中科微点-全球专利检索

  1. Login
  2. Sign Up

Search Results

865 records (took 0.023 seconds)

    Heterarylbenzene compounds
    161.
    发明申请
    Heterarylbenzene compounds 失效

    公开(公告)号：US20030111956A1

    公开(公告)日：2003-06-19

    申请号：US10316507

    申请日：2002-12-11

    Applicant: Academia Sinica, a Taiwan research institution

    Inventor： Jiann T?apos;Suen Lin ,  Iuan-Yuan Wu ,  Yu-Tai Tao ,  E. Balasubramaniam

    IPC: H01J001/62 ,  H01J063/04 ,  C07D49/14 ,  C07D43/14

    CPC classification number: C07D409/04 ,  C07D333/36 ,  C07D409/14

    Abstract: A method of preparing a compound of formula I is described. 1 In this compound, each of R1-R6 is, independently, 2 in which Y is O, S, NH, or C(R7)nullC(R8). Each of R7-R11 is, independently, H, substituted or unsubstituted C1-6 alkyl, substituted or unsubstituted C2-6 alkenyl, substituted or unsubstituted C2-6 alkynyl, substituted or unsubstituted C6-20 aryl, or substituted or unsubstituted C4-20 heteroaryl. Alternatively, each of R7-R11 is OH, C1-6 alkoxy, or N(R12)(R13), in which each of R12 and R13 is, independently, H, substituted or unsubstituted C1-6 alkyl, substituted or unsubstituted C2-6 alkenyl, substituted or unsubstituted C2-6 alkynyl, or substituted or unsubstituted C6-20 aryl. Each of R7-R11 can also be NO2, CN, or CO2R14, in which R14 is H or C1-6 alkyl.

    Compounds for uses in pharmacological induction of HBF for treatment of sickle cell disease and ß-thalassemia
    165.
    发明授权
    Compounds for uses in pharmacological induction of HBF for treatment of sickle cell disease and ß-thalassemia 有权

    公开(公告)号：US12246021B2

    公开(公告)日：2025-03-11

    申请号：US17439630

    申请日：2020-03-25

    Applicant: Academia Sinica ,  National Health Research Institutes

    Inventor： Weir-Torn Jiaang ,  Che-Kun James Shen

    IPC: A61K31/52 ,  A61K31/5377 ,  A61P7/06 ,  C07D473/16 ,  C07D473/18

    Abstract: Provided herein are compounds of Formula (I). The compounds described herein are useful in treating a disease associated with the expression of endogenous embryonic/fetal globin (e.g., γ globin) in erythrocytes (e.g., treating β-thalassemia and/or sickle cell disease through at least the induction of the globin gene expression in erythrocytes), and/or anemia (β-thalassemia and/or sickle cell anemia). The compounds described herein are useful in treating, delaying, and/or preventing the adverse effects of β-thalassemia and/or sickle cell disease, inducing γ globin production, and/or inducing the expression of embryonic/fetal globin genes in a subject, cell, tissue, or biological sample. Also provided in the present disclosure are pharmaceutical compositions, kits, and methods of using the compounds for inducing γ globin production described herein and for treating any of the target diseases described herein.

    METHOD FOR PROMOTING GROWTH OF PLANTS
    168.
    发明公开
    METHOD FOR PROMOTING GROWTH OF PLANTS 审中-公开

    公开(公告)号：US20240352477A1

    公开(公告)日：2024-10-24

    申请号：US18645166

    申请日：2024-04-24

    Applicant: ACADEMIA SINICA

    Inventor： Su-May YU ,  Hsiang-Ting LEE ,  Tuan-Hua David HO

    IPC: C12N15/82 ,  C12N9/12

    CPC classification number: C12N15/8261 ,  C12N9/12 ,  C12N15/8227 ,  C12N15/8262 ,  C12N15/8273 ,  C12Y207/11001

    Abstract: The present invention relates to a method for promoting growth of plants. Particularly, the method of the present invention features overexpression of a calcineurin B-like (CBL) interacting protein kinase15 (CIPK15) having an isoleucine (Ile) residue at position 48 (e.g. a CIPK15 from rice) in plants which can promote growth of the plants. The present invention also relates to a recombinant construct comprising a nucleic acid encoding the CIPK15 operably linked to a promoter. The present invention further relates to a transgenic plant overexpressing the CIPK15 exhibiting improved growth compared to a non-transgenic plant counterpart.

Patent Agency Ranking