公开(公告)号：US20140205608A1

公开(公告)日：2014-07-24

申请号：US14126878

申请日：2012-07-17

Applicant: Stefan Steidl ,  John Allan Hamilton ,  Andrew David Cook

Inventor： Stefan Steidl ,  John Allan Hamilton ,  Andrew David Cook

IPC: C07K16/28 ,  C07K16/24

CPC classification number: C07K16/2866 ,  A61K2039/505 ,  C07K16/243 ,  C07K16/244 ,  C07K16/249 ,  C07K2317/76

Abstract: The present invention relates generally to a method for the treatment and/or prophylaxis of osteoarthritis (OA) and/or pain. In accordance with the present invention, an antagonist of c-Fms is effective in the treatment of osteoarthritis and/or pain. An antagonist of M-CSF includes, but is not limited to, an antibody that is specific for M-CSF, IL-34 or c-Fms.

Abstract translation: 本发明一般涉及治疗和/或预防骨关节炎（OA）和/或疼痛的方法。 根据本发明，c-Fms的拮抗剂对于治疗骨关节炎和/或疼痛是有效的。 M-CSF的拮抗剂包括但不限于对M-CSF，IL-34或c-Fms特异性的抗体。

公开(公告)号：US08506984B2

公开(公告)日：2013-08-13

申请号：US11493324

申请日：2006-07-26

Applicant: David Cook ,  Robert Falotico ,  Lily Kuo ,  Jonathon Z. Zhao

Inventor： David Cook ,  Robert Falotico ,  Lily Kuo ,  Jonathon Z. Zhao

IPC: A61F2/02 ,  A61K31/4745

CPC classification number: A61L31/10 ,  A61F2/07 ,  A61F2/91 ,  A61F2/95 ,  A61F2/954 ,  A61F2002/065 ,  A61F2002/075 ,  A61L31/16 ,  A61L2300/416 ,  A61L2300/606

Abstract: Medical devices, and in particular implantable medical devices, may be coated to minimize or substantially eliminate a biological organism's reaction to the introduction of the medical device to the organism. The medical devices may be coated with any number of biocompatible materials. Therapeutic drugs, agents or compounds may be mixed with the biocompatible materials and affixed to at least a portion of the medical device. These therapeutic agents or compounds may also further reduce a biological organism's reaction to the introduction of the medical device to the organism. In addition, these therapeutic drugs, agents and/or compounds may be utilized to promote healing, including the prevention of thrombosis. The drugs, agents, and/or compounds may also be utilized to treat specific disorders, including vulnerable plaque. Implantable coated medical devices may be processed through annealing to better control the elution characteristics of the therapeutic agents. Furthermore, annealing leads to better therapeutic agent stability and a larger device shelf-life.

Abstract translation: 可以涂覆医疗装置，特别是可植入医疗装置，以最小化或基本上消除生物体对将生物体引入医疗装置的反应。 医疗装置可以涂覆任何数量的生物相容性材料。 治疗药物，药剂或化合物可以与生物相容性材料混合并固定在医疗装置的至少一部分上。 这些治疗剂或化合物还可以进一步减少生物体对将生物体引入医疗装置的反应。 此外，这些治疗药物，药剂和/或化合物可用于促进愈合，包括预防血栓形成。 药物，药剂和/或化合物也可用于治疗特定疾病，包括易损斑块。 可以通过退火处理可植入的涂覆的医疗装置，以更好地控制治疗剂的洗脱特性。 此外，退火导致更好的治疗剂稳定性和更大的器件保质期。

公开(公告)号：US20120291716A1

公开(公告)日：2012-11-22

申请号：US13109552

申请日：2011-05-17

Applicant: Donald David Cook ,  Kevin F. Masterson

Inventor： Donald David Cook ,  Kevin F. Masterson

IPC: A01K13/00

CPC classification number: A01K17/00 ,  A01K13/00

Abstract: An apparatus for shedding antlers is disclosed. The apparatus includes a rod, wherein the rod includes a threaded end that is exposed. A mold substantially surrounds the rod and includes protrusions. The apparatus further includes a mount having a hole. The hole allows the threaded and exposed end of the rod to be inserted therein. The mount is coupled to a deer feeder or tree. The apparatus is constructed to exert sufficient force to shed the antlers when the antlers come into proximity with the apparatus.

Abstract translation: 公开了一种用于脱落鹿角的装置。 该装置包括杆，其中杆包括暴露的螺纹端。 模具基本上围绕杆并且包括突起。 该装置还包括具有孔的安装件。 孔允许将杆的螺纹和暴露端插入其中。 安装座连接到鹿饲喂器或树上。 该装置被构造成当鹿角与装置接近时施加足够的力来摆脱鹿角。

公开(公告)号：US08173056B2

公开(公告)日：2012-05-08

申请号：US12514537

申请日：2007-11-13

Applicant: David Cook ,  Philippe Lencou

Inventor： David Cook ,  Philippe Lencou

IPC: B29C39/10 ,  B29C39/22 ,  B29C39/24 ,  B29C39/36

CPC classification number: G06K19/077 ,  B29C39/10 ,  B29C45/0053 ,  B29C45/14639 ,  B29C45/14647 ,  B29C2045/0079 ,  B29L2031/3456 ,  G06K19/07716 ,  G06K19/07724

Abstract: A method of fabricating an electronic entity includes the steps of: forming at least part of the entity by hardening a material (28) in a mold, and (26); personalizing the entity while in the mould (26). A corresponding device is also described.

Abstract translation: 制造电子实体的方法包括以下步骤：通过硬化模具中的材料（28）来形成所述实体的至少一部分，和（26）; 在模具中个性化实体（26）。 还描述了相应的装置。

公开(公告)号：US08141433B2

公开(公告)日：2012-03-27

申请号：US12455119

申请日：2009-05-28

Applicant: Charles Michael Nadin ,  David Cook

Inventor： Charles Michael Nadin ,  David Cook

IPC: G01F1/74

CPC classification number: G01F1/74 ,  G01F1/704 ,  G01M3/28 ,  G01M3/30

Abstract: A method of measuring the gas flow of an incondensable gas in a flowing mixture of said incondensable gas and a condensable gas comprising the steps of calibrating a leak detector; injecting a known quantity of gauge gas at a known mass flow rate into said flowing mixture of gases; drawing a sample of the said gauge mix off at a sample point; passing said sample through a condenser so as to remove said condensable gas from the gauge mix, resulting in a test mix; passing the said test mix into the leak detector so as to measure the concentration of the gauge gas within the test mix; and calculating the mass flow rate of said incondensable gas within said flowing mixture. There is also provided a method of measuring the rate of ingress of an incondensable gas at an ingress point along a flow path of a flowing mixture of said incondensable gas and a condensable gas.

Abstract translation: 一种测量所述不可冷凝气体和可冷凝气体的流动混合物中的不可冷凝气体的气体流量的方法，包括校准泄漏检测器的步骤; 将已知量的气体以已知的质量流速注入所述流动的气体混合物中; 在样品点处抽出所述量规混合物的样品; 使所述样品通过冷凝器，以从所述量规混合器中除去所述可冷凝气体，得到测试混合物; 将所述测试混合物通入泄漏检测器中，以测量测试混合物内的气体浓度; 以及计算所述流动混合物内的所述不可冷凝气体的质量流量。 还提供了一种测量沿着所述不可冷凝气体和可冷凝气体的流动混合物的流动路径的入口处的不可冷凝气体的进入速率的方法。

公开(公告)号：US20110270505A1

公开(公告)日：2011-11-03

申请号：US12661587

申请日：2010-03-18

Applicant: Nalin Chaturvedi ,  Christopher Mayhew ,  Sungbae Park ,  Jasim Ahmed ,  Aleksandar Kojic ,  Hanho Song ,  David Cook ,  Karl Lukas Knierim

Inventor： Nalin Chaturvedi ,  Christopher Mayhew ,  Sungbae Park ,  Jasim Ahmed ,  Aleksandar Kojic ,  Hanho Song ,  David Cook ,  Karl Lukas Knierim

IPC: F02D28/00

CPC classification number: F02D41/3029 ,  F02D41/1498 ,  F02D2200/1015 ,  F02N2300/2008 ,  G01M15/11 ,  Y02T10/128

Abstract: A method for predicting and correcting an impending misfire in a homogeneous charge compression ignition (HCCI) engine includes: modeling HCCI engine operation in a nominal, steady-state operating region and in unstable operating regions bordering the steady-state operating region, using a zero-dimensional model; predicting an occurrence of an engine misfire based on the modeling of the HCCI engine operation; and providing a remedial corrective measure when an engine misfire is predicted. The remedial corrective measure includes one of: (a) late injection to avoid full combustion during a trapping cycle, and a reduction in amount of injected fuel to account for residual fuel of the previous cycle; or (b) earlier exhaust valve closing to trigger combustion of residual fuel within the trapping cycle, and a later injection and reduction of injected fuel to account for residual fuel of the previous cycle.

Abstract translation: 用于预测和校正均质充气压缩点火（HCCI）发动机即将发生的失火的方法包括：在标称稳态工作区域和毗邻稳态工作区域的不稳定工作区域中对HCCI发动机进行建模，使用零 维度模型; 基于HCCI发动机操作的建模来预测发动机失火的发生; 并在预测发动机失火时提供补救措施。 补救措施包括：（a）延迟注射以避免在捕集周期期间的完全燃烧，以及减少喷射燃料量以解决上一个循环的残余燃料; 或（b）较早的排气门关闭以在捕集循环内触发残余燃料的燃烧，以及稍后喷射和减少注入的燃料以解决前一循环的残余燃料。

公开(公告)号：US20110072818A1

公开(公告)日：2011-03-31

申请号：US12884157

申请日：2010-09-16

Applicant: David Cook

Inventor： David Cook

IPC: F01K13/00 ,  F01K23/06

CPC classification number: F01K23/065 ,  F01K13/02 ,  F01K25/10

Abstract: To mitigate the potential significant impact on our society due to the continued reliance on high-cost diesel hydrocarbon fuel and the implementation of increasingly strict emission controls, an apparatus is disclosed which provides the means for extracting additional heat from an internal combustion engine while providing the cooling needed to meet stricter emissions standards. The present disclosure describes an apparatus operating on a Rankine cycle for recovering waste heat energy from an internal combustion engine, the apparatus including a closed loop for a working fluid with a single shared low pressure condenser serving a pair of independent high pressure circuits each containing zero or more controlled or passive fluid splitters and mixers, one or more pressure pumps, one or more heat exchangers, and one or more expanders, and the means for controlling said apparatus.

Abstract translation: 为了减轻由于继续依赖高成本柴油碳氢化合物燃料和实施越来越严格的排放控制对我们社会的潜在重大影响，公开了一种提供从内燃机中提取额外热量的手段的装置， 冷却需要达到更严格的排放标准。 本公开描述了一种在兰金循环上操作的装置，用于从内燃机中回收废热能，该装置包括用于工作流体的闭合回路，其中单个共用低压冷凝器用于一对独立的高压回路，每个独立的高压回路各自包含零 或更多的受控或被动流体分流器和混合器，一个或多个压力泵，一个或多个热交换器和一个或多个膨胀器，以及用于控制所述装置的装置。

公开(公告)号：US20100299957A1

公开(公告)日：2010-12-02

申请号：US12597815

申请日：2008-04-28

Applicant: Marcia Kilgore ,  David Cook

Inventor： Marcia Kilgore ,  David Cook

IPC: A43B3/12 ,  A43B13/38 ,  A43B17/00 ,  A43D8/00 ,  A43C11/00 ,  A43B7/14

CPC classification number: A43B13/188 ,  A43B3/108 ,  A43B3/128 ,  A43B7/14 ,  A43B13/141 ,  A43B13/16 ,  A43B17/02 ,  A63B23/0205 ,  A63B23/0233 ,  A63B23/04 ,  A63B26/003 ,  B29D35/122 ,  B29K2023/083

Abstract: An item of footwear for increasing leg-muscle and/or lower-abdominal-/back-muscle tone comprising: a securing means for securing the item of footwear to a foot of a user; and a sole comprising at least an upper layer, for engaging a foot of a user in use or a further upper layer, and a lower layer, for engaging the ground in use, wherein the upper layer comprises two or more materials of different compressive resistances, or densities, arranged as a frontal/toe region, an arch region and a heel region, the sole is arranged such that application of a user's weight, during use, causes instability in at least one portion of the upper layer, which requires balance correction by a user.

Abstract translation: 一种用于增加腿肌和/或腹部 - 背部肌肉紧张度的鞋类物品，包括：固定装置，用于将鞋类物品固定到使用者的脚上; 以及至少包括上层的鞋底，用于在使用中接合使用者的脚或另一上层，以及用于在使用中接合地面的下层，其中上层包括两种或更多种不同抗压性的材料 或密度，布置为正面/脚趾区域，拱形区域和脚跟区域，鞋底布置成使得使用者的使用体重在使用过程中施加在上层的至少一部分中的不稳定性，这需要平衡 用户修正

公开(公告)号：US20100209341A1

公开(公告)日：2010-08-19

申请号：US12707297

申请日：2010-02-17

Applicant: Gino Luigi Vairo ,  John Allan Hamilton ,  Andrew David Cook

Inventor： Gino Luigi Vairo ,  John Allan Hamilton ,  Andrew David Cook

IPC: A61K51/00 ,  A61K39/395 ,  A61K38/20 ,  A61P19/02 ,  C07K14/54 ,  C07K16/24

CPC classification number: C07K16/2866 ,  A61K38/1793 ,  A61K38/202 ,  A61K39/3955 ,  A61K51/1021 ,  A61K51/1033 ,  A61K2039/505 ,  C07K16/244 ,  C07K2317/21 ,  C07K2317/24 ,  C07K2317/41 ,  C07K2317/52 ,  C07K2317/72 ,  C07K2317/73 ,  C07K2317/732 ,  C07K2317/734 ,  C07K2317/76

Abstract: A method for the treatment of a chronic inflammatory condition in a patient which comprises administration to the patient of an agent which blocks or inhibits IL-3 signalling events in the patient.

Abstract translation: 一种治疗患者慢性炎性病症的方法，其包括向患者施用阻断或抑制患者中IL-3信号传导事件的药剂。

公开(公告)号：US20100117660A1

公开(公告)日：2010-05-13

申请号：US12523255

申请日：2007-01-19

Applicant: Malcolm F. Douglas ,  David Cook ,  Richard A. Loyd

Inventor： Malcolm F. Douglas ,  David Cook ,  Richard A. Loyd

IPC: G01R27/26

CPC classification number: H03K17/955 ,  H03K2217/960705 ,  H03K2217/960755

Abstract: A capacitive proximity sensor assembly comprises: (i) a capacitive proximity sensor (1) for mounting to a body for sensing external objects, the sensor comprising a dielectric substrate (2) having front and rear major surfaces which, in use of the sensor, face respectively outward from and towards the body; a sensor conductor (3) on the front major surface; and a guard conductor on at least one of the major surfaces to provide an electrical shield for the sensor conductor; and (ii) a cable (16) for transmitting electrical signals from the sensor (1) to an electronic control unit; the cable comprising a dielectric film substrate having, on a first major surface thereof, a first electrical conductor (13) that is connected to the sensor conductor (3) for transmitting electrical signals therefrom and, on both major surfaces thereof, an electrically-conductive layer (14) that is connected to the guard conductor to provide an electrical shield for the said first conductor (13).

Abstract translation: 电容式接近传感器组件包括：（i）用于安装到身体以感测外部物体的电容式接近传感器（1），所述传感器包括电介质基底（2），所述电介质基底具有前和后主表面， 脸朝向身体分别朝外; 前主表面上的传感器导体（3）; 以及在至少一个主表面上的保护导体，以提供用于传感器导体的电气屏蔽; 和（ii）用于将电信号从所述传感器（1）传送到电子控制单元的电缆（16）; 所述电缆包括电介质膜基底，其第一主表面上具有连接到所述传感器导体（3）的第一电导体（13），用于从其传输电信号，并且在其两个主表面上具有导电 层（14），其连接到防护导体以提供用于所述第一导体（13）的电屏蔽。