公开(公告)号：US20210291137A1

公开(公告)日：2021-09-23

申请号：US17257816

申请日：2019-07-01

Applicant: Arizona Board of Regents on Behalf of Arizona State University

Inventor： Quan Qing ,  Ching-wei Tsao ,  Peiming Zhang

IPC: B01J19/00 ,  C07K1/04

Abstract: The present disclosure provides an apparatus for synthesizing a biopolymer, a method for preparing an apparatus for synthesizing a biopolymer, and a method of synthesizing a biopolymer. The apparatus comprises (a) a substrate comprising a top surface and a plurality of wells, wherein each of the plurality of wells comprises a first electrode disposed on the bottom of the well and a linker attached to the sides of the well; and (b) a fluidic chamber system disposed on the top surface of the substrate.

公开(公告)号：US11125743B2

公开(公告)日：2021-09-21

申请号：US16279045

申请日：2019-02-19

Applicant: Arizona Board of Regents on behalf of Arizona State University

Inventor： Alexander Green ,  Duo Ma ,  Luhui Shen ,  Chris Diehnelt

IPC: G01N33/543 ,  G01N33/53 ,  G01N33/569 ,  C07K19/00

Abstract: Provided herein are methods and systems for low-cost, low-equipment detection of pathogens in biological sample. In particular, provided herein is a low-cost method for detecting norovirus that provides reliable, visible test with femtomolar, attomolar, and zeptomolar detection limits and that uses materials suitable for deployment of the methods in the field.

公开(公告)号：US11117212B2

公开(公告)日：2021-09-14

申请号：US15901643

申请日：2018-02-21

Applicant: Arizona Board of Regents on behalf of Arizona State University

Inventor： Keng Hsu ,  Anagh Deshpande

IPC: B23K20/10 ,  B33Y10/00 ,  B33Y30/00 ,  B33Y70/00

Abstract: Ultrasonic filament modeling systems and methods may be utilized to achieve room-temperature 3-D printing of solid (>95%) metal materials. A vibrating tool is applied to a metal filament to form a voxel, inducing mechanical deformation as well as inter-and intra-layer mass transport. Desired structures may be built on a voxel-by-voxel basis. Additionally, by varying the applied ultrasonic energy, the microstructure of the resulting structure may be controlled.

公开(公告)号：US20210269869A1

公开(公告)日：2021-09-02

申请号：US17184201

申请日：2021-02-24

Applicant: Arizona Board of Regents on behalf of Arizona State University

Inventor： Stuart Lindsay

IPC: C12Q1/6869 ,  C12Q1/00 ,  G01N33/487 ,  G16B30/20 ,  G16B40/10

Abstract: The present disclosure provides devices, systems, and methods related to sequencing a biopolymer. In particular, the present disclosure provides methods of obtaining a bioelectronic signature based on current fluctuations that correspond to the activity of an enzyme-of-interest. As described herein, certain aspects of the bioelectronic signature can be used to determine the sequence of a biopolymer.

公开(公告)号：US20210268050A1

公开(公告)日：2021-09-02

申请号：US17259849

申请日：2019-07-12

Applicant: Arizona board of regents on behalf of Arizona state university

Inventor： Douglas Grant MCFADDEN ,  John CHRISTIE ,  Joseph BLATTMAN ,  Mohammed Masmudur RAHMAN

IPC: A61K35/768 ,  C07K14/525 ,  A61K35/28 ,  A61K35/14 ,  A61K45/06 ,  A61P35/00

Abstract: Disclosed herein, in certain embodiments, is a method of inhibiting or treating a cancer with use of a TNF expressing myxoma virus. Also disclosed herein are methods of inhibiting or treating a cancer with use of a mononuclear peripheral blood cells and/or a bone marrow cells treated with a TNF-expressing myxoma virus. Some aspects relate to engineered myxoma virus and pharmaceutical compositions for use with one or more of the methods described herein.

公开(公告)号：US11075026B2

公开(公告)日：2021-07-27

申请号：US16399924

申请日：2019-04-30

Applicant: ARIZONA BOARD OF REGENTS ON BEHALF OF ARIZONA STATE UNIVERSITY

Inventor： Minglu Liu ,  Karl Sieradzki ,  Brandon Dowd ,  Rodolfo E. Diaz

IPC: H01F1/147 ,  H01F41/26 ,  C25D3/12 ,  B32B15/08 ,  C22C19/03 ,  B32B7/025

Abstract: Embodiments herein describe techniques for a magnetic conductive device including a substrate, an under layer above the substrate, and a magnetic conductive layer including NiFe alloy formed on the under layer. A method for forming a magnetic conductive device includes forming a support stack including an under layer above a substrate, cleaning the support stack, and performing electrodeposition on the under layer by placing the support stack into a plating bath to form NiFe alloy on the under layer. The NiFe alloy includes Ni in a range of about 74% to about 84%, and Fe in a range of about 26% to about 16%. Other embodiments may be described and/or claimed.

公开(公告)号：US20210223257A1

公开(公告)日：2021-07-22

申请号：US17249863

申请日：2021-03-16

Applicant: Arizona Board of Regents on behalf of Arizona State University

Inventor： Stephen Albert JOHNSTON ,  Phillip STAFFORD ,  Jian ZHANG ,  Luhui SHEN

IPC: G01N33/68 ,  A61K39/00 ,  A61K45/06

Abstract: Disclosed herein are methods and systems for determining microsatellite instability. In some embodiments, the disclosed methods and systems are used for determining whether a cancer patient has high microsatellite instability (MSI-H). MSI-H patients have remarkably good responses to immunotherapy, such as checkpoint inhibitors immunotherapy. Therefore, the disclosed methods and systems can be used for identifying MSI-H and thus, patients as candidates for immunotherapy. In turn, the disclosed methods and systems can be used to predict responsiveness to immunotherapy. In some embodiments, the methods further include providing an immunotherapy to the MSI-H patient. Also disclosed are vaccines and compositions.

公开(公告)号：US11045169B2

公开(公告)日：2021-06-29

申请号：US15631672

申请日：2017-06-23

Applicant: ARIZONA BOARD OF REGENTS ON BEHALF OF ARIZONA STATE UNIVERSITY ,  Joel Barkley

Inventor： Barbara Smith ,  Joel Barkley ,  Christopher Miranda

IPC: A61B8/00 ,  A61B8/08 ,  A61B5/00 ,  A61B10/02 ,  G02B23/24 ,  H04N5/232

Abstract: A device comprises a cannula having a first end, a second end, and a channel between the first end and the second end; an imaging probe couplable to the first end of the cannula, where the imaging probe includes: a transducer, and a reflective surface; and a biopsy device coupled to the cannula, where the biopsy device is configured to collect a tissue sample from an organ of a patient.

公开(公告)号：US20210189238A1

公开(公告)日：2021-06-24

申请号：US17192337

申请日：2021-03-04

Applicant: ARIZONA BOARD OF REGENTS ON BEHALF OF ARIZONA STATE UNIVERSITY

Inventor： Edward Kavazanjian ,  Nasser Hamdan ,  Hamed Khodadadi Tirkolaei ,  Abdullah Almajed

IPC: C09K17/44 ,  C04B28/00 ,  C04B24/14 ,  E02D3/12

Abstract: The present disclosure provides a method of biocementation comprising contacting a granular, cohesionless soil with a solution, wherein the solution comprises urea, urease, a source of calcium ions, and a source of non-urease proteins, wherein the urea, urease, source of calcium ions, and source of non-urease proteins are provided in effective amounts suitable to cause crystallization of calcium carbonate.

公开(公告)号：US11034662B2

公开(公告)日：2021-06-15

申请号：US16659308

申请日：2019-10-21

Applicant: ARIZONA BOARD OF REGENTS ON BEHALF OF ARIZONA STATE UNIVERSITY

Inventor： Sidney Hecht ,  Omar Khdour ,  Sandipan Roy Chowdhury ,  Indrajit Bandyopadhyay

IPC: C07D279/18 ,  C07D279/20 ,  C07D417/04 ,  C07D417/14

Abstract: The invention provides compounds formula (I) and salts thereof: wherein R1, R2, R3, R6 and Y have any of the values defined in the specification. The compounds are useful for treatment or suppression of diseases associated with decreased mitochondrial function resulting in diminished ATP production and/or oxidative stress and/or lipid peroxidation.