公开(公告)号：US09274058B2

公开(公告)日：2016-03-01

申请号：US13879245

申请日：2010-10-20

Applicant: Zhiyong Li ,  R. Stanley Williams

Inventor： Zhiyong Li ,  R. Stanley Williams

IPC: G01N21/65 ,  G01N21/64

CPC classification number: G01N21/658 ,  G01N21/648

Abstract: A metallic-nanofinger device for chemical sensing. The device includes a substrate, and a plurality of nanofingers. A nanofinger includes a flexible column, and a metallic cap coupled to an apex of the flexible column. At least the nanofinger and a second nanofinger are to self-arrange into a close-packed configuration with at least one analyte molecule disposed between at least the metallic cap and a second metallic cap of respective nanofinger and second nanofinger. A morphology of the metallic cap is to generate a shifted plasmonic-resonance peak associated with amplified luminescence from the analyte molecule. A coating encapsulating the metallic cap to respond upon exposure to a liquid, and a chemical-sensing chip including the metallic-nanofinger device are also provided.

Abstract translation: 用于化学感应的金属纳米膜装置。 该装置包括基板和多个纳米装置。 纳米针框包括柔性柱和与柔性柱的顶点相连的金属帽。 至少纳米酮和第二纳米酮将自排列成紧密堆积的构型，其中至少一个分析物分子设置在至少金属盖和相应的纳芬酮和第二纳米酮之间的第二金属盖之间。 金属帽的形态是产生与来自分析物分子的放大发光相关的移位等离子体共振峰。 还提供了包封金属盖以在暴露于液体时响应的涂层，以及包括金属纳米酮装置的化学感测芯片。

公开(公告)号：US09244015B2

公开(公告)日：2016-01-26

申请号：US13636784

申请日：2010-04-20

Applicant: Zhiyong Li ,  Min Hu ,  Fung Suong Ou ,  Wei Wu

Inventor： Zhiyong Li ,  Min Hu ,  Fung Suong Ou ,  Wei Wu

IPC: G01J3/44 ,  B05D5/06 ,  B44C1/22 ,  C23C16/48 ,  C25D5/02 ,  G02B5/08 ,  G01N21/65

CPC classification number: G01N21/658 ,  G01N21/648

Abstract: A self-arranging, luminescence-enhancement device 101 for surface-enhanced luminescence. The self-arranging, luminescence-enhancement device 101 for surface-enhanced luminescence includes a substrate 110, and a plurality 120 of flexible columnar structures. A flexible columnar structure 120-1 of the plurality 120 includes a flexible column 120-1A, and a metallic cap 120-1B coupled to the apex 120-1 C of the flexible column 120-1A. At least the flexible columnar structure 120-1 and a second flexible columnar structure 120-2 are configured to self-arrange into a close-packed configuration with at least one molecule 220-1 disposed between at least the metallic cap 120-1B and a second metallic cap 120-2B of respective flexible columnar structure 120-1 and second flexible columnar structure 120-2.

Abstract translation: 用于表面增强发光的自配置发光增强装置101。 用于表面增强发光的自配置发光增强装置101包括基板110和多个120个柔性柱状结构。 多个120的柔性柱状结构120-1包括柔性柱120-1A以及耦合到柔性柱120-1A的顶点120-1C的金属盖120-1B。 至少柔性柱状结构120-1和第二柔性柱状结构120-2构造成自配置成紧密堆积构造，其中至少一个分子220-1设置在至少金属盖120-1B和 各个柔性柱状结构120-1的第二金属盖120-2B和第二柔性柱状结构120-2。

公开(公告)号：US20150173656A1

公开(公告)日：2015-06-25

申请号：US14406601

申请日：2012-07-29

Applicant: Steven Barcelo ,  Zhiyong Li ,  Ansoon Kim ,  Gary Gibson

Inventor： Steven Barcelo ,  Zhiyong Li ,  Ansoon Kim ,  Gary Gibson

IPC: A61B5/1459 ,  A61B5/00

CPC classification number: A61B5/1459 ,  A61B5/0075 ,  A61B5/6862 ,  G01N21/658

Abstract: An implantable nanosensor includes a stent to be implanted inside a fluid conduit. The stent has a well in a surface of the stent. The implantable nanosensor further includes a nanoscale-patterned sensing substrate disposed in the well. The nanoscale-patterned sensing substrate is to produce an optical scattering response signal indicative of a presence of an analyte in a fluid carried by the fluid conduit when interrogated by an optical stimulus signal.

Abstract translation: 可植入纳米传感器包括待植入流体导管内的支架。 支架在支架表面有一个井。 可植入纳米传感器还包括设置在井中的纳米级图案感测基片。 纳米级图案化感测衬底将产生光学散射响应信号，该信号指示由光学刺激信号询问时由流体导管携带的流体中的分析物的存在。

公开(公告)号：US20150116706A1

公开(公告)日：2015-04-30

申请号：US14394287

申请日：2012-04-24

Applicant: Steven Barcelo ,  Zhiyong Li ,  Alexandre M. Bratkovski ,  Ansoon Kim

Inventor： Steven Barcelo ,  Zhiyong Li ,  Alexandre M. Bratkovski ,  Ansoon Kim

IPC: G01N21/65

CPC classification number: G01N21/658 ,  B82Y15/00 ,  G01N2201/06113 ,  Y10S977/954

Abstract: An apparatus for performing a sensing application includes a reservoir to contain a solution, a dispenser to dispense the solution from the reservoir, and a substrate having a plurality of nano-fingers positioned to receive the dispensed solution, in which the plurality of nano-fingers are flexible, such that the plurality of nano-fingers are configurable with respect to each other. The apparatus also includes an illumination source to illuminate the received solution, an analyte introduced around the plurality of nano-fingers, and the plurality of nano-fingers, in which light is to be emitted from the analyte in response to being illuminated. The apparatus further includes a detector to detect the light emitted from the analyte.

Abstract translation: 用于执行感测应用的装置包括容纳溶液的储存器，用于从储存器分配溶液的分配器以及具有多个纳米手指的基板，该多个纳米手指定位成接收分配的溶液，其中多个纳米手指 是柔性的，使得多个纳米手指可相对于彼此配置。 所述装置还包括照亮所接收的溶液的照明源，围绕所述多个纳米手指引入的分析物和所述多个纳米手指，其中光将响应于被照亮从分析物发射。 该装置还包括检测器，用于检测从分析物发射的光。

公开(公告)号：US08842265B2

公开(公告)日：2014-09-23

申请号：US13090016

申请日：2011-04-19

Applicant: David A. Fattal ,  Raymond G. Beausoieil ,  Zhiyong Li

Inventor： David A. Fattal ,  Raymond G. Beausoieil ,  Zhiyong Li

IPC: G01J3/44 ,  B82Y20/00 ,  G02B5/18 ,  B29D11/00

CPC classification number: B82Y20/00 ,  B29D11/00346 ,  B29D11/0074 ,  G02B5/1809 ,  G02B5/1828

Abstract: A configurable grating based on collapsing nano-fingers includes a substrate; and a plurality of bendable nano-fingers supported on the substrate. The nano-fingers may be formed in a regular first array and the nano-fingers may be formed in a spacing that, upon closing at their tops, forms a second array to act as an optical grating or a diagnostic tool. A method of fabricating a configurable optical grating based on collapsing nano-fingers is also disclosed, as well as a method of determining an open or closed state for a plurality of nano-fingers.

Abstract translation: 基于塌陷纳米指的可配置光栅包括基底; 以及支撑在基板上的多个可弯曲的纳米手指。 纳米指可以形成为规则的第一阵列，并且纳米指可以以间隔形成，在其顶部关闭时，形成第二阵列以用作光栅或诊断工具。 还公开了一种基于塌陷纳米手指制造可配置光栅的方法，以及确定多个纳米手指的打开或关闭状态的方法。

公开(公告)号：US08773882B2

公开(公告)日：2014-07-08

申请号：US12761300

申请日：2010-04-15

Applicant: Zhiyong Li ,  Warren Robinett

Inventor： Zhiyong Li ,  Warren Robinett

IPC: G11C5/06 ,  G11C5/12 ,  B82Y10/00 ,  B82B1/00 ,  B82B3/00 ,  B82Y40/00

CPC classification number: G11C5/06 ,  B82B1/00 ,  B82B3/00 ,  B82Y10/00 ,  B82Y40/00 ,  G11C5/12 ,  G11C2213/81 ,  H01L29/0665 ,  H01L29/0673 ,  H01L29/0676 ,  H01L29/068 ,  H01L51/0595 ,  Y10S977/762 ,  Y10S977/94

Abstract: Certain embodiments of the present invention are directed to a method of programming nanowire-to-conductive element electrical connections. The method comprises: providing a substrate including a number of conductive elements overlaid with a first layer of nanowires, at least some of the conductive elements electrically coupled to more than one of the nanowires through individual switching junctions, each of the switching junctions configured in either a low-conductance state or a high-conductance state; and switching a portion of the switching junctions from the low-conductance state to the high-conductance state or the high-conductance state to the low-conductance state so that individual nanowires of the first layer of nanowires are electrically coupled to different conductive elements of the number of conductive elements using a different one of the switching junctions configured in the high-conductance state. Other embodiments of the present invention are directed to a nanowire structure including a mixed-scale interface.

Abstract translation: 本发明的某些实施例涉及一种编程纳米线至导电元件电连接的方法。 该方法包括：提供包括覆盖有第一纳米线层的多个导电元件的衬底，至少一些导电元件通过单独的开关结与多于一个的纳米线电耦合，每个开关结配置在 低电导状态或高电导状态; 以及将所述开关结的一部分从所述低电导状态切换到所述高电导状态或所述高电导状态至所述低电导状态，使得所述第一纳米线层的单个纳米线电耦合到不同的导电元件 使用在高电导状态下配置的不同的一个开关结的导电元件的数量。 本发明的其它实施方案涉及包括混合规模界面的纳米线结构。

公开(公告)号：US08665432B2

公开(公告)日：2014-03-04

申请号：US12915148

申请日：2010-10-29

Applicant: Min Hu ,  Michael Josef Stuke ,  Zhiyong Li ,  Wei Wu ,  Fung Suong Ou ,  Shih-Yuan Wang ,  Lars Helge Thylen

Inventor： Min Hu ,  Michael Josef Stuke ,  Zhiyong Li ,  Wei Wu ,  Fung Suong Ou ,  Shih-Yuan Wang ,  Lars Helge Thylen

IPC: G01N21/65

CPC classification number: G01J3/44 ,  G01N21/658

Abstract: An apparatus for performing surface enhanced Raman spectroscopy (SERS) includes a substrate and a plurality of nano-pillars, each of the plurality of nano-pillars having a first end attached to the substrate, a second end located distally from the substrate, and a body portion extending between the first end and the second end, in which the plurality of nano-pillars are arranged in an array on the substrate, and in which each of the plurality of nano-pillars is formed of a polymer material that is functionalized to expand in the presence of a fluid to cause gaps between the plurality of nano-pillars to shrink when the fluid is supplied onto the nano-pillars.

Abstract translation: 用于进行表面增强拉曼光谱（SERS）的设备包括基底和多个纳米柱，多个纳米柱中的每一个具有连接到基底的第一端，位于远离基底的第二端，以及 主体部分在所述第一端和所述第二端之间延伸，其中所述多个纳米柱以阵列布置在所述基底上，并且所述多个纳米柱中的每一个由聚合物材料形成，所述聚合物材料被官能化为 在存在流体的情况下膨胀，以便当将流体供应到纳米支柱上时，使多个纳米柱之间的间隙收缩。

公开(公告)号：US20140024131A1

公开(公告)日：2014-01-23

申请号：US14006721

申请日：2011-03-23

Applicant: Ansoon Kim ,  Zhiyong Li ,  Stanley R. Williams

Inventor： Ansoon Kim ,  Zhiyong Li ,  Stanley R. Williams

IPC: G01N21/00

CPC classification number: G01N21/00 ,  G01N21/554 ,  G01N21/648 ,  G01N21/658

Abstract: A hybrid nanostructure for molecular analysis is disclosed. The structure includes a plurality of nanofingers wherein each nanofinger is coated with a metal coating, is attached at one end to a substrate, and is freely bendable along its length such that the second ends of each nanofinger are capable of movement toward each other to form a cavity. The structure further includes a nanoparticle trapped in the cavity. An array of hybrid nanostructures and a method for fabricating the hybrid nanostructures are also disclosed.

Abstract translation: 公开了用于分子分析的杂化纳米结构。 该结构包括多个纳米针，其中每个纳米针涂覆有金属涂层，其一端连接到基底，并且可沿其长度自由弯曲，使得每个纳米针的第二端能够朝向彼此移动以形成 一个空腔。 该结构还包括捕获在空腔中的纳米颗粒。 还公开了一系列混合纳米结构和制备混合纳米结构的方法。

公开(公告)号：US08559003B2

公开(公告)日：2013-10-15

申请号：US13384456

申请日：2009-09-17

Applicant: Huei Pei Kuo ,  Shih-Yuan Wang ,  Min Hu ,  Zhiyong Li ,  Alexandre M. Bratkovski

Inventor： Huei Pei Kuo ,  Shih-Yuan Wang ,  Min Hu ,  Zhiyong Li ,  Alexandre M. Bratkovski

IPC: G01J3/44

CPC classification number: G01N21/658 ,  B82Y15/00 ,  B82Y30/00

Abstract: An electrically driven device for surface enhanced Raman spectroscopy includes a first electrode, a substrate positioned proximate to the first electrode, a plurality of cone shaped protrusions formed integrally with or on a substrate surface, a Raman signal-enhancing material coated on each protrusion, and a second electrode positioned relative to the first electrode at a predetermined distance. Each of the protrusions has a tip with a radius of curvature ranging from about 0.1 nm to about 100 nm. The second electrode is positioned relative to the first electrode such that the electrodes together produce an electric field when a voltage bias is applied therebetween. The electric field has a field distribution that creates a stronger field gradient at a region proximate to the tips than at other portions of the substrate.

Abstract translation: 用于表面增强拉曼光谱的电驱动装置包括第一电极，靠近第一电极定位的基板，与基底表面一体地形成的多个锥形突起，涂覆在每个突起上的拉曼信号增强材料，以及 相对于第一电极以预定距离定位的第二电极。 每个突起具有具有约0.1nm至约100nm范围的曲率半径的尖端。 第二电极相对于第一电极定位，使得当在其之间施加电压偏置时，电极一起产生电场。 电场具有场分布，其在靠近尖端的区域处产生比在衬底的其它部分更强的场梯度。

公开(公告)号：US08520202B2

公开(公告)日：2013-08-27

申请号：US13233671

申请日：2011-09-15

Applicant: Zhiyong Li

Inventor： Zhiyong Li

IPC: G01J3/44 ,  G01N21/65

CPC classification number: G01N21/658

Abstract: An asymmetrical-nanofinger device for surface-enhanced luminescence. The device includes a substrate, and a plurality of nanofingers coupled with the substrate. The plurality of nanofingers includes a primary nanofinger having a primary active-material cap, and a secondary nanofinger having a secondary active-material cap. An average diameter of the primary active-material cap is substantially greater than an average diameter of the secondary active-material cap. The primary nanofinger and secondary nanofinger of the plurality of nanofingers are to self-arrange into a close-packed configuration with an analyte molecule disposed between the primary active-material cap and the secondary active-material cap. A method for fabricating the asymmetrical-nanofinger device, and an optical apparatus including an optical component that includes the asymmetrical-nanofinger device are also provided.

Abstract translation: 用于表面增强发光的非对称纳米方形器件。 该器件包括衬底和与衬底耦合的多个纳米器件。 多个纳米针包括具有主要活性材料帽的初级纳米针，和具有次级活性材料帽的次级纳米针。 初级活性材料盖的平均直径基本上大于第二活性材料盖的平均直径。 多个纳米针的初级纳米针和次级纳米针将自动排列成紧密堆积的构型，分析物分子设置在主活性材料帽和辅助活性材料帽之间。 还提供了一种用于制造非对称纳米酮装置的方法，以及包括包括非对称纳米装置的光学部件的光学装置。