089 ,  A61B2017/320008 ,  A61B2017/320084 ,  A61B2017/32032 ,  A61F13/00068 ,  A61F2013/0017 ,  A61F2013/00174 ,  A61F2013/0028 ,  A61F2013/00357 ,  A61F2013/00582 ,  A61L2/10 ,  A61L2202/11 ,  A61M1/0084 ,  A61M3/0229 ,  A61M3/0275

Abstract: A treatment system for debriding a treatment area of a tissue site and applying negative pressure is disclosed. In some embodiments, the treatment system may include an ultrasonic bubble generator fluidly coupled to a negative-pressure source, fluid source, and a dressing. Fluid may be drawn from the fluid source to the ultrasonic bubble generator, whereby micro-bubbles and ultrasonic waves may be generated in the fluid before the fluid is instilled to the dressing.

Abstract translation: 公开了一种用于清除组织部位的治疗区域并施加负压的治疗系统。 在一些实施例中，治疗系统可以包括流体耦合到负压源，流体源和敷料的超声波气泡发生器。 流体可以从流体源被抽出到超声波发泡器，由此在流体被灌注到敷料之前可能在流体中产生微小气泡和超声波。

公开(公告)号：US09452245B2

公开(公告)日：2016-09-27

申请号：US14546947

申请日：2014-11-18

Applicant: KCI Licensing, Inc.

Inventor： Jonathan Paul Jaeb ,  Richard Daniel John Coulthard ,  Timothy Mark Robinson ,  Christopher Brian Locke ,  Aidan Marcus Tout

IPC: A61F13/02 ,  A61F13/00 ,  A61M1/00

CPC classification number: A61M1/0049 ,  A61F13/00063 ,  A61F13/00068 ,  A61F2013/00174 ,  A61F2013/00412 ,  A61F2013/00536 ,  A61F2013/00544 ,  A61M1/0031 ,  A61M1/0052 ,  A61M1/0088 ,  A61M1/009 ,  A61M1/0092 ,  A61M2205/15 ,  A61M2205/7536

Abstract: A reduced pressure treatment system includes a reduced pressure source and a reduced pressure dressing. The dressing includes an interface layer adapted to be positioned at a tissue site and an absorbent layer in fluid communication with the interface layer to absorb liquid from at least one of the interface layer and the tissue site. A diverter layer is positioned adjacent the absorbent layer, and the diverter layer includes a plurality of apertures in fluid communication with the absorbent layer to distribute a reduced pressure to the absorbent layer. A cover is positioned over the diverter layer to maintain the reduced pressure at the tissue site.