Abstract:
This invention provides a method that allows selection of antibodies against cells (e.g., tumor cells) in situ using laser capture microdissection. By restricting antibody selection to binders of internalizing epitopes, a panel of phage antibodies was generated that targets clinically represented prostate cancer antigens.
Abstract:
The present invention provides certain imidazole carboxamide derivatives, pharmaceutical compositions thereof, methods of using the same and processes for preparing the same.
Abstract:
A ring binder mechanism includes a housing and first and second hinge plates supported by the housing for pivoting movement relative thereto. A first ring member is mounted on the first hinge plate and moveable with the pivoting motion of the first hinge plate relative to a second ring member between a closed position and an opened position. An interlocking formation locks the first ring member and second ring member in the closed position. An actuator is mounted on the housing for movement relative to the housing. The actuator is adapted to pivot the first and second hinge plates and to translate the first hinge plate relative to the second hinge plate in a direction substantially parallel to a longitudinal axis of the housing.
Abstract:
A device for detecting wobbles on an optical disc is provided, where the device is utilized for generating a wobble signal according to a plurality of detection signals. The device includes an analog signal processing circuit, a pair of analog-to-digital converters (ADCs), and a digital signal processing circuit. The analog signal processing circuit is arranged to perform analog signal processing on the detection signals to generate a plurality of output signals. In addition, the pair of ADCs are arranged to digitalize the output signals to generate a plurality of digital values. Additionally, the digital signal processing circuit is arranged to perform digital signal processing on the digital values and generate an arithmetic output, where the arithmetic output is utilized for generating the wobble signal or utilized as the wobble signal. An associated method for detecting wobbles on an optical disc is further provided.
Abstract:
A defibrillator includes a defibrillator mainframe and a defibrillating electrode. The defibrillator mainframe includes a main control unit and a master device electrically connected to the main control unit. The defibrillating electrode comprises a slave device supporting a bus protocol, the master device and slave device being interconnected through a bus.
Abstract:
A communications receiver architecture characterized by a relatively low intermediate frequency (IF) and a polyphase filter. The receiver includes an input amplifier coupled to a carrier signal. Respective I and Q demodulators are coupled to the output of the input amplifier. A quadrature local oscillator (LO) generator provides respective LO_I and LO_Q inputs to the I demodulator and LO_Q inputs to the I demodulator and to the Q demodulator. The quadrature LO generator is driven by a phase-locked LO, and the LO frequency is such that an IF of, in one embodiment, approximately 1 MHz results. The I demodulator and Q demodulator outputs are applied through respective AID converters to a polyphase filter. The polyphase filter outputs are then processed by a digital I/Q demodulator. Although a low IF is not generally understood to promote the image rejection performance of a receiver, substantial image rejection is afforded by the polyphase filter, thereby enabling the receiver to be realized almost entirely as a monolithic integrated semiconductor device.
Abstract:
Disclosed are embodiments of systems and methods to stitch two or more images together into a composite image. By finding matching point pairs for a pair of images, a homography transform may be obtained for the pair of images. The homography transform may be used to generate a composite image of the image pair. In an embodiment, the process of identifying a homography transform may be iterated. In an embodiment, when forming the composite image, the transformed foreground regions may be selected such that there is no intersection of foreground pixel regions. In an embodiment, foreground pixel regions on the border of an image may be removed. The resulting composite image is a larger image generated from the selected regions from the input images. In embodiments, the process may be repeated for sets of images with more than two images.
Abstract:
In certain aspects, the present invention provides methods for increasing the replication capacity of influenza viruses in hens' eggs and/or cell culture, recombinant and/or reassortant influenza viruses with increased replication capacity, and immunogenic and vaccine compositions comprising such recombinant and/or reassortant influenza viruses. In other aspects, the invention further provides nucleic acids encoding influenza genes associated with increased replication capacity, expression vectors comprising the nucleic acids of the invention, methods for making influenza viruses with increased replication capacity, and kits useful for practice of the methods.
Abstract:
This invention relates to an isolated nucleic acid fragment encoding a protein involved in regulation of gene expression. The invention also relates to the construction of a chimeric gene encoding all or a portion of the protein involved in regulation of gene expression, in sense or antisense orientation, wherein expression of the chimeric gene results in production of altered levels of the protein involved in regulation of gene expression in a transformed host cell.