公开(公告)号：US20130012911A1

公开(公告)日：2013-01-10

申请号：US13613381

申请日：2012-09-13

Applicant: Jared GARFIELD ,  John SLUMP ,  Gregory LYON

Inventor： Jared GARFIELD ,  John SLUMP ,  Gregory LYON

IPC: A61J1/22

CPC classification number: A61J1/22 ,  A61J1/1406 ,  A61J1/201 ,  A61J1/2017 ,  A61J1/2048 ,  A61J1/2051 ,  A61J1/2055 ,  A61J1/2062 ,  A61J1/2072 ,  A61J1/2096 ,  B65B3/003

Abstract: A medicament transport system includes a syringe adapter assembly; and a vial adapter assembly including a base defining an opening having a seal member disposed therewithin, a stem extending from the base and defining a lumen therethrough and an opening through a wall thereof, a needle shuttle valve slidably disposed within the lumen of the stem and supporting a transfer needle and a vacuum needle; and a vacuum cup slidably supported on the stem, wherein a vacuum chamber is defined in the space between the base, the stem and the vacuum cup. The medicament transport system includes a condition where the transfer needle and the vacuum needles penetrate the seal member of the vial adapter assembly, and the vacuum cup is moved to draw a vacuum through the vacuum needle. An automation system is provided that utilizes a medicament transport system for forming a medicament solution from a liquid/non-liquid solution.

公开(公告)号：US20130006211A1

公开(公告)日：2013-01-03

申请号：US13634089

申请日：2011-03-10

Applicant: Masafumi Takemoto

Inventor： Masafumi Takemoto

IPC: A61J1/14

CPC classification number: A61J1/2089 ,  A61J1/10 ,  A61J1/14 ,  A61J1/201 ,  A61J1/2051 ,  A61J1/2055 ,  A61M5/162 ,  A61M39/00 ,  A61M39/10 ,  A61M2039/1077

Abstract: A first connector 2 is provided with: a first connector body composed of a cylindrical outer tube 4, a cylindrical inner tube 7, and a hub 12; a hollow needle 5 supported by the hub 12; a first sealing member supported by the inner tube 7; a coil spring 8 serving as a biasing means which biases the hub 12 in a proximal direction and also serving as a to-be-pierced section biasing means which biases the first sealing member in the distal direction; and gripping and pressing members disposed on the outer tube 4. A plurality of pawls 126 are formed on a flange 124 of the hub 12. A plurality of ratchet teeth 41 are formed on the inner circumferential portion of a proximal portion of the outer tube 4. Each of the ratchet teeth 41 and each of the pawls 126 of the hub 12 form an engagement-disengagement mechanism 13.

Abstract translation: 第一连接器2设置有：由圆柱形外管4，圆柱形内管7和毂12组成的第一连接器主体; 由毂12支撑的中空针5; 由内管7支撑的第一密封构件; 用作偏置装置的螺旋弹簧8，其沿近端方向偏置轮毂12，并且还用作在远端方向上偏压第一密封构件的被刺穿部分偏压装置; 以及设置在外管4上的夹紧和按压构件。多个爪126形成在轮毂12的凸缘124上。多个棘轮齿41形成在外管4的近端部分的内圆周部分上 每个棘轮齿41和轮毂12的棘爪126中的每一个形成啮合分离机构13。

公开(公告)号：US20120330280A1

公开(公告)日：2012-12-27

申请号：US13507273

申请日：2012-06-18

Applicant: David L. Reynolds ,  Daniel MacDonald ,  Roger McCarthy

Inventor： David L. Reynolds ,  Daniel MacDonald ,  Roger McCarthy

IPC: A61M5/31

CPC classification number: A61M5/385 ,  A61J1/201 ,  A61J1/2055 ,  A61J1/2096

Abstract: A method for transferring and mixing a pharmaceutical mixture utilizing a by-pass cartridge and a syringe. After mixing the dry component and the diluent in the by-pass cartridge, the mixture can be passed to a syringe which includes a syringe plunger having a fluid passageway therein with a hydrophobic membrane covering the passageway. The mixture can be transferred back and forth between the by-pass cartridge and the syringe through a small bore to achieve mixing, particularly in the case of microspheres held in suspension.

Abstract translation: 一种利用旁路药筒和注射器转运和混合药物混合物的方法。 在旁路盒中混合干燥组分和稀释剂之后，可以将混合物送入注射器，该注射器包括其中具有流体通道的注射器柱塞，其中覆盖通道的疏水膜。 混合物可以通过小孔在旁路筒和注射器之间来回传递以实现混合，特别是在保持悬浮的微球的情况下。

公开(公告)号：US20120330269A1

公开(公告)日：2012-12-27

申请号：US13531335

申请日：2012-06-22

Applicant: Thomas F. Fangrow ,  Dee E. Warren ,  Dan Lopez

Inventor： Thomas F. Fangrow ,  Dee E. Warren ,  Dan Lopez

IPC: A61J1/20 ,  B23P11/00

CPC classification number: A61J1/22 ,  A61J1/1406 ,  A61J1/1412 ,  A61J1/201 ,  A61J1/2048 ,  A61J1/2055 ,  A61J1/2065 ,  A61J1/2072 ,  A61J1/2075 ,  A61J1/2079 ,  A61J1/2082 ,  A61J1/2086 ,  A61J1/2089 ,  A61J1/2096 ,  A61J2200/10 ,  A61J2200/76 ,  Y10T29/49826 ,  Y10T29/49885 ,  Y10T137/0402

Abstract: In certain embodiments, a vial adaptor for removing liquid contents from a vial comprises a piercing member and a bag. The bag can be contained within the piercing member such that the bag is introduced to the vial when the vial adaptor is coupled with the vial. In some embodiments, the bag expands within the vial as liquid is removed from the vial via the adaptor, thereby regulating pressure within the vial. In other embodiments, a vial comprises a bag for regulating pressure within the vial as liquid is removed therefrom. In some embodiments, a vial adaptor is coupled with the vial in order to remove the liquid. In some embodiments, as the liquid is removed from the vial via the adaptor, the bag expands within the vial, and in other embodiments, the bag contracts within the vial.

Abstract translation: 在某些实施例中，用于从小瓶中去除液体内容物的小瓶适配器包括刺穿构件和袋。 袋子可以被包含在刺穿构件内，使得当小瓶适配器与小瓶联接时将袋子引入到小瓶中。 在一些实施例中，当液体通过适配器从小瓶中移出时，袋子在小瓶内膨胀，从而调节小瓶内的压力。 在其他实施例中，小瓶包括用于在液体从其中移除时用于调节小瓶内的压力的袋。 在一些实施例中，将小瓶适配器与小瓶联接以便去除液体。 在一些实施例中，当液体经由适配器从小瓶中移出时，袋在小瓶内膨胀，并且在其他实施例中，袋在小瓶内收缩。

公开(公告)号：US20120323063A1

公开(公告)日：2012-12-20

申请号：US13427428

申请日：2012-03-22

Applicant: Jerry COSTANZO

Inventor： Jerry COSTANZO

IPC: A61M36/04

CPC classification number: A61M5/1782 ,  A61J1/201 ,  A61J1/2031 ,  A61J1/2044 ,  A61J1/2055 ,  A61J1/2096 ,  A61M5/162 ,  A61M39/26 ,  A61M2039/1077 ,  A61M2039/262 ,  A61M2039/267 ,  A61M2039/268 ,  A61M2207/00 ,  B65B3/003

Abstract: An apparatus for the handling of hazardous fluids includes a collection vessel, a collection vessel connector, a dose control connector, a unit dose container, a delivery control connector, and a delivery site access device. The collection vessel contains the fluid prior to dispensing, the unit dose container contains a predetermined amount of the fluid for dispensing, the delivery site access device provides access to an intended delivery site, and the connector attaches pieces of the apparatus to one another. The method of the invention allows needle-free connections to be made for the apparatus, using a predetermined arrangement of the pieces of the apparatus, and in one embodiment, employs deformable elastomeric valves capable of creating a decreased pressure at a valve surface, so that upon closure of said valves, a fluid on the surface on the valves is withdrawn within the connector.

Abstract translation: 用于处理危险流体的装置包括收集容器，收集容器连接器，剂量控制连接器，单位剂量容器，输送控制连接器和递送部位进入装置。 收集容器在分配之前包含流体，单位剂量容器含有预定量的用于分配的流体，输送站点访问装置提供对预期输送位置的访问，并且连接器将装置的一部分彼此附接。 本发明的方法允许使用设备件的预定布置为设备制造无针连接，并且在一个实施例中，使用能够在阀表面产生降低的压力的可变形弹性阀，使得 在关闭所述阀时，阀的表面上的流体在连接器内被抽出。

公开(公告)号：US20120296309A1

公开(公告)日：2012-11-22

申请号：US13407518

申请日：2012-02-28

Applicant: Christine Smith ,  Rey Halili ,  Hong Qi

Inventor： Christine Smith ,  Rey Halili ,  Hong Qi

IPC: A61J1/20

CPC classification number: A61J1/2096 ,  A61J1/201 ,  A61M5/002

Abstract: The present invention provides devices and methods for mixing a formulation containing two or more constituents, such as a drug product and a diluent. The devices have a chamber for securing a container of the drug product. Various embodiments are presented. In one embodiment the device has two or more sides connected by a hinge, the two or more sides defining the chamber between them, and a handle for grasping and manipulating the device. In another embodiment the device has a housing with two or more side bars defining the chamber, the container being visible from outside the housing between the side bars and having a stopping element at the distal end, and a handle having two arms for grasping.

Abstract translation: 本发明提供了用于混合含有两种或更多种成分（例如药物产品和稀释剂）的制剂的装置和方法。 这些装置具有用于固定药物产品的容器的腔室。 呈现各种实施例。 在一个实施例中，该装置具有通过铰链连接的两个或多个侧面，两个或多个侧面在它们之间限定室，以及用于抓握和操纵该装置的手柄。 在另一个实施例中，该装置具有壳体，其具有限定腔室的两个或多个侧杆，该容器从侧杆之间的壳体外部可见，并且在远端具有止动元件，以及具有两个抓握臂的手柄。

公开(公告)号：US20120296307A1

公开(公告)日：2012-11-22

申请号：US13503508

申请日：2010-10-22

Applicant: Mark Dominis Holt ,  Alexander Stuart Cairns

Inventor： Mark Dominis Holt ,  Alexander Stuart Cairns

IPC: A61J1/22 ,  A61J1/20

CPC classification number: A61J1/201 ,  A61J1/2051 ,  A61J1/2055 ,  A61J1/2089 ,  A61J1/2096 ,  A61M1/14 ,  A61M2005/1581 ,  Y10S604/905

Abstract: A vial adapter includes a base having first and second opposing sides, a spike depending from the first side of the base, the spike having a spike passageway, and a connector disposed on the second side of the base, the connector having a connector passageway that is in fluid communication with the spike passageway. The vial adapter may be combined with a vial.

Abstract translation: 小瓶适配器包括具有第一和第二相对侧的基座，从基座的第一侧悬垂的尖峰，尖钉具有尖峰通道，以及设置在基座的第二侧上的连接器，该连接器具有连接器通道， 与尖峰通道流体连通。 小瓶适配器可以与小瓶组合。

公开(公告)号：US08303566B2

公开(公告)日：2012-11-06

申请号：US12833702

申请日：2010-07-09

Applicant: Matthew J. Stepovich ,  Michael I. Falkel

Inventor： Matthew J. Stepovich ,  Michael I. Falkel

IPC: A61M5/32

CPC classification number: A61J1/2089 ,  A61J1/1406 ,  A61J1/201 ,  A61J1/2017 ,  A61J1/2072 ,  A61J1/2096 ,  A61M5/1782

Abstract: A system for transferring solutions from a first cartridge into a second cartridge comprises a cartridge holder, a plunger driver, and a cartridge connector. The cartridge connector carries a transfer needle and an exhaust needle. The cartridge holder positions the first cartridge against the cartridge connector so that the transfer needle penetrates the first cartridge septum. The second cartridge is removably inserted into another end of the cartridge connector so that both the transfer needle and the exhaust needle penetrate the second cartridge septum. The plunger driver is disposed to advance a plunger on the first cartridge to transfer solution from the first cartridge into the second cartridge thus displacing solution from the second cartridge through the exhaust needle. The cartridge connector includes a sealed interior waste chamber for receiving the solution from the second cartridge.

Abstract translation: 将解决方案从第一盒传送到第二盒中的系统包括盒保持器，柱塞驱动器和盒连接器。 墨盒连接器承载转印针和排气针。 药筒保持器将第一药筒定位在药筒连接器上，使得转移针穿透第一药筒隔膜。 第二盒可移除地插入盒连接器的另一端，使得传送针和排气针都穿过第二盒隔膜。 柱塞驱动器设置成将柱塞推进在第一盒上，以将溶液从第一盒传送到第二盒中，从而将溶液从第二盒通过排气针排出。 盒式连接器包括用于从第二盒接收溶液的密封的内部废物室。

公开(公告)号：US08286671B1

公开(公告)日：2012-10-16

申请号：US13069745

申请日：2011-03-23

Applicant: Saverio Roberto Strangis

Inventor： Saverio Roberto Strangis

IPC: B65B3/04

CPC classification number: B65B43/58 ,  A61J1/201 ,  A61J1/2096 ,  A61J3/002 ,  A61M5/1782 ,  A61M5/1785 ,  B65B3/003 ,  B65B7/28 ,  B65B43/40 ,  B65B43/60 ,  G21G1/0005

Abstract: The disclosure pertains to an automated apparatus for filling capped needle syringes. The syringes are held in a rotatable motor controlled carousel. The carousel turns to place a syringe proximate to a dispenser mechanism. A rotatable plate on top of the dispenser mechanism holds an automated cap extractor/installer and at least one inverted vial having a needle perforatable surface. The rotatable plate can also move up and down relative to the top of the dispenser mechanism. The cap can be removed by the automated cap extractor/installer and the rotatable plate rotated to place the inverted vial over the exposed syringe needle. The rotatable plate can descend so that the needle perforates the surface of the vial. A syringe plunger tool of the dispenser mechanism engages the syringe plunger and pulls it downward. The syringe plunger tool can disengage and return to its original position. The rotatable plate can raise to remove the needle from the vial. The rotatable plate can rotate to place the automated cap extractor/installer over the exposed needle. The automated cap extractor/installer holding the syringe needle cap can descend and the cap reattached to the syringe. The carousel can rotate to present the filled and capped syringe to an automated syringe inverter/extractor component that removes the capped syringe from the carousel and places the syringe in a holder.

Abstract translation: 本公开涉及用于填充封盖针注射器的自动化装置。 注射器保持在可旋转的马达控制转盘中。 转盘转动使注射器靠近分配器机构。 在分配器机构顶部的可旋转板保持自动盖提取器/安装器和至少一个具有针可穿孔表面的倒置小瓶。 旋转板也可以相对于分配器机构的顶部上下移动。 盖可以通过自动盖提取器/安装者移除，旋转板旋转以将倒置的小瓶放置在暴露的注射器针上。 旋转板可以下降，使得针穿过小瓶的表面。 分配器机构的注射器柱塞工具接合注射器柱塞并将其向下拉。 注射器柱塞工具可以脱离并返回其初始位置。 旋转板可以升高以从小瓶中取出针头。 旋转板可旋转以将自动盖提取器/安装者放置在暴露的针上。 保持注射器针头帽的自动盖提取器/安装器可以下降，盖重新连接到注射器。 旋转盘可以旋转以将填充和加盖的注射器呈现到自动注射器逆变器/提取器部件，其将旋转式注射器从转盘中移除并将注射器置于保持器中。

公开(公告)号：US08267127B2

公开(公告)日：2012-09-18

申请号：US13275835

申请日：2011-10-18

Applicant: Marino Kriheli

Inventor： Marino Kriheli

IPC: B65B3/04

CPC classification number: A61J1/2096 ,  A61J1/10 ,  A61J1/145 ,  A61J1/1475 ,  A61J1/201 ,  A61J1/2013 ,  A61J1/2017 ,  A61J1/2055 ,  A61J1/2072 ,  A61J3/002 ,  A61M5/162 ,  A61M39/24 ,  A61M2005/1623 ,  B65D51/002 ,  Y10T29/49826

Abstract: A method for contamination-free transfer of liquid from one container to another, and devices to carry out the method are disclosed. Contamination-free transfer means that during the transfer process there is no (1) leakage of (a) the liquid, (b) air contaminated by the liquid, and (c) vapor from the liquid to the surroundings, and (2) surrounding contaminants from outside the containers that contact the liquid. The method's advantages include its simplicity, and the contamination-free transfer as defined above. The devices are adapted to effect contamination-free transfer of a hazardous drug to and from any container equipped with a standard connector port.

Abstract translation: 公开了一种用于将液体从一个容器到另一个的无污染转移的方法，以及用于执行该方法的装置。 无污染转移意味着在转移过程中没有（1）泄漏（a）液体，（b）被液体污染的空气，（c）从液体到周围的蒸气，（2）周围的 容器外部接触液体的污染物。 该方法的优点包括其简单性和如上所述的无污染转移。 这些装置适用于将有害药物无污染地转移到装有标准连接器端口的任何容器中。